Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 96


Toxoplasma rhoptry protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6.

Ong YC, Reese ML, Boothroyd JC.

J Biol Chem. 2010 Sep 10;285(37):28731-40. doi: 10.1074/jbc.M110.112359. Epub 2010 Jul 12.


Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control.

Butcher BA, Fox BA, Rommereim LM, Kim SG, Maurer KJ, Yarovinsky F, Herbert DR, Bzik DJ, Denkers EY.

PLoS Pathog. 2011 Sep;7(9):e1002236. doi: 10.1371/journal.ppat.1002236. Epub 2011 Sep 8.


Toxoplasma gondii rhoptry 16 kinase promotes host resistance to oral infection and intestinal inflammation only in the context of the dense granule protein GRA15.

Jensen KD, Hu K, Whitmarsh RJ, Hassan MA, Julien L, Lu D, Chen L, Hunter CA, Saeij JP.

Infect Immun. 2013 Jun;81(6):2156-67. doi: 10.1128/IAI.01185-12. Epub 2013 Apr 1.


A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3.

Yamamoto M, Standley DM, Takashima S, Saiga H, Okuyama M, Kayama H, Kubo E, Ito H, Takaura M, Matsuda T, Soldati-Favre D, Takeda K.

J Exp Med. 2009 Nov 23;206(12):2747-60. doi: 10.1084/jem.20091703. Epub 2009 Nov 9.


Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue.

Saeij JP, Coller S, Boyle JP, Jerome ME, White MW, Boothroyd JC.

Nature. 2007 Jan 18;445(7125):324-7. Epub 2006 Dec 20.


Neospora caninum ROP16 play an important role in the pathogenicity by phosphorylating host cell STAT3.

Ma L, Liu G, Liu J, Li M, Zhang H, Tang D, Liu Q.

Vet Parasitol. 2017 Aug 30;243:135-147. doi: 10.1016/j.vetpar.2017.04.020. Epub 2017 May 19.


[Advances in research of Toxoplasma gondii rhoptry protein ROP16].

Liu GZ, Wang B, Wang HF.

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2015 Apr;27(2):217-20. Review. Chinese.


Targeted disruption of CK1α in Toxoplasma gondii increases acute virulence in mice.

Wang Z, Wang S, Wang W, Gu Y, Liu H, Wei F, Liu Q.

Eur J Protistol. 2016 Oct;56:90-101. doi: 10.1016/j.ejop.2016.07.006. Epub 2016 Aug 4.


Toxoplasma gondii Rhoptry Protein ROP16 Mediates Partially SH-SY5Y Cells Apoptosis and Cell Cycle Arrest by Directing Ser15/37 Phosphorylation of p53.

Chang S, Shan X, Li X, Fan W, Zhang SQ, Zhang J, Jiang N, Ma D, Mao Z.

Int J Biol Sci. 2015 Aug 15;11(10):1215-25. doi: 10.7150/ijbs.10516. eCollection 2015.


The Toxoplasma gondii Rhoptry Kinome Is Essential for Chronic Infection.

Fox BA, Rommereim LM, Guevara RB, Falla A, Hortua Triana MA, Sun Y, Bzik DJ.

MBio. 2016 May 10;7(3). pii: e00193-16. doi: 10.1128/mBio.00193-16.


Transcriptional profile of SH-SY5Y human neuroblastoma cells transfected by Toxoplasma rhoptry protein 16.

Fan W, Chang S, Shan X, Gao D, Zhang SQ, Zhang J, Jiang N, Ma D, Mao Z.

Mol Med Rep. 2016 Nov;14(5):4099-4108. doi: 10.3892/mmr.2016.5758. Epub 2016 Sep 21.


Toxoplasma co-opts host cells it does not invade.

Koshy AA, Dietrich HK, Christian DA, Melehani JH, Shastri AJ, Hunter CA, Boothroyd JC.

PLoS Pathog. 2012;8(7):e1002825. doi: 10.1371/journal.ppat.1002825. Epub 2012 Jul 26.


The Toxoplasma pseudokinase ROP5 forms complexes with ROP18 and ROP17 kinases that synergize to control acute virulence in mice.

Etheridge RD, Alaganan A, Tang K, Lou HJ, Turk BE, Sibley LD.

Cell Host Microbe. 2014 May 14;15(5):537-50. doi: 10.1016/j.chom.2014.04.002.


Polymorphic secreted kinases are key virulence factors in toxoplasmosis.

Saeij JP, Boyle JP, Coller S, Taylor S, Sibley LD, Brooke-Powell ET, Ajioka JW, Boothroyd JC.

Science. 2006 Dec 15;314(5806):1780-3.


Have it your way: how polymorphic, injected kinases and pseudokinases enable Toxoplasma to subvert host defenses.

Boothroyd JC.

PLoS Pathog. 2013;9(4):e1003296. doi: 10.1371/journal.ppat.1003296. Epub 2013 Apr 25. No abstract available.


Toxoplasma gondii virulence factor ROP18 inhibits the host NF-κB pathway by promoting p65 degradation.

Du J, An R, Chen L, Shen Y, Chen Y, Cheng L, Jiang Z, Zhang A, Yu L, Chu D, Shen Y, Luo Q, Chen H, Wan L, Li M, Xu X, Shen J.

J Biol Chem. 2014 May 2;289(18):12578-92. doi: 10.1074/jbc.M113.544718. Epub 2014 Mar 19.


Modulation of innate immunity by Toxoplasma gondii virulence effectors.

Hunter CA, Sibley LD.

Nat Rev Microbiol. 2012 Nov;10(11):766-78. doi: 10.1038/nrmicro2858. Review.


Toxoplasma gondii triggers phosphorylation and nuclear translocation of dendritic cell STAT1 while simultaneously blocking IFNγ-induced STAT1 transcriptional activity.

Schneider AG, Abi Abdallah DS, Butcher BA, Denkers EY.

PLoS One. 2013;8(3):e60215. doi: 10.1371/journal.pone.0060215. Epub 2013 Mar 20.


ATF6beta is a host cellular target of the Toxoplasma gondii virulence factor ROP18.

Yamamoto M, Ma JS, Mueller C, Kamiyama N, Saiga H, Kubo E, Kimura T, Okamoto T, Okuyama M, Kayama H, Nagamune K, Takashima S, Matsuura Y, Soldati-Favre D, Takeda K.

J Exp Med. 2011 Jul 4;208(7):1533-46. doi: 10.1084/jem.20101660. Epub 2011 Jun 13.

Supplemental Content

Support Center