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Items: 1 to 20 of 109

1.

IFI16 is an innate immune sensor for intracellular DNA.

Unterholzner L, Keating SE, Baran M, Horan KA, Jensen SB, Sharma S, Sirois CM, Jin T, Latz E, Xiao TS, Fitzgerald KA, Paludan SR, Bowie AG.

Nat Immunol. 2010 Nov;11(11):997-1004. doi: 10.1038/ni.1932. Epub 2010 Oct 3.

2.

BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses.

Dutta D, Dutta S, Veettil MV, Roy A, Ansari MA, Iqbal J, Chikoti L, Kumar B, Johnson KE, Chandran B.

PLoS Pathog. 2015 Jun 29;11(6):e1005030. doi: 10.1371/journal.ppat.1005030. eCollection 2015 Jun.

3.

Histone H2B-IFI16 Recognition of Nuclear Herpesviral Genome Induces Cytoplasmic Interferon-β Responses.

Iqbal J, Ansari MA, Kumar B, Dutta D, Roy A, Chikoti L, Pisano G, Dutta S, Vahedi S, Veettil MV, Chandran B.

PLoS Pathog. 2016 Oct 20;12(10):e1005967. doi: 10.1371/journal.ppat.1005967. eCollection 2016 Oct.

4.

The emerging role of human PYHIN proteins in innate immunity: implications for health and disease.

Connolly DJ, Bowie AG.

Biochem Pharmacol. 2014 Dec 1;92(3):405-14. doi: 10.1016/j.bcp.2014.08.031. Epub 2014 Sep 6.

PMID:
25199457
5.

Herpesvirus Genome Recognition Induced Acetylation of Nuclear IFI16 Is Essential for Its Cytoplasmic Translocation, Inflammasome and IFN-β Responses.

Ansari MA, Dutta S, Veettil MV, Dutta D, Iqbal J, Kumar B, Roy A, Chikoti L, Singh VV, Chandran B.

PLoS Pathog. 2015 Jul 2;11(7):e1005019. doi: 10.1371/journal.ppat.1005019. eCollection 2015 Jul.

6.

Differential roles for the interferon-inducible IFI16 and AIM2 innate immune sensors for cytosolic DNA in cellular senescence of human fibroblasts.

Duan X, Ponomareva L, Veeranki S, Panchanathan R, Dickerson E, Choubey D.

Mol Cancer Res. 2011 May;9(5):589-602. doi: 10.1158/1541-7786.MCR-10-0565. Epub 2011 Apr 6.

7.
8.

Priming and Activation of Inflammasome by Canarypox Virus Vector ALVAC via the cGAS/IFI16-STING-Type I IFN Pathway and AIM2 Sensor.

Liu F, Niu Q, Fan X, Liu C, Zhang J, Wei Z, Hou W, Kanneganti TD, Robb ML, Kim JH, Michael NL, Sun J, Soong L, Hu H.

J Immunol. 2017 Nov 1;199(9):3293-3305. doi: 10.4049/jimmunol.1700698. Epub 2017 Sep 25.

9.

The interferon-inducible DNA-sensor protein IFI16: a key player in the antiviral response.

Dell'Oste V, Gatti D, Giorgio AG, Gariglio M, Landolfo S, De Andrea M.

New Microbiol. 2015 Jan;38(1):5-20. Epub 2015 Jan 1. Review.

10.

Interferon-inducible p200-family protein IFI16, an innate immune sensor for cytosolic and nuclear double-stranded DNA: regulation of subcellular localization.

Veeranki S, Choubey D.

Mol Immunol. 2012 Jan;49(4):567-71. doi: 10.1016/j.molimm.2011.11.004. Epub 2011 Dec 2. Review.

11.

IFI16 protein mediates the anti-inflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes.

Veeranki S, Duan X, Panchanathan R, Liu H, Choubey D.

PLoS One. 2011;6(10):e27040. doi: 10.1371/journal.pone.0027040. Epub 2011 Oct 28.

12.

Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.

Diner BA, Lum KK, Javitt A, Cristea IM.

Mol Cell Proteomics. 2015 Sep;14(9):2341-56. doi: 10.1074/mcp.M114.047068. Epub 2015 Feb 18.

13.

Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein.

Orzalli MH, DeLuca NA, Knipe DM.

Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):E3008-17. doi: 10.1073/pnas.1211302109. Epub 2012 Oct 1.

14.

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity.

Ishikawa H, Ma Z, Barber GN.

Nature. 2009 Oct 8;461(7265):788-92. doi: 10.1038/nature08476. Epub 2009 Sep 23.

15.

Cutting Edge: Genetic Association between IFI16 Single Nucleotide Polymorphisms and Resistance to Genital Herpes Correlates with IFI16 Expression Levels and HSV-2-Induced IFN-β Expression.

Eriksson K, Svensson A, Hait AS, Schlüter K, Tunbäck P, Nordström I, Padyukov L, Liljeqvist JÅ, Mogensen TH, Paludan SR.

J Immunol. 2017 Oct 15;199(8):2613-2617. doi: 10.4049/jimmunol.1700385. Epub 2017 Sep 11.

16.

The emerging role of nuclear viral DNA sensors.

Diner BA, Lum KK, Cristea IM.

J Biol Chem. 2015 Oct 30;290(44):26412-21. doi: 10.1074/jbc.R115.652289. Epub 2015 Sep 9. Review.

17.

Role for a Filamentous Nuclear Assembly of IFI16, DNA, and Host Factors in Restriction of Herpesviral Infection.

Merkl PE, Knipe DM.

MBio. 2019 Jan 22;10(1). pii: e02621-18. doi: 10.1128/mBio.02621-18.

18.

Herpes Simplex Virus 1 Tegument Protein VP22 Abrogates cGAS/STING-Mediated Antiviral Innate Immunity.

Huang J, You H, Su C, Li Y, Chen S, Zheng C.

J Virol. 2018 Jul 17;92(15). pii: e00841-18. doi: 10.1128/JVI.00841-18. Print 2018 Aug 1.

19.

The PYHIN protein family as mediators of host defenses.

Schattgen SA, Fitzgerald KA.

Immunol Rev. 2011 Sep;243(1):109-18. doi: 10.1111/j.1600-065X.2011.01053.x. Review.

PMID:
21884171
20.

Evasion of the STING DNA-Sensing Pathway by VP11/12 of Herpes Simplex Virus 1.

Deschamps T, Kalamvoki M.

J Virol. 2017 Jul 27;91(16). pii: e00535-17. doi: 10.1128/JVI.00535-17. Print 2017 Aug 15.

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