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Items: 1 to 20 of 116

1.

Autoantibodies to amyloid beta-peptide (Abeta) are increased in Alzheimer's disease patients and Abeta antibodies can enhance Abeta neurotoxicity: implications for disease pathogenesis and vaccine development.

Nath A, Hall E, Tuzova M, Dobbs M, Jons M, Anderson C, Woodward J, Guo Z, Fu W, Kryscio R, Wekstein D, Smith C, Markesbery WR, Mattson MP.

Neuromolecular Med. 2003;3(1):29-39.

PMID:
12665674
2.

Human intravenous immunoglobulin provides protection against Aβ toxicity by multiple mechanisms in a mouse model of Alzheimer's disease.

Magga J, Puli L, Pihlaja R, Kanninen K, Neulamaa S, Malm T, Härtig W, Grosche J, Goldsteins G, Tanila H, Koistinaho J, Koistinaho M.

J Neuroinflammation. 2010 Dec 7;7:90. doi: 10.1186/1742-2094-7-90.

3.

Active immunization with the peptide epitope vaccine Aβ3-10-KLH induces a Th2-polarized anti-Aβ antibody response and decreases amyloid plaques in APP/PS1 transgenic mice.

Ding L, Meng Y, Zhang HY, Yin WC, Yan Y, Cao YP.

Neurosci Lett. 2016 Nov 10;634:1-6. doi: 10.1016/j.neulet.2016.09.050. Epub 2016 Sep 28.

PMID:
27693663
4.

Mannan-Abeta28 conjugate prevents Abeta-plaque deposition, but increases microhemorrhages in the brains of vaccinated Tg2576 (APPsw) mice.

Petrushina I, Ghochikyan A, Mkrtichyan M, Mamikonyan G, Movsesyan N, Ajdari R, Vasilevko V, Karapetyan A, Lees A, Agadjanyan MG, Cribbs DH.

J Neuroinflammation. 2008 Sep 29;5:42. doi: 10.1186/1742-2094-5-42.

5.

Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Abeta species in amyloid precursor protein transgenic mice.

Petrushina I, Ghochikyan A, Mktrichyan M, Mamikonyan G, Movsesyan N, Davtyan H, Patel A, Head E, Cribbs DH, Agadjanyan MG.

J Neurosci. 2007 Nov 14;27(46):12721-31.

6.

IFN-γ Production by amyloid β-specific Th1 cells promotes microglial activation and increases plaque burden in a mouse model of Alzheimer's disease.

Browne TC, McQuillan K, McManus RM, O'Reilly JA, Mills KH, Lynch MA.

J Immunol. 2013 Mar 1;190(5):2241-51. doi: 10.4049/jimmunol.1200947. Epub 2013 Jan 30.

7.

An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ.

Adolfsson O, Pihlgren M, Toni N, Varisco Y, Buccarello AL, Antoniello K, Lohmann S, Piorkowska K, Gafner V, Atwal JK, Maloney J, Chen M, Gogineni A, Weimer RM, Mortensen DL, Friesenhahn M, Ho C, Paul R, Pfeifer A, Muhs A, Watts RJ.

J Neurosci. 2012 Jul 11;32(28):9677-89. doi: 10.1523/JNEUROSCI.4742-11.2012.

8.

Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: implications for the pathogenesis and treatment of Alzheimer's disease.

Monsonego A, Maron R, Zota V, Selkoe DJ, Weiner HL.

Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10273-8. Epub 2001 Aug 21.

9.

Serum β-amyloid peptide levels spike in the early stage of Alzheimer-like plaque pathology in an APP/PS1 double transgenic mouse model.

He J, Qiao JP, Zhu S, Xue M, Chen W, Wang X, Tempier A, Huang Q, Kong J, Li XM.

Curr Alzheimer Res. 2013 Nov;10(9):979-86.

PMID:
24117120
10.

Immunogenicity, efficacy, safety, and mechanism of action of epitope vaccine (Lu AF20513) for Alzheimer's disease: prelude to a clinical trial.

Davtyan H, Ghochikyan A, Petrushina I, Hovakimyan A, Davtyan A, Poghosyan A, Marleau AM, Movsesyan N, Kiyatkin A, Rasool S, Larsen AK, Madsen PJ, Wegener KM, Ditlevsen DK, Cribbs DH, Pedersen LO, Agadjanyan MG.

J Neurosci. 2013 Mar 13;33(11):4923-34. doi: 10.1523/JNEUROSCI.4672-12.2013.

11.

A cyclic undecamer peptide mimics a turn in folded Alzheimer amyloid β and elicits antibodies against oligomeric and fibrillar amyloid and plaques.

Hoogerhout P, Kamphuis W, Brugghe HF, Sluijs JA, Timmermans HA, Westdijk J, Zomer G, Boog CJ, Hol EM, van den Dobbelsteen GP.

PLoS One. 2011 Apr 19;6(4):e19110. doi: 10.1371/journal.pone.0019110.

12.

A comparative evaluation of a novel vaccine in APP/PS1 mouse models of Alzheimer's disease.

Carrera I, Etcheverría I, Fernández-Novoa L, Lombardi VR, Lakshmana MK, Cacabelos R, Vigo C.

Biomed Res Int. 2015;2015:807146. doi: 10.1155/2015/807146. Epub 2015 Feb 11.

13.

Autoreactive-Aβ antibodies promote APP β-secretase processing.

Deng J, Hou H, Giunta B, Mori T, Wang YJ, Fernandez F, Weggen S, Araki W, Obregon D, Tan J.

J Neurochem. 2012 Mar;120(5):732-40. doi: 10.1111/j.1471-4159.2011.07629.x. Epub 2012 Jan 23.

14.

An aqueous orally active vaccine targeted against a RAGE/AB complex as a novel therapeutic for Alzheimer's disease.

Webster SJ, Mruthinti S, Hill WD, Buccafusco JJ, Terry AV Jr.

Neuromolecular Med. 2012 Jun;14(2):119-30. doi: 10.1007/s12017-012-8176-z. Epub 2012 Mar 14.

PMID:
22415896
15.

Active vaccination with ankyrin G reduces β-amyloid pathology in APP transgenic mice.

Santuccione AC, Merlini M, Shetty A, Tackenberg C, Bali J, Ferretti MT, McAfoose J, Kulic L, Bernreuther C, Welt T, Grimm J, Glatzel M, Rajendran L, Hock C, Nitsch RM.

Mol Psychiatry. 2013 Mar;18(3):358-68. doi: 10.1038/mp.2012.70. Epub 2012 Jun 12.

PMID:
22688190
16.
17.

Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease.

Yin Z, Raj D, Saiepour N, Van Dam D, Brouwer N, Holtman IR, Eggen BJL, Möller T, Tamm JA, Abdourahman A, Hol EM, Kamphuis W, Bayer TA, De Deyn PP, Boddeke E.

Neurobiol Aging. 2017 Jul;55:115-122. doi: 10.1016/j.neurobiolaging.2017.03.021. Epub 2017 Mar 27.

PMID:
28434692
18.

Immunization with the SDPM1 peptide lowers amyloid plaque burden and improves cognitive function in the APPswePSEN1(A246E) transgenic mouse model of Alzheimer's disease.

Wang CM, Devries S, Camboni M, Glass M, Martin PT.

Neurobiol Dis. 2010 Sep;39(3):409-22. doi: 10.1016/j.nbd.2010.05.013. Epub 2010 May 20.

19.

Strikingly reduced amyloid burden and improved behavioral performance in Alzheimer's disease mice immunized with recombinant chimeric vaccines by hexavalent foldable Aβ₁₋₁₅ fused to toxin-derived carrier proteins.

Yu YZ, Wang WB, Chen A, Chang Q, Liu S, Zhao M, Wang S, Qiu WY, Pang XB, Xu Q, Sun ZW.

J Alzheimers Dis. 2014;41(1):243-60. doi: 10.3233/JAD-132177.

PMID:
24625800
20.

CD40L disruption enhances Abeta vaccine-mediated reduction of cerebral amyloidosis while minimizing cerebral amyloid angiopathy and inflammation.

Obregon D, Hou H, Bai Y, Nikolic WV, Mori T, Luo D, Zeng J, Ehrhart J, Fernandez F, Morgan D, Giunta B, Town T, Tan J.

Neurobiol Dis. 2008 Feb;29(2):336-53. Epub 2007 Oct 16.

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