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NALP1 influences susceptibility to human congenital toxoplasmosis, proinflammatory cytokine response, and fate of Toxoplasma gondii-infected monocytic cells.

Witola WH, Mui E, Hargrave A, Liu S, Hypolite M, Montpetit A, Cavailles P, Bisanz C, Cesbron-Delauw MF, Fournié GJ, McLeod R.

Infect Immun. 2011 Feb;79(2):756-66. doi: 10.1128/IAI.00898-10. Epub 2010 Nov 22.


Production of IL-1β and Inflammasome with Up-Regulated Expressions of NOD-Like Receptor Related Genes in Toxoplasma gondii-Infected THP-1 Macrophages.

Chu JQ, Shi G, Fan YM, Choi IW, Cha GH, Zhou Y, Lee YH, Quan JH.

Korean J Parasitol. 2016 Dec;54(6):711-717. doi: 10.3347/kjp.2016.54.6.711. Epub 2016 Dec 31.


ALOX12 in human toxoplasmosis.

Witola WH, Liu SR, Montpetit A, Welti R, Hypolite M, Roth M, Zhou Y, Mui E, Cesbron-Delauw MF, Fournie GJ, Cavailles P, Bisanz C, Boyer K, Withers S, Noble AG, Swisher CN, Heydemann PT, Rabiah P, Muench SP, McLeod R.

Infect Immun. 2014 Jul;82(7):2670-9. doi: 10.1128/IAI.01505-13. Epub 2014 Mar 31.


Dual role for inflammasome sensors NLRP1 and NLRP3 in murine resistance to Toxoplasma gondii.

Gorfu G, Cirelli KM, Melo MB, Mayer-Barber K, Crown D, Koller BH, Masters S, Sher A, Leppla SH, Moayeri M, Saeij JP, Grigg ME.

MBio. 2014 Feb 18;5(1). pii: e01117-13. doi: 10.1128/mBio.01117-13.


Human innate immunity to Toxoplasma gondii is mediated by host caspase-1 and ASC and parasite GRA15.

Gov L, Karimzadeh A, Ueno N, Lodoen MB.

MBio. 2013 Jul 9;4(4). pii: e00255-13. doi: 10.1128/mBio.00255-13.


NLRP1 is an inflammasome sensor for Toxoplasma gondii.

Ewald SE, Chavarria-Smith J, Boothroyd JC.

Infect Immun. 2014 Jan;82(1):460-8. doi: 10.1128/IAI.01170-13. Epub 2013 Nov 11.


Impaired innate immunity in mice deficient in interleukin-1 receptor-associated kinase 4 leads to defective type 1 T cell responses, B cell expansion, and enhanced susceptibility to infection with Toxoplasma gondii.

Béla SR, Dutra MS, Mui E, Montpetit A, Oliveira FS, Oliveira SC, Arantes RM, Antonelli LR, McLeod R, Gazzinelli RT.

Infect Immun. 2012 Dec;80(12):4298-308. doi: 10.1128/IAI.00328-12. Epub 2012 Oct 1.


A highly conserved Toxo1 haplotype directs resistance to toxoplasmosis and its associated caspase-1 dependent killing of parasite and host macrophage.

Cavailles P, Flori P, Papapietro O, Bisanz C, Lagrange D, Pilloux L, Massera C, Cristinelli S, Jublot D, Bastien O, Loeuillet C, Aldebert D, Touquet B, Fournié GJ, Cesbron-Delauw MF.

PLoS Pathog. 2014 Apr 3;10(4):e1004005. doi: 10.1371/journal.ppat.1004005. eCollection 2014 Apr.


From cells to signaling cascades: manipulation of innate immunity by Toxoplasma gondii.

Denkers EY.

FEMS Immunol Med Microbiol. 2003 Dec 5;39(3):193-203. Review.


Congenital toxoplasmosis: candidate host immune genes relevant for vertical transmission and pathogenesis.

Ortiz-Alegría LB, Caballero-Ortega H, Cañedo-Solares I, Rico-Torres CP, Sahagún-Ruiz A, Medina-Escutia ME, Correa D.

Genes Immun. 2010 Jul;11(5):363-73. doi: 10.1038/gene.2010.21. Epub 2010 May 6. Review.


Differential apoptosis in BeWo cells after infection with highly (RH) or moderately (ME49) virulent strains of Toxoplasma gondii is related to the cytokine profile secreted, the death receptor Fas expression and phosphorylated ERK1/2 expression.

Angeloni MB, Guirelli PM, Franco PS, Barbosa BF, Gomes AO, Castro AS, Silva NM, Martins-Filho OA, Mineo TW, Silva DA, Mineo JR, Ferro EA.

Placenta. 2013 Nov;34(11):973-82. doi: 10.1016/j.placenta.2013.09.005. Epub 2013 Sep 18.


The NLRP1 inflammasomes.

Chavarría-Smith J, Vance RE.

Immunol Rev. 2015 May;265(1):22-34. doi: 10.1111/imr.12283. Review.


Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response.

Kummer JA, Broekhuizen R, Everett H, Agostini L, Kuijk L, Martinon F, van Bruggen R, Tschopp J.

J Histochem Cytochem. 2007 May;55(5):443-52. Epub 2006 Dec 12.


Do the placental barrier, parasite genotype and Toll-like receptor polymorphisms contribute to the course of primary infection with various Toxoplasma gondii genotypes in pregnant women?

Wujcicka W, Wilczyński J, Nowakowska D.

Eur J Clin Microbiol Infect Dis. 2014 May;33(5):703-9. doi: 10.1007/s10096-013-2017-3. Epub 2013 Nov 30. Review.


Natural killer cell intrinsic toll-like receptor MyD88 signaling contributes to IL-12-dependent IFN-γ production by mice during infection with Toxoplasma gondii.

Ge Y, Chen J, Qiu X, Zhang J, Cui L, Qi Y, Liu X, Qiu J, Shi Z, Lun Z, Shen J, Wang Y.

Int J Parasitol. 2014 Jun;44(7):475-84. doi: 10.1016/j.ijpara.2014.03.004. Epub 2014 Apr 13.


Kinetics of IL-23 and IL-12 secretion in response to Toxoplasma gondii antigens from THP-1 monocytic cells.

Quan JH, Zhou W, Cha GH, Choi IW, Shin DW, Lee YH.

Korean J Parasitol. 2013 Feb;51(1):85-92. doi: 10.3347/kjp.2013.51.1.85. Epub 2013 Feb 18.


Curcumin ameliorates neuropathic pain by down-regulating spinal IL-1β via suppressing astroglial NALP1 inflammasome and JAK2-STAT3 signalling.

Liu S, Li Q, Zhang MT, Mao-Ying QL, Hu LY, Wu GC, Mi WL, Wang YQ.

Sci Rep. 2016 Jul 6;6:28956. doi: 10.1038/srep28956.


The NALP1 inflammasome controls cytokine production and nociception in a rat fracture model of complex regional pain syndrome.

Li WW, Guo TZ, Liang D, Shi X, Wei T, Kingery WS, Clark JD.

Pain. 2009 Dec 15;147(1-3):277-86. doi: 10.1016/j.pain.2009.09.032. Epub 2009 Oct 22.


Trophoblast cells are able to regulate monocyte activity to control Toxoplasma gondii infection.

Castro AS, Alves CM, Angeloni MB, Gomes AO, Barbosa BF, Franco PS, Silva DA, Martins-Filho OA, Mineo JR, Mineo TW, Ferro EA.

Placenta. 2013 Mar;34(3):240-7. doi: 10.1016/j.placenta.2012.12.006. Epub 2013 Jan 5.

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