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Cationic amino acid transporter-2 regulates immunity by modulating arginase activity.

Thompson RW, Pesce JT, Ramalingam T, Wilson MS, White S, Cheever AW, Ricklefs SM, Porcella SF, Li L, Ellies LG, Wynn TA.

PLoS Pathog. 2008 Mar 14;4(3):e1000023. doi: 10.1371/journal.ppat.1000023.


Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism.

Hesse M, Modolell M, La Flamme AC, Schito M, Fuentes JM, Cheever AW, Pearce EJ, Wynn TA.

J Immunol. 2001 Dec 1;167(11):6533-44.


Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis.

Pesce JT, Ramalingam TR, Mentink-Kane MM, Wilson MS, El Kasmi KC, Smith AM, Thompson RW, Cheever AW, Murray PJ, Wynn TA.

PLoS Pathog. 2009 Apr;5(4):e1000371. doi: 10.1371/journal.ppat.1000371. Epub 2009 Apr 10.


The IL-21 receptor augments Th2 effector function and alternative macrophage activation.

Pesce J, Kaviratne M, Ramalingam TR, Thompson RW, Urban JF Jr, Cheever AW, Young DA, Collins M, Grusby MJ, Wynn TA.

J Clin Invest. 2006 Jul;116(7):2044-55. Epub 2006 Jun 15.


IL-4 receptor signaling is required for mannose receptor expression by macrophages recruited to granulomata but not resident cells in mice infected with Schistosoma mansoni.

Linehan SA, Coulson PS, Wilson RA, Mountford AP, Brombacher F, Martínez-Pomares L, Gordon S.

Lab Invest. 2003 Aug;83(8):1223-31.


Macrophage arginase-1 controls bacterial growth and pathology in hypoxic tuberculosis granulomas.

Duque-Correa MA, Kühl AA, Rodriguez PC, Zedler U, Schommer-Leitner S, Rao M, Weiner J 3rd, Hurwitz R, Qualls JE, Kosmiadi GA, Murray PJ, Kaufmann SH, Reece ST.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):E4024-32. doi: 10.1073/pnas.1408839111. Epub 2014 Sep 8.


Role of arginase 1 from myeloid cells in th2-dominated lung inflammation.

Barron L, Smith AM, El Kasmi KC, Qualls JE, Huang X, Cheever A, Borthwick LA, Wilson MS, Murray PJ, Wynn TA.

PLoS One. 2013 Apr 24;8(4):e61961. doi: 10.1371/journal.pone.0061961. Print 2013.


Helminth-induced arginase-1 exacerbates lung inflammation and disease severity in tuberculosis.

Monin L, Griffiths KL, Lam WY, Gopal R, Kang DD, Ahmed M, Rajamanickam A, Cruz-Lagunas A, Zúñiga J, Babu S, Kolls JK, Mitreva M, Rosa BA, Ramos-Payan R, Morrison TE, Murray PJ, Rangel-Moreno J, Pearce EJ, Khader SA.

J Clin Invest. 2015 Dec;125(12):4699-713. doi: 10.1172/JCI77378. Epub 2015 Nov 16.


Cationic amino acid transporter 2 enhances innate immunity during Helicobacter pylori infection.

Barry DP, Asim M, Scull BP, Piazuelo MB, de Sablet T, Lewis ND, Coburn LA, Singh K, Ellies LG, Gobert AP, Chaturvedi R, Wilson KT.

PLoS One. 2011;6(12):e29046. doi: 10.1371/journal.pone.0029046. Epub 2011 Dec 14.


TLR3 modulates immunopathology during a Schistosoma mansoni egg-driven Th2 response in the lung.

Joshi AD, Schaller MA, Lukacs NW, Kunkel SL, Hogaboam CM.

Eur J Immunol. 2008 Dec;38(12):3436-49. doi: 10.1002/eji.200838629.


Retnla (relmalpha/fizz1) suppresses helminth-induced Th2-type immunity.

Pesce JT, Ramalingam TR, Wilson MS, Mentink-Kane MM, Thompson RW, Cheever AW, Urban JF Jr, Wynn TA.

PLoS Pathog. 2009 Apr;5(4):e1000393. doi: 10.1371/journal.ppat.1000393. Epub 2009 Apr 17.


Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages.

Donnelly S, Stack CM, O'Neill SM, Sayed AA, Williams DL, Dalton JP.

FASEB J. 2008 Nov;22(11):4022-32. doi: 10.1096/fj.08-106278. Epub 2008 Aug 15.


IPSE/alpha-1 of Schistosoma mansoni egg induces enlargement of granuloma but does not alter Th2 balance after infection.

Fahel JS, Macedo GC, Pinheiro CS, Caliari MV, Oliveira SC.

Parasite Immunol. 2010 May;32(5):345-53. doi: 10.1111/j.1365-3024.2009.01192.x.


The cationic amino acid transporter 2 is induced in inflammatory lung models and regulates lung fibrosis.

Niese KA, Chiaramonte MG, Ellies LG, Rothenberg ME, Zimmermann N.

Respir Res. 2010 Jun 24;11:87. doi: 10.1186/1465-9921-11-87.

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