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Structure-based analysis of Toxoplasma gondii profilin: a parasite-specific motif is required for recognition by Toll-like receptor 11.

Kucera K, Koblansky AA, Saunders LP, Frederick KB, De La Cruz EM, Ghosh S, Modis Y.

J Mol Biol. 2010 Nov 5;403(4):616-29. doi: 10.1016/j.jmb.2010.09.022. Epub 2010 Sep 17.


Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii.

Koblansky AA, Jankovic D, Oh H, Hieny S, Sungnak W, Mathur R, Hayden MS, Akira S, Sher A, Ghosh S.

Immunity. 2013 Jan 24;38(1):119-30. doi: 10.1016/j.immuni.2012.09.016. Epub 2012 Dec 13.


The antigen-specific response to Toxoplasma gondii profilin, a TLR11/12 ligand, depends on its intrinsic adjuvant properties.

Hedhli D, Moiré N, Akbar H, Laurent F, Héraut B, Dimier-Poisson I, Mévélec MN.

Med Microbiol Immunol. 2016 Aug;205(4):345-52. doi: 10.1007/s00430-016-0452-3. Epub 2016 Mar 2.


Toxoplasma profilin is essential for host cell invasion and TLR11-dependent induction of an interleukin-12 response.

Plattner F, Yarovinsky F, Romero S, Didry D, Carlier MF, Sher A, Soldati-Favre D.

Cell Host Microbe. 2008 Feb 14;3(2):77-87. doi: 10.1016/j.chom.2008.01.001.


TLR11 activation of dendritic cells by a protozoan profilin-like protein.

Yarovinsky F, Zhang D, Andersen JF, Bannenberg GL, Serhan CN, Hayden MS, Hieny S, Sutterwala FS, Flavell RA, Ghosh S, Sher A.

Science. 2005 Jun 10;308(5728):1626-9. Epub 2005 Apr 28.


Proteolytic activity of Plasmodium falciparum subtilisin-like protease 3 on parasite profilin, a multifunctional protein.

Alam A, Bhatnagar RK, Relan U, Mukherjee P, Chauhan VS.

Mol Biochem Parasitol. 2013 Oct;191(2):58-62. doi: 10.1016/j.molbiopara.2013.09.006. Epub 2013 Sep 27.


Toxoplasma gondii profilin promotes recruitment of Ly6Chi CCR2+ inflammatory monocytes that can confer resistance to bacterial infection.

Neal LM, Knoll LJ.

PLoS Pathog. 2014 Jun 12;10(6):e1004203. doi: 10.1371/journal.ppat.1004203. eCollection 2014 Jun.


Toll-like receptor recognition of Toxoplasma gondii.

Yarovinsky F, Sher A.

Int J Parasitol. 2006 Mar;36(3):255-9. Epub 2006 Jan 13. Review.


Structural basis for parasite-specific functions of the divergent profilin of Plasmodium falciparum.

Kursula I, Kursula P, Ganter M, Panjikar S, Matuschewski K, Schüler H.

Structure. 2008 Nov 12;16(11):1638-48. doi: 10.1016/j.str.2008.09.008.


Toxoplasma gondii- derived profilin triggers human toll-like receptor 5-dependent cytokine production.

Salazar Gonzalez RM, Shehata H, O'Connell MJ, Yang Y, Moreno-Fernandez ME, Chougnet CA, Aliberti J.

J Innate Immun. 2014;6(5):685-94. doi: 10.1159/000362367. Epub 2014 May 23.


Cooperation of TLR12 and TLR11 in the IRF8-dependent IL-12 response to Toxoplasma gondii profilin.

Raetz M, Kibardin A, Sturge CR, Pifer R, Li H, Burstein E, Ozato K, Larin S, Yarovinsky F.

J Immunol. 2013 Nov 1;191(9):4818-27. doi: 10.4049/jimmunol.1301301. Epub 2013 Sep 27.


UNC93B1 is essential for TLR11 activation and IL-12-dependent host resistance to Toxoplasma gondii.

Pifer R, Benson A, Sturge CR, Yarovinsky F.

J Biol Chem. 2011 Feb 4;286(5):3307-14. doi: 10.1074/jbc.M110.171025. Epub 2010 Nov 19.


Toxoplasma gondii profilin acts primarily to sequester G-actin while formins efficiently nucleate actin filament formation in vitro.

Skillman KM, Daher W, Ma CI, Soldati-Favre D, Sibley LD.

Biochemistry. 2012 Mar 27;51(12):2486-95. doi: 10.1021/bi201704y. Epub 2012 Mar 16.


Of mice and man: TLR11 (finally) finds profilin.

Lauw FN, Caffrey DR, Golenbock DT.

Trends Immunol. 2005 Oct;26(10):509-11. Review.


Toll-like receptor recognition regulates immunodominance in an antimicrobial CD4+ T cell response.

Yarovinsky F, Kanzler H, Hieny S, Coffman RL, Sher A.

Immunity. 2006 Oct;25(4):655-64. Epub 2006 Sep 28.


Naturally occurring Toll-like receptor 11 (TLR11) and Toll-like receptor 12 (TLR12) polymorphisms are not associated with Toxoplasma gondii infection in wild wood mice.

Morger J, Bajnok J, Boyce K, Craig PS, Rogan MT, Lun ZR, Hide G, Tschirren B.

Infect Genet Evol. 2014 Aug;26:180-4. doi: 10.1016/j.meegid.2014.05.032. Epub 2014 Jun 6.


[Prokaryotic Expression and Immunoreactivity Analysis on Profilin of Toxoplasma gondii].

Yuan F, Liu ZZ, Zhang B, Cao JP, Zheng KY, Wang DG.

Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2015 Feb;33(1):21-4. Chinese.


Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice.

Andrade WA, Souza Mdo C, Ramos-Martinez E, Nagpal K, Dutra MS, Melo MB, Bartholomeu DC, Ghosh S, Golenbock DT, Gazzinelli RT.

Cell Host Microbe. 2013 Jan 16;13(1):42-53. doi: 10.1016/j.chom.2012.12.003. Epub 2013 Jan 3.


Protective immunity against Toxoplasma challenge in mice by coadministration of T. gondii antigens and Eimeria profilin-like protein as an adjuvant.

Hedhli D, Dimier-Poisson I, Judge JW, Rosenberg B, Mévélec MN.

Vaccine. 2009 Apr 6;27(16):2274-81. doi: 10.1016/j.vaccine.2009.01.100. Epub 2009 Jan 31.


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