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Items: 1 to 20 of 137

1.

SP600125 suppresses Cdk1 and induces endoreplication directly from G2 phase, independent of JNK inhibition.

Kim JA, Lee J, Margolis RL, Fotedar R.

Oncogene. 2010 Mar 18;29(11):1702-16. doi: 10.1038/onc.2009.464.

2.

Phosphorylation of Plk1 at S137 and T210 is inhibited in response to DNA damage.

Tsvetkov L, Stern DF.

Cell Cycle. 2005 Jan;4(1):166-71.

PMID:
15611664
3.

Cdk1 activity is required for mitotic activation of aurora A during G2/M transition of human cells.

Van Horn RD, Chu S, Fan L, Yin T, Du J, Beckmann R, Mader M, Zhu G, Toth J, Blanchard K, Ye XS.

J Biol Chem. 2010 Jul 9;285(28):21849-57. doi: 10.1074/jbc.M110.141010.

4.

Inhibition of c-Jun-N-terminal-kinase sensitizes tumor cells to CD95-induced apoptosis and induces G2/M cell cycle arrest.

Kuntzen C, Sonuc N, De Toni EN, Opelz C, Mucha SR, Gerbes AL, Eichhorst ST.

Cancer Res. 2005 Aug 1;65(15):6780-8.

5.

Induction of endoreduplication by a JNK inhibitor SP600125 in human lung carcinoma A 549 cells.

Miyamoto-Yamasaki Y, Yamasaki M, Tachibana H, Yamada K.

Cell Biol Int. 2007 Dec;31(12):1501-6.

PMID:
17904874
6.

Loss of p53 induces M-phase retardation following G2 DNA damage checkpoint abrogation.

Minemoto Y, Uchida S, Ohtsubo M, Shimura M, Sasagawa T, Hirata M, Nakagama H, Ishizaka Y, Yamashita K.

Arch Biochem Biophys. 2003 Apr 1;412(1):13-9.

PMID:
12646262
7.

Delta MEKK3:ER* activation induces a p38 alpha/beta 2-dependent cell cycle arrest at the G2 checkpoint.

Garner AP, Weston CR, Todd DE, Balmanno K, Cook SJ.

Oncogene. 2002 Nov 21;21(53):8089-104.

8.

The c-Jun N-terminal kinase JNK functions upstream of Aurora B to promote entry into mitosis.

Oktay K, Buyuk E, Oktem O, Oktay M, Giancotti FG.

Cell Cycle. 2008 Feb 15;7(4):533-41.

PMID:
18431843
9.
10.

Mitotic progression becomes irreversible in prometaphase and collapses when Wee1 and Cdc25 are inhibited.

Potapova TA, Sivakumar S, Flynn JN, Li R, Gorbsky GJ.

Mol Biol Cell. 2011 Apr 15;22(8):1191-206. doi: 10.1091/mbc.E10-07-0599.

11.

SAPK/JNK regulates cdc2/cyclin B kinase through phosphorylation and inhibition of cdc25c.

Goss VL, Cross JV, Ma K, Qian Y, Mola PW, Templeton DJ.

Cell Signal. 2003 Jul;15(7):709-18.

PMID:
12742231
12.
13.

Activation of NAG-1 via JNK signaling revealed an isochaihulactone-triggered cell death in human LNCaP prostate cancer cells.

Chiu SC, Wang MJ, Yang HH, Chen SP, Huang SY, Chen YL, Lin SZ, Harn HJ, Pang CY.

BMC Cancer. 2011 Apr 20;11:146. doi: 10.1186/1471-2407-11-146.

14.
15.

Bleomycin-induced over-replication involves sustained inhibition of mitotic entry through the ATM/ATR pathway.

Nakayama Y, Igarashi A, Kikuchi I, Obata Y, Fukumoto Y, Yamaguchi N.

Exp Cell Res. 2009 Sep 10;315(15):2515-28. doi: 10.1016/j.yexcr.2009.06.007.

PMID:
19527713
16.

Inhibition of JNK reduces G2/M transit independent of p53, leading to endoreduplication, decreased proliferation, and apoptosis in breast cancer cells.

Mingo-Sion AM, Marietta PM, Koller E, Wolf DM, Van Den Berg CL.

Oncogene. 2004 Jan 15;23(2):596-604.

PMID:
14724588
17.

ATR enforces the topoisomerase II-dependent G2 checkpoint through inhibition of Plk1 kinase.

Deming PB, Flores KG, Downes CS, Paules RS, Kaufmann WK.

J Biol Chem. 2002 Sep 27;277(39):36832-8.

18.

G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently.

O'Connor PM, Ferris DK, Pagano M, Draetta G, Pines J, Hunter T, Longo DL, Kohn KW.

J Biol Chem. 1993 Apr 15;268(11):8298-308.

19.

The Catalytic Subunit of DNA-Dependent Protein Kinase Coordinates with Polo-Like Kinase 1 to Facilitate Mitotic Entry.

Lee KJ, Shang ZF, Lin YF, Sun J, Morotomi-Yano K, Saha D, Chen BP.

Neoplasia. 2015 Apr;17(4):329-38. doi: 10.1016/j.neo.2015.02.004.

20.

JIP4 is a PLK1 binding protein that regulates p38MAPK activity in G2 phase.

Pinder A, Loo D, Harrington B, Oakes V, Hill MM, Gabrielli B.

Cell Signal. 2015 Nov;27(11):2296-303. doi: 10.1016/j.cellsig.2015.08.009.

PMID:
26291670

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