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Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA.

Amieva MR, Vogelmann R, Covacci A, Tompkins LS, Nelson WJ, Falkow S.

Science. 2003 May 30;300(5624):1430-4.


Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity.

Saadat I, Higashi H, Obuse C, Umeda M, Murata-Kamiya N, Saito Y, Lu H, Ohnishi N, Azuma T, Suzuki A, Ohno S, Hatakeyama M.

Nature. 2007 May 17;447(7142):330-3.


H. pylori-encoded CagA disrupts tight junctions and induces invasiveness of AGS gastric carcinoma cells via Cdx2-dependent targeting of Claudin-2.

Song X, Chen HX, Wang XY, Deng XY, Xi YX, He Q, Peng TL, Chen J, Chen W, Wong BC, Chen MH.

Cell Immunol. 2013 Nov-Dec;286(1-2):22-30. doi: 10.1016/j.cellimm.2013.10.008. Epub 2013 Nov 9.


Helicobacter pylori alters the distribution of ZO-1 and p120ctn in primary human gastric epithelial cells.

Krueger S, Hundertmark T, Kuester D, Kalinski T, Peitz U, Roessner A.

Pathol Res Pract. 2007;203(6):433-44. Epub 2007 May 16.


Focal adhesion kinase is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA.

Tsutsumi R, Takahashi A, Azuma T, Higashi H, Hatakeyama M.

Mol Cell Biol. 2006 Jan;26(1):261-76.


Helicobacter pylori infection and CagA protein translocation in human primary gastric epithelial cell culture.

Lai YP, Yang JC, Lin TZ, Lin JT, Wang JT.

Helicobacter. 2006 Oct;11(5):451-9. Erratum in: Helicobacter. 2007 Jun;12(3):274.


Structural and functional diversity in the PAR1b/MARK2-binding region of Helicobacter pylori CagA.

Lu HS, Saito Y, Umeda M, Murata-Kamiya N, Zhang HM, Higashi H, Hatakeyama M.

Cancer Sci. 2008 Oct;99(10):2004-11. doi: 10.1111/j.1349-7006.2008.00950.x.


SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein.

Higashi H, Tsutsumi R, Muto S, Sugiyama T, Azuma T, Asaka M, Hatakeyama M.

Science. 2002 Jan 25;295(5555):683-6. Epub 2001 Dec 13.


Helicobacter pylori CagA -- a bacterial intruder conspiring gastric carcinogenesis.

Hatakeyama M.

Int J Cancer. 2006 Sep 15;119(6):1217-23. Review.


Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites.

Higashi H, Tsutsumi R, Fujita A, Yamazaki S, Asaka M, Azuma T, Hatakeyama M.

Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14428-33. Epub 2002 Oct 21.


CagA associates with c-Met, E-cadherin, and p120-catenin in a multiproteic complex that suppresses Helicobacter pylori-induced cell-invasive phenotype.

Oliveira MJ, Costa AM, Costa AC, Ferreira RM, Sampaio P, Machado JC, Seruca R, Mareel M, Figueiredo C.

J Infect Dis. 2009 Sep 1;200(5):745-55. doi: 10.1086/604727.


The CagA protein of Helicobacter pylori is translocated into epithelial cells and binds to SHP-2 in human gastric mucosa.

Yamazaki S, Yamakawa A, Ito Y, Ohtani M, Higashi H, Hatakeyama M, Azuma T.

J Infect Dis. 2003 Jan 15;187(2):334-7. Epub 2002 Dec 19.


Helicobacter pylori CagA protein induces factors involved in the epithelial to mesenchymal transition (EMT) in infected gastric epithelial cells in an EPIYA- phosphorylation-dependent manner.

Sougleri IS, Papadakos KS, Zadik MP, Mavri-Vavagianni M, Mentis AF, Sgouras DN.

FEBS J. 2016 Jan;283(2):206-20. doi: 10.1111/febs.13592. Epub 2015 Dec 11.


Helicobacter pylori perturbs iron trafficking in the epithelium to grow on the cell surface.

Tan S, Noto JM, Romero-Gallo J, Peek RM Jr, Amieva MR.

PLoS Pathog. 2011 May;7(5):e1002050. doi: 10.1371/journal.ppat.1002050. Epub 2011 May 12.


Helicobacter pylori vesicles carrying CagA localize in the vicinity of cell-cell contacts and induce histone H1 binding to ATP in epithelial cells.

Turkina MV, Olofsson A, Magnusson KE, Arnqvist A, Vikström E.

FEMS Microbiol Lett. 2015 Jun;362(11). pii: fnv076. doi: 10.1093/femsle/fnv076. Epub 2015 May 7.


Helicobacter pylori stimulates epithelial cell migration via CagA-mediated perturbation of host cell signaling.

Kikuchi K, Murata-Kamiya N, Kondo S, Hatakeyama M.

Microbes Infect. 2012 May;14(5):470-6. doi: 10.1016/j.micinf.2011.12.003. Epub 2011 Dec 11.


Helicobacter pylori counteracts the apoptotic action of its VacA toxin by injecting the CagA protein into gastric epithelial cells.

Oldani A, Cormont M, Hofman V, Chiozzi V, Oregioni O, Canonici A, Sciullo A, Sommi P, Fabbri A, Ricci V, Boquet P.

PLoS Pathog. 2009 Oct;5(10):e1000603. doi: 10.1371/journal.ppat.1000603. Epub 2009 Oct 2.


A novel inhibitory domain of Helicobacter pylori protein CagA reduces CagA effects on host cell biology.

Pelz C, Steininger S, Weiss C, Coscia F, Vogelmann R.

J Biol Chem. 2011 Mar 18;286(11):8999-9008. doi: 10.1074/jbc.M110.166504. Epub 2011 Jan 6.

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