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Influenza a virus polymerase is an integral component of the CPSF30-NS1A protein complex in infected cells.

Kuo RL, Krug RM.

J Virol. 2009 Feb;83(4):1611-6. doi: 10.1128/JVI.01491-08. Epub 2008 Dec 3.


The H5N1 influenza virus NS genes selected after 1998 enhance virus replication in mammalian cells.

Twu KY, Kuo RL, Marklund J, Krug RM.

J Virol. 2007 Aug;81(15):8112-21. Epub 2007 May 23.


Structural basis for suppression of a host antiviral response by influenza A virus.

Das K, Ma LC, Xiao R, Radvansky B, Aramini J, Zhao L, Marklund J, Kuo RL, Twu KY, Arnold E, Krug RM, Montelione GT.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13093-8. doi: 10.1073/pnas.0805213105. Epub 2008 Aug 25.


The CPSF30 binding site on the NS1A protein of influenza A virus is a potential antiviral target.

Twu KY, Noah DL, Rao P, Kuo RL, Krug RM.

J Virol. 2006 Apr;80(8):3957-65.


Influenza A/Hong Kong/156/1997(H5N1) virus NS1 gene mutations F103L and M106I both increase IFN antagonism, virulence and cytoplasmic localization but differ in binding to RIG-I and CPSF30.

Dankar SK, Miranda E, Forbes NE, Pelchat M, Tavassoli A, Selman M, Ping J, Jia J, Brown EG.

Virol J. 2013 Jul 25;10:243. doi: 10.1186/1743-422X-10-243.


Virtual screening of potential inhibitors from TCM for the CPSF30 binding site on the NS1A protein of influenza A virus.

Ai H, Zhang L, Chang AK, Wei H, Che Y, Liu H.

J Mol Model. 2014 Mar;20(3):2142. doi: 10.1007/s00894-014-2142-7. Epub 2014 Feb 23.


The virulence of 1997 H5N1 influenza viruses in the mouse model is increased by correcting a defect in their NS1 proteins.

Spesock A, Malur M, Hossain MJ, Chen LM, Njaa BL, Davis CT, Lipatov AS, York IA, Krug RM, Donis RO.

J Virol. 2011 Jul;85(14):7048-58. doi: 10.1128/JVI.00417-11. Epub 2011 May 18.


Biophysical characterization of the complex between double-stranded RNA and the N-terminal domain of the NS1 protein from influenza A virus: evidence for a novel RNA-binding mode.

Chien CY, Xu Y, Xiao R, Aramini JM, Sahasrabudhe PV, Krug RM, Montelione GT.

Biochemistry. 2004 Feb 24;43(7):1950-62.


[Development of a yeast two-hybrid screen for selection of A/H1N1 influenza NS1 non-structural protein and human CPSF30 protein interaction inhibitors].

Kong JQ, Shen JH, Huang Y, Ruan RY, Xiang B, Zheng XD, Cheng KD, Wang W.

Yao Xue Xue Bao. 2010 Mar;45(3):388-94. Chinese.


Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus.

He X, Zhou J, Bartlam M, Zhang R, Ma J, Lou Z, Li X, Li J, Joachimiak A, Zeng Z, Ge R, Rao Z, Liu Y.

Nature. 2008 Aug 28;454(7208):1123-6. doi: 10.1038/nature07120. Epub 2008 Jul 9.


Influenza virus nucleoprotein interacts with influenza virus polymerase proteins.

Biswas SK, Boutz PL, Nayak DP.

J Virol. 1998 Jul;72(7):5493-501.


Dimer interface of the effector domain of non-structural protein 1 from influenza A virus: an interface with multiple functions.

Aramini JM, Ma LC, Zhou L, Schauder CM, Hamilton K, Amer BR, Mack TR, Lee HW, Ciccosanti CT, Zhao L, Xiao R, Krug RM, Montelione GT.

J Biol Chem. 2011 Jul 22;286(29):26050-60. doi: 10.1074/jbc.M111.248765. Epub 2011 May 26.


The influenza A virus NS1 protein interacts with the nucleoprotein of viral ribonucleoprotein complexes.

Robb NC, Chase G, Bier K, Vreede FT, Shaw PC, Naffakh N, Schwemmle M, Fodor E.

J Virol. 2011 May;85(10):5228-31. doi: 10.1128/JVI.02562-10. Epub 2011 Mar 16.


Functional domains of the influenza A virus PB2 protein: identification of NP- and PB1-binding sites.

Poole E, Elton D, Medcalf L, Digard P.

Virology. 2004 Mar 30;321(1):120-33.


NP body domain and PB2 contribute to increased virulence of H5N1 highly pathogenic avian influenza viruses in chickens.

Tada T, Suzuki K, Sakurai Y, Kubo M, Okada H, Itoh T, Tsukamoto K.

J Virol. 2011 Feb;85(4):1834-46. doi: 10.1128/JVI.01648-10. Epub 2010 Dec 1.


Interaction of the influenza a virus nucleocapsid protein with the viral RNA polymerase potentiates unprimed viral RNA replication.

Newcomb LL, Kuo RL, Ye Q, Jiang Y, Tao YJ, Krug RM.

J Virol. 2009 Jan;83(1):29-36. doi: 10.1128/JVI.02293-07. Epub 2008 Oct 22.

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