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Effect of antigen turnover rate and expression level on antibody penetration into tumor spheroids.

Ackerman ME, Pawlowski D, Wittrup KD.

Mol Cancer Ther. 2008 Jul;7(7):2233-40. doi: 10.1158/1535-7163.MCT-08-0067.


Quantitative spatiotemporal analysis of antibody fragment diffusion and endocytic consumption in tumor spheroids.

Thurber GM, Wittrup KD.

Cancer Res. 2008 May 1;68(9):3334-41. doi: 10.1158/0008-5472.CAN-07-3018.


Influence of affinity and antigen internalization on the uptake and penetration of Anti-HER2 antibodies in solid tumors.

Rudnick SI, Lou J, Shaller CC, Tang Y, Klein-Szanto AJ, Weiner LM, Marks JD, Adams GP.

Cancer Res. 2011 Mar 15;71(6):2250-9. doi: 10.1158/0008-5472.CAN-10-2277.


The effect of antigen concentration, antibody valency and size, and tumor architecture on antibody binding in multicell spheroids.

Langmuir VK, McGann JK, Buchegger F, Sutherland RM.

Int J Rad Appl Instrum B. 1991;18(7):753-64.


Uptake, penetration, and binding of monoclonal antibodies with increasing affinity in human osteosarcoma multicell spheroids.

Hjelstuen MH, Rasch-Halvorsen K, Bruland O, De L Davies C.

Anticancer Res. 1998 Sep-Oct;18(5A):3153-61.


Discovery of internalizing antibodies to tumor antigens from phage libraries.

Zhou Y, Marks JD.

Methods Enzymol. 2012;502:43-66. doi: 10.1016/B978-0-12-416039-2.00003-3.


A33 antigen displays persistent surface expression.

Ackerman ME, Chalouni C, Schmidt MM, Raman VV, Ritter G, Old LJ, Mellman I, Wittrup KD.

Cancer Immunol Immunother. 2008 Jul;57(7):1017-27. doi: 10.1007/s00262-007-0433-x.


Pulsed ultrasound enhances nanoparticle penetration into breast cancer spheroids.

Grainger SJ, Serna JV, Sunny S, Zhou Y, Deng CX, El-Sayed ME.

Mol Pharm. 2010 Dec 6;7(6):2006-19. doi: 10.1021/mp100280b. Epub 2010 Oct 29.


Kinetics of anti-carcinoembryonic antigen antibody internalization: effects of affinity, bivalency, and stability.

Schmidt MM, Thurber GM, Wittrup KD.

Cancer Immunol Immunother. 2008 Dec;57(12):1879-90. doi: 10.1007/s00262-008-0518-1. Epub 2008 Apr 12.


Predicted and observed effects of antibody affinity and antigen density on monoclonal antibody uptake in solid tumors.

Sung C, Shockley TR, Morrison PF, Dvorak HF, Yarmush ML, Dedrick RL.

Cancer Res. 1992 Jan 15;52(2):377-84.


Spatial distribution of tumor-specific monoclonal antibodies in human melanoma xenografts.

Shockley TR, Lin K, Nagy JA, Tompkins RG, Yarmush ML, Dvorak HF.

Cancer Res. 1992 Jan 15;52(2):367-76.


Rapid and specific targeting of monoclonal antibody A33 to a colon cancer xenograft in nude mice.

Barendswaard EC, Scott AM, Divgi CR, Williams C Jr, Coplan K, Riedel E, Yao TJ, Gansow OA, Finn RD, Larson SM, Old LJ, Welt S.

Int J Oncol. 1998 Jan;12(1):45-53.


The development and characterization of a human mesothelioma in vitro 3D model to investigate immunotoxin therapy.

Xiang X, Phung Y, Feng M, Nagashima K, Zhang J, Broaddus VC, Hassan R, Fitzgerald D, Ho M.

PLoS One. 2011 Jan 31;6(1):e14640. doi: 10.1371/journal.pone.0014640.


Internalizing cancer antibodies from phage libraries selected on tumor cells and yeast-displayed tumor antigens.

Zhou Y, Zou H, Zhang S, Marks JD.

J Mol Biol. 2010 Nov 19;404(1):88-99. doi: 10.1016/j.jmb.2010.09.006. Epub 2010 Sep 17.


Micropharmacology of monoclonal antibodies in solid tumors: direct experimental evidence for a binding site barrier.

Juweid M, Neumann R, Paik C, Perez-Bacete MJ, Sato J, van Osdol W, Weinstein JN.

Cancer Res. 1992 Oct 1;52(19):5144-53.

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