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Items: 1 to 20 of 503


The family 6 carbohydrate binding module CmCBM6-2 contains two ligand-binding sites with distinct specificities.

Henshaw JL, Bolam DN, Pires VM, Czjzek M, Henrissat B, Ferreira LM, Fontes CM, Gilbert HJ.

J Biol Chem. 2004 May 14;279(20):21552-9. Epub 2004 Mar 5.


The crystal structure of the family 6 carbohydrate binding module from Cellvibrio mixtus endoglucanase 5a in complex with oligosaccharides reveals two distinct binding sites with different ligand specificities.

Pires VM, Henshaw JL, Prates JA, Bolam DN, Ferreira LM, Fontes CM, Henrissat B, Planas A, Gilbert HJ, Czjzek M.

J Biol Chem. 2004 May 14;279(20):21560-8. Epub 2004 Mar 8.


The family 11 carbohydrate-binding module of Clostridium thermocellum Lic26A-Cel5E accommodates beta-1,4- and beta-1,3-1,4-mixed linked glucans at a single binding site.

Carvalho AL, Goyal A, Prates JA, Bolam DN, Gilbert HJ, Pires VM, Ferreira LM, Planas A, Romão MJ, Fontes CM.

J Biol Chem. 2004 Aug 13;279(33):34785-93. Epub 2004 Jun 10.


Family 6 carbohydrate binding modules recognize the non-reducing end of beta-1,3-linked glucans by presenting a unique ligand binding surface.

van Bueren AL, Morland C, Gilbert HJ, Boraston AB.

J Biol Chem. 2005 Jan 7;280(1):530-7. Epub 2004 Oct 22.


The location of the ligand-binding site of carbohydrate-binding modules that have evolved from a common sequence is not conserved.

Czjzek M, Bolam DN, Mosbah A, Allouch J, Fontes CM, Ferreira LM, Bornet O, Zamboni V, Darbon H, Smith NL, Black GW, Henrissat B, Gilbert HJ.

J Biol Chem. 2001 Dec 21;276(51):48580-7. Epub 2001 Oct 22.


Evidence for synergy between family 2b carbohydrate binding modules in Cellulomonas fimi xylanase 11A.

Bolam DN, Xie H, White P, Simpson PJ, Hancock SM, Williamson MP, Gilbert HJ.

Biochemistry. 2001 Feb 27;40(8):2468-77.


The structural basis for the ligand specificity of family 2 carbohydrate-binding modules.

Simpson PJ, Xie H, Bolam DN, Gilbert HJ, Williamson MP.

J Biol Chem. 2000 Dec 29;275(52):41137-42.


Carbohydrate-binding domains: multiplicity of biological roles.

Guillén D, Sánchez S, Rodríguez-Sanoja R.

Appl Microbiol Biotechnol. 2010 Feb;85(5):1241-9. doi: 10.1007/s00253-009-2331-y. Epub 2009 Nov 12. Review.


Clostridium thermocellum Xyn10B carbohydrate-binding module 22-2: the role of conserved amino acids in ligand binding.

Xie H, Gilbert HJ, Charnock SJ, Davies GJ, Williamson MP, Simpson PJ, Raghothama S, Fontes CM, Dias FM, Ferreira LM, Bolam DN.

Biochemistry. 2001 Aug 7;40(31):9167-76.


A structural and functional analysis of alpha-glucan recognition by family 25 and 26 carbohydrate-binding modules reveals a conserved mode of starch recognition.

Boraston AB, Healey M, Klassen J, Ficko-Blean E, Lammerts van Bueren A, Law V.

J Biol Chem. 2006 Jan 6;281(1):587-98. Epub 2005 Oct 17.


The modular architecture of Cellvibrio japonicus mannanases in glycoside hydrolase families 5 and 26 points to differences in their role in mannan degradation.

Hogg D, Pell G, Dupree P, Goubet F, Martín-Orúe SM, Armand S, Gilbert HJ.

Biochem J. 2003 May 1;371(Pt 3):1027-43.


Structure of a family 15 carbohydrate-binding module in complex with xylopentaose. Evidence that xylan binds in an approximate 3-fold helical conformation.

Szabo L, Jamal S, Xie H, Charnock SJ, Bolam DN, Gilbert HJ, Davies GJ.

J Biol Chem. 2001 Dec 28;276(52):49061-5. Epub 2001 Oct 11.


X4 modules represent a new family of carbohydrate-binding modules that display novel properties.

Bolam DN, Xie H, Pell G, Hogg D, Galbraith G, Henrissat B, Gilbert HJ.

J Biol Chem. 2004 May 28;279(22):22953-63. Epub 2004 Mar 5.


The topology of the substrate binding clefts of glycosyl hydrolase family 10 xylanases are not conserved.

Charnock SJ, Spurway TD, Xie H, Beylot MH, Virden R, Warren RA, Hazlewood GP, Gilbert HJ.

J Biol Chem. 1998 Nov 27;273(48):32187-99.


Xyloglucan is recognized by carbohydrate-binding modules that interact with beta-glucan chains.

Najmudin S, Guerreiro CI, Carvalho AL, Prates JA, Correia MA, Alves VD, Ferreira LM, Romão MJ, Gilbert HJ, Bolam DN, Fontes CM.

J Biol Chem. 2006 Mar 31;281(13):8815-28. Epub 2005 Nov 28.


Family 6 carbohydrate-binding modules display multiple beta1,3-linked glucan-specific binding interfaces.

Correia MA, Pires VM, Gilbert HJ, Bolam DN, Fernandes VO, Alves VD, Prates JA, Ferreira LM, Fontes CM.

FEMS Microbiol Lett. 2009 Nov;300(1):48-57. doi: 10.1111/j.1574-6968.2009.01764.x. Epub 2009 Aug 19.


Recognition of cello-oligosaccharides by a family 17 carbohydrate-binding module: an X-ray crystallographic, thermodynamic and mutagenic study.

Notenboom V, Boraston AB, Chiu P, Freelove AC, Kilburn DG, Rose DR.

J Mol Biol. 2001 Dec 7;314(4):797-806.


Structure and ligand binding of carbohydrate-binding module CsCBM6-3 reveals similarities with fucose-specific lectins and "galactose-binding" domains.

Boraston AB, Notenboom V, Warren RA, Kilburn DG, Rose DR, Davies G.

J Mol Biol. 2003 Mar 28;327(3):659-69.


Importance of hydrophobic and polar residues in ligand binding in the family 15 carbohydrate-binding module from Cellvibrio japonicus Xyn10C.

Pell G, Williamson MP, Walters C, Du H, Gilbert HJ, Bolam DN.

Biochemistry. 2003 Aug 12;42(31):9316-23.


Structural and biochemical analysis of Cellvibrio japonicus xylanase 10C: how variation in substrate-binding cleft influences the catalytic profile of family GH-10 xylanases.

Pell G, Szabo L, Charnock SJ, Xie H, Gloster TM, Davies GJ, Gilbert HJ.

J Biol Chem. 2004 Mar 19;279(12):11777-88. Epub 2003 Dec 11.

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