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Sphingomyelin functions as a novel receptor for Helicobacter pylori VacA.

Gupta VR, Patel HK, Kostolansky SS, Ballivian RA, Eichberg J, Blanke SR.

PLoS Pathog. 2008 May 23;4(5):e1000073. doi: 10.1371/journal.ppat.1000073.


Sphingomyelin is important for the cellular entry and intracellular localization of Helicobacter pylori VacA.

Gupta VR, Wilson BA, Blanke SR.

Cell Microbiol. 2010 Oct;12(10):1517-33. doi: 10.1111/j.1462-5822.2010.01487.x.


Targeting of Helicobacter pylori vacuolating toxin to lipid raft membrane domains analysed by atomic force microscopy.

Geisse NA, Cover TL, Henderson RM, Edwardson JM.

Biochem J. 2004 Aug 1;381(Pt 3):911-7.


Determinants of Raft Partitioning of the Helicobacter pylori Pore-Forming Toxin VacA.

Raghunathan K, Foegeding NJ, Campbell AM, Cover TL, Ohi MD, Kenworthy AK.

Infect Immun. 2018 Apr 23;86(5). pii: e00872-17. doi: 10.1128/IAI.00872-17. Print 2018 May.


Association of Helicobacter pylori vacuolating toxin (VacA) with lipid rafts.

Schraw W, Li Y, McClain MS, van der Goot FG, Cover TL.

J Biol Chem. 2002 Sep 13;277(37):34642-50. Epub 2002 Jul 16.


Helicobacter pylori VacA cytotoxin: a probe for a clathrin-independent and Cdc42-dependent pinocytic pathway routed to late endosomes.

Gauthier NC, Monzo P, Kaddai V, Doye A, Ricci V, Boquet P.

Mol Biol Cell. 2005 Oct;16(10):4852-66. Epub 2005 Jul 29.


Plasma membrane cholesterol modulates cellular vacuolation induced by the Helicobacter pylori vacuolating cytotoxin.

Patel HK, Willhite DC, Patel RM, Ye D, Williams CL, Torres EM, Marty KB, MacDonald RA, Blanke SR.

Infect Immun. 2002 Aug;70(8):4112-23.


Formation of anion-selective channels in the cell plasma membrane by the toxin VacA of Helicobacter pylori is required for its biological activity.

Szabò I, Brutsche S, Tombola F, Moschioni M, Satin B, Telford JL, Rappuoli R, Montecucco C, Papini E, Zoratti M.

EMBO J. 1999 Oct 15;18(20):5517-27.


Vacuolating cytotoxin A (VacA) - A multi-talented pore-forming toxin from Helicobacter pylori.

Junaid M, Linn AK, Javadi MB, Al-Gubare S, Ali N, Katzenmeier G.

Toxicon. 2016 Aug;118:27-35. doi: 10.1016/j.toxicon.2016.04.037. Epub 2016 Apr 20. Review.


Clustering of Helicobacter pylori VacA in lipid rafts, mediated by its receptor, receptor-like protein tyrosine phosphatase beta, is required for intoxication in AZ-521 Cells.

Nakayama M, Hisatsune J, Yamasaki E, Nishi Y, Wada A, Kurazono H, Sap J, Yahiro K, Moss J, Hirayama T.

Infect Immun. 2006 Dec;74(12):6571-80. Epub 2006 Oct 9.


Functional properties of the p33 and p55 domains of the Helicobacter pylori vacuolating cytotoxin.

Torres VJ, Ivie SE, McClain MS, Cover TL.

J Biol Chem. 2005 Jun 3;280(22):21107-14. Epub 2005 Apr 6.


Remodeling the host environment: modulation of the gastric epithelium by the Helicobacter pylori vacuolating toxin (VacA).

Kim IJ, Blanke SR.

Front Cell Infect Microbiol. 2012 Mar 27;2:37. doi: 10.3389/fcimb.2012.00037. eCollection 2012. Review.


Free-soluble and outer membrane vesicle-associated VacA from Helicobacter pylori: Two forms of release, a different activity.

Ricci V, Chiozzi V, Necchi V, Oldani A, Romano M, Solcia E, Ventura U.

Biochem Biophys Res Commun. 2005 Nov 11;337(1):173-8.


Association of Vibrio parahaemolyticus thermostable direct hemolysin with lipid rafts is essential for cytotoxicity but not hemolytic activity.

Matsuda S, Kodama T, Okada N, Okayama K, Honda T, Iida T.

Infect Immun. 2010 Feb;78(2):603-10. doi: 10.1128/IAI.00946-09. Epub 2009 Nov 23.


A dominant negative mutant of Helicobacter pylori vacuolating toxin (VacA) inhibits VacA-induced cell vacuolation.

Vinion-Dubiel AD, McClain MS, Czajkowsky DM, Iwamoto H, Ye D, Cao P, Schraw W, Szabo G, Blanke SR, Shao Z, Cover TL.

J Biol Chem. 1999 Dec 31;274(53):37736-42.

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