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Items: 1 to 20 of 207

1.

Influenza A virus strains that circulate in humans differ in the ability of their NS1 proteins to block the activation of IRF3 and interferon-β transcription.

Kuo RL, Zhao C, Malur M, Krug RM.

Virology. 2010 Dec 20;408(2):146-58. doi: 10.1016/j.virol.2010.09.012. Epub 2010 Oct 8.

2.

Virulence determinants of avian H5N1 influenza A virus in mammalian and avian hosts: role of the C-terminal ESEV motif in the viral NS1 protein.

Zielecki F, Semmler I, Kalthoff D, Voss D, Mauel S, Gruber AD, Beer M, Wolff T.

J Virol. 2010 Oct;84(20):10708-18. doi: 10.1128/JVI.00610-10. Epub 2010 Aug 4.

3.

Role of N Terminus-Truncated NS1 Proteins of Influenza A Virus in Inhibiting IRF3 Activation.

Kuo RL, Li LH, Lin SJ, Li ZH, Chen GW, Chang CK, Wang YR, Tam EH, Gong YN, Krug RM, Shih SR.

J Virol. 2016 Apr 14;90(9):4696-4705. doi: 10.1128/JVI.02843-15. Print 2016 May.

4.

Shortening the unstructured, interdomain region of the non-structural protein NS1 of an avian H1N1 influenza virus increases its replication and pathogenicity in chickens.

Trapp S, Soubieux D, Marty H, Esnault E, Hoffmann TW, Chandenier M, Lion A, Kut E, Quéré P, Larcher T, Ledevin M, Munier S, Naffakh N, Marc D.

J Gen Virol. 2014 Jun;95(Pt 6):1233-43. doi: 10.1099/vir.0.063776-0. Epub 2014 Apr 2.

PMID:
24694396
5.

A Conserved Residue, Tyrosine (Y) 84, in H5N1 Influenza A Virus NS1 Regulates IFN Signaling Responses to Enhance Viral Infection.

Wang BX, Wei L, Kotra LP, Brown EG, Fish EN.

Viruses. 2017 May 12;9(5). pii: E107. doi: 10.3390/v9050107.

6.

Differential effects of NS1 proteins of human pandemic H1N1/2009, avian highly pathogenic H5N1, and low pathogenic H5N2 influenza A viruses on cellular pre-mRNA polyadenylation and mRNA translation.

Kainov DE, Müller KH, Theisen LL, Anastasina M, Kaloinen M, Muller CP.

J Biol Chem. 2011 Mar 4;286(9):7239-47. doi: 10.1074/jbc.M110.203489. Epub 2010 Dec 16.

7.

Influenza virus non-structural protein 1 (NS1) disrupts interferon signaling.

Jia D, Rahbar R, Chan RW, Lee SM, Chan MC, Wang BX, Baker DP, Sun B, Peiris JS, Nicholls JM, Fish EN.

PLoS One. 2010 Nov 10;5(11):e13927. doi: 10.1371/journal.pone.0013927.

8.

Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 protein.

Rajsbaum R, Albrecht RA, Wang MK, Maharaj NP, Versteeg GA, Nistal-Villán E, García-Sastre A, Gack MU.

PLoS Pathog. 2012;8(11):e1003059. doi: 10.1371/journal.ppat.1003059. Epub 2012 Nov 29.

9.

Effects of the S42 residue of the H1N1 swine influenza virus NS1 protein on interferon responses and virus replication.

Cheng J, Zhang C, Tao J, Li B, Shi Y, Liu H.

Virol J. 2018 Mar 27;15(1):57. doi: 10.1186/s12985-018-0971-1.

10.

The N- and C-terminal domains of the NS1 protein of influenza B virus can independently inhibit IRF-3 and beta interferon promoter activation.

Donelan NR, Dauber B, Wang X, Basler CF, Wolff T, García-Sastre A.

J Virol. 2004 Nov;78(21):11574-82.

11.

A Naturally Occurring Deletion in the Effector Domain of H5N1 Swine Influenza Virus Nonstructural Protein 1 Regulates Viral Fitness and Host Innate Immunity.

Wang J, Zeng Y, Xu S, Yang J, Wang W, Zhong B, Ge J, Yin L, Bu Z, Shu HB, Chen H, Lei CQ, Zhu Q.

J Virol. 2018 May 14;92(11). pii: e00149-18. doi: 10.1128/JVI.00149-18. Print 2018 Jun 1.

12.

Phosphorylation of influenza A virus NS1 protein at threonine 49 suppresses its interferon antagonistic activity.

Kathum OA, Schräder T, Anhlan D, Nordhoff C, Liedmann S, Pande A, Mellmann A, Ehrhardt C, Wixler V, Ludwig S.

Cell Microbiol. 2016 Jun;18(6):784-91. doi: 10.1111/cmi.12559. Epub 2016 Jan 27.

13.

NS1 Protein Mutation I64T Affects Interferon Responses and Virulence of Circulating H3N2 Human Influenza A Viruses.

DeDiego ML, Nogales A, Lambert-Emo K, Martinez-Sobrido L, Topham DJ.

J Virol. 2016 Oct 14;90(21):9693-9711. doi: 10.1128/JVI.01039-16. Print 2016 Nov 1.

14.

Multiple anti-interferon actions of the influenza A virus NS1 protein.

Kochs G, García-Sastre A, Martínez-Sobrido L.

J Virol. 2007 Jul;81(13):7011-21. Epub 2007 Apr 18.

15.

Inhibition of host innate immune responses and pathogenicity of recombinant Newcastle disease viruses expressing NS1 genes of influenza A viruses.

Kim SH, Samal SK.

J Gen Virol. 2010 Aug;91(Pt 8):1996-2001. doi: 10.1099/vir.0.021766-0. Epub 2010 Apr 21.

PMID:
20410312
16.

LGP2 downregulates interferon production during infection with seasonal human influenza A viruses that activate interferon regulatory factor 3.

Malur M, Gale M Jr, Krug RM.

J Virol. 2012 Oct;86(19):10733-8. doi: 10.1128/JVI.00510-12. Epub 2012 Jul 25.

17.

Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation.

Meyerson NR, Zhou L, Guo YR, Zhao C, Tao YJ, Krug RM, Sawyer SL.

Cell Host Microbe. 2017 Nov 8;22(5):627-638.e7. doi: 10.1016/j.chom.2017.10.003. Epub 2017 Nov 5.

18.

NS1 Protein Amino Acid Changes D189N and V194I Affect Interferon Responses, Thermosensitivity, and Virulence of Circulating H3N2 Human Influenza A Viruses.

Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML.

J Virol. 2017 Feb 14;91(5). pii: e01930-16. doi: 10.1128/JVI.01930-16. Print 2017 Mar 1.

19.

Structure-Guided Functional Annotation of the Influenza A Virus NS1 Protein Reveals Dynamic Evolution of the p85β-Binding Site during Circulation in Humans.

Lopes AM, Domingues P, Zell R, Hale BG.

J Virol. 2017 Oct 13;91(21). pii: e01081-17. doi: 10.1128/JVI.01081-17. Print 2017 Nov 1.

20.

Heterologous interactions between NS1 proteins from different influenza A virus subtypes/strains.

Li W, Zhang H, Wang G, Zhang C, Zeng X, Liu H, Chen X, Xu Y, Li K.

Sci China Life Sci. 2012 Jun;55(6):507-15. doi: 10.1007/s11427-012-4335-6. Epub 2012 Jun 29.

PMID:
22744180

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