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Items: 1 to 20 of 207


Formyl-methionyl-leucyl-phenylalanine-induced dopaminergic neurotoxicity via microglial activation: a mediator between peripheral infection and neurodegeneration?

Gao X, Hu X, Qian L, Yang S, Zhang W, Zhang D, Wu X, Fraser A, Wilson B, Flood PM, Block M, Hong JS.

Environ Health Perspect. 2008 May;116(5):593-8. doi: 10.1289/ehp.11031.


Squamosamide derivative FLZ protects dopaminergic neurons against inflammation-mediated neurodegeneration through the inhibition of NADPH oxidase activity.

Zhang D, Hu X, Wei SJ, Liu J, Gao H, Qian L, Wilson B, Liu G, Hong JS.

J Neuroinflammation. 2008 May 28;5:21. doi: 10.1186/1742-2094-5-21.


Nanometer size diesel exhaust particles are selectively toxic to dopaminergic neurons: the role of microglia, phagocytosis, and NADPH oxidase.

Block ML, Wu X, Pei Z, Li G, Wang T, Qin L, Wilson B, Yang J, Hong JS, Veronesi B.

FASEB J. 2004 Oct;18(13):1618-20. Epub 2004 Aug 19.


The role of microglia in paraquat-induced dopaminergic neurotoxicity.

Wu XF, Block ML, Zhang W, Qin L, Wilson B, Zhang WQ, Veronesi B, Hong JS.

Antioxid Redox Signal. 2005 May-Jun;7(5-6):654-61.


NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia.

Qin L, Liu Y, Wang T, Wei SJ, Block ML, Wilson B, Liu B, Hong JS.

J Biol Chem. 2004 Jan 9;279(2):1415-21. Epub 2003 Oct 24.


beta2 Adrenergic receptor activation induces microglial NADPH oxidase activation and dopaminergic neurotoxicity through an ERK-dependent/protein kinase A-independent pathway.

Qian L, Hu X, Zhang D, Snyder A, Wu HM, Li Y, Wilson B, Lu RB, Hong JS, Flood PM.

Glia. 2009 Nov 15;57(15):1600-9. doi: 10.1002/glia.20873.


Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity.

Zhang D, Hu X, Qian L, Chen SH, Zhou H, Wilson B, Miller DS, Hong JS.

J Neuroinflammation. 2011 Jan 13;8(1):3. doi: 10.1186/1742-2094-8-3.


Ultrafine carbon particles promote rotenone-induced dopamine neuronal loss through activating microglial NADPH oxidase.

Wang Y, Liu D, Zhang H, Wang Y, Wei L, Liu Y, Liao J, Gao HM, Zhou H.

Toxicol Appl Pharmacol. 2017 May 1;322:51-59. doi: 10.1016/j.taap.2017.03.005. Epub 2017 Mar 7.


Microglial NADPH oxidase mediates leucine enkephalin dopaminergic neuroprotection.

Qin L, Liu Y, Qian X, Hong JS, Block ML.

Ann N Y Acad Sci. 2005 Aug;1053:107-20.


Potent regulation of microglia-derived oxidative stress and dopaminergic neuron survival: substance P vs. dynorphin.

Block ML, Li G, Qin L, Wu X, Pei Z, Wang T, Wilson B, Yang J, Hong JS.

FASEB J. 2006 Feb;20(2):251-8.


Resveratrol protects dopamine neurons against lipopolysaccharide-induced neurotoxicity through its anti-inflammatory actions.

Zhang F, Shi JS, Zhou H, Wilson B, Hong JS, Gao HM.

Mol Pharmacol. 2010 Sep;78(3):466-77. doi: 10.1124/mol.110.064535. Epub 2010 Jun 16. Erratum in: Mol Pharmacol. 2010 Nov;78(5):981.


A pivotal role of matrix metalloproteinase-3 activity in dopaminergic neuronal degeneration via microglial activation.

Kim YS, Choi DH, Block ML, Lorenzl S, Yang L, Kim YJ, Sugama S, Cho BP, Hwang O, Browne SE, Kim SY, Hong JS, Beal MF, Joh TH.

FASEB J. 2007 Jan;21(1):179-87. Epub 2006 Nov 20.


Pituitary adenylate cyclase-activating polypeptide (PACAP) 38 and PACAP4-6 are neuroprotective through inhibition of NADPH oxidase: potent regulators of microglia-mediated oxidative stress.

Yang S, Yang J, Yang Z, Chen P, Fraser A, Zhang W, Pang H, Gao X, Wilson B, Hong JS, Block ML.

J Pharmacol Exp Ther. 2006 Nov;319(2):595-603. Epub 2006 Aug 4.


Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease.

Zhang W, Wang T, Pei Z, Miller DS, Wu X, Block ML, Wilson B, Zhang W, Zhou Y, Hong JS, Zhang J.

FASEB J. 2005 Apr;19(6):533-42.


Role and mechanism of microglial activation in iron-induced selective and progressive dopaminergic neurodegeneration.

Zhang W, Yan ZF, Gao JH, Sun L, Huang XY, Liu Z, Yu SY, Cao CJ, Zuo LJ, Chen ZJ, Hu Y, Wang F, Hong JS, Wang XM.

Mol Neurobiol. 2014 Jun;49(3):1153-65. doi: 10.1007/s12035-013-8586-4. Epub 2013 Nov 26.


Verapamil protects dopaminergic neuron damage through a novel anti-inflammatory mechanism by inhibition of microglial activation.

Liu Y, Lo YC, Qian L, Crews FT, Wilson B, Chen HL, Wu HM, Chen SH, Wei K, Lu RB, Ali S, Hong JS.

Neuropharmacology. 2011 Feb-Mar;60(2-3):373-80. doi: 10.1016/j.neuropharm.2010.10.002. Epub 2010 Oct 13.

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