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Items: 1 to 20 of 139

1.

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.

Huang SM, Mishina YM, Liu S, Cheung A, Stegmeier F, Michaud GA, Charlat O, Wiellette E, Zhang Y, Wiessner S, Hild M, Shi X, Wilson CJ, Mickanin C, Myer V, Fazal A, Tomlinson R, Serluca F, Shao W, Cheng H, Shultz M, Rau C, Schirle M, Schlegl J, Ghidelli S, Fawell S, Lu C, Curtis D, Kirschner MW, Lengauer C, Finan PM, Tallarico JA, Bouwmeester T, Porter JA, Bauer A, Cong F.

Nature. 2009 Oct 1;461(7264):614-20. doi: 10.1038/nature08356. Epub 2009 Sep 16.

PMID:
19759537
2.

The ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signaling.

Lui TT, Lacroix C, Ahmed SM, Goldenberg SJ, Leach CA, Daulat AM, Angers S.

Mol Cell Biol. 2011 May;31(10):2053-65. doi: 10.1128/MCB.01094-10. Epub 2011 Mar 7.

3.

Drug discovery: Propping up a destructive regime.

Peterson RT.

Nature. 2009 Oct 1;461(7264):599-600. doi: 10.1038/461599a. No abstract available.

PMID:
19794479
4.

Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells.

Bao R, Christova T, Song S, Angers S, Yan X, Attisano L.

PLoS One. 2012;7(11):e48670. doi: 10.1371/journal.pone.0048670. Epub 2012 Nov 7.

5.

The Poly(ADP-ribose) Polymerase Enzyme Tankyrase Antagonizes Activity of the β-Catenin Destruction Complex through ADP-ribosylation of Axin and APC2.

Croy HE, Fuller CN, Giannotti J, Robinson P, Foley AV, Yamulla RJ, Cosgriff S, Greaves BD, von Kleeck RA, An HH, Powers CM, Tran JK, Tocker AM, Jacob KD, Davis BK, Roberts DM.

J Biol Chem. 2016 Jun 10;291(24):12747-60. doi: 10.1074/jbc.M115.705442. Epub 2016 Apr 11.

6.

Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling.

Callow MG, Tran H, Phu L, Lau T, Lee J, Sandoval WN, Liu PS, Bheddah S, Tao J, Lill JR, Hongo JA, Davis D, Kirkpatrick DS, Polakis P, Costa M.

PLoS One. 2011;6(7):e22595. doi: 10.1371/journal.pone.0022595. Epub 2011 Jul 25.

7.

Tankyrase inhibitors attenuate WNT/β-catenin signaling and inhibit growth of hepatocellular carcinoma cells.

Ma L, Wang X, Jia T, Wei W, Chua MS, So S.

Oncotarget. 2015 Sep 22;6(28):25390-401. doi: 10.18632/oncotarget.4455.

8.

Tankyrase Inhibitors Stimulate the Ability of Tankyrases to Bind Axin and Drive Assembly of β-Catenin Degradation-Competent Axin Puncta.

Martino-Echarri E, Brocardo MG, Mills KM, Henderson BR.

PLoS One. 2016 Mar 1;11(3):e0150484. doi: 10.1371/journal.pone.0150484. eCollection 2016.

9.

WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling.

James RG, Davidson KC, Bosch KA, Biechele TL, Robin NC, Taylor RJ, Major MB, Camp ND, Fowler K, Martins TJ, Moon RT.

PLoS One. 2012;7(12):e50457. doi: 10.1371/journal.pone.0050457. Epub 2012 Dec 5.

10.

Evidence for tankyrases as antineoplastic targets in lung cancer.

Busch AM, Johnson KC, Stan RV, Sanglikar A, Ahmed Y, Dmitrovsky E, Freemantle SJ.

BMC Cancer. 2013 Apr 28;13:211. doi: 10.1186/1471-2407-13-211.

11.

RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling.

Zhang Y, Liu S, Mickanin C, Feng Y, Charlat O, Michaud GA, Schirle M, Shi X, Hild M, Bauer A, Myer VE, Finan PM, Porter JA, Huang SM, Cong F.

Nat Cell Biol. 2011 May;13(5):623-9. doi: 10.1038/ncb2222. Epub 2011 Apr 10.

PMID:
21478859
12.

LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin.

Cselenyi CS, Jernigan KK, Tahinci E, Thorne CA, Lee LA, Lee E.

Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):8032-7. doi: 10.1073/pnas.0803025105. Epub 2008 May 28.

13.

A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth.

Lau T, Chan E, Callow M, Waaler J, Boggs J, Blake RA, Magnuson S, Sambrone A, Schutten M, Firestein R, Machon O, Korinek V, Choo E, Diaz D, Merchant M, Polakis P, Holsworth DD, Krauss S, Costa M.

Cancer Res. 2013 May 15;73(10):3132-44. doi: 10.1158/0008-5472.CAN-12-4562. Epub 2013 Mar 28.

14.

The Anti-Tumor Activity of Succinyl Macrolactin A Is Mediated through the β-Catenin Destruction Complex via the Suppression of Tankyrase and PI3K/Akt.

Regmi SC, Park SY, Kim SJ, Banskota S, Shah S, Kim DH, Kim JA.

PLoS One. 2015 Nov 6;10(11):e0141753. doi: 10.1371/journal.pone.0141753. eCollection 2015.

15.

PARsing the phrase "all in for Axin"- Wnt pathway targets in cancer.

Fearon ER.

Cancer Cell. 2009 Nov 6;16(5):366-8. doi: 10.1016/j.ccr.2009.10.007. Review.

16.

Tankyrase 1 inhibitior XAV939 increases chemosensitivity in colon cancer cell lines via inhibition of the Wnt signaling pathway.

Wu X, Luo F, Li J, Zhong X, Liu K.

Int J Oncol. 2016 Apr;48(4):1333-40. doi: 10.3892/ijo.2016.3360. Epub 2016 Jan 26.

17.

Destruction of a destructor: a new avenue for cancer therapeutics targeting the Wnt pathway.

Liu C, He X.

J Mol Cell Biol. 2010 Apr;2(2):70-3. doi: 10.1093/jmcb/mjp040. Epub 2009 Dec 11.

18.

The Discovery and Characterization of K-756, a Novel Wnt/β-Catenin Pathway Inhibitor Targeting Tankyrase.

Okada-Iwasaki R, Takahashi Y, Watanabe Y, Ishida H, Saito J, Nakai R, Asai A.

Mol Cancer Ther. 2016 Jul;15(7):1525-34. doi: 10.1158/1535-7163.MCT-15-0938. Epub 2016 Apr 25.

19.

Wnt/Wingless Pathway Activation Is Promoted by a Critical Threshold of Axin Maintained by the Tumor Suppressor APC and the ADP-Ribose Polymerase Tankyrase.

Wang Z, Tacchelly-Benites O, Yang E, Thorne CA, Nojima H, Lee E, Ahmed Y.

Genetics. 2016 May;203(1):269-81. doi: 10.1534/genetics.115.183244. Epub 2016 Mar 14.

20.

Formation of Tankyrase Inhibitor-Induced Degradasomes Requires Proteasome Activity.

Pedersen NM, Thorvaldsen TE, Schultz SW, Wenzel EM, Stenmark H.

PLoS One. 2016 Aug 2;11(8):e0160507. doi: 10.1371/journal.pone.0160507. eCollection 2016.

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