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Neurotoxic effects of the HCV core protein are mediated by sustained activation of ERK via TLR2 signaling.

Paulino AD, Ubhi K, Rockenstein E, Adame A, Crews L, Letendre S, Ellis R, Everall IP, Grant I, Masliah E.

J Neurovirol. 2011 Aug;17(4):327-40. doi: 10.1007/s13365-011-0039-0. Epub 2011 Jun 10.


Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins.

Chang S, Dolganiuc A, Szabo G.

J Leukoc Biol. 2007 Sep;82(3):479-87. Epub 2007 Jun 26.


Hepatitis C virus activates Bcl-2 and MMP-2 expression through multiple cellular signaling pathways.

Li Y, Zhang Q, Liu Y, Luo Z, Kang L, Qu J, Liu W, Xia X, Liu Y, Wu K, Wu J.

J Virol. 2012 Dec;86(23):12531-43. doi: 10.1128/JVI.01136-12. Epub 2012 Sep 5.


Hepatitis C virus core protein induces neuroimmune activation and potentiates Human Immunodeficiency Virus-1 neurotoxicity.

Vivithanaporn P, Maingat F, Lin LT, Na H, Richardson CD, Agrawal B, Cohen EA, Jhamandas JH, Power C.

PLoS One. 2010 Sep 21;5(9):e12856. doi: 10.1371/journal.pone.0012856.


Hepatitis C virus core protein enhances HIV-1 replication in human macrophages through TLR2, JNK, and MEK1/2-dependent upregulation of TNF-α and IL-6.

Swaminathan G, Pascual D, Rival G, Perales-Linares R, Martin-Garcia J, Navas-Martin S.

FEBS Lett. 2014 Sep 17;588(18):3501-10. doi: 10.1016/j.febslet.2014.08.009. Epub 2014 Aug 14.


HCV-induced miR-21 contributes to evasion of host immune system by targeting MyD88 and IRAK1.

Chen Y, Chen J, Wang H, Shi J, Wu K, Liu S, Liu Y, Wu J.

PLoS Pathog. 2013;9(4):e1003248. doi: 10.1371/journal.ppat.1003248. Epub 2013 Apr 25.


Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation.

Dolganiuc A, Oak S, Kodys K, Golenbock DT, Finberg RW, Kurt-Jones E, Szabo G.

Gastroenterology. 2004 Nov;127(5):1513-24.


Effects of HCV on basal and tat-induced HIV LTR activation.

Sengupta S, Powell E, Kong L, Blackard JT.

PLoS One. 2013 Jun 10;8(6):e64956. doi: 10.1371/journal.pone.0064956. Print 2013.


Hepatitis C virus core protein induces fibrogenic actions of hepatic stellate cells via toll-like receptor 2.

Coenen M, Nischalke HD, Krämer B, Langhans B, Glässner A, Schulte D, Körner C, Sauerbruch T, Nattermann J, Spengler U.

Lab Invest. 2011 Sep;91(9):1375-82. doi: 10.1038/labinvest.2011.78. Epub 2011 May 2.


Hepatitis C virus core protein triggers expansion and activation of CD4(+)CD25(+) regulatory T cells in chronic hepatitis C patients.

Zhai N, Chi X, Li T, Song H, Li H, Jin X, Crispe IN, Su L, Niu J, Tu Z.

Cell Mol Immunol. 2015 Nov;12(6):743-9. doi: 10.1038/cmi.2014.119. Epub 2014 Dec 22.


HCV core protein inhibits polarization and activity of both M1 and M2 macrophages through the TLR2 signaling pathway.

Zhang Q, Wang Y, Zhai N, Song H, Li H, Yang Y, Li T, Guo X, Chi B, Niu J, Crispe IN, Su L, Tu Z.

Sci Rep. 2016 Oct 27;6:36160. doi: 10.1038/srep36160.


HIV and HCV Co-Culture Promotes Profibrogenic Gene Expression through an Epimorphin-Mediated ERK Signaling Pathway in Hepatic Stellate Cells.

Shi L, Qin E, Zhou J, Zhao J, Nie W, Jiang T, Chen W, Wu D, Huang L, Liu L, Lv L, Zhao M, Zhang Z, Wang F.

PLoS One. 2016 Jun 30;11(6):e0158386. doi: 10.1371/journal.pone.0158386. eCollection 2016.


Involvement of hepatitis C virus NS5A hyperphosphorylation mediated by casein kinase I-α in infectious virus production.

Masaki T, Matsunaga S, Takahashi H, Nakashima K, Kimura Y, Ito M, Matsuda M, Murayama A, Kato T, Hirano H, Endo Y, Lemon SM, Wakita T, Sawasaki T, Suzuki T.

J Virol. 2014 Jul;88(13):7541-55. doi: 10.1128/JVI.03170-13. Epub 2014 Apr 23.


Extracellular hepatitis C virus core protein activates STAT3 in human monocytes/macrophages/dendritic cells via an IL-6 autocrine pathway.

Tacke RS, Tosello-Trampont A, Nguyen V, Mullins DW, Hahn YS.

J Biol Chem. 2011 Mar 25;286(12):10847-55. doi: 10.1074/jbc.M110.217653. Epub 2011 Jan 31.


Hepatic TLR2 & TLR4 expression correlates with hepatic inflammation and TNF-α in HCV & HCV/HIV infection.

Berzsenyi MD, Roberts SK, Preiss S, Woollard DJ, Beard MR, Skinner NA, Bowden DS, Visvanathan K.

J Viral Hepat. 2011 Dec;18(12):852-60. doi: 10.1111/j.1365-2893.2010.01390.x. Epub 2010 Nov 3.


Hepatitis C Virus Induces MDSCs-Like Monocytes through TLR2/PI3K/AKT/STAT3 Signaling.

Zhai N, Li H, Song H, Yang Y, Cui A, Li T, Niu J, Crispe IN, Su L, Tu Z.

PLoS One. 2017 Jan 23;12(1):e0170516. doi: 10.1371/journal.pone.0170516. eCollection 2017.


Hepatitis C virus core protein induces homotolerance and cross-tolerance to Toll-like receptor ligands by activation of Toll-like receptor 2.

Chung H, Watanabe T, Kudo M, Chiba T.

J Infect Dis. 2010 Sep 15;202(6):853-61. doi: 10.1086/655812.


Hepatitis C virus core protein triggers hepatic angiogenesis by a mechanism including multiple pathways.

Hassan M, Selimovic D, Ghozlan H, Abdel-kader O.

Hepatology. 2009 May;49(5):1469-82. doi: 10.1002/hep.22849.


Induction of interleukin-6 by hepatitis C virus core protein in hepatitis C-associated mixed cryoglobulinemia and B-cell non-Hodgkin's lymphoma.

Feldmann G, Nischalke HD, Nattermann J, Banas B, Berg T, Teschendorf C, Schmiegel W, Dührsen U, Halangk J, Iwan A, Sauerbruch T, Caselmann WH, Spengler U.

Clin Cancer Res. 2006 Aug 1;12(15):4491-8.


Dysregulation of toll-like receptor (TLR) 2 expression on monocytes and upregulation of the frequency of T cells expressing TLR2 in patients with chronic hepatitis C virus infection.

Ronit A, Salem M, Hartling HJ, Gaardbo JC, Ullum H, Gerstoft J, Nielsen SD.

APMIS. 2013 May;121(5):437-46. doi: 10.1111/apm.12013. Epub 2012 Oct 22.


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