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Items: 1 to 20 of 140

1.

Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii.

Watford WT, Hissong BD, Durant LR, Yamane H, Muul LM, Kanno Y, Tato CM, Ramos HL, Berger AE, Mielke L, Pesu M, Solomon B, Frucht DM, Paul WE, Sher A, Jankovic D, Tsichlis PN, O'Shea JJ.

J Exp Med. 2008 Nov 24;205(12):2803-12. doi: 10.1084/jem.20081461. Epub 2008 Nov 10.

2.

Pharmacological inhibition of TPL2/MAP3K8 blocks human cytotoxic T lymphocyte effector functions.

Chowdhury FZ, Estrada LD, Murray S, Forman J, Farrar JD.

PLoS One. 2014 Mar 18;9(3):e92187. doi: 10.1371/journal.pone.0092187. eCollection 2014.

3.

Tumor Progression Locus 2 Promotes Induction of IFNλ, Interferon Stimulated Genes and Antigen-Specific CD8+ T Cell Responses and Protects against Influenza Virus.

Kuriakose T, Tripp RA, Watford WT.

PLoS Pathog. 2015 Aug 4;11(8):e1005038. doi: 10.1371/journal.ppat.1005038. eCollection 2015 Aug.

4.

Identification of STAT4-dependent and independent mechanisms of resistance to Toxoplasma gondii.

Cai G, Radzanowski T, Villegas EN, Kastelein R, Hunter CA.

J Immunol. 2000 Sep 1;165(5):2619-27.

5.

Tumor progression locus 2 differentially regulates IFNγ and IL-17 production by effector CD4+ T cells in a T cell transfer model of colitis.

Acuff NV, Li X, Kirkland R, Nagy T, Watford WT.

PLoS One. 2015 Mar 17;10(3):e0119885. doi: 10.1371/journal.pone.0119885. eCollection 2015.

6.

Tpl2 Promotes Innate Cell Recruitment and Effector T Cell Differentiation To Limit Citrobacter rodentium Burden and Dissemination.

Acuff NV, Li X, Latha K, Nagy T, Watford WT.

Infect Immun. 2017 Sep 20;85(10). pii: e00193-17. doi: 10.1128/IAI.00193-17. Print 2017 Oct.

7.

Tumor Progression Locus 2 (Tpl2) Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Inhibits Forkhead Box P3 (FoxP3) Expression, and Limits Regulatory T Cell (Treg) Immunosuppressive Functions.

Li X, Acuff NV, Peeks AR, Kirkland R, Wyatt KD, Nagy T, Watford WT.

J Biol Chem. 2016 Aug 5;291(32):16802-15. doi: 10.1074/jbc.M116.718783. Epub 2016 Jun 3.

8.

A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation.

Sugimoto K, Ohata M, Miyoshi J, Ishizaki H, Tsuboi N, Masuda A, Yoshikai Y, Takamoto M, Sugane K, Matsuo S, Shimada Y, Matsuguchi T.

J Clin Invest. 2004 Sep;114(6):857-66.

9.

Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production.

Mielke LA, Elkins KL, Wei L, Starr R, Tsichlis PN, O'Shea JJ, Watford WT.

J Immunol. 2009 Dec 15;183(12):7984-93. doi: 10.4049/jimmunol.0901336.

10.

Natural killer cell intrinsic toll-like receptor MyD88 signaling contributes to IL-12-dependent IFN-γ production by mice during infection with Toxoplasma gondii.

Ge Y, Chen J, Qiu X, Zhang J, Cui L, Qi Y, Liu X, Qiu J, Shi Z, Lun Z, Shen J, Wang Y.

Int J Parasitol. 2014 Jun;44(7):475-84. doi: 10.1016/j.ijpara.2014.03.004. Epub 2014 Apr 13.

PMID:
24727091
11.

T cell-intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii.

Shaw MH, Reimer T, Sánchez-Valdepeñas C, Warner N, Kim YG, Fresno M, Nuñez G.

Nat Immunol. 2009 Dec;10(12):1267-74. doi: 10.1038/ni.1816. Epub 2009 Nov 1.

13.

The transcription factor T-bet is induced by multiple pathways and prevents an endogenous Th2 cell program during Th1 cell responses.

Zhu J, Jankovic D, Oler AJ, Wei G, Sharma S, Hu G, Guo L, Yagi R, Yamane H, Punkosdy G, Feigenbaum L, Zhao K, Paul WE.

Immunity. 2012 Oct 19;37(4):660-73. doi: 10.1016/j.immuni.2012.09.007. Epub 2012 Oct 4.

14.

Ablation of tumor progression locus 2 promotes a type 2 Th cell response in Ovalbumin-immunized mice.

Watford WT, Wang CC, Tsatsanis C, Mielke LA, Eliopoulos AG, Daskalakis C, Charles N, Odom S, Rivera J, O'Shea J, Tsichlis PN.

J Immunol. 2010 Jan 1;184(1):105-13. doi: 10.4049/jimmunol.0803730. Epub 2009 Dec 2.

15.

TPL2 Kinase Is a Crucial Signaling Factor and Mediator of NKT Effector Cytokine Expression in Immune-Mediated Liver Injury.

Vyrla D, Nikolaidis G, Oakley F, Perugorria MJ, Tsichlis PN, Mann DA, Eliopoulos AG.

J Immunol. 2016 May 15;196(10):4298-310. doi: 10.4049/jimmunol.1501609. Epub 2016 Apr 6.

16.

Host resistance and immune deviation in pigeon cytochrome c T-cell receptor transgenic mice infected with Toxoplasma gondii.

Collazo CM, Miller C, Yap G, Hieny S, Caspar P, Schwartz RH, Sher A.

Infect Immun. 2000 May;68(5):2713-9.

17.
19.

Identification of a role for NF-kappa B2 in the regulation of apoptosis and in maintenance of T cell-mediated immunity to Toxoplasma gondii.

Caamaño J, Tato C, Cai G, Villegas EN, Speirs K, Craig L, Alexander J, Hunter CA.

J Immunol. 2000 Nov 15;165(10):5720-8.

20.

Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells.

Tsatsanis C, Vaporidi K, Zacharioudaki V, Androulidaki A, Sykulev Y, Margioris AN, Tsichlis PN.

Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2987-92. doi: 10.1073/pnas.0708381104. Epub 2008 Feb 19.

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