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Items: 1 to 20 of 125

1.

Mammalian Pragmin regulates Src family kinases via the Glu-Pro-Ile-Tyr-Ala (EPIYA) motif that is exploited by bacterial effectors.

Safari F, Murata-Kamiya N, Saito Y, Hatakeyama M.

Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14938-43. doi: 10.1073/pnas.1107740108. Epub 2011 Aug 22.

2.

C-terminal Src kinase-mediated EPIYA phosphorylation of Pragmin creates a feed-forward C-terminal Src kinase activation loop that promotes cell motility.

Senda Y, Murata-Kamiya N, Hatakeyama M.

Cancer Sci. 2016 Jul;107(7):972-80. doi: 10.1111/cas.12962. Epub 2016 Jun 13.

3.

EPIYA motif is a membrane-targeting signal of Helicobacter pylori virulence factor CagA in mammalian cells.

Higashi H, Yokoyama K, Fujii Y, Ren S, Yuasa H, Saadat I, Murata-Kamiya N, Azuma T, Hatakeyama M.

J Biol Chem. 2005 Jun 17;280(24):23130-7. Epub 2005 Apr 13.

4.

Bacterial EPIYA effectors--where do they come from? What are they? Where are they going?

Hayashi T, Morohashi H, Hatakeyama M.

Cell Microbiol. 2013 Mar;15(3):377-85. doi: 10.1111/cmi.12040. Epub 2012 Nov 1. Review.

5.

c-Src and c-Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strains.

Mueller D, Tegtmeyer N, Brandt S, Yamaoka Y, De Poire E, Sgouras D, Wessler S, Torres J, Smolka A, Backert S.

J Clin Invest. 2012 Apr;122(4):1553-66. doi: 10.1172/JCI61143. Epub 2012 Mar 1.

6.

Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagA.

Naito M, Yamazaki T, Tsutsumi R, Higashi H, Onoe K, Yamazaki S, Azuma T, Hatakeyama M.

Gastroenterology. 2006 Apr;130(4):1181-90.

PMID:
16618412
7.

Structural basis and functional consequence of Helicobacter pylori CagA multimerization in cells.

Ren S, Higashi H, Lu H, Azuma T, Hatakeyama M.

J Biol Chem. 2006 Oct 27;281(43):32344-52. Epub 2006 Sep 5.

8.

Attenuation of Helicobacter pylori CagA x SHP-2 signaling by interaction between CagA and C-terminal Src kinase.

Tsutsumi R, Higashi H, Higuchi M, Okada M, Hatakeyama M.

J Biol Chem. 2003 Feb 7;278(6):3664-70. Epub 2002 Nov 21.

9.

Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of Western-type Helicobacter pylori strains.

Lind J, Backert S, Pfleiderer K, Berg DE, Yamaoka Y, Sticht H, Tegtmeyer N.

PLoS One. 2014 May 6;9(5):e96488. doi: 10.1371/journal.pone.0096488. eCollection 2014.

10.

Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of East Asian-type Helicobacter pylori strains.

Lind J, Backert S, Hoffmann R, Eichler J, Yamaoka Y, Perez-Perez GI, Torres J, Sticht H, Tegtmeyer N.

BMC Microbiol. 2016 Sep 2;16(1):201. doi: 10.1186/s12866-016-0820-6.

11.

c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs.

Stein M, Bagnoli F, Halenbeck R, Rappuoli R, Fantl WJ, Covacci A.

Mol Microbiol. 2002 Feb;43(4):971-80.

12.

C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK)--endogenous negative regulators of Src-family protein kinases.

Chong YP, Mulhern TD, Cheng HC.

Growth Factors. 2005 Sep;23(3):233-44. Review.

PMID:
16243715
13.

The Haemophilus ducreyi LspA1 protein inhibits phagocytosis by using a new mechanism involving activation of C-terminal Src kinase.

Dodd DA, Worth RG, Rosen MK, Grinstein S, van Oers NS, Hansen EJ.

MBio. 2014 May 20;5(3):e01178-14. doi: 10.1128/mBio.01178-14.

14.

Activation of Abl by Helicobacter pylori: a novel kinase for CagA and crucial mediator of host cell scattering.

Tammer I, Brandt S, Hartig R, König W, Backert S.

Gastroenterology. 2007 Apr;132(4):1309-19. Epub 2007 Feb 1.

PMID:
17408661
15.

Helicobacter pylori VacA, acting through receptor protein tyrosine phosphatase α, is crucial for CagA phosphorylation in human duodenum carcinoma cell line AZ-521.

Nakano M, Yahiro K, Yamasaki E, Kurazono H, Akada J, Yamaoka Y, Niidome T, Hatakeyama M, Suzuki H, Yamamoto T, Moss J, Isomoto H, Hirayama T.

Dis Model Mech. 2016 Dec 1;9(12):1473-1481.

16.

Focal adhesion kinase is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA.

Tsutsumi R, Takahashi A, Azuma T, Higashi H, Hatakeyama M.

Mol Cell Biol. 2006 Jan;26(1):261-76.

17.

Structural elements and allosteric mechanisms governing regulation and catalysis of CSK-family kinases and their inhibition of Src-family kinases.

Ia KK, Mills RD, Hossain MI, Chan KC, Jarasrassamee B, Jorissen RN, Cheng HC.

Growth Factors. 2010 Oct;28(5):329-50. doi: 10.3109/08977194.2010.484424. Review.

PMID:
20476842
18.

Role of Abl and Src family kinases in actin-cytoskeletal rearrangements induced by the Helicobacter pylori CagA protein.

Tegtmeyer N, Backert S.

Eur J Cell Biol. 2011 Nov;90(11):880-90. doi: 10.1016/j.ejcb.2010.11.006. Epub 2011 Jan 17. Review.

PMID:
21247656
19.

Mechanism of Csk-mediated down-regulation of Src family tyrosine kinases in epidermal growth factor signaling.

Matsuoka H, Nada S, Okada M.

J Biol Chem. 2004 Feb 13;279(7):5975-83. Epub 2003 Nov 12.

20.

C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases.

Chong YP, Chan AS, Chan KC, Williamson NA, Lerner EC, Smithgall TE, Bjorge JD, Fujita DJ, Purcell AW, Scholz G, Mulhern TD, Cheng HC.

J Biol Chem. 2006 Nov 3;281(44):32988-99. Epub 2006 Sep 7. Erratum in: J Biol Chem. 2015 Jan 2;290(1):240.

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