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Taxifolin synergizes Andrographolide-induced cell death by attenuation of autophagy and augmentation of caspase dependent and independent cell death in HeLa cells.

Alzaharna M, Alqouqa I, Cheung HY.

PLoS One. 2017 Feb 9;12(2):e0171325. doi: 10.1371/journal.pone.0171325. eCollection 2017.


Andrographolide promotes vincristine-induced SK-NEP-1 tumor cell death via PI3K-AKT-p53 signaling pathway.

Zhang M, Xue E, Shao W.

Drug Des Devel Ther. 2016 Sep 28;10:3143-3152. eCollection 2016.


Prospects in the development of natural radioprotective therapeutics with anti-cancer properties from the plants of Uttarakhand region of India.

Painuli S, Kumar N.

J Ayurveda Integr Med. 2016 Mar;7(1):62-8. doi: 10.1016/j.jaim.2015.09.001. Epub 2016 May 28. Review.


Cytotoxicity and cell cycle arrest induced by andrographolide lead to programmed cell death of MDA-MB-231 breast cancer cell line.

Banerjee M, Chattopadhyay S, Choudhuri T, Bera R, Kumar S, Chakraborty B, Mukherjee SK.

J Biomed Sci. 2016 Apr 16;23:40. doi: 10.1186/s12929-016-0257-0.


Andrographolide inhibits prostate cancer by targeting cell cycle regulators, CXCR3 and CXCR7 chemokine receptors.

Mir H, Kapur N, Singh R, Sonpavde G, Lillard JW Jr, Singh S.

Cell Cycle. 2016;15(6):819-26. doi: 10.1080/15384101.2016.1148836.


Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials.

Jantan I, Ahmad W, Bukhari SN.

Front Plant Sci. 2015 Aug 25;6:655. doi: 10.3389/fpls.2015.00655. eCollection 2015. Review.


Andrographolide sodium bisulphite-induced inactivation of urease: inhibitory potency, kinetics and mechanism.

Mo ZZ, Wang XF, Zhang X, Su JY, Chen HM, Liu YH, Zhang ZB, Xie JH, Su ZR.

BMC Complement Altern Med. 2015 Jul 16;15:238. doi: 10.1186/s12906-015-0775-4.


Andrographis paniculata (Burm. f.) Wall. ex Nees: a review of ethnobotany, phytochemistry, and pharmacology.

Hossain MS, Urbi Z, Sule A, Hafizur Rahman KM.

ScientificWorldJournal. 2014;2014:274905. doi: 10.1155/2014/274905. Epub 2014 Dec 24. Review.


Andrographolide inhibits hypoxia-inducible factor-1 through phosphatidylinositol 3-kinase/AKT pathway and suppresses breast cancer growth.

Li J, Zhang C, Jiang H, Cheng J.

Onco Targets Ther. 2015 Feb 13;8:427-35. doi: 10.2147/OTT.S76116. eCollection 2015.


Chemopreventive efficacy of Andrographis paniculata on azoxymethane-induced aberrant colon crypt foci in vivo.

Al-Henhena N, Ying RP, Ismail S, Najm W, Khalifa SA, El-Seedi H, Ameen Abdulla M.

PLoS One. 2014 Nov 12;9(11):e111118. doi: 10.1371/journal.pone.0111118. eCollection 2014. Erratum in: PLoS One. 2015;10(4):e0119354. Najm, Wala [correct to Najm, Walaa]; Abdulla, Mahmood Ameen [corrected to Ameen Abdulla, Mahmood].


Andrographolide induces apoptosis of C6 glioma cells via the ERK-p53-caspase 7-PARP pathway.

Yang SH, Wang SM, Syu JP, Chen Y, Wang SD, Peng YS, Kuo MF, Kung HN.

Biomed Res Int. 2014;2014:312847. doi: 10.1155/2014/312847. Epub 2014 Aug 5.


Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitis-associated cancer.

Guo W, Sun Y, Liu W, Wu X, Guo L, Cai P, Wu X, Wu X, Shen Y, Shu Y, Gu Y, Xu Q.

Autophagy. 2014 Jun;10(6):972-85. doi: 10.4161/auto.28374.


Andrographolide suppress tumor growth by inhibiting TLR4/NF-κB signaling activation in insulinoma.

Zhang QQ, Ding Y, Lei Y, Qi CL, He XD, Lan T, Li JC, Gong P, Yang X, Geng JG, Wang LJ.

Int J Biol Sci. 2014 Mar 21;10(4):404-14. doi: 10.7150/ijbs.7723. eCollection 2014.


Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis.

Cabrera D, Gutiérrez J, Cabello-Verrugio C, Morales MG, Mezzano S, Fadic R, Casar JC, Hancke JL, Brandan E.

Skelet Muscle. 2014 Mar 21;4:6. doi: 10.1186/2044-5040-4-6. eCollection 2014.


Therapeutic Potential of Andrographolide Isolated from the Leaves of Andrographis paniculata Nees for Treating Lung Adenocarcinomas.

Tung YT, Chen HL, Tsai HC, Yang SH, Chang YC, Chen CM.

Evid Based Complement Alternat Med. 2013;2013:305898. doi: 10.1155/2013/305898. Epub 2013 Aug 20.


Experimental and Clinical Pharmacology of Andrographis paniculata and Its Major Bioactive Phytoconstituent Andrographolide.

Jayakumar T, Hsieh CY, Lee JJ, Sheu JR.

Evid Based Complement Alternat Med. 2013;2013:846740. doi: 10.1155/2013/846740. Epub 2013 Mar 24.


Taxifolin enhances andrographolide-induced mitotic arrest and apoptosis in human prostate cancer cells via spindle assembly checkpoint activation.

Zhang ZR, Al Zaharna M, Wong MM, Chiu SK, Cheung HY.

PLoS One. 2013;8(1):e54577. doi: 10.1371/journal.pone.0054577. Epub 2013 Jan 28.


HMPL-004 (Andrographis paniculata extract) prevents development of murine colitis by inhibiting T-cell proliferation and TH1/TH17 responses.

Michelsen KS, Wong MH, Ko B, Thomas LS, Dhall D, Targan SR.

Inflamm Bowel Dis. 2013 Jan;19(1):151-64. doi: 10.1002/ibd.22983.

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