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Items: 1 to 20 of 186

1.

Human subtilase SKI-1/S1P is a master regulator of the HCV Lifecycle and a potential host cell target for developing indirect-acting antiviral agents.

Olmstead AD, Knecht W, Lazarov I, Dixit SB, Jean F.

PLoS Pathog. 2012 Jan;8(1):e1002468. doi: 10.1371/journal.ppat.1002468. Epub 2012 Jan 5.

2.

Human Subtilisin Kexin Isozyme-1 (SKI-1)/Site-1 Protease (S1P) regulates cytoplasmic lipid droplet abundance: A potential target for indirect-acting anti-dengue virus agents.

Hyrina A, Meng F, McArthur SJ, Eivemark S, Nabi IR, Jean F.

PLoS One. 2017 Mar 24;12(3):e0174483. doi: 10.1371/journal.pone.0174483. eCollection 2017.

3.

SKI-1/S1P inhibitor PF-429242 impairs the onset of HCV infection.

Blanchet M, Sureau C, Guévin C, Seidah NG, Labonté P.

Antiviral Res. 2015 Mar;115:94-104. doi: 10.1016/j.antiviral.2014.12.017. Epub 2015 Jan 5.

PMID:
25573299
4.

The Hepatitis C Virus-induced NLRP3 Inflammasome Activates the Sterol Regulatory Element-binding Protein (SREBP) and Regulates Lipid Metabolism.

McRae S, Iqbal J, Sarkar-Dutta M, Lane S, Nagaraj A, Ali N, Waris G.

J Biol Chem. 2016 Feb 12;291(7):3254-67. doi: 10.1074/jbc.M115.694059. Epub 2015 Dec 23.

5.

Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals.

Hawkins JL, Robbins MD, Warren LC, Xia D, Petras SF, Valentine JJ, Varghese AH, Wang IK, Subashi TA, Shelly LD, Hay BA, Landschulz KT, Geoghegan KF, Harwood HJ Jr.

J Pharmacol Exp Ther. 2008 Sep;326(3):801-8. doi: 10.1124/jpet.108.139626. Epub 2008 Jun 24.

6.

Gene set enrichment analysis reveals several globally affected pathways due to SKI-1/S1P inhibition in HepG2 cells.

De Windt A, Rai M, Bernier L, Thelen K, Soini J, Lefebvre C, Chintawar S, Lavigne J, Saarinen L, Kytömäki L, Munzer JS, Lütjohann D, Pandolfo M, Davignon J, Seidah NG, Laaksonen R.

DNA Cell Biol. 2007 Nov;26(11):765-72.

PMID:
17867930
7.

Hepatitis C virus stimulates low-density lipoprotein receptor expression to facilitate viral propagation.

Syed GH, Tang H, Khan M, Hassanein T, Liu J, Siddiqui A.

J Virol. 2014 Mar;88(5):2519-29. doi: 10.1128/JVI.02727-13. Epub 2013 Dec 18.

8.

Targeting the proteolytic processing of the viral glycoprotein precursor is a promising novel antiviral strategy against arenaviruses.

Rojek JM, Pasqual G, Sanchez AB, Nguyen NT, de la Torre JC, Kunz S.

J Virol. 2010 Jan;84(1):573-84. doi: 10.1128/JVI.01697-09.

9.

SKI-1/S1P inhibition: a promising surrogate to statins to block hepatitis C virus replication.

Blanchet M, Seidah NG, Labonté P.

Antiviral Res. 2012 Aug;95(2):159-66. doi: 10.1016/j.antiviral.2012.05.006. Epub 2012 May 22. Review.

PMID:
22626636
10.

Suppressive Effects of the Site 1 Protease (S1P) Inhibitor, PF-429242, on Dengue Virus Propagation.

Uchida L, Urata S, Ulanday GE, Takamatsu Y, Yasuda J, Morita K, Hayasaka D.

Viruses. 2016 Feb 10;8(2). pii: E46. doi: 10.3390/v8020046.

11.

Molecular characterization of the processing of arenavirus envelope glycoprotein precursors by subtilisin kexin isozyme-1/site-1 protease.

Burri DJ, Pasqual G, Rochat C, Seidah NG, Pasquato A, Kunz S.

J Virol. 2012 May;86(9):4935-46. doi: 10.1128/JVI.00024-12. Epub 2012 Feb 22.

12.

Recombinant expression, purification, and kinetic and inhibitor characterisation of human site-1-protease.

Bodvard K, Mohlin J, Knecht W.

Protein Expr Purif. 2007 Feb;51(2):308-19. Epub 2006 Aug 1.

PMID:
16973377
13.

A Molecular Sensor To Characterize Arenavirus Envelope Glycoprotein Cleavage by Subtilisin Kexin Isozyme 1/Site 1 Protease.

Oppliger J, da Palma JR, Burri DJ, Bergeron E, Khatib AM, Spiropoulou CF, Pasquato A, Kunz S.

J Virol. 2015 Oct 28;90(2):705-14. doi: 10.1128/JVI.01751-15. Print 2016 Jan 15.

14.

Hepatitis C Virus Increases Occludin Expression via the Upregulation of Adipose Differentiation-Related Protein.

Branche E, Conzelmann S, Parisot C, Bedert L, Lévy PL, Bartosch B, Clément S, Negro F.

PLoS One. 2016 Jan 5;11(1):e0146000. doi: 10.1371/journal.pone.0146000. eCollection 2016.

15.

Site-1 protease, a novel metabolic target for glioblastoma.

Caruana BT, Skoric A, Brown AJ, Lutze-Mann LH.

Biochem Biophys Res Commun. 2017 Aug 26;490(3):760-766. doi: 10.1016/j.bbrc.2017.06.114. Epub 2017 Jun 20.

PMID:
28645614
16.
17.

Differential recognition of Old World and New World arenavirus envelope glycoproteins by subtilisin kexin isozyme 1 (SKI-1)/site 1 protease (S1P).

Burri DJ, da Palma JR, Seidah NG, Zanotti G, Cendron L, Pasquato A, Kunz S.

J Virol. 2013 Jun;87(11):6406-14. doi: 10.1128/JVI.00072-13. Epub 2013 Mar 27.

18.

Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis.

Patra D, DeLassus E, Liang G, Sandell LJ.

PLoS One. 2014 Aug 22;9(8):e105674. doi: 10.1371/journal.pone.0105674. eCollection 2014.

19.

Zymogen activation and subcellular activity of subtilisin kexin isozyme 1/site 1 protease.

da Palma JR, Burri DJ, Oppliger J, Salamina M, Cendron L, de Laureto PP, Seidah NG, Kunz S, Pasquato A.

J Biol Chem. 2014 Dec 26;289(52):35743-56. doi: 10.1074/jbc.M114.588525. Epub 2014 Nov 5.

20.

Reduced sterol regulatory element-binding protein (SREBP) processing through site-1 protease (S1P) inhibition alters oligodendrocyte differentiation in vitro.

Monnerie H, Romer M, Jensen BK, Millar JS, Jordan-Sciutto KL, Kim SF, Grinspan JB.

J Neurochem. 2017 Jan;140(1):53-67. doi: 10.1111/jnc.13721. Epub 2016 Aug 2.

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