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Cell death regulation during influenza A virus infection by matrix (M1) protein: a model of viral control over the cellular survival pathway.

Halder UC, Bagchi P, Chattopadhyay S, Dutta D, Chawla-Sarkar M.

Cell Death Dis. 2011 Sep 1;2:e197. doi: 10.1038/cddis.2011.75.


Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome.

Beere HM, Wolf BB, Cain K, Mosser DD, Mahboubi A, Kuwana T, Tailor P, Morimoto RI, Cohen GM, Green DR.

Nat Cell Biol. 2000 Aug;2(8):469-75.


Negative regulation of the Apaf-1 apoptosome by Hsp70.

Saleh A, Srinivasula SM, Balkir L, Robbins PD, Alnemri ES.

Nat Cell Biol. 2000 Aug;2(8):476-83.


Reduction of caspase-8 and -9 cleavage is associated with increased c-FLIP and increased binding of Apaf-1 and Hsp70 after neonatal hypoxic/ischemic injury in mice overexpressing Hsp70.

Matsumori Y, Northington FJ, Hong SM, Kayama T, Sheldon RA, Vexler ZS, Ferriero DM, Weinstein PR, Liu J.

Stroke. 2006 Feb;37(2):507-12. Epub 2006 Jan 5.


PHAPI, CAS, and Hsp70 promote apoptosome formation by preventing Apaf-1 aggregation and enhancing nucleotide exchange on Apaf-1.

Kim HE, Jiang X, Du F, Wang X.

Mol Cell. 2008 Apr 25;30(2):239-47. doi: 10.1016/j.molcel.2008.03.014. Erratum in: Mol Cell. 2008 Dec 26;32(6):888.


MicroRNA-17-mediated down-regulation of apoptotic protease activating factor 1 attenuates apoptosome formation and subsequent apoptosis of cardiomyocytes.

Song S, Seo HH, Lee SY, Lee CY, Lee J, Yoo KJ, Yoon C, Choi E, Hwang KC, Lee S.

Biochem Biophys Res Commun. 2015 Sep 18;465(2):299-304. doi: 10.1016/j.bbrc.2015.08.028. Epub 2015 Aug 8.


Phosphorylation drives an apoptotic protein to activate antiapoptotic genes: paradigm of influenza A matrix 1 protein function.

Halder UC, Bhowmick R, Roy Mukherjee T, Nayak MK, Chawla-Sarkar M.

J Biol Chem. 2013 May 17;288(20):14554-68. doi: 10.1074/jbc.M112.447086. Epub 2013 Apr 2.


Hsp70 mutant proteins modulate additional apoptotic pathways and improve cell survival.

Ran R, Zhou G, Lu A, Zhang L, Tang Y, Rigby AC, Sharp FR.

Cell Stress Chaperones. 2004 Autumn;9(3):229-42.


Differential sensitivity to apoptosome apparatus activation in non-small cell lung carcinoma and the lung.

Moravcikova E, Krepela E, Prochazka J, Benkova K, Pauk N.

Int J Oncol. 2014 May;44(5):1443-54. doi: 10.3892/ijo.2014.2333. Epub 2014 Mar 10.


The chaperone function of hsp70 is required for protection against stress-induced apoptosis.

Mosser DD, Caron AW, Bourget L, Meriin AB, Sherman MY, Morimoto RI, Massie B.

Mol Cell Biol. 2000 Oct;20(19):7146-59.


Pro-apoptotic proteins released from the mitochondria regulate the protein composition and caspase-processing activity of the native Apaf-1/caspase-9 apoptosome complex.

Twiddy D, Brown DG, Adrain C, Jukes R, Martin SJ, Cohen GM, MacFarlane M, Cain K.

J Biol Chem. 2004 May 7;279(19):19665-82. Epub 2004 Mar 1.


Interaction of influenza A virus M1 matrix protein with caspases.

Zhirnov OP, Ksenofontov AL, Kuzmina SG, Klenk HD.

Biochemistry (Mosc). 2002 May;67(5):534-9.


Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation.

Stankiewicz AR, Lachapelle G, Foo CP, Radicioni SM, Mosser DD.

J Biol Chem. 2005 Nov 18;280(46):38729-39. Epub 2005 Sep 19.


Heat-shock protein 70 antagonizes apoptosis-inducing factor.

Ravagnan L, Gurbuxani S, Susin SA, Maisse C, Daugas E, Zamzami N, Mak T, Jäättelä M, Penninger JM, Garrido C, Kroemer G.

Nat Cell Biol. 2001 Sep;3(9):839-43.


Vaccinia Virus Encodes a Novel Inhibitor of Apoptosis That Associates with the Apoptosome.

Ryerson MR, Richards MM, Kvansakul M, Hawkins CJ, Shisler JL.

J Virol. 2017 Nov 14;91(23). pii: e01385-17. doi: 10.1128/JVI.01385-17. Print 2017 Dec 1.


Defective molecular timer in the absence of nucleotides leads to inefficient caspase activation.

Zhang H, Gogada R, Yadav N, Lella RK, Badeaux M, Ayres M, Gandhi V, Tang DG, Chandra D.

PLoS One. 2011 Jan 27;6(1):e16379. doi: 10.1371/journal.pone.0016379.


PSAP induces a unique Apaf-1 and Smac-dependent mitochondrial apoptotic pathway independent of Bcl-2 family proteins.

Li T, Zeng L, Gao W, Cui MZ, Fu X, Xu X.

Biochim Biophys Acta. 2013 Mar;1832(3):453-74. doi: 10.1016/j.bbadis.2012.11.016. Epub 2012 Nov 30.


Heat shock protein 70 inhibits the activity of Influenza A virus ribonucleoprotein and blocks the replication of virus in vitro and in vivo.

Li G, Zhang J, Tong X, Liu W, Ye X.

PLoS One. 2011 Feb 24;6(2):e16546. doi: 10.1371/journal.pone.0016546.


Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes.

Bratton SB, Walker G, Srinivasula SM, Sun XM, Butterworth M, Alnemri ES, Cohen GM.

EMBO J. 2001 Mar 1;20(5):998-1009.


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