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Items: 1 to 20 of 94


Coordinate control of host centrosome position, organelle distribution, and migratory response by Toxoplasma gondii via host mTORC2.

Wang Y, Weiss LM, Orlofsky A.

J Biol Chem. 2010 May 14;285(20):15611-8. doi: 10.1074/jbc.M109.095778. Epub 2010 Mar 17.


Mechanical regulation of glycogen synthase kinase 3β (GSK3β) in mesenchymal stem cells is dependent on Akt protein serine 473 phosphorylation via mTORC2 protein.

Case N, Thomas J, Sen B, Styner M, Xie Z, Galior K, Rubin J.

J Biol Chem. 2011 Nov 11;286(45):39450-6. doi: 10.1074/jbc.M111.265330. Epub 2011 Sep 28.


Fierce competition between Toxoplasma and Chlamydia for host cell structures in dually infected cells.

Romano JD, de Beaumont C, Carrasco JA, Ehrenman K, Bavoil PM, Coppens I.

Eukaryot Cell. 2013 Feb;12(2):265-77. doi: 10.1128/EC.00313-12. Epub 2012 Dec 14.


Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c.

Hagiwara A, Cornu M, Cybulski N, Polak P, Betz C, Trapani F, Terracciano L, Heim MH, Rüegg MA, Hall MN.

Cell Metab. 2012 May 2;15(5):725-38. doi: 10.1016/j.cmet.2012.03.015. Epub 2012 Apr 19.


ER stress inhibits mTORC2 and Akt signaling through GSK-3β-mediated phosphorylation of rictor.

Chen CH, Shaikenov T, Peterson TR, Aimbetov R, Bissenbaev AK, Lee SW, Wu J, Lin HK, Sarbassov dos D.

Sci Signal. 2011 Feb 22;4(161):ra10. doi: 10.1126/scisignal.2001731.


Involvement of PI 3 kinase/Akt-dependent Bad phosphorylation in Toxoplasma gondii-mediated inhibition of host cell apoptosis.

Quan JH, Cha GH, Zhou W, Chu JQ, Nishikawa Y, Lee YH.

Exp Parasitol. 2013 Apr;133(4):462-71. doi: 10.1016/j.exppara.2013.01.005. Epub 2013 Jan 16.


Besnoitia besnoiti and Toxoplasma gondii: two apicomplexan strategies to manipulate the host cell centrosome and Golgi apparatus.

Cardoso R, Nolasco S, Gonçalves J, Cortes HC, Leitão A, Soares H.

Parasitology. 2014 Sep;141(11):1436-54. doi: 10.1017/S0031182014000493. Epub 2014 Jun 3.


Rapamycin reverses pulmonary artery smooth muscle cell proliferation in pulmonary hypertension.

Houssaini A, Abid S, Mouraret N, Wan F, Rideau D, Saker M, Marcos E, Tissot CM, Dubois-Randé JL, Amsellem V, Adnot S.

Am J Respir Cell Mol Biol. 2013 May;48(5):568-77. doi: 10.1165/rcmb.2012-0429OC.


mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.

Julien LA, Carriere A, Moreau J, Roux PP.

Mol Cell Biol. 2010 Feb;30(4):908-21. doi: 10.1128/MCB.00601-09. Epub 2009 Dec 7.


Pivotal role of mTORC2 and involvement of ribosomal protein S6 in cardioprotective signaling.

Yano T, Ferlito M, Aponte A, Kuno A, Miura T, Murphy E, Steenbergen C.

Circ Res. 2014 Apr 11;114(8):1268-80. doi: 10.1161/CIRCRESAHA.114.303562. Epub 2014 Feb 20.


Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.

Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM.

Dev Cell. 2006 Dec;11(6):859-71.


Intracellular parasitism with Toxoplasma gondii stimulates mammalian-target-of-rapamycin-dependent host cell growth despite impaired signalling to S6K1 and 4E-BP1.

Wang Y, Weiss LM, Orlofsky A.

Cell Microbiol. 2009 Jun;11(6):983-1000. doi: 10.1111/j.1462-5822.2009.01305.x. Epub 2009 Feb 27.


Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility.

Gulati N, Karsy M, Albert L, Murali R, Jhanwar-Uniyal M.

Int J Oncol. 2009 Oct;35(4):731-40.


Inhibition of 14-3-3 binding to Rictor of mTORC2 for Akt phosphorylation at Ser473 is regulated by selenoprotein W.

Jeon YH, Park YH, Kwon JH, Lee JH, Kim IY.

Biochim Biophys Acta. 2013 Oct;1833(10):2135-42. doi: 10.1016/j.bbamcr.2013.05.005. Epub 2013 May 13.


XPLN is an endogenous inhibitor of mTORC2.

Khanna N, Fang Y, Yoon MS, Chen J.

Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):15979-84. doi: 10.1073/pnas.1310434110. Epub 2013 Sep 16.


Hydrophobic motif site-phosphorylated protein kinase CβII between mTORC2 and Akt regulates high glucose-induced mesangial cell hypertrophy.

Das F, Ghosh-Choudhury N, Mariappan MM, Kasinath BS, Choudhury GG.

Am J Physiol Cell Physiol. 2016 Apr 1;310(7):C583-96. doi: 10.1152/ajpcell.00266.2015. Epub 2016 Jan 6.


New host nuclear functions are not required for the modifications of the parasitophorous vacuole of Toxoplasma.

Romano JD, Bano N, Coppens I.

Cell Microbiol. 2008 Feb;10(2):465-76. Epub 2007 Oct 28.


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