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Items: 1 to 20 of 160

1.

A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity.

Kim TW, Staschke K, Bulek K, Yao J, Peters K, Oh KH, Vandenburg Y, Xiao H, Qian W, Hamilton T, Min B, Sen G, Gilmour R, Li X.

J Exp Med. 2007 May 14;204(5):1025-36. Epub 2007 Apr 30.

2.

IRAK4 in TLR/IL-1R signaling: possible clinical applications.

Li X.

Eur J Immunol. 2008 Mar;38(3):614-8. doi: 10.1002/eji.200838161.

3.

Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling.

Kawagoe T, Sato S, Jung A, Yamamoto M, Matsui K, Kato H, Uematsu S, Takeuchi O, Akira S.

J Exp Med. 2007 May 14;204(5):1013-24. Epub 2007 May 7.

4.

Interleukin 1/Toll-like receptor-induced autophosphorylation activates interleukin 1 receptor-associated kinase 4 and controls cytokine induction in a cell type-specific manner.

Cushing L, Stochaj W, Siegel M, Czerwinski R, Dower K, Wright Q, Hirschfield M, Casanova JL, Picard C, Puel A, Lin LL, Rao VR.

J Biol Chem. 2014 Apr 11;289(15):10865-75. doi: 10.1074/jbc.M113.544809. Epub 2014 Feb 24.

5.

IRAK4 kinase activity is not required for induction of endotoxin tolerance but contributes to TLR2-mediated tolerance.

Xiong Y, Pennini M, Vogel SN, Medvedev AE.

J Leukoc Biol. 2013 Aug;94(2):291-300. doi: 10.1189/jlb.0812401. Epub 2013 May 21.

6.

Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling.

De Nardo D, Balka KR, Cardona Gloria Y, Rao VR, Latz E, Masters SL.

J Biol Chem. 2018 Sep 28;293(39):15195-15207. doi: 10.1074/jbc.RA118.003314. Epub 2018 Aug 3.

7.

Characterization of the interleukin 1 receptor-associated kinase 4 (IRAK4)-encoding gene in salmonid fish: the functional copy is rearranged in Oncorhynchus mykiss and that factor can impair TLR signaling in mammalian cells.

Brietzke A, Goldammer T, Rebl H, Korytář T, Köllner B, Yang W, Rebl A, Seyfert HM.

Fish Shellfish Immunol. 2014 Jan;36(1):206-14. doi: 10.1016/j.fsi.2013.11.005. Epub 2013 Nov 12.

PMID:
24239597
8.

Deficiency in IRAK4 activity attenuates manifestations of murine Lupus.

Murphy M, Pattabiraman G, Manavalan TT, Medvedev AE.

Eur J Immunol. 2017 May;47(5):880-891. doi: 10.1002/eji.201646641. Epub 2017 Mar 31.

9.

Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice.

Pauls E, Nanda SK, Smith H, Toth R, Arthur JSC, Cohen P.

J Immunol. 2013 Sep 1;191(5):2717-30. doi: 10.4049/jimmunol.1203268. Epub 2013 Aug 5. Erratum in: J Immunol. 2013 Nov 15;191(10):5317.

10.

The kinase activity of IL-1 receptor-associated kinase 4 is required for interleukin-1 receptor/toll-like receptor-induced TAK1-dependent NFkappaB activation.

Fraczek J, Kim TW, Xiao H, Yao J, Wen Q, Li Y, Casanova JL, Pryjma J, Li X.

J Biol Chem. 2008 Nov 14;283(46):31697-705. doi: 10.1074/jbc.M804779200. Epub 2008 Sep 15.

11.

IRAK4 kinase activity is required for Th17 differentiation and Th17-mediated disease.

Staschke KA, Dong S, Saha J, Zhao J, Brooks NA, Hepburn DL, Xia J, Gulen MF, Kang Z, Altuntas CZ, Tuohy VK, Gilmour R, Li X, Na S.

J Immunol. 2009 Jul 1;183(1):568-77. doi: 10.4049/jimmunol.0802361.

12.

IRAK4 activity controls immune responses to intracellular bacteria Listeria monocytogenes and Mycobacterium smegmatis.

Pattabiraman G, Murphy M, Agliano F, Karlinsey K, Medvedev AE.

J Leukoc Biol. 2018 Oct;104(4):811-820. doi: 10.1002/JLB.2A1117-449R. Epub 2018 May 11.

PMID:
29749650
13.

Protein tyrosine phosphatase SHP-1 positively regulates TLR-induced IL-12p40 production in macrophages through inhibition of phosphatidylinositol 3-kinase.

Zhou D, Collins CA, Wu P, Brown EJ.

J Leukoc Biol. 2010 May;87(5):845-55. doi: 10.1189/jlb.0409289. Epub 2010 Feb 9.

PMID:
20145200
14.

Solving the IRAK-4 enigma: application of kinase-dead knock-in mice.

Koziczak-Holbro M, Joyce C, Glück A, Kinzel B, Müller M, Gram H.

Ernst Schering Found Symp Proc. 2007;(3):63-82.

PMID:
18510099
15.

IRAK-4 kinase activity is required for IRAK-4-dependent innate and adaptive immune responses.

Lye E, Dhanji S, Calzascia T, Elford AR, Ohashi PS.

Eur J Immunol. 2008 Mar;38(3):870-6. doi: 10.1002/eji.200737429.

16.

A central role for the Hsp90.Cdc37 molecular chaperone module in interleukin-1 receptor-associated-kinase-dependent signaling by toll-like receptors.

De Nardo D, Masendycz P, Ho S, Cross M, Fleetwood AJ, Reynolds EC, Hamilton JA, Scholz GM.

J Biol Chem. 2005 Mar 18;280(11):9813-22. Epub 2005 Jan 12.

17.

Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use.

Sun J, Li N, Oh KS, Dutta B, Vayttaden SJ, Lin B, Ebert TS, De Nardo D, Davis J, Bagirzadeh R, Lounsbury NW, Pasare C, Latz E, Hornung V, Fraser ID.

Sci Signal. 2016 Jan 5;9(409):ra3. doi: 10.1126/scisignal.aab2191.

18.

Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction.

Uematsu S, Sato S, Yamamoto M, Hirotani T, Kato H, Takeshita F, Matsuda M, Coban C, Ishii KJ, Kawai T, Takeuchi O, Akira S.

J Exp Med. 2005 Mar 21;201(6):915-23. Epub 2005 Mar 14.

19.

IRAK-M regulates the inhibition of TLR-mediated macrophage immune response during late in vitro Leishmania donovani infection.

Srivastav S, Saha A, Barua J, Ukil A, Das PK.

Eur J Immunol. 2015 Oct;45(10):2787-97. doi: 10.1002/eji.201445336. Epub 2015 Jul 21.

20.

MNK kinases regulate multiple TLR pathways and innate proinflammatory cytokines in macrophages.

Rowlett RM, Chrestensen CA, Nyce M, Harp MG, Pelo JW, Cominelli F, Ernst PB, Pizarro TT, Sturgill TW, Worthington MT.

Am J Physiol Gastrointest Liver Physiol. 2008 Feb;294(2):G452-9. Epub 2007 Nov 21.

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