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Structural analysis of the contacts anchoring moenomycin to peptidoglycan glycosyltransferases and implications for antibiotic design.

Yuan Y, Fuse S, Ostash B, Sliz P, Kahne D, Walker S.

ACS Chem Biol. 2008 Jul 18;3(7):429-36. doi: 10.1021/cb800078a.


The molecular biology of moenomycins: towards novel antibiotics based on inhibition of bacterial peptidoglycan glycosyltransferases.

Ostash B, Doud E, Fedorenko V.

Biol Chem. 2010 May;391(5):499-504. doi: 10.1515/BC.2010.053. Review.


Tuning the moenomycin pharmacophore to enable discovery of bacterial cell wall synthesis inhibitors.

Gampe CM, Tsukamoto H, Doud EH, Walker S, Kahne D.

J Am Chem Soc. 2013 Mar 13;135(10):3776-9. doi: 10.1021/ja4000933. Epub 2013 Mar 4.


Functional and structural analysis of a key region of the cell wall inhibitor moenomycin.

Fuse S, Tsukamoto H, Yuan Y, Wang TS, Zhang Y, Bolla M, Walker S, Sliz P, Kahne D.

ACS Chem Biol. 2010 Jul 16;5(7):701-11. doi: 10.1021/cb100048q.


Moenomycin resistance mutations in Staphylococcus aureus reduce peptidoglycan chain length and cause aberrant cell division.

Rebets Y, Lupoli T, Qiao Y, Schirner K, Villet R, Hooper D, Kahne D, Walker S.

ACS Chem Biol. 2014 Feb 21;9(2):459-67. doi: 10.1021/cb4006744. Epub 2013 Nov 20.


Targeting Bacterial Cell Wall Peptidoglycan Synthesis by Inhibition of Glycosyltransferase Activity.

Mesleh MF, Rajaratnam P, Conrad M, Chandrasekaran V, Liu CM, Pandya BA, Hwang YS, Rye PT, Muldoon C, Becker B, Zuegg J, Meutermans W, Moy TI.

Chem Biol Drug Des. 2016 Feb;87(2):190-9. doi: 10.1111/cbdd.12662. Epub 2015 Oct 9.


Complete characterization of the seventeen step moenomycin biosynthetic pathway.

Ostash B, Doud EH, Lin C, Ostash I, Perlstein DL, Fuse S, Wolpert M, Kahne D, Walker S.

Biochemistry. 2009 Sep 22;48(37):8830-41. doi: 10.1021/bi901018q.


Analysis of glycan polymers produced by peptidoglycan glycosyltransferases.

Barrett D, Wang TS, Yuan Y, Zhang Y, Kahne D, Walker S.

J Biol Chem. 2007 Nov 2;282(44):31964-71. Epub 2007 Aug 18.


Structural insight into the transglycosylation step of bacterial cell-wall biosynthesis.

Lovering AL, de Castro LH, Lim D, Strynadka NC.

Science. 2007 Mar 9;315(5817):1402-5.


Structure-based design, synthesis, and biological evaluation of isatin derivatives as potential glycosyltransferase inhibitors.

Wang Y, Chan FY, Sun N, Lui HK, So PK, Yan SC, Chan KF, Chiou J, Chen S, Abagyan R, Leung YC, Wong KY.

Chem Biol Drug Des. 2014 Dec;84(6):685-96. doi: 10.1111/cbdd.12361. Epub 2014 Aug 14.


Positive cooperativity between acceptor and donor sites of the peptidoglycan glycosyltransferase.

Bury D, Dahmane I, Derouaux A, Dumbre S, Herdewijn P, Matagne A, Breukink E, Mueller-Seitz E, Petz M, Terrak M.

Biochem Pharmacol. 2015 Jan 15;93(2):141-50. doi: 10.1016/j.bcp.2014.11.003. Epub 2014 Nov 14.


Synthesis of modified peptidoglycan precursor analogues for the inhibition of glycosyltransferase.

Dumbre S, Derouaux A, Lescrinier E, Piette A, Joris B, Terrak M, Herdewijn P.

J Am Chem Soc. 2012 Jun 6;134(22):9343-51. doi: 10.1021/ja302099u. Epub 2012 May 25.


Crystal structure of a peptidoglycan glycosyltransferase suggests a model for processive glycan chain synthesis.

Yuan Y, Barrett D, Zhang Y, Kahne D, Sliz P, Walker S.

Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5348-53. Epub 2007 Mar 8.


Characterization of the active site of S. aureus monofunctional glycosyltransferase (Mtg) by site-directed mutation and structural analysis of the protein complexed with moenomycin.

Heaslet H, Shaw B, Mistry A, Miller AA.

J Struct Biol. 2009 Aug;167(2):129-35. doi: 10.1016/j.jsb.2009.04.010. Epub 2009 May 3.


Biochemistry. A new target for antibiotic development.

Wright GD.

Science. 2007 Mar 9;315(5817):1373-4. No abstract available.


Isolated peptidoglycan glycosyltransferases from different organisms produce different glycan chain lengths.

Wang TS, Manning SA, Walker S, Kahne D.

J Am Chem Soc. 2008 Oct 29;130(43):14068-9. doi: 10.1021/ja806016y. Epub 2008 Oct 4.


Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity.

Zuegg J, Muldoon C, Adamson G, McKeveney D, Le Thanh G, Premraj R, Becker B, Cheng M, Elliott AG, Huang JX, Butler MS, Bajaj M, Seifert J, Singh L, Galley NF, Roper DI, Lloyd AJ, Dowson CG, Cheng TJ, Cheng WC, Demon D, Meyer E, Meutermans W, Cooper MA.

Nat Commun. 2015 Jul 21;6:7719. doi: 10.1038/ncomms8719.


A surface plasmon resonance analysis of the interaction between the antibiotic moenomycin A and penicillin-binding protein 1b.

Stembera K, Vogel S, Buchynskyy A, Ayala JA, Welzel P.

Chembiochem. 2002 Jun 3;3(6):559-65.


The role of the jaw subdomain of peptidoglycan glycosyltransferases for lipid II polymerization.

Punekar AS, Samsudin F, Lloyd AJ, Dowson CG, Scott DJ, Khalid S, Roper DI.

Cell Surf. 2018 Jun;2:54-66. doi: 10.1016/j.tcsw.2018.06.002.


Structure-based design of bacterial transglycosylase inhibitors incorporating biphenyl, amine linker and 2-alkoxy-3-phosphorylpropanoate moieties.

Yu JY, Cheng HJ, Wu HR, Wu WS, Lu JW, Cheng TJ, Wu YT, Fang JM.

Eur J Med Chem. 2018 Apr 25;150:729-741. doi: 10.1016/j.ejmech.2018.03.034. Epub 2018 Mar 15.


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