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Items: 1 to 20 of 140

1.

Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex.

Guo Z, Wu YW, Tan KT, Bon RS, Guiu-Rozas E, Delon C, Nguyen TU, Wetzel S, Arndt S, Goody RS, Blankenfeldt W, Alexandrov K, Waldmann H.

Angew Chem Int Ed Engl. 2008;47(20):3747-50. doi: 10.1002/anie.200705795. No abstract available.

PMID:
18399557
2.

Design, synthesis, and characterization of peptide-based rab geranylgeranyl transferase inhibitors.

Tan KT, Guiu-Rozas E, Bon RS, Guo Z, Delon C, Wetzel S, Arndt S, Alexandrov K, Waldmann H, Goody RS, Wu YW, Blankenfeldt W.

J Med Chem. 2009 Dec 24;52(24):8025-37. doi: 10.1021/jm901117d.

PMID:
19894725
3.

Development of selective, potent RabGGTase inhibitors.

Stigter EA, Guo Z, Bon RS, Wu YW, Choidas A, Wolf A, Menninger S, Waldmann H, Blankenfeldt W, Goody RS.

J Med Chem. 2012 Oct 11;55(19):8330-40. doi: 10.1021/jm300624s.

PMID:
22963166
4.

Molecular modeling and bioinformatical analysis of the antibacterial target enzyme MurA from a drug design perspective.

Klein CD, Bachelier A.

J Comput Aided Mol Des. 2006 Oct-Nov;20(10-11):621-8.

PMID:
17124631
5.

Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase.

Deraeve C, Guo Z, Bon RS, Blankenfeldt W, DiLucrezia R, Wolf A, Menninger S, Stigter EA, Wetzel S, Choidas A, Alexandrov K, Waldmann H, Goody RS, Wu YW.

J Am Chem Soc. 2012 May 2;134(17):7384-91. doi: 10.1021/ja211305j.

PMID:
22480322
6.

Structure-guided development of selective RabGGTase inhibitors.

Bon RS, Guo Z, Stigter EA, Wetzel S, Menninger S, Wolf A, Choidas A, Alexandrov K, Blankenfeldt W, Goody RS, Waldmann H.

Angew Chem Int Ed Engl. 2011 May 16;50(21):4957-61. doi: 10.1002/anie.201101210. No abstract available.

PMID:
21520375
7.

Non-thiol 3-aminomethylbenzamide inhibitors of farnesyl-protein transferase.

Ciccarone TM, MacTough SC, Williams TM, Dinsmore CJ, O'Neill TJ, Shah D, Culberson JC, Koblan KS, Kohl NE, Gibbs JB, Oliff AI, Graham SL, Hartman GD.

Bioorg Med Chem Lett. 1999 Jul 19;9(14):1991-6.

PMID:
10450968
9.

Aromatic farnesyl diphosphate analogues: vinyl triflate-mediated synthesis and preliminary enzymatic evaluation.

Zhou C, Shao Y, Gibbs RA.

Bioorg Med Chem Lett. 2002 May 20;12(10):1417-20.

PMID:
11992789
10.

Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability.

Tong Y, Lin NH, Wang L, Hasvold L, Wang W, Leonard N, Li T, Li Q, Cohen J, Gu WZ, Zhang H, Stoll V, Bauch J, Marsh K, Rosenberg SH, Sham HL.

Bioorg Med Chem Lett. 2003 May 5;13(9):1571-4.

PMID:
12699757
11.

Inhibitors of protein: geranylgeranyl transferases.

El Oualid F, Cohen LH, van der Marel GA, Overhand M.

Curr Med Chem. 2006;13(20):2385-427. Review.

PMID:
16918362
12.

[CAAX peptidomimetics: their farnesyltransferase inhibition activity and antitumor effect].

Ohkanda J.

Seikagaku. 2002 Jan;74(1):46-50. Review. Japanese. No abstract available.

PMID:
11889772
13.

Design and synthesis of piperidine farnesyltransferase inhibitors with reduced glucuronidation potential.

Tanaka R, Rubio A, Harn NK, Gernert D, Grese TA, Eishima J, Hara M, Yoda N, Ohashi R, Kuwabara T, Soga S, Akinaga S, Nara S, Kanda Y.

Bioorg Med Chem. 2007 Feb 1;15(3):1363-82.

PMID:
17127066
14.

Novel and selective imidazole-containing biphenyl inhibitors of protein farnesyltransferase.

Curtin ML, Florjancic AS, Cohen J, Gu WZ, Frost DJ, Muchmore SW, Sham HL.

Bioorg Med Chem Lett. 2003 Apr 7;13(7):1367-71.

PMID:
12657284
15.

Conformational restriction of flexible ligands guided by the transferred noe experiment: potent macrocyclic inhibitors of farnesyltransferase.

Dinsmore CJ, Bogusky MJ, Culberson JC, Bergman JM, Homnick CF, Zartman CB, Mosser SD, Schaber MD, Robinson RG, Koblan KS, Huber HE, Graham SL, Hartman GD, Huff JR, Williams TM.

J Am Chem Soc. 2001 Mar 7;123(9):2107-8. No abstract available.

PMID:
11456854
16.

Solid-phase synthesis and biological evaluation of a pepticinnamin E library.

Thutewohl M, Kissau L, Popkirova B, Karaguni IM, Nowak T, Bate M, Kuhlmann J, Müller O, Waldmann H.

Angew Chem Int Ed Engl. 2002 Oct 4;41(19):3616-20; 3516. No abstract available.

PMID:
12370908
17.

Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold.

Ohkanda J, Lockman JW, Kothare MA, Qian Y, Blaskovich MA, Sebti SM, Hamilton AD.

J Med Chem. 2002 Jan 3;45(1):177-88.

PMID:
11754590
19.

Design and structure-activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): tetramic, tetronic acids and dihydropyridin-2-ones.

Peukert S, Sun Y, Zhang R, Hurley B, Sabio M, Shen X, Gray C, Dzink-Fox J, Tao J, Cebula R, Wattanasin S.

Bioorg Med Chem Lett. 2008 Mar 15;18(6):1840-4. doi: 10.1016/j.bmcl.2008.02.009.

PMID:
18295483
20.

Design, synthesis, and evaluation of potent and selective benzoyleneurea-based inhibitors of protein geranylgeranyltransferase-I.

Carrico D, Blaskovich MA, Bucher CJ, Sebti SM, Hamilton AD.

Bioorg Med Chem. 2005 Feb 1;13(3):677-88.

PMID:
15653335
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