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HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis.

Lan KH, Sheu ML, Hwang SJ, Yen SH, Chen SY, Wu JC, Wang YJ, Kato N, Omata M, Chang FY, Lee SD.

Oncogene. 2002 Jul 18;21(31):4801-11.


The oncogenic role of NS5A of hepatitis C virus is mediated by up-regulation of survivin gene expression in the hepatocellular cell through p53 and NF-κB pathways.

Jiang YF, He B, Li NP, Ma J, Gong GZ, Zhang M.

Cell Biol Int. 2011 Dec;35(12):1225-32. doi: 10.1042/CBI20110102.


The Hepatitis C virus NS5A protein activates a phosphoinositide 3-kinase-dependent survival signaling cascade.

Street A, Macdonald A, Crowder K, Harris M.

J Biol Chem. 2004 Mar 26;279(13):12232-41. Epub 2004 Jan 5.


Wild-type p53 induces apoptosis in Hep3B through up-regulation of bax expression.

Mitry RR, Sarraf CE, Wu CG, Pignatelli M, Habib NA.

Lab Invest. 1997 Oct;77(4):369-78.


Nuclear targeting of Bax during apoptosis in human colorectal cancer cells.

Mandal M, Adam L, Mendelsohn J, Kumar R.

Oncogene. 1998 Aug 27;17(8):999-1007.


Characterization of a HCV NS5A protein derived from a patient with hepatoma.

Yeh CT, Chang MH, Shyu WC, Chang ML, Yang PY, Tsao ML, Lai HY.

Biochem Biophys Res Commun. 2005 Feb 11;327(2):516-22.


Hepatitis C virus promotes hepatocellular carcinogenesis by targeting TIPE2, a new regulator of DNA damage response.

Wang Y, Jiang Y, Zhou J, Song W, Li J, Wang M, Chen J, Xu R, Zhang J, Ma F, Chen YH, Ma Y.

Tumour Biol. 2016 Nov;37(11):15265-15274. Epub 2016 Sep 30.


Studies on the role of NS3 and NS5A non-structural genes of hepatitis C virus genotype 3a local isolates in apoptosis.

Sabri S, Idrees M, Rafique S, Ali A, Iqbal M.

Int J Infect Dis. 2014 Aug;25:38-44. doi: 10.1016/j.ijid.2014.01.010. Epub 2014 May 17.


Localization determines function: N-terminally truncated NS5A fragments accumulate in the nucleus and impair HCV replication.

Sauter D, Himmelsbach K, Kriegs M, Carvajal Yepes M, Hildt E.

J Hepatol. 2009 May;50(5):861-71. doi: 10.1016/j.jhep.2008.11.024. Epub 2009 Jan 31.


Hepatitis C Virus NS5A Protein Promotes the Lysosomal Degradation of Hepatocyte Nuclear Factor 1α via Chaperone-Mediated Autophagy.

Matsui C, Deng L, Minami N, Abe T, Koike K, Shoji I.

J Virol. 2018 Jun 13;92(13). pii: e00639-18. doi: 10.1128/JVI.00639-18. Print 2018 Jul 1.


A novel interaction of nucleophosmin with BCL2-associated X protein regulating death evasion and drug sensitivity in human hepatoma cells.

Lo SJ, Fan LC, Tsai YF, Lin KY, Huang HL, Wang TH, Liu H, Chen TC, Huang SF, Chang CJ, Lin YJ, Yung BY, Hsieh SY.

Hepatology. 2013 May;57(5):1893-905. doi: 10.1002/hep.26209. Epub 2013 Apr 1.


Dulxanthone A induces cell cycle arrest and apoptosis via up-regulation of p53 through mitochondrial pathway in HepG2 cells.

Tian Z, Shen J, Moseman AP, Yang Q, Yang J, Xiao P, Wu E, Kohane IS.

Int J Cancer. 2008 Jan 1;122(1):31-8.


Hepatitis C virus core protein inhibits tumor suppressor protein promyelocytic leukemia function in human hepatoma cells.

Herzer K, Weyer S, Krammer PH, Galle PR, Hofmann TG.

Cancer Res. 2005 Dec 1;65(23):10830-7.


Characterization of the effects of hepatitis C virus nonstructural 5A protein expression in human cell lines and on interferon-sensitive virus replication.

Polyak SJ, Paschal DM, McArdle S, Gale MJ Jr, Moradpour D, Gretch DR.

Hepatology. 1999 Apr;29(4):1262-71.


Hepatitis C Virus Nonstructural 5A Protein (HCV-NS5A) Inhibits Hepatocyte Apoptosis through the NF-κb/miR-503/bcl-2 Pathway.

Xie Z, Xiao Z, Wang F.

Mol Cells. 2017 Mar;40(3):202-210. doi: 10.14348/molcells.2017.2299. Epub 2017 Mar 27.


Nonstructural 5A protein activates beta-catenin signaling cascades: implication of hepatitis C virus-induced liver pathogenesis.

Park CY, Choi SH, Kang SM, Kang JI, Ahn BY, Kim H, Jung G, Choi KY, Hwang SB.

J Hepatol. 2009 Nov;51(5):853-64. doi: 10.1016/j.jhep.2009.06.026. Epub 2009 Aug 12.


Effect of Bcl-2 and Bax on survival of side population cells from hepatocellular carcinoma cells.

Fan J, Li R, Zhang R, Liu HL, Zhang N, Zhang FQ, Dou KF.

World J Gastroenterol. 2007 Dec 7;13(45):6053-9.

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