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The Helicobacter pylori CagA protein induces cortactin dephosphorylation and actin rearrangement by c-Src inactivation.

Selbach M, Moese S, Hurwitz R, Hauck CR, Meyer TF, Backert S.

EMBO J. 2003 Feb 3;22(3):515-28.


Role of Abl and Src family kinases in actin-cytoskeletal rearrangements induced by the Helicobacter pylori CagA protein.

Tegtmeyer N, Backert S.

Eur J Cell Biol. 2011 Nov;90(11):880-90. doi: 10.1016/j.ejcb.2010.11.006. Epub 2011 Jan 17. Review.


Activation of Abl by Helicobacter pylori: a novel kinase for CagA and crucial mediator of host cell scattering.

Tammer I, Brandt S, Hartig R, König W, Backert S.

Gastroenterology. 2007 Apr;132(4):1309-19. Epub 2007 Feb 1.


The Helicobacter pylori CagA protein induces tyrosine dephosphorylation of ezrin.

Selbach M, Moese S, Backert S, Jungblut PR, Meyer TF.

Proteomics. 2004 Oct;4(10):2961-8.


Interaction between the Helicobacter pylori CagA and alpha-Pix in gastric epithelial AGS cells.

Baek HY, Lim JW, Kim H.

Ann N Y Acad Sci. 2007 Jan;1096:18-23.


Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagA.

Naito M, Yamazaki T, Tsutsumi R, Higashi H, Onoe K, Yamazaki S, Azuma T, Hatakeyama M.

Gastroenterology. 2006 Apr;130(4):1181-90.


Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites.

Higashi H, Tsutsumi R, Fujita A, Yamazaki S, Asaka M, Azuma T, Hatakeyama M.

Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14428-33. Epub 2002 Oct 21.


Attenuation of Helicobacter pylori CagA x SHP-2 signaling by interaction between CagA and C-terminal Src kinase.

Tsutsumi R, Higashi H, Higuchi M, Okada M, Hatakeyama M.

J Biol Chem. 2003 Feb 7;278(6):3664-70. Epub 2002 Nov 21.


c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs.

Stein M, Bagnoli F, Halenbeck R, Rappuoli R, Fantl WJ, Covacci A.

Mol Microbiol. 2002 Feb;43(4):971-80.


Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo.

Selbach M, Moese S, Hauck CR, Meyer TF, Backert S.

J Biol Chem. 2002 Mar 1;277(9):6775-8. Epub 2002 Jan 11.


Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation.

Higashi H, Nakaya A, Tsutsumi R, Yokoyama K, Fujii Y, Ishikawa S, Higuchi M, Takahashi A, Kurashima Y, Teishikata Y, Tanaka S, Azuma T, Hatakeyama M.

J Biol Chem. 2004 Apr 23;279(17):17205-16. Epub 2004 Feb 12.


EPIYA motif is a membrane-targeting signal of Helicobacter pylori virulence factor CagA in mammalian cells.

Higashi H, Yokoyama K, Fujii Y, Ren S, Yuasa H, Saadat I, Murata-Kamiya N, Azuma T, Hatakeyama M.

J Biol Chem. 2005 Jun 17;280(24):23130-7. Epub 2005 Apr 13.


The effects of cure of Helicobacter pylori infection on the signal transduction of gastric epithelial cells.

Azuma T, Yamazaki S, Yamakawa A, Ito Y, Ohtani M, Dojo M, Yamazaki Y, Higashi H, Hatakeyama M.

Aliment Pharmacol Ther. 2003 Jul;18 Suppl 1:39-44.


The CagA protein of Helicobacter pylori is translocated into epithelial cells and binds to SHP-2 in human gastric mucosa.

Yamazaki S, Yamakawa A, Ito Y, Ohtani M, Higashi H, Hatakeyama M, Azuma T.

J Infect Dis. 2003 Jan 15;187(2):334-7. Epub 2002 Dec 19.


Focal adhesion kinase is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA.

Tsutsumi R, Takahashi A, Azuma T, Higashi H, Hatakeyama M.

Mol Cell Biol. 2006 Jan;26(1):261-76.


Structural basis and functional consequence of Helicobacter pylori CagA multimerization in cells.

Ren S, Higashi H, Lu H, Azuma T, Hatakeyama M.

J Biol Chem. 2006 Oct 27;281(43):32344-52. Epub 2006 Sep 5.


Functional analysis of the cag pathogenicity island in Helicobacter pylori isolates from patients with gastritis, peptic ulcer, and gastric cancer.

Backert S, Schwarz T, Miehlke S, Kirsch C, Sommer C, Kwok T, Gerhard M, Goebel UB, Lehn N, Koenig W, Meyer TF.

Infect Immun. 2004 Feb;72(2):1043-56.


The Helicobacter pylori CagA protein disrupts matrix adhesion of gastric epithelial cells by dephosphorylation of vinculin.

Moese S, Selbach M, Brinkmann V, Karlas A, Haimovich B, Backert S, Meyer TF.

Cell Microbiol. 2007 May;9(5):1148-61. Epub 2007 Jan 9.


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