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Hepatitis C virus NS2 protein triggers endoplasmic reticulum stress and suppresses its own viral replication.

von dem Bussche A, Machida R, Li K, Loevinsohn G, Khander A, Wang J, Wakita T, Wands JR, Li J.

J Hepatol. 2010 Nov;53(5):797-804. doi: 10.1016/j.jhep.2010.05.022. Epub 2010 Jul 24.


Activation of the ER stress gene gadd153 by hepatitis C virus sensitizes cells to oxidant injury.

Ciccaglione AR, Marcantonio C, Tritarelli E, Equestre M, Vendittelli F, Costantino A, Geraci A, Rapicetta M.

Virus Res. 2007 Jun;126(1-2):128-38. Epub 2007 Mar 19.


A concerted action of hepatitis C virus p7 and nonstructural protein 2 regulates core localization at the endoplasmic reticulum and virus assembly.

Boson B, Granio O, Bartenschlager R, Cosset FL.

PLoS Pathog. 2011 Jul;7(7):e1002144. doi: 10.1371/journal.ppat.1002144. Epub 2011 Jul 21.


PKR-dependent mechanisms of gene expression from a subgenomic hepatitis C virus clone.

Rivas-Estilla AM, Svitkin Y, Lopez Lastra M, Hatzoglou M, Sherker A, Koromilas AE.

J Virol. 2002 Nov;76(21):10637-53.


Detergent-resistant membrane association of NS2 and E2 during hepatitis C virus replication.

Shanmugam S, Saravanabalaji D, Yi M.

J Virol. 2015 Apr;89(8):4562-74. doi: 10.1128/JVI.00123-15. Epub 2015 Feb 11.


The regulation of hepatitis C virus (HCV) internal ribosome-entry site-mediated translation by HCV replicons and nonstructural proteins.

He Y, Yan W, Coito C, Li Y, Gale M Jr, Katze MG.

J Gen Virol. 2003 Mar;84(Pt 3):535-43.


Activation of endoplasmic reticulum stress response by hepatitis C virus proteins.

Ciccaglione AR, Costantino A, Tritarelli E, Marcantonio C, Equestre M, Marziliano N, Rapicetta M.

Arch Virol. 2005 Jul;150(7):1339-56. Epub 2005 Mar 17.


Novel nucleotide and amino acid covariation between the 5'UTR and the NS2/NS3 proteins of hepatitis C virus: bioinformatic and functional analyses.

Sun HY, Ou NY, Wang SW, Liu WC, Cheng TF, Shr SJ, Sun KT, Chang TT, Young KC.

PLoS One. 2011;6(9):e25530. doi: 10.1371/journal.pone.0025530. Epub 2011 Sep 28.


NS2 protein of hepatitis C virus interacts with structural and non-structural proteins towards virus assembly.

Popescu CI, Callens N, Trinel D, Roingeard P, Moradpour D, Descamps V, Duverlie G, Penin F, Héliot L, Rouillé Y, Dubuisson J.

PLoS Pathog. 2011 Feb 10;7(2):e1001278. doi: 10.1371/journal.ppat.1001278.


Transient receptor potential vanilloid 1 agonists cause endoplasmic reticulum stress and cell death in human lung cells.

Thomas KC, Sabnis AS, Johansen ME, Lanza DL, Moos PJ, Yost GS, Reilly CA.

J Pharmacol Exp Ther. 2007 Jun;321(3):830-8. Epub 2007 Mar 1.


Intracellular accumulation of hepatitis C virus proteins in a human hepatoma cell line.

Brazzoli M, Crotta S, Bianchi A, Bagnoli F, Monaghan P, Wileman T, Abrignani S, Merola M.

J Hepatol. 2007 Jan;46(1):53-9. Epub 2006 Oct 26.


Endoplasmic reticulum stress is induced and modulated by enterovirus 71.

Jheng JR, Lau KS, Tang WF, Wu MS, Horng JT.

Cell Microbiol. 2010 Jun;12(6):796-813. doi: 10.1111/j.1462-5822.2010.01434.x. Epub 2010 Jan 11.


Phosphatidylserine-specific phospholipase A1 involved in hepatitis C virus assembly through NS2 complex formation.

Guo M, Pei R, Yang Q, Cao H, Wang Y, Wu C, Chen J, Zhou Y, Hu X, Lu M, Chen X.

J Virol. 2015 Feb;89(4):2367-77. doi: 10.1128/JVI.02982-14. Epub 2014 Dec 10.


A conserved NS3 surface patch orchestrates NS2 protease stimulation, NS5A hyperphosphorylation and HCV genome replication.

Isken O, Langerwisch U, Jirasko V, Rehders D, Redecke L, Ramanathan H, Lindenbach BD, Bartenschlager R, Tautz N.

PLoS Pathog. 2015 Mar 16;11(3):e1004736. doi: 10.1371/journal.ppat.1004736. eCollection 2015 Mar. Erratum in: PLoS Pathog. 2016 Jan;12(1):e1005394.


Hepatitis C virus non-structural protein NS4B can modulate an unfolded protein response.

Zheng Y, Gao B, Ye L, Kong L, Jing W, Yang X, Wu Z, Ye L.

J Microbiol. 2005 Dec;43(6):529-36.


Hepatitis C virus NS2 protein inhibits gene expression from different cellular and viral promoters in hepatic and nonhepatic cell lines.

Dumoulin FL, von dem Bussche A, Li J, Khamzina L, Wands JR, Sauerbruch T, Spengler U.

Virology. 2003 Jan 20;305(2):260-6.


Hepatitis C virus NS2/3 protease regulates HCV IRES-dependent translation and NS5B RdRp activity.

She Y, Han T, Ye L, Wu Z.

Arch Virol. 2009;154(9):1465-73. doi: 10.1007/s00705-009-0469-7. Epub 2009 Aug 18.


Hepatitis C virus NS2/3 processing is required for NS3 stability and viral RNA replication.

Welbourn S, Green R, Gamache I, Dandache S, Lohmann V, Bartenschlager R, Meerovitch K, Pause A.

J Biol Chem. 2005 Aug 19;280(33):29604-11. Epub 2005 Jun 24.

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