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Focal adhesion kinase is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA.

Tsutsumi R, Takahashi A, Azuma T, Higashi H, Hatakeyama M.

Mol Cell Biol. 2006 Jan;26(1):261-76.


Attenuation of Helicobacter pylori CagA x SHP-2 signaling by interaction between CagA and C-terminal Src kinase.

Tsutsumi R, Higashi H, Higuchi M, Okada M, Hatakeyama M.

J Biol Chem. 2003 Feb 7;278(6):3664-70. Epub 2002 Nov 21.


Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation.

Higashi H, Nakaya A, Tsutsumi R, Yokoyama K, Fujii Y, Ishikawa S, Higuchi M, Takahashi A, Kurashima Y, Teishikata Y, Tanaka S, Azuma T, Hatakeyama M.

J Biol Chem. 2004 Apr 23;279(17):17205-16. Epub 2004 Feb 12.


The CagA protein of Helicobacter pylori is translocated into epithelial cells and binds to SHP-2 in human gastric mucosa.

Yamazaki S, Yamakawa A, Ito Y, Ohtani M, Higashi H, Hatakeyama M, Azuma T.

J Infect Dis. 2003 Jan 15;187(2):334-7. Epub 2002 Dec 19.


Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagA.

Naito M, Yamazaki T, Tsutsumi R, Higashi H, Onoe K, Yamazaki S, Azuma T, Hatakeyama M.

Gastroenterology. 2006 Apr;130(4):1181-90.


EPIYA motif is a membrane-targeting signal of Helicobacter pylori virulence factor CagA in mammalian cells.

Higashi H, Yokoyama K, Fujii Y, Ren S, Yuasa H, Saadat I, Murata-Kamiya N, Azuma T, Hatakeyama M.

J Biol Chem. 2005 Jun 17;280(24):23130-7. Epub 2005 Apr 13.


The effects of cure of Helicobacter pylori infection on the signal transduction of gastric epithelial cells.

Azuma T, Yamazaki S, Yamakawa A, Ito Y, Ohtani M, Dojo M, Yamazaki Y, Higashi H, Hatakeyama M.

Aliment Pharmacol Ther. 2003 Jul;18 Suppl 1:39-44.


Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity.

Saadat I, Higashi H, Obuse C, Umeda M, Murata-Kamiya N, Saito Y, Lu H, Ohnishi N, Azuma T, Suzuki A, Ohno S, Hatakeyama M.

Nature. 2007 May 17;447(7142):330-3.


Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites.

Higashi H, Tsutsumi R, Fujita A, Yamazaki S, Asaka M, Azuma T, Hatakeyama M.

Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14428-33. Epub 2002 Oct 21.


Structural basis and functional consequence of Helicobacter pylori CagA multimerization in cells.

Ren S, Higashi H, Lu H, Azuma T, Hatakeyama M.

J Biol Chem. 2006 Oct 27;281(43):32344-52. Epub 2006 Sep 5.


Interaction of CagA with Crk plays an important role in Helicobacter pylori-induced loss of gastric epithelial cell adhesion.

Suzuki M, Mimuro H, Suzuki T, Park M, Yamamoto T, Sasakawa C.

J Exp Med. 2005 Nov 7;202(9):1235-47.


Potentiation of Helicobacter pylori CagA protein virulence through homodimerization.

Nagase L, Murata-Kamiya N, Hatakeyama M.

J Biol Chem. 2011 Sep 23;286(38):33622-31. doi: 10.1074/jbc.M111.258673. Epub 2011 Aug 3.


CagA phosphorylation-dependent MMP-9 expression in gastric epithelial cells.

Nam YH, Ryu E, Lee D, Shim HJ, Lee YC, Lee ST.

Helicobacter. 2011 Aug;16(4):276-83. doi: 10.1111/j.1523-5378.2011.00851.x.


The Helicobacter pylori CagA protein induces cortactin dephosphorylation and actin rearrangement by c-Src inactivation.

Selbach M, Moese S, Hurwitz R, Hauck CR, Meyer TF, Backert S.

EMBO J. 2003 Feb 3;22(3):515-28.


SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein.

Higashi H, Tsutsumi R, Muto S, Sugiyama T, Azuma T, Asaka M, Hatakeyama M.

Science. 2002 Jan 25;295(5555):683-6. Epub 2001 Dec 13.


Helicobacter pylori CagA -- a bacterial intruder conspiring gastric carcinogenesis.

Hatakeyama M.

Int J Cancer. 2006 Sep 15;119(6):1217-23. Review.


Helicobacter pylori CagA: a new paradigm for bacterial carcinogenesis.

Hatakeyama M, Higashi H.

Cancer Sci. 2005 Dec;96(12):835-43. Review.


Structural and functional diversity in the PAR1b/MARK2-binding region of Helicobacter pylori CagA.

Lu HS, Saito Y, Umeda M, Murata-Kamiya N, Zhang HM, Higashi H, Hatakeyama M.

Cancer Sci. 2008 Oct;99(10):2004-11. doi: 10.1111/j.1349-7006.2008.00950.x.


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