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Anti-CD25 antibody-mediated depletion of effector T cell populations enhances susceptibility of mice to acute but not chronic Toxoplasma gondii infection.

Couper KN, Lanthier PA, Perona-Wright G, Kummer LW, Chen W, Smiley ST, Mohrs M, Johnson LL.

J Immunol. 2009 Apr 1;182(7):3985-94. doi: 10.4049/jimmunol.0803053.


Depletion of CD25⁺ cells during acute toxoplasmosis does not significantly increase mortality in Swiss OF1 mice.

Akbar H, Germon S, Berthon P, Dimier-Poisson I, Moiré N.

Mem Inst Oswaldo Cruz. 2012 Mar;107(2):155-62.


Administration of anti-CD25 mAb leads to impaired α-galactosylceramide-mediated induction of IFN-γ production in a murine model.

Rosalia RA, Štěpánek I, Polláková V, Šímová J, Bieblová J, Indrová M, Moravcová S, Přibylová H, Bontkes HJ, Bubeník J, Sparwasser T, Reiniš M.

Immunobiology. 2013 Jun;218(6):851-9. doi: 10.1016/j.imbio.2012.10.012. Epub 2012 Oct 26.


Depletion of natural CD4+CD25+ T regulatory cells with anti-CD25 antibody does not change the course of Pseudomonas aeruginosa-induced acute lung infection in mice.

Carrigan SO, Yang YJ, Issekutz T, Forward N, Hoskin D, Johnston B, Lin TJ.

Immunobiology. 2009;214(3):211-22. doi: 10.1016/j.imbio.2008.07.027. Epub 2008 Sep 18.


IL-2 contributes to maintaining a balance between CD4+Foxp3+ regulatory T cells and effector CD4+ T cells required for immune control of blood-stage malaria infection.

Berretta F, St-Pierre J, Piccirillo CA, Stevenson MM.

J Immunol. 2011 Apr 15;186(8):4862-71. doi: 10.4049/jimmunol.1003777. Epub 2011 Mar 9.


Depletion with PC61 mAb before Toxoplasma gondii infection eliminates mainly Tregs in BALB/c mice, but activated cells in C57BL/6J mice.

Tenorio EP, Fernández J, Olguín JE, Saavedra R.

FEMS Immunol Med Microbiol. 2011 Aug;62(3):362-7. doi: 10.1111/j.1574-695X.2011.00805.x. Epub 2011 May 6.


Partial depletion of CD4(+)CD25(+)Foxp3(+) T regulatory cells significantly increases morbidity during acute phase Toxoplasma gondii infection in resistant BALB/c mice.

Morampudi V, De Craeye S, Le Moine A, Detienne S, Braun MY, D'Souza S.

Microbes Infect. 2011 Apr;13(4):394-404. doi: 10.1016/j.micinf.2011.01.006. Epub 2011 Jan 22.


Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis.

Scumpia PO, Delano MJ, Kelly KM, O'Malley KA, Efron PA, McAuliffe PF, Brusko T, Ungaro R, Barker T, Wynn JL, Atkinson MA, Reeves WH, Salzler MJ, Moldawer LL.

J Immunol. 2006 Dec 1;177(11):7943-9.


Anti-IL-2 treatment impairs the expansion of T(reg) cell population during acute malaria and enhances the Th1 cell response at the chronic disease.

Zago CA, Bortoluci KR, Sardinha LR, Pretel FD, Castillo-Méndez SI, Freitas do Rosário AP, Hiyane MI, Muxel SM, Rodriguez-Málaga SM, Abrahamsohn IA, Álvarez JM, D'Império Lima MR.

PLoS One. 2012;7(1):e29894. doi: 10.1371/journal.pone.0029894. Epub 2012 Jan 17.


CD4+CD25+ regulatory T cell depletion modulates anxiety and depression-like behaviors in mice.

Kim SJ, Lee H, Lee G, Oh SJ, Shin MK, Shim I, Bae H.

PLoS One. 2012;7(7):e42054. doi: 10.1371/journal.pone.0042054. Epub 2012 Jul 31.


Tolerogenic dendritic cells induce CD4+CD25hiFoxp3+ regulatory T cell differentiation from CD4+CD25-/loFoxp3- effector T cells.

Huang H, Dawicki W, Zhang X, Town J, Gordon JR.

J Immunol. 2010 Nov 1;185(9):5003-10. doi: 10.4049/jimmunol.0903446. Epub 2010 Sep 24.


[Changes of CD4+CD25+ T cells in the spleen of mice infected with Toxoplasma gondii].

Ge YY, Zhang G, Wu JP, Wang Y, Hu W, Tan MJ.

Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2007 Jun;25(3):189-92. Chinese.


The dysfunction of CD4(+)CD25(+) regulatory T cells contributes to the abortion of mice caused by Toxoplasma gondii excreted-secreted antigens in early pregnancy.

Chen JL, Ge YY, Zhang J, Qiu XY, Qiu JF, Wu JP, Wang Y.

PLoS One. 2013 Jul 17;8(7):e69012. doi: 10.1371/journal.pone.0069012. Print 2013.


Increased sensitivity of CD4+ T-effector cells to CD4+CD25+ Treg suppression compensates for reduced Treg number in asymptomatic HIV-1 infection.

Thorborn G, Pomeroy L, Isohanni H, Perry M, Peters B, Vyakarnam A.

PLoS One. 2010 Feb 17;5(2):e9254. doi: 10.1371/journal.pone.0009254.


The effect of immunosuppressive drug rapamycin on regulatory CD4+CD25+Foxp3+T cells in mice.

Qu Y, Zhang B, Zhao L, Liu G, Ma H, Rao E, Zeng C, Zhao Y.

Transpl Immunol. 2007 Apr;17(3):153-61. Epub 2007 Jan 24.


CD4(+) CD25(low) GITR(+) cells: a novel human CD4(+) T-cell population with regulatory activity.

Bianchini R, Bistoni O, Alunno A, Petrillo MG, Ronchetti S, Sportoletti P, Bocci EB, Nocentini G, Gerli R, Riccardi C.

Eur J Immunol. 2011 Aug;41(8):2269-78. doi: 10.1002/eji.201040943. Epub 2011 Jul 4.


Anti-CD25 treatment depletes Treg cells and decreases disease severity in susceptible and resistant mice infected with Paracoccidioides brasiliensis.

Felonato M, Pina A, de Araujo EF, Loures FV, Bazan SB, Feriotti C, Calich VL.

PLoS One. 2012;7(11):e51071. doi: 10.1371/journal.pone.0051071. Epub 2012 Nov 30.


Anti-CD25 mAb administration prevents spontaneous liver transplant tolerance.

Li W, Carper K, Liang Y, Zheng XX, Kuhr CS, Reyes JD, Perkins DL, Thomson AW, Perkins JD.

Transplant Proc. 2006 Dec;38(10):3207-8.


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