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Salivary agglutinin/glycoprotein-340/DMBT1: a single molecule with variable composition and with different functions in infection, inflammation and cancer.

Ligtenberg AJ, Veerman EC, Nieuw Amerongen AV, Mollenhauer J.

Biol Chem. 2007 Dec;388(12):1275-89. Review.


Deleted in malignant brain tumors-1 protein (DMBT1): a pattern recognition receptor with multiple binding sites.

Ligtenberg AJ, Karlsson NG, Veerman EC.

Int J Mol Sci. 2010;11(12):5212-33. doi: 10.3390/ijms1112521. Epub 2010 Dec 17. Review.


Human salivary agglutinin binds to lung surfactant protein-D and is identical with scavenger receptor protein gp-340.

Ligtenberg TJ, Bikker FJ, Groenink J, Tornoe I, Leth-Larsen R, Veerman EC, Nieuw Amerongen AV, Holmskov U.

Biochem J. 2001 Oct 1;359(Pt 1):243-8.


Identification of the bacteria-binding peptide domain on salivary agglutinin (gp-340/DMBT1), a member of the scavenger receptor cysteine-rich superfamily.

Bikker FJ, Ligtenberg AJ, Nazmi K, Veerman EC, van't Hof W, Bolscher JG, Poustka A, Nieuw Amerongen AV, Mollenhauer J.

J Biol Chem. 2002 Aug 30;277(35):32109-15. Epub 2002 Jun 5.


DMBT1 encodes a protein involved in the immune defense and in epithelial differentiation and is highly unstable in cancer.

Mollenhauer J, Herbertz S, Holmskov U, Tolnay M, Krebs I, Merlo A, Schrøder HD, Maier D, Breitling F, Wiemann S, Gröne HJ, Poustka A.

Cancer Res. 2000 Mar 15;60(6):1704-10.


Hensin, the polarity reversal protein, is encoded by DMBT1, a gene frequently deleted in malignant gliomas.

Takito J, Yan L, Ma J, Hikita C, Vijayakumar S, Warburton D, Al-Awqati Q.

Am J Physiol. 1999 Aug;277(2 Pt 2):F277-89.


A common binding motif for various bacteria of the bacteria-binding peptide SRCRP2 of DMBT1/gp-340/salivary agglutinin.

Leito JT, Ligtenberg AJ, Nazmi K, de Blieck-Hogervorst JM, Veerman EC, Nieuw Amerongen AV.

Biol Chem. 2008 Sep;389(9):1193-200. doi: 10.1515/BC.2008.135.


Bacteria binding by DMBT1/SAG/gp-340 is confined to the VEVLXXXXW motif in its scavenger receptor cysteine-rich domains.

Bikker FJ, Ligtenberg AJ, End C, Renner M, Blaich S, Lyer S, Wittig R, van't Hof W, Veerman EC, Nazmi K, de Blieck-Hogervorst JM, Kioschis P, Nieuw Amerongen AV, Poustka A, Mollenhauer J.

J Biol Chem. 2004 Nov 12;279(46):47699-703. Epub 2004 Sep 7.


Binding of salivary agglutinin to IgA.

Ligtenberg AJ, Bikker FJ, De Blieck-Hogervorst JM, Veerman EC, Nieuw Amerongen AV.

Biochem J. 2004 Oct 1;383(Pt 1):159-64.


The SRCR/SID region of DMBT1 defines a complex multi-allele system representing the major basis for its variability in cancer.

Mollenhauer J, Müller H, Kollender G, Lyer S, Diedrichs L, Helmke B, Holmskov U, Ligtenberg T, Herbertz S, Krebs I, Madsen J, Bikker F, Schmitt L, Wiemann S, Scheurlen W, Otto HF, von Deimling A, Poustka A.

Genes Chromosomes Cancer. 2002 Nov;35(3):242-55.


Molecular characterization of the porcine deleted in malignant brain tumors 1 gene (DMBT1).

Haase B, Humphray SJ, Lyer S, Renner M, Poustka A, Mollenhauer J, Leeb T.

Gene. 2006 Jul 19;376(2):184-91. Epub 2006 Mar 20.


DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours.

Mollenhauer J, Wiemann S, Scheurlen W, Korn B, Hayashi Y, Wilgenbus KK, von Deimling A, Poustka A.

Nat Genet. 1997 Sep;17(1):32-9.


Generation of a vector system facilitating cloning of DMBT1 variants and recombinant expression of functional full-length DMBT1.

End C, Lyer S, Renner M, Stahl C, Ditzer J, Holloschi A, Kuhn HM, Flammann HT, Poustka A, Hafner M, Mollenhauer J, Kioschis P.

Protein Expr Purif. 2005 Jun;41(2):275-86.


Review: Gp-340/DMBT1 in mucosal innate immunity.

Madsen J, Mollenhauer J, Holmskov U.

Innate Immun. 2010 Jun;16(3):160-7. doi: 10.1177/1753425910368447. Epub 2010 Apr 23. Review.


DMBT1 confers mucosal protection in vivo and a deletion variant is associated with Crohn's disease.

Renner M, Bergmann G, Krebs I, End C, Lyer S, Hilberg F, Helmke B, Gassler N, Autschbach F, Bikker F, Strobel-Freidekind O, Gronert-Sum S, Benner A, Blaich S, Wittig R, Hudler M, Ligtenberg AJ, Madsen J, Holmskov U, Annese V, Latiano A, Schirmacher P, Amerongen AV, D'Amato M, Kioschis P, Hafner M, Poustka A, Mollenhauer J.

Gastroenterology. 2007 Nov;133(5):1499-509. Epub 2007 Aug 3.


The Scavenger Receptor Cysteine-Rich (SRCR) domain: an ancient and highly conserved protein module of the innate immune system.

Sarrias MR, Grønlund J, Padilla O, Madsen J, Holmskov U, Lozano F.

Crit Rev Immunol. 2004;24(1):1-37. Review.


Deleted in Malignant Brain Tumors 1 is a versatile mucin-like molecule likely to play a differential role in digestive tract cancer.

Mollenhauer J, Herbertz S, Helmke B, Kollender G, Krebs I, Madsen J, Holmskov U, Sorger K, Schmitt L, Wiemann S, Otto HF, Gröne HJ, Poustka A.

Cancer Res. 2001 Dec 15;61(24):8880-6.


The genomic structure of the DMBT1 gene: evidence for a region with susceptibility to genomic instability.

Mollenhauer J, Holmskov U, Wiemann S, Krebs I, Herbertz S, Madsen J, Kioschis P, Coy JF, Poustka A.

Oncogene. 1999 Nov 4;18(46):6233-40.


Evolution of the rapidly mutating human salivary agglutinin gene (DMBT1) and population subsistence strategy.

Polley S, Louzada S, Forni D, Sironi M, Balaskas T, Hains DS, Yang F, Hollox EJ.

Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5105-10. doi: 10.1073/pnas.1416531112. Epub 2015 Apr 6.

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