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p66Alpha-MBD2 coiled-coil interaction and recruitment of Mi-2 are critical for globin gene silencing by the MBD2-NuRD complex.

Gnanapragasam MN, Scarsdale JN, Amaya ML, Webb HD, Desai MA, Walavalkar NM, Wang SZ, Zu Zhu S, Ginder GD, Williams DC Jr.

Proc Natl Acad Sci U S A. 2011 May 3;108(18):7487-92. doi: 10.1073/pnas.1015341108. Epub 2011 Apr 13.


An intrinsically disordered region of methyl-CpG binding domain protein 2 (MBD2) recruits the histone deacetylase core of the NuRD complex.

Desai MA, Webb HD, Sinanan LM, Scarsdale JN, Walavalkar NM, Ginder GD, Williams DC Jr.

Nucleic Acids Res. 2015 Mar 31;43(6):3100-13. doi: 10.1093/nar/gkv168. Epub 2015 Mar 9.


p66alpha and p66beta of the Mi-2/NuRD complex mediate MBD2 and histone interaction.

Brackertz M, Gong Z, Leers J, Renkawitz R.

Nucleic Acids Res. 2006 Jan 13;34(2):397-406. Print 2006.


MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing.

Jin SG, Jiang CL, Rauch T, Li H, Pfeifer GP.

J Biol Chem. 2005 Apr 1;280(13):12700-9. Epub 2005 Jan 27.


MBD2 and multiple domains of CHD4 are required for transcriptional repression by Mi-2/NuRD complexes.

Ramírez J, Dege C, Kutateladze TG, Hagman J.

Mol Cell Biol. 2012 Dec;32(24):5078-88. doi: 10.1128/MCB.00819-12. Epub 2012 Oct 15.


Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells.

Amaya M, Desai M, Gnanapragasam MN, Wang SZ, Zu Zhu S, Williams DC Jr, Ginder GD.

Blood. 2013 Apr 25;121(17):3493-501. doi: 10.1182/blood-2012-11-466227. Epub 2013 Feb 26.


The proto-oncoprotein FBI-1 interacts with MBD3 to recruit the Mi-2/NuRD-HDAC complex and BCoR and to silence p21WAF/CDKN1A by DNA methylation.

Choi WI, Jeon BN, Yoon JH, Koh DI, Kim MH, Yu MY, Lee KM, Kim Y, Kim K, Hur SS, Lee CE, Kim KS, Hur MW.

Nucleic Acids Res. 2013 Jul;41(13):6403-20. doi: 10.1093/nar/gkt359. Epub 2013 May 8.


MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex.

Jiang CL, Jin SG, Pfeifer GP.

J Biol Chem. 2004 Dec 10;279(50):52456-64. Epub 2004 Sep 28.


SUMO modification enhances p66-mediated transcriptional repression of the Mi-2/NuRD complex.

Gong Z, Brackertz M, Renkawitz R.

Mol Cell Biol. 2006 Jun;26(12):4519-28.


Structure and function insights into the NuRD chromatin remodeling complex.

Torchy MP, Hamiche A, Klaholz BP.

Cell Mol Life Sci. 2015 Jul;72(13):2491-507. doi: 10.1007/s00018-015-1880-8. Epub 2015 Mar 22. Review.


Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.

Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D.

Genes Dev. 1999 Aug 1;13(15):1924-35.


MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.

Le Guezennec X, Vermeulen M, Brinkman AB, Hoeijmakers WA, Cohen A, Lasonder E, Stunnenberg HG.

Mol Cell Biol. 2006 Feb;26(3):843-51.


Tagging methyl-CpG-binding domain proteins reveals different spatiotemporal expression and supports distinct functions.

Wood KH, Johnson BS, Welsh SA, Lee JY, Cui Y, Krizman E, Brodkin ES, Blendy JA, Robinson MB, Bartolomei MS, Zhou Z.

Epigenomics. 2016 Apr;8(4):455-73. doi: 10.2217/epi-2015-0004. Epub 2016 Apr 12.


Methyl binding domain protein 2 mediates gamma-globin gene silencing in adult human betaYAC transgenic mice.

Rupon JW, Wang SZ, Gaensler K, Lloyd J, Ginder GD.

Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6617-22. Epub 2006 Apr 11.


Role of the GATA-1/FOG-1/NuRD pathway in the expression of human beta-like globin genes.

Miccio A, Blobel GA.

Mol Cell Biol. 2010 Jul;30(14):3460-70. doi: 10.1128/MCB.00001-10. Epub 2010 May 3.


NuRD-mediated deacetylation of H3K27 facilitates recruitment of Polycomb Repressive Complex 2 to direct gene repression.

Reynolds N, Salmon-Divon M, Dvinge H, Hynes-Allen A, Balasooriya G, Leaford D, Behrens A, Bertone P, Hendrich B.

EMBO J. 2012 Feb 1;31(3):593-605. doi: 10.1038/emboj.2011.431. Epub 2011 Dec 2.


MBD2 is a critical component of a methyl cytosine-binding protein complex isolated from primary erythroid cells.

Kransdorf EP, Wang SZ, Zhu SZ, Langston TB, Rupon JW, Ginder GD.

Blood. 2006 Oct 15;108(8):2836-45. Epub 2006 Jun 15.


Ctbp2 Modulates NuRD-Mediated Deacetylation of H3K27 and Facilitates PRC2-Mediated H3K27me3 in Active Embryonic Stem Cell Genes During Exit from Pluripotency.

Kim TW, Kang BH, Jang H, Kwak S, Shin J, Kim H, Lee SE, Lee SM, Lee JH, Kim JH, Kim SY, Cho EJ, Kim JH, Park KS, Che JH, Han DW, Kang MJ, Yi EC, Youn HD.

Stem Cells. 2015 Aug;33(8):2442-55. doi: 10.1002/stem.2046. Epub 2015 May 26.

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