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Items: 1 to 20 of 86

1.

Influenza A virus NS1 protein binds p85beta and activates phosphatidylinositol-3-kinase signaling.

Hale BG, Jackson D, Chen YH, Lamb RA, Randall RE.

Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14194-9. Epub 2006 Sep 8.

2.

SH3 binding motif 1 in influenza A virus NS1 protein is essential for PI3K/Akt signaling pathway activation.

Shin YK, Li Y, Liu Q, Anderson DH, Babiuk LA, Zhou Y.

J Virol. 2007 Dec;81(23):12730-9. Epub 2007 Sep 19.

3.
4.

Inability of NS1 protein from an H5N1 influenza virus to activate PI3K/Akt signaling pathway correlates to the enhanced virus replication upon PI3K inhibition.

Li W, Wang G, Zhang H, Shen Y, Dai J, Wu L, Zhou J, Jiang Z, Li K.

Vet Res. 2012 Apr 24;43:36. doi: 10.1186/1297-9716-43-36.

5.

Mechanism of influenza A virus NS1 protein interaction with the p85beta, but not the p85alpha, subunit of phosphatidylinositol 3-kinase (PI3K) and up-regulation of PI3K activity.

Li Y, Anderson DH, Liu Q, Zhou Y.

J Biol Chem. 2008 Aug 22;283(34):23397-409. doi: 10.1074/jbc.M802737200. Epub 2008 Jun 5.

6.

Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses.

Ehrhardt C, Wolff T, Pleschka S, Planz O, Beermann W, Bode JG, Schmolke M, Ludwig S.

J Virol. 2007 Apr;81(7):3058-67. Epub 2007 Jan 17.

7.

Unexpected Functional Divergence of Bat Influenza Virus NS1 Proteins.

Turkington HL, Juozapaitis M, Tsolakos N, Corrales-Aguilar E, Schwemmle M, Hale BG.

J Virol. 2018 Feb 12;92(5). pii: e02097-17. doi: 10.1128/JVI.02097-17. Print 2018 Mar 1.

8.

Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling.

Heikkinen LS, Kazlauskas A, Melén K, Wagner R, Ziegler T, Julkunen I, Saksela K.

J Biol Chem. 2008 Feb 29;283(9):5719-27. doi: 10.1074/jbc.M707195200. Epub 2007 Dec 28.

9.

Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein.

Hale BG, Kerry PS, Jackson D, Precious BL, Gray A, Killip MJ, Randall RE, Russell RJ.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):1954-9. doi: 10.1073/pnas.0910715107. Epub 2010 Jan 19.

10.

Binding of influenza A virus NS1 protein to the inter-SH2 domain of p85 suggests a novel mechanism for phosphoinositide 3-kinase activation.

Hale BG, Batty IH, Downes CP, Randall RE.

J Biol Chem. 2008 Jan 18;283(3):1372-80. Epub 2007 Nov 20.

11.

Structure-Guided Functional Annotation of the Influenza A Virus NS1 Protein Reveals Dynamic Evolution of the p85β-Binding Site during Circulation in Humans.

Lopes AM, Domingues P, Zell R, Hale BG.

J Virol. 2017 Oct 13;91(21). pii: e01081-17. doi: 10.1128/JVI.01081-17. Print 2017 Nov 1.

12.

PI3K signalling during influenza A virus infections.

Hale BG, Randall RE.

Biochem Soc Trans. 2007 Apr;35(Pt 2):186-7.

PMID:
17371234
13.

Synergistic effect of the PDZ and p85β-binding domains of the NS1 protein on virulence of an avian H5N1 influenza A virus.

Fan S, Macken CA, Li C, Ozawa M, Goto H, Iswahyudi NF, Nidom CA, Chen H, Neumann G, Kawaoka Y.

J Virol. 2013 May;87(9):4861-71. doi: 10.1128/JVI.02608-12. Epub 2013 Feb 13.

14.

Heterologous SH3-p85beta inhibits influenza A virus replication.

Zhang DG, Li WZ, Wang GF, Su Y, Zeng J, Zhang C, Zeng XX, Chen XX, Xu YX, Li KS.

Virol J. 2010 Jul 23;7:170. doi: 10.1186/1743-422X-7-170.

15.
16.

Reorganization of the host cell Crk(L)-PI3 kinase signaling complex by the influenza A virus NS1 protein.

Ylösmäki L, Schmotz C, Ylösmäki E, Saksela K.

Virology. 2015 Oct;484:146-52. doi: 10.1016/j.virol.2015.06.009. Epub 2015 Jun 19.

17.

Nuclear Translocation of Crk Adaptor Proteins by the Influenza A Virus NS1 Protein.

Ylösmäki L, Fagerlund R, Kuisma I, Julkunen I, Saksela K.

Viruses. 2016 Apr 15;8(4):101. doi: 10.3390/v8040101.

18.

Loss of function of the influenza A virus NS1 protein promotes apoptosis but this is not due to a failure to activate phosphatidylinositol 3-kinase (PI3K).

Jackson D, Killip MJ, Galloway CS, Russell RJ, Randall RE.

Virology. 2010 Jan 5;396(1):94-105. doi: 10.1016/j.virol.2009.10.004. Epub 2009 Oct 31.

19.

A new player in a deadly game: influenza viruses and the PI3K/Akt signalling pathway.

Ehrhardt C, Ludwig S.

Cell Microbiol. 2009 Jun;11(6):863-71. doi: 10.1111/j.1462-5822.2009.01309.x. Epub 2009 Mar 12. Review.

PMID:
19290913
20.

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