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Items: 1 to 20 of 118


Reduced expression of fatty acid biosynthesis genes in the prefrontal cortex of patients with major depressive disorder.

McNamara RK, Liu Y.

J Affect Disord. 2011 Mar;129(1-3):359-63. doi: 10.1016/j.jad.2010.08.021. Epub 2010 Sep 21.


Elevated delta-6 desaturase (FADS2) expression in the postmortem prefrontal cortex of schizophrenic patients: relationship with fatty acid composition.

Liu Y, Jandacek R, Rider T, Tso P, McNamara RK.

Schizophr Res. 2009 Apr;109(1-3):113-20. doi: 10.1016/j.schres.2008.12.027. Epub 2009 Feb 4.


Elevated Delta-6 desaturase (FADS2) gene expression in the prefrontal cortex of patients with bipolar disorder.

Liu Y, McNamara RK.

J Psychiatr Res. 2011 Feb;45(2):269-72. doi: 10.1016/j.jpsychires.2010.06.010. Epub 2010 Jul 7.


The aging human orbitofrontal cortex: decreasing polyunsaturated fatty acid composition and associated increases in lipogenic gene expression and stearoyl-CoA desaturase activity.

McNamara RK, Liu Y, Jandacek R, Rider T, Tso P.

Prostaglandins Leukot Essent Fatty Acids. 2008 Apr-May;78(4-5):293-304. doi: 10.1016/j.plefa.2008.04.001. Epub 2008 May 21.


Gene expression of desaturase (FADS1 and FADS2) and Elongase (ELOVL5) enzymes in peripheral blood: association with polyunsaturated fatty acid levels and atopic eczema in 4-year-old children.

Chisaguano AM, Montes R, Pérez-Berezo T, Castellote AI, Guerendiain M, Bustamante M, Morales E, García-Esteban R, Sunyer J, Franch A, López-Sabater MC.

PLoS One. 2013 Oct 22;8(10):e78245. doi: 10.1371/journal.pone.0078245. eCollection 2013.


Biosynthesis of Polyunsaturated Fatty Acids in Octopus vulgaris: Molecular Cloning and Functional Characterisation of a Stearoyl-CoA Desaturase and an Elongation of Very Long-Chain Fatty Acid 4 Protein.

Monroig Ó, de Llanos R, Varó I, Hontoria F, Tocher DR, Puig S, Navarro JC.

Mar Drugs. 2017 Mar 21;15(3). pii: E82. doi: 10.3390/md15030082.


Differential effects of antipsychotic medications on polyunsaturated fatty acid biosynthesis in rats: Relationship with liver delta6-desaturase expression.

McNamara RK, Jandacek R, Rider T, Tso P, Cole-Strauss A, Lipton JW.

Schizophr Res. 2011 Jun;129(1):57-65. doi: 10.1016/j.schres.2011.03.006. Epub 2011 Mar 31.


Delta6-, Stearoyl CoA-, and Delta5-desaturase enzymes are expressed in beta-cells and are altered by increases in exogenous PUFA concentrations.

Ramanadham S, Zhang S, Ma Z, Wohltmann M, Bohrer A, Hsu FF, Turk J.

Biochim Biophys Acta. 2002 Jan 30;1580(1):40-56.


Long chain polyunsaturated fatty acid synthesis in a marine vertebrate: ontogenetic and nutritional regulation of a fatty acyl desaturase with Δ4 activity.

Morais S, Castanheira F, Martinez-Rubio L, Conceição LE, Tocher DR.

Biochim Biophys Acta. 2012 Apr;1821(4):660-71. doi: 10.1016/j.bbalip.2011.12.011. Epub 2012 Jan 8.


Fatty acid composition of chicken breast meat is dependent on genotype-related variation of FADS1 and FADS2 gene expression and desaturating activity.

Boschetti E, Bordoni A, Meluzzi A, Castellini C, Dal Bosco A, Sirri F.

Animal. 2016 Apr;10(4):700-8. doi: 10.1017/S1751731115002712. Epub 2015 Dec 16.


Cloning and functional characterization of fads2 desaturase and elovl5 elongase from Japanese flounder Paralichthys olivaceus.

Kabeya N, Chiba M, Haga Y, Satoh S, Yoshizaki G.

Comp Biochem Physiol B Biochem Mol Biol. 2017 Dec;214:36-46. doi: 10.1016/j.cbpb.2017.09.002. Epub 2017 Sep 22.


Three unsaturated fatty acid biosynthesis-related genes in yellow catfish Pelteobagrus fulvidraco: Molecular characterization, tissue expression and transcriptional regulation by leptin.

Song YF, Luo Z, Pan YX, Zhang LH, Chen QL, Zheng JL.

Gene. 2015 May 25;563(1):1-9. doi: 10.1016/j.gene.2014.12.014. Epub 2014 Dec 10.


Fatty acid composition of the postmortem prefrontal cortex of patients with schizophrenia, bipolar disorder, and major depressive disorder.

Hamazaki K, Maekawa M, Toyota T, Dean B, Hamazaki T, Yoshikawa T.

Psychiatry Res. 2015 Jun 30;227(2-3):353-9. doi: 10.1016/j.psychres.2015.01.004. Epub 2015 Jan 23.


Role of maternal tissue in the synthesis of polyunsaturated fatty acids in response to a lipid-deficient diet during pregnancy and lactation in rats.

González RS, Rodriguez-Cruz M, Maldonado J, Saavedra FJ.

Gene. 2014 Oct 1;549(1):7-23. doi: 10.1016/j.gene.2014.06.057. Epub 2014 Jul 19.


Omega-3 fatty acid deficiency selectively up-regulates delta6-desaturase expression and activity indices in rat liver: prevention by normalization of omega-3 fatty acid status.

Hofacer R, Jandacek R, Rider T, Tso P, Magrisso IJ, Benoit SC, McNamara RK.

Nutr Res. 2011 Sep;31(9):715-22. doi: 10.1016/j.nutres.2011.08.007.


DNA methylation perturbations in genes involved in polyunsaturated Fatty Acid biosynthesis associated with depression and suicide risk.

Haghighi F, Galfalvy H, Chen S, Huang YY, Cooper TB, Burke AK, Oquendo MA, Mann JJ, Sublette ME.

Front Neurol. 2015 Apr 28;6:92. doi: 10.3389/fneur.2015.00092. eCollection 2015.


Gender affects liver desaturase expression in a rat model of n-3 fatty acid repletion.

Extier A, Langelier B, Perruchot MH, Guesnet P, Van Veldhoven PP, Lavialle M, Alessandri JM.

J Nutr Biochem. 2010 Mar;21(3):180-7. doi: 10.1016/j.jnutbio.2008.10.008. Epub 2009 Jan 20.


Metabolic engineering of omega-3 long-chain polyunsaturated fatty acids in plants using an acyl-CoA Delta6-desaturase with omega3-preference from the marine microalga Micromonas pusilla.

Petrie JR, Shrestha P, Mansour MP, Nichols PD, Liu Q, Singh SP.

Metab Eng. 2010 May;12(3):233-40. doi: 10.1016/j.ymben.2009.12.001. Epub 2009 Dec 21.


Isoform-level brain expression profiling of the spermidine/spermine N1-Acetyltransferase1 (SAT1) gene in major depression and suicide.

Pantazatos SP, Andrews SJ, Dunning-Broadbent J, Pang J, Huang YY, Arango V, Nagy PL, John Mann J.

Neurobiol Dis. 2015 Jul;79:123-34. doi: 10.1016/j.nbd.2015.04.014. Epub 2015 May 8.


Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs.

Smink W, Gerrits WJ, Gloaguen M, Ruiter A, van Baal J.

Animal. 2012 Feb;6(2):262-70. doi: 10.1017/S1751731111001479.


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