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Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation.

Shaw MH, Freeman GJ, Scott MF, Fox BA, Bzik DJ, Belkaid Y, Yap GS.

J Immunol. 2006 Jun 15;176(12):7263-71.


IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available.

Khader SA, Pearl JE, Sakamoto K, Gilmartin L, Bell GK, Jelley-Gibbs DM, Ghilardi N, deSauvage F, Cooper AM.

J Immunol. 2005 Jul 15;175(2):788-95.


Tyk2-dependent bystander activation of conventional and nonconventional Th1 cell subsets contributes to innate host defense against Listeria monocytogenes infection.

Hashiguchi T, Oyamada A, Sakuraba K, Shimoda K, Nakayama KI, Iwamoto Y, Yoshikai Y, Yamada H.

J Immunol. 2014 May 15;192(10):4739-47. doi: 10.4049/jimmunol.1303067. Epub 2014 Apr 11.


IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12.

Lieberman LA, Cardillo F, Owyang AM, Rennick DM, Cua DJ, Kastelein RA, Hunter CA.

J Immunol. 2004 Aug 1;173(3):1887-93.


A role for IL-27 in early regulation of Th1 differentiation.

Owaki T, Asakawa M, Morishima N, Hata K, Fukai F, Matsui M, Mizuguchi J, Yoshimoto T.

J Immunol. 2005 Aug 15;175(4):2191-200.


Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function.

Shimoda K, Kato K, Aoki K, Matsuda T, Miyamoto A, Shibamori M, Yamashita M, Numata A, Takase K, Kobayashi S, Shibata S, Asano Y, Gondo H, Sekiguchi K, Nakayama K, Nakayama T, Okamura T, Okamura S, Niho Y, Nakayama K.

Immunity. 2000 Oct;13(4):561-71.


Partial impairment of cytokine responses in Tyk2-deficient mice.

Karaghiosoff M, Neubauer H, Lassnig C, Kovarik P, Schindler H, Pircher H, McCoy B, Bogdan C, Decker T, Brem G, Pfeffer K, Müller M.

Immunity. 2000 Oct;13(4):549-60.


Cysteine protease B of Leishmania mexicana inhibits host Th1 responses and protective immunity.

Buxbaum LU, Denise H, Coombs GH, Alexander J, Mottram JC, Scott P.

J Immunol. 2003 Oct 1;171(7):3711-7.


IL-10 regulates early IL-12-mediated immune responses induced by the radiation-attenuated schistosome vaccine.

Hogg KG, Kumkate S, Mountford AP.

Int Immunol. 2003 Dec;15(12):1451-9.


TLR ligands can activate dendritic cells to provide a MyD88-dependent negative signal for Th2 cell development.

Sun J, Walsh M, Villarino AV, Cervi L, Hunter CA, Choi Y, Pearce EJ.

J Immunol. 2005 Jan 15;174(2):742-51.


IL-10 is not required to prevent immune hyperactivity during memory responses to Toxoplasma gondii.

Wille U, Nishi M, Lieberman L, Wilson EH, Roos DS, Hunter CA.

Parasite Immunol. 2004 May;26(5):229-36.


Stat4 regulates multiple components of IFN-gamma-inducing signaling pathways.

Lawless VA, Zhang S, Ozes ON, Bruns HA, Oldham I, Hoey T, Grusby MJ, Kaplan MH.

J Immunol. 2000 Dec 15;165(12):6803-8.


Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection.

Jankovic D, Kullberg MC, Feng CG, Goldszmid RS, Collazo CM, Wilson M, Wynn TA, Kamanaka M, Flavell RA, Sher A.

J Exp Med. 2007 Feb 19;204(2):273-83. Epub 2007 Feb 5.


Partial impairment of interleukin-12 (IL-12) and IL-18 signaling in Tyk2-deficient mice.

Shimoda K, Tsutsui H, Aoki K, Kato K, Matsuda T, Numata A, Takase K, Yamamoto T, Nukina H, Hoshino T, Asano Y, Gondo H, Okamura T, Okamura S, Nakayama K, Nakanishi K, Niho Y, Harada M.

Blood. 2002 Mar 15;99(6):2094-9.


Expression of Tyk2 in dendritic cells is required for IL-12, IL-23, and IFN-gamma production and the induction of Th1 cell differentiation.

Tokumasa N, Suto A, Kagami S, Furuta S, Hirose K, Watanabe N, Saito Y, Shimoda K, Iwamoto I, Nakajima H.

Blood. 2007 Jul 15;110(2):553-60. Epub 2007 Mar 29.


Blockade of IL-10 signaling during bacillus Calmette-Guérin vaccination enhances and sustains Th1, Th17, and innate lymphoid IFN-γ and IL-17 responses and increases protection to Mycobacterium tuberculosis infection.

Pitt JM, Stavropoulos E, Redford PS, Beebe AM, Bancroft GJ, Young DB, O'Garra A.

J Immunol. 2012 Oct 15;189(8):4079-87. doi: 10.4049/jimmunol.1201061. Epub 2012 Sep 12.

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