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Items: 1 to 20 of 182

1.

Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties.

Genis C, Sippel KH, Case N, Cao W, Avvaru BS, Tartaglia LJ, Govindasamy L, Tu C, Agbandje-McKenna M, Silverman DN, Rosser CJ, McKenna R.

Biochemistry. 2009 Feb 17;48(6):1322-31. doi: 10.1021/bi802035f.

2.

Saccharin: a lead compound for structure-based drug design of carbonic anhydrase IX inhibitors.

Mahon BP, Hendon AM, Driscoll JM, Rankin GM, Poulsen SA, Supuran CT, McKenna R.

Bioorg Med Chem. 2015 Feb 15;23(4):849-54. doi: 10.1016/j.bmc.2014.12.030. Epub 2014 Dec 23.

3.

Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX.

Alterio V, Hilvo M, Di Fiore A, Supuran CT, Pan P, Parkkila S, Scaloni A, Pastorek J, Pastorekova S, Pedone C, Scozzafava A, Monti SM, De Simone G.

Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16233-8. doi: 10.1073/pnas.0908301106. Epub 2009 Sep 14.

4.

Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases.

Pinard MA, Boone CD, Rife BD, Supuran CT, McKenna R.

Bioorg Med Chem. 2013 Nov 15;21(22):7210-5. doi: 10.1016/j.bmc.2013.08.033. Epub 2013 Aug 28.

PMID:
24090602
5.

Structural insights into carbonic anhydrase IX isoform specificity of carbohydrate-based sulfamates.

Moeker J, Mahon BP, Bornaghi LF, Vullo D, Supuran CT, McKenna R, Poulsen SA.

J Med Chem. 2014 Oct 23;57(20):8635-45. doi: 10.1021/jm5012935. Epub 2014 Oct 8.

6.

Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX.

Alterio V, Vitale RM, Monti SM, Pedone C, Scozzafava A, Cecchi A, De Simone G, Supuran CT.

J Am Chem Soc. 2006 Jun 28;128(25):8329-35.

PMID:
16787097
7.

Design and synthesis of novel 4-(4-oxo-2-arylthiazolidin-3-yl)benzenesulfonamides as selective inhibitors of carbonic anhydrase IX over I and II with potential anticancer activity.

Suthar SK, Bansal S, Lohan S, Modak V, Chaudhary A, Tiwari A.

Eur J Med Chem. 2013 Aug;66:372-9. doi: 10.1016/j.ejmech.2013.06.003. Epub 2013 Jun 12.

PMID:
23827177
8.

Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, cancer-associated isozyme IX with lipophilic sulfonamides.

Franchi M, Vullo D, Gallori E, Pastorek J, Russo A, Scozzafava A, Pastorekova S, Supuran CT.

J Enzyme Inhib Med Chem. 2003 Aug;18(4):333-8.

PMID:
14567548
9.
10.

Recent advances in structural studies of the carbonic anhydrase family: the crystal structure of human CA IX and CA XIII.

Supuran CT, Di Fiore A, Alterio V, Monti SM, De Simone G.

Curr Pharm Des. 2010;16(29):3246-54. Review.

PMID:
20819069
11.

Efficient Expression and Crystallization System of Cancer-Associated Carbonic Anhydrase Isoform IX.

Leitans J, Kazaks A, Balode A, Ivanova J, Zalubovskis R, Supuran CT, Tars K.

J Med Chem. 2015 Nov 25;58(22):9004-9. doi: 10.1021/acs.jmedchem.5b01343. Epub 2015 Nov 10.

PMID:
26522624
12.

Effect of incorporating a thiophene tail in the scaffold of acetazolamide on the inhibition of human carbonic anhydrase isoforms I, II, IX and XII.

Biswas S, McKenna R, Supuran CT.

Bioorg Med Chem Lett. 2013 Oct 15;23(20):5646-9. doi: 10.1016/j.bmcl.2013.08.019. Epub 2013 Aug 13.

PMID:
23993330
14.

A sucrose-binding site provides a lead towards an isoform-specific inhibitor of the cancer-associated enzyme carbonic anhydrase IX.

Pinard MA, Aggarwal M, Mahon BP, Tu C, McKenna R.

Acta Crystallogr F Struct Biol Commun. 2015 Oct;71(Pt 10):1352-8. doi: 10.1107/S2053230X1501239X. Epub 2015 Sep 23.

15.
16.

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.

Puccetti L, Fasolis G, Cecchi A, Winum JY, Gamberi A, Montero JL, Scozzafava A, Supuran CT.

Bioorg Med Chem Lett. 2005 May 2;15(9):2359-64.

PMID:
15837325
17.

5-Substituted-(1,2,3-triazol-4-yl)thiophene-2-sulfonamides strongly inhibit human carbonic anhydrases I, II, IX and XII: solution and X-ray crystallographic studies.

Leitans J, Sprudza A, Tanc M, Vozny I, Zalubovskis R, Tars K, Supuran CT.

Bioorg Med Chem. 2013 Sep 1;21(17):5130-8. doi: 10.1016/j.bmc.2013.06.041. Epub 2013 Jun 27.

PMID:
23859774
18.

Drug design studies of the novel antitumor targets carbonic anhydrase IX and XII.

Guler OO, De Simone G, Supuran CT.

Curr Med Chem. 2010;17(15):1516-26. Review.

PMID:
20166929
19.

N-β-glycosyl sulfamides are selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII.

Rodríguez OM, Maresca A, Témpera CA, Bravo RD, Colinas PA, Supuran CT.

Bioorg Med Chem Lett. 2011 Aug 1;21(15):4447-50. doi: 10.1016/j.bmcl.2011.06.031. Epub 2011 Jun 16.

PMID:
21723123
20.

Targeting tumor-associated carbonic anhydrase IX in cancer therapy.

Thiry A, Dogné JM, Masereel B, Supuran CT.

Trends Pharmacol Sci. 2006 Nov;27(11):566-73. Epub 2006 Sep 25.

PMID:
16996620

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