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Items: 1 to 20 of 124

1.

Hepatitis C virus NS5A is a direct substrate of casein kinase I-alpha, a cellular kinase identified by inhibitor affinity chromatography using specific NS5A hyperphosphorylation inhibitors.

Quintavalle M, Sambucini S, Summa V, Orsatti L, Talamo F, De Francesco R, Neddermann P.

J Biol Chem. 2007 Feb 23;282(8):5536-44. Epub 2006 Dec 13.

2.

The alpha isoform of protein kinase CKI is responsible for hepatitis C virus NS5A hyperphosphorylation.

Quintavalle M, Sambucini S, Di Pietro C, De Francesco R, Neddermann P.

J Virol. 2006 Nov;80(22):11305-12. Epub 2006 Aug 30.

3.

Involvement of hepatitis C virus NS5A hyperphosphorylation mediated by casein kinase I-α in infectious virus production.

Masaki T, Matsunaga S, Takahashi H, Nakashima K, Kimura Y, Ito M, Matsuda M, Murayama A, Kato T, Hirano H, Endo Y, Lemon SM, Wakita T, Sawasaki T, Suzuki T.

J Virol. 2014 Jul;88(13):7541-55. doi: 10.1128/JVI.03170-13. Epub 2014 Apr 23.

4.

Phosphorylation of hepatitis C virus NS5A nonstructural protein: a new paradigm for phosphorylation-dependent viral RNA replication?

Huang Y, Staschke K, De Francesco R, Tan SL.

Virology. 2007 Jul 20;364(1):1-9. Epub 2007 Apr 2. Review.

5.

Reduction of hepatitis C virus NS5A hyperphosphorylation by selective inhibition of cellular kinases activates viral RNA replication in cell culture.

Neddermann P, Quintavalle M, Di Pietro C, Clementi A, Cerretani M, Altamura S, Bartholomew L, De Francesco R.

J Virol. 2004 Dec;78(23):13306-14.

7.

Hepatitis C virus NS5A protein is phosphorylated by casein kinase II.

Kim J, Lee D, Choe J.

Biochem Biophys Res Commun. 1999 Apr 21;257(3):777-81.

PMID:
10208859
8.
9.

Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A.

Tanji Y, Kaneko T, Satoh S, Shimotohno K.

J Virol. 1995 Jul;69(7):3980-6.

10.

NS5A phosphorylation and hyperphosphorylation.

Neddermann P.

Methods Mol Biol. 2009;510:95-110. doi: 10.1007/978-1-59745-394-3_8.

PMID:
19009256
11.

Hepatitis C virus NS5A protein modulates template selection by the RNA polymerase in in vitro system.

Ivanov AV, Tunitskaya VL, Ivanova ON, Mitkevich VA, Prassolov VS, Makarov AA, Kukhanova MK, Kochetkov SN.

FEBS Lett. 2009 Jan 22;583(2):277-80. doi: 10.1016/j.febslet.2008.12.016. Epub 2008 Dec 13.

12.

Structural and molecular basis of interaction of HCV non-structural protein 5A with human casein kinase 1α and PKR.

Sudha G, Yamunadevi S, Tyagi N, Das S, Srinivasan N.

BMC Struct Biol. 2012 Nov 13;12:28. doi: 10.1186/1472-6807-12-28.

13.

Polo-like kinase 1 is involved in hepatitis C virus replication by hyperphosphorylating NS5A.

Chen YC, Su WC, Huang JY, Chao TC, Jeng KS, Machida K, Lai MM.

J Virol. 2010 Aug;84(16):7983-93. doi: 10.1128/JVI.00068-10. Epub 2010 Jun 9.

14.
15.

The effects of NS5A inhibitors on NS5A phosphorylation, polyprotein processing and localization.

Qiu D, Lemm JA, O'Boyle DR 2nd, Sun JH, Nower PT, Nguyen V, Hamann LG, Snyder LB, Deon DH, Ruediger E, Meanwell NA, Belema M, Gao M, Fridell RA.

J Gen Virol. 2011 Nov;92(Pt 11):2502-11. doi: 10.1099/vir.0.034801-0. Epub 2011 Jul 27.

PMID:
21795470
16.

A link between translation of the hepatitis C virus polyprotein and polymerase function; possible consequences for hyperphosphorylation of NS5A.

McCormick CJ, Brown D, Griffin S, Challinor L, Rowlands DJ, Harris M.

J Gen Virol. 2006 Jan;87(Pt 1):93-102.

PMID:
16361421
17.

Purification and characterization of hepatitis C virus non-structural protein 5A expressed in Escherichia coli.

Huang L, Sineva EV, Hargittai MR, Sharma SD, Suthar M, Raney KD, Cameron CE.

Protein Expr Purif. 2004 Sep;37(1):144-53.

PMID:
15294292
18.

Raf-1 kinase associates with Hepatitis C virus NS5A and regulates viral replication.

Bürckstümmer T, Kriegs M, Lupberger J, Pauli EK, Schmittel S, Hildt E.

FEBS Lett. 2006 Jan 23;580(2):575-80. Epub 2005 Dec 29.

19.

Phosphorylation of nonstructural 5A protein of hepatitis C virus: HCV group-specific hyperphosphorylation.

Hirota M, Satoh S, Asabe S, Kohara M, Tsukiyama-Kohara K, Kato N, Hijikata M, Shimotohno K.

Virology. 1999 Apr 25;257(1):130-7.

20.

Ser(2194) is a highly conserved major phosphorylation site of the hepatitis C virus nonstructural protein NS5A.

Katze MG, Kwieciszewski B, Goodlett DR, Blakely CM, Neddermann P, Tan SL, Aebersold R.

Virology. 2000 Dec 20;278(2):501-13.

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