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The CD40-autophagy pathway is needed for host protection despite IFN-Γ-dependent immunity and CD40 induces autophagy via control of P21 levels.

Portillo JA, Okenka G, Reed E, Subauste A, Van Grol J, Gentil K, Komatsu M, Tanaka K, Landreth G, Levine B, Subauste CS.

PLoS One. 2010 Dec 31;5(12):e14472. doi: 10.1371/journal.pone.0014472.


The protein kinase double-stranded RNA-dependent (PKR) enhances protection against disease cause by a non-viral pathogen.

Ogolla PS, Portillo JA, White CL, Patel K, Lamb B, Sen GC, Subauste CS.

PLoS Pathog. 2013;9(8):e1003557. doi: 10.1371/journal.ppat.1003557. Epub 2013 Aug 22.


Identification of Signaling Pathways by Which CD40 Stimulates Autophagy and Antimicrobial Activity against Toxoplasma gondii in Macrophages.

Liu E, Lopez Corcino Y, Portillo JA, Miao Y, Subauste CS.

Infect Immun. 2016 Aug 19;84(9):2616-26. doi: 10.1128/IAI.00101-16. Print 2016 Sep.


CD40 induces anti-Toxoplasma gondii activity in nonhematopoietic cells dependent on autophagy proteins.

Van Grol J, Muniz-Feliciano L, Portillo JA, Bonilha VL, Subauste CS.

Infect Immun. 2013 Jun;81(6):2002-11. doi: 10.1128/IAI.01145-12. Epub 2013 Mar 18.


CD40 restrains in vivo growth of Toxoplasma gondii independently of gamma interferon.

Subauste CS, Wessendarp M.

Infect Immun. 2006 Mar;74(3):1573-9.


CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes.

Andrade RM, Wessendarp M, Gubbels MJ, Striepen B, Subauste CS.

J Clin Invest. 2006 Sep;116(9):2366-77.


Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens.

Zhao Z, Fux B, Goodwin M, Dunay IR, Strong D, Miller BC, Cadwell K, Delgado MA, Ponpuak M, Green KG, Schmidt RE, Mizushima N, Deretic V, Sibley LD, Virgin HW.

Cell Host Microbe. 2008 Nov 13;4(5):458-69. doi: 10.1016/j.chom.2008.10.003.


Role of mouse and human autophagy proteins in IFN-γ-induced cell-autonomous responses against Toxoplasma gondii.

Ohshima J, Lee Y, Sasai M, Saitoh T, Su Ma J, Kamiyama N, Matsuura Y, Pann-Ghill S, Hayashi M, Ebisu S, Takeda K, Akira S, Yamamoto M.

J Immunol. 2014 Apr 1;192(7):3328-35. doi: 10.4049/jimmunol.1302822. Epub 2014 Feb 21.


Rapid elimination of Toxoplasma gondii by gamma interferon-primed mouse macrophages is independent of CD40 signaling.

Zhao Y, Wilson D, Matthews S, Yap GS.

Infect Immun. 2007 Oct;75(10):4799-803. Epub 2007 Aug 6.


The CD40/CD40 ligand interaction is required for resistance to toxoplasmic encephalitis.

Reichmann G, Walker W, Villegas EN, Craig L, Cai G, Alexander J, Hunter CA.

Infect Immun. 2000 Mar;68(3):1312-8.


CD40, autophagy and Toxoplasma gondii.

Subauste CS.

Mem Inst Oswaldo Cruz. 2009 Mar;104(2):267-72.


Host cell autophagy is induced by Toxoplasma gondii and contributes to parasite growth.

Wang Y, Weiss LM, Orlofsky A.

J Biol Chem. 2009 Jan 16;284(3):1694-701. doi: 10.1074/jbc.M807890200. Epub 2008 Nov 21.


Toxoplasma gondii-induced activation of EGFR prevents autophagy protein-mediated killing of the parasite.

Muniz-Feliciano L, Van Grol J, Portillo JA, Liew L, Liu B, Carlin CR, Carruthers VB, Matthews S, Subauste CS.

PLoS Pathog. 2013;9(12):e1003809. doi: 10.1371/journal.ppat.1003809. Epub 2013 Dec 19.


A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells.

Selleck EM, Orchard RC, Lassen KG, Beatty WL, Xavier RJ, Levine B, Virgin HW, Sibley LD.

MBio. 2015 Sep 8;6(5):e01157-15. doi: 10.1128/mBio.01157-15.

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