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Items: 1 to 20 of 124

1.

In vivo characterization and therapeutic efficacy of a C5-specific inhibitor from the soft tick Ornithodoros moubata.

Hepburn NJ, Williams AS, Nunn MA, Chamberlain-Banoub JC, Hamer J, Morgan BP, Harris CL.

J Biol Chem. 2007 Mar 16;282(11):8292-9. Epub 2007 Jan 10.

2.

Complement inhibitor of C5 activation from the soft tick Ornithodoros moubata.

Nunn MA, Sharma A, Paesen GC, Adamson S, Lissina O, Willis AC, Nuttall PA.

J Immunol. 2005 Feb 15;174(4):2084-91.

3.

Ornithodoros moubata complement inhibitor is an equally effective C5 inhibitor in pigs and humans.

Barratt-Due A, Thorgersen EB, Lindstad JK, Pharo A, Lissina O, Lambris JD, Nunn MA, Mollnes TE.

J Immunol. 2011 Nov 1;187(9):4913-9. doi: 10.4049/jimmunol.1101000. Epub 2011 Sep 30.

4.

Combined inhibition of complement C5 and CD14 markedly attenuates inflammation, thrombogenicity, and hemodynamic changes in porcine sepsis.

Barratt-Due A, Thorgersen EB, Egge K, Pischke S, Sokolov A, Hellerud BC, Lindstad JK, Pharo A, Bongoni AK, Rieben R, Nunn M, Scott H, Mollnes TE.

J Immunol. 2013 Jul 15;191(2):819-27. doi: 10.4049/jimmunol.1201909. Epub 2013 Jun 12.

5.

PASylated Coversin, a C5-Specific Complement Inhibitor with Extended Pharmacokinetics, Shows Enhanced Anti-Hemolytic Activity in Vitro.

Kuhn N, Schmidt CQ, Schlapschy M, Skerra A.

Bioconjug Chem. 2016 Oct 19;27(10):2359-2371. Epub 2016 Sep 26.

PMID:
27598771
6.

The structure of OMCI, a novel lipocalin inhibitor of the complement system.

Roversi P, Lissina O, Johnson S, Ahmat N, Paesen GC, Ploss K, Boland W, Nunn MA, Lea SM.

J Mol Biol. 2007 Jun 8;369(3):784-93. Epub 2007 Mar 30.

7.
8.

Formation of high affinity C5 convertase of the classical pathway of complement.

Rawal N, Pangburn MK.

J Biol Chem. 2003 Oct 3;278(40):38476-83. Epub 2003 Jul 23.

9.

Activation of complement component C5: comparison of C5 convertases of the lectin pathway and the classical pathway of complement.

Rawal N, Rajagopalan R, Salvi VP.

J Biol Chem. 2008 Mar 21;283(12):7853-63. doi: 10.1074/jbc.M707591200. Epub 2008 Jan 18.

10.

Self-assembled protein arrays from an Ornithodoros moubata salivary gland expression library.

Manzano-Román R, Díaz-Martín V, González-González M, Matarraz S, Álvarez-Prado AF, LaBaer J, Orfao A, Pérez-Sánchez R, Fuentes M.

J Proteome Res. 2012 Dec 7;11(12):5972-82. doi: 10.1021/pr300696h. Epub 2012 Nov 20.

PMID:
23140423
11.

Formation of high-affinity C5 convertases of the alternative pathway of complement.

Rawal N, Pangburn M.

J Immunol. 2001 Feb 15;166(4):2635-42.

12.

The many effects of complement C3- and C5-binding proteins in renal injury.

Puri TS, Quigg RJ.

Semin Nephrol. 2007 May;27(3):321-37. Review.

PMID:
17533009
13.

Structure/function of C5 convertases of complement.

Rawal N, Pangburn MK.

Int Immunopharmacol. 2001 Mar;1(3):415-22. Review.

PMID:
11367526
14.

The cleavage site of C5 from man and animals as a common target for neutralizing human monoclonal antibodies: in vitro and in vivo studies.

Marzari R, Sblattero D, Macor P, Fischetti F, Gennaro R, Marks JD, Bradbury A, Tedesco F.

Eur J Immunol. 2002 Oct;32(10):2773-82.

15.

Purification and characterisation of a P-selectin-binding molecule from the salivary glands of Ornithodoros moubata that induces protective anti-tick immune responses in pigs.

García-Varas S, Manzano-Román R, Fernández-Soto P, Encinas-Grandes A, Oleaga A, Pérez-Sánchez R.

Int J Parasitol. 2010 Mar 1;40(3):313-26. doi: 10.1016/j.ijpara.2009.08.011. Epub 2009 Sep 6.

PMID:
19735664
18.

Bifunctional lipocalin ameliorates murine immune complex-induced acute lung injury.

Roversi P, Ryffel B, Togbe D, Maillet I, Teixeira M, Ahmat N, Paesen GC, Lissina O, Boland W, Ploss K, Caesar JJ, Leonhartsberger S, Lea SM, Nunn MA.

J Biol Chem. 2013 Jun 28;288(26):18789-802. doi: 10.1074/jbc.M112.420331. Epub 2013 Apr 26.

19.
20.

Prevention of experimental autoimmune myasthenia gravis by rat Crry-Ig: A model agent for long-term complement inhibition in vivo.

Hepburn NJ, Chamberlain-Banoub JL, Williams AS, Morgan BP, Harris CL.

Mol Immunol. 2008 Jan;45(2):395-405. Epub 2007 Jul 24.

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