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Items: 1 to 20 of 130

1.

Stability and CDR composition biases enrich binder functionality landscapes.

Hackel BJ, Ackerman ME, Howland SW, Wittrup KD.

J Mol Biol. 2010 Aug 6;401(1):84-96. doi: 10.1016/j.jmb.2010.06.004. Epub 2010 Jun 9.

2.

Phage-displayed antibody libraries of synthetic heavy chain complementarity determining regions.

Sidhu SS, Li B, Chen Y, Fellouse FA, Eigenbrot C, Fuh G.

J Mol Biol. 2004 Apr 23;338(2):299-310.

PMID:
15066433
3.

A novel heavy domain antibody library with functionally optimized complementarity determining regions.

Mandrup OA, Friis NA, Lykkemark S, Just J, Kristensen P.

PLoS One. 2013 Oct 8;8(10):e76834. doi: 10.1371/journal.pone.0076834. eCollection 2013.

4.

High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries.

Fellouse FA, Esaki K, Birtalan S, Raptis D, Cancasci VJ, Koide A, Jhurani P, Vasser M, Wiesmann C, Kossiakoff AA, Koide S, Sidhu SS.

J Mol Biol. 2007 Nov 2;373(4):924-40. Epub 2007 Aug 19.

PMID:
17825836
5.

Characterization of a high-affinity human antibody with a disulfide bridge in the third complementarity-determining region of the heavy chain.

Almagro JC, Raghunathan G, Beil E, Janecki DJ, Chen Q, Dinh T, LaCombe A, Connor J, Ware M, Kim PH, Swanson RV, Fransson J.

J Mol Recognit. 2012 Mar;25(3):125-35. doi: 10.1002/jmr.1168.

PMID:
22407976
6.

Side chain requirements for affinity and specificity in D5, an HIV-1 antibody derived from the VH1-69 germline segment.

Stewart A, Harrison JS, Regula LK, Lai JR.

BMC Biochem. 2013 Apr 8;14:9. doi: 10.1186/1471-2091-14-9.

7.

A large human domain antibody library combining heavy and light chain CDR3 diversity.

Chen W, Zhu Z, Feng Y, Dimitrov DS.

Mol Immunol. 2010 Jan;47(4):912-21. doi: 10.1016/j.molimm.2009.09.039. Epub 2009 Nov 1.

8.
9.

High-affinity human antibodies from phage-displayed synthetic Fab libraries with a single framework scaffold.

Lee CV, Liang WC, Dennis MS, Eigenbrot C, Sidhu SS, Fuh G.

J Mol Biol. 2004 Jul 23;340(5):1073-93.

PMID:
15236968
10.

Defining the complementarities between antibodies and haptens to refine our understanding and aid the prediction of a successful binding interaction.

Al Qaraghuli MM, Palliyil S, Broadbent G, Cullen DC, Charlton KA, Porter AJ.

BMC Biotechnol. 2015 Oct 24;15:99. doi: 10.1186/s12896-015-0217-x.

11.

A Gradient of Sitewise Diversity Promotes Evolutionary Fitness for Binder Discovery in a Three-Helix Bundle Protein Scaffold.

Woldring DR, Holec PV, Stern LA, Du Y, Hackel BJ.

Biochemistry. 2017 Mar 21;56(11):1656-1671. doi: 10.1021/acs.biochem.6b01142. Epub 2017 Mar 9.

12.

A Novel Human scFv Library with Non-Combinatorial Synthetic CDR Diversity.

Bai X, Kim J, Kang S, Kim W, Shim H.

PLoS One. 2015 Oct 20;10(10):e0141045. doi: 10.1371/journal.pone.0141045. eCollection 2015.

13.

Bispecific engineered antibody domains (nanoantibodies) that interact noncompetitively with an HIV-1 neutralizing epitope and FcRn.

Gong R, Wang Y, Ying T, Dimitrov DS.

PLoS One. 2012;7(8):e42288. doi: 10.1371/journal.pone.0042288. Epub 2012 Aug 7.

14.

A focused antibody library for improved hapten recognition.

Persson H, Lantto J, Ohlin M.

J Mol Biol. 2006 Mar 24;357(2):607-20. Epub 2006 Jan 19.

PMID:
16445941
15.

A Single-Framework Synthetic Antibody Library Containing a Combination of Canonical and Variable Complementarity-Determining Regions.

Maruthachalam BV, El-Sayed A, Liu J, Sutherland AR, Hill W, Alam MK, Pastushok L, Fonge H, Barreto K, Geyer CR.

Chembiochem. 2017 Nov 16;18(22):2247-2259. doi: 10.1002/cbic.201700279. Epub 2017 Oct 20.

PMID:
28884521
16.

The diversity of H3 loops determines the antigen-binding tendencies of antibody CDR loops.

Tsuchiya Y, Mizuguchi K.

Protein Sci. 2016 Apr;25(4):815-25. doi: 10.1002/pro.2874. Epub 2016 Jan 20.

17.

A structure-based database of antibody variable domain diversity.

Bond CJ, Wiesmann C, Marsters JC Jr, Sidhu SS.

J Mol Biol. 2005 May 6;348(3):699-709.

PMID:
15826665
18.

Binding of CDR-derived peptides is mechanistically different from that of high-affinity parental antibodies.

Timmerman P, Shochat SG, Desmet J, Barderas R, Casal JI, Meloen RH, Altschuh D.

J Mol Recognit. 2010 Nov-Dec;23(6):559-68. doi: 10.1002/jmr.1017.

PMID:
21038356
19.

Synthetic antibody libraries focused towards peptide ligands.

Cobaugh CW, Almagro JC, Pogson M, Iverson B, Georgiou G.

J Mol Biol. 2008 May 2;378(3):622-33. doi: 10.1016/j.jmb.2008.02.037. Epub 2008 Mar 4.

20.

The human combinatorial antibody library HuCAL GOLD combines diversification of all six CDRs according to the natural immune system with a novel display method for efficient selection of high-affinity antibodies.

Rothe C, Urlinger S, Löhning C, Prassler J, Stark Y, Jäger U, Hubner B, Bardroff M, Pradel I, Boss M, Bittlingmaier R, Bataa T, Frisch C, Brocks B, Honegger A, Urban M.

J Mol Biol. 2008 Feb 29;376(4):1182-200. doi: 10.1016/j.jmb.2007.12.018. Epub 2007 Dec 15.

PMID:
18191144

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