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Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells.

Toller IM, Neelsen KJ, Steger M, Hartung ML, Hottiger MO, Stucki M, Kalali B, Gerhard M, Sartori AA, Lopes M, Müller A.

Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14944-9. doi: 10.1073/pnas.1100959108. Epub 2011 Sep 6.


Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair.

Moon SH, Lin L, Zhang X, Nguyen TA, Darlington Y, Waldman AS, Lu X, Donehower LA.

J Biol Chem. 2010 Apr 23;285(17):12935-47. doi: 10.1074/jbc.M109.071696. Epub 2010 Jan 29.


DNA damage signaling in response to double-strand breaks during mitosis.

Giunta S, Belotserkovskaya R, Jackson SP.

J Cell Biol. 2010 Jul 26;190(2):197-207. doi: 10.1083/jcb.200911156.


Lycopene inhibits Helicobacter pylori-induced ATM/ATR-dependent DNA damage response in gastric epithelial AGS cells.

Jang SH, Lim JW, Morio T, Kim H.

Free Radic Biol Med. 2012 Feb 1;52(3):607-615. doi: 10.1016/j.freeradbiomed.2011.11.010. Epub 2011 Nov 20.


Chronic hypoxia compromises repair of DNA double-strand breaks to drive genetic instability.

Kumareswaran R, Ludkovski O, Meng A, Sykes J, Pintilie M, Bristow RG.

J Cell Sci. 2012 Jan 1;125(Pt 1):189-99. doi: 10.1242/jcs.092262. Epub 2012 Jan 20.


Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks.

Sordet O, Redon CE, Guirouilh-Barbat J, Smith S, Solier S, Douarre C, Conti C, Nakamura AJ, Das BB, Nicolas E, Kohn KW, Bonner WM, Pommier Y.

EMBO Rep. 2009 Aug;10(8):887-93. doi: 10.1038/embor.2009.97. Epub 2009 Jun 26.


Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA-PK.

Meyer B, Voss KO, Tobias F, Jakob B, Durante M, Taucher-Scholz G.

Nucleic Acids Res. 2013 Jul;41(12):6109-18. doi: 10.1093/nar/gkt304. Epub 2013 Apr 24.


STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage.

Townsend PA, Cragg MS, Davidson SM, McCormick J, Barry S, Lawrence KM, Knight RA, Hubank M, Chen PL, Latchman DS, Stephanou A.

J Cell Sci. 2005 Apr 15;118(Pt 8):1629-39. Epub 2005 Mar 22. Retraction in: J Cell Sci. 2015 Mar 1;128(5):1064.


53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair.

Noon AT, Shibata A, Rief N, Löbrich M, Stewart GS, Jeggo PA, Goodarzi AA.

Nat Cell Biol. 2010 Feb;12(2):177-84. doi: 10.1038/ncb2017. Epub 2010 Jan 17.


PTIP regulates 53BP1 and SMC1 at the DNA damage sites.

Wu J, Prindle MJ, Dressler GR, Yu X.

J Biol Chem. 2009 Jul 3;284(27):18078-84. doi: 10.1074/jbc.M109.002527. Epub 2009 May 4.


The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax.

Goodarzi AA, Jeggo P, Lobrich M.

DNA Repair (Amst). 2010 Dec 10;9(12):1273-82. doi: 10.1016/j.dnarep.2010.09.013. Epub 2010 Oct 30. Review.


Role of ATM and the damage response mediator proteins 53BP1 and MDC1 in the maintenance of G(2)/M checkpoint arrest.

Shibata A, Barton O, Noon AT, Dahm K, Deckbar D, Goodarzi AA, Löbrich M, Jeggo PA.

Mol Cell Biol. 2010 Jul;30(13):3371-83. doi: 10.1128/MCB.01644-09. Epub 2010 Apr 26.


MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites.

Pei H, Zhang L, Luo K, Qin Y, Chesi M, Fei F, Bergsagel PL, Wang L, You Z, Lou Z.

Nature. 2011 Feb 3;470(7332):124-8. doi: 10.1038/nature09658.


Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin.

Savic V, Yin B, Maas NL, Bredemeyer AL, Carpenter AC, Helmink BA, Yang-Iott KS, Sleckman BP, Bassing CH.

Mol Cell. 2009 May 15;34(3):298-310. doi: 10.1016/j.molcel.2009.04.012.


Dephosphorylation of γ-H2AX by WIP1: an important homeostatic regulatory event in DNA repair and cell cycle control.

Moon SH, Nguyen TA, Darlington Y, Lu X, Donehower LA.

Cell Cycle. 2010 Jun 1;9(11):2092-6. Epub 2010 Jun 1.


Targeting protein for xenopus kinesin-like protein 2 (TPX2) regulates γ-histone 2AX (γ-H2AX) levels upon ionizing radiation.

Neumayer G, Helfricht A, Shim SY, Le HT, Lundin C, Belzil C, Chansard M, Yu Y, Lees-Miller SP, Gruss OJ, van Attikum H, Helleday T, Nguyen MD.

J Biol Chem. 2012 Dec 7;287(50):42206-22. doi: 10.1074/jbc.M112.385674. Epub 2012 Oct 8.


The opportunistic pathogen Pseudomonas aeruginosa activates the DNA double-strand break signaling and repair pathway in infected cells.

Elsen S, Collin-Faure V, Gidrol X, Lemercier C.

Cell Mol Life Sci. 2013 Nov;70(22):4385-97. doi: 10.1007/s00018-013-1392-3. Epub 2013 Jun 13.


Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells.

Rass E, Chandramouly G, Zha S, Alt FW, Xie A.

J Biol Chem. 2013 Mar 8;288(10):7086-95. doi: 10.1074/jbc.M112.445825. Epub 2013 Jan 26.


ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks.

Lee KY, Im JS, Shibata E, Dutta A.

Mol Cell. 2017 Oct 5;68(1):61-75.e5. doi: 10.1016/j.molcel.2017.08.021. Epub 2017 Sep 21.


Growth of persistent foci of DNA damage checkpoint factors is essential for amplification of G1 checkpoint signaling.

Yamauchi M, Oka Y, Yamamoto M, Niimura K, Uchida M, Kodama S, Watanabe M, Sekine I, Yamashita S, Suzuki K.

DNA Repair (Amst). 2008 Mar 1;7(3):405-17. doi: 10.1016/j.dnarep.2007.11.011. Epub 2008 Jan 8.


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