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Items: 1 to 20 of 196

1.

The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse.

Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM.

J Neurosci. 2001 Nov 1;21(21):8370-7.

2.

Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.

Lim GP, Yang F, Chu T, Chen P, Beech W, Teter B, Tran T, Ubeda O, Ashe KH, Frautschy SA, Cole GM.

J Neurosci. 2000 Aug 1;20(15):5709-14.

3.

Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo.

Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM.

J Biol Chem. 2005 Feb 18;280(7):5892-901. Epub 2004 Dec 7.

4.

Transgenic AD model mice, effects of potential anti-AD treatments on inflammation, and pathology.

van Groen T, Miettinen P, Kadish I.

J Alzheimers Dis. 2011;24(2):301-13. doi: 10.3233/JAD-2011-101479.

PMID:
21239852
5.

SEN1500, a novel oral amyloid-β aggregation inhibitor, attenuates brain pathology in a mouse model of Alzheimer's disease.

Brunner D, Flunkert S, Neddens J, Duller S, Scopes DIC, Treherne JM, Hutter-Paier B.

Neurosci Lett. 2017 Nov 1;660:96-102. doi: 10.1016/j.neulet.2017.09.028. Epub 2017 Sep 14.

PMID:
28917978
6.

NSAID and antioxidant prevention of Alzheimer's disease: lessons from in vitro and animal models.

Cole GM, Morihara T, Lim GP, Yang F, Begum A, Frautschy SA.

Ann N Y Acad Sci. 2004 Dec;1035:68-84. Review.

PMID:
15681801
7.

Curcumin derivative with the substitution at C-4 position, but not curcumin, is effective against amyloid pathology in APP/PS1 mice.

Yanagisawa D, Ibrahim NF, Taguchi H, Morikawa S, Hirao K, Shirai N, Sogabe T, Tooyama I.

Neurobiol Aging. 2015 Jan;36(1):201-10. doi: 10.1016/j.neurobiolaging.2014.07.041. Epub 2014 Aug 2.

PMID:
25179227
8.

Ibuprofen suppresses interleukin-1beta induction of pro-amyloidogenic alpha1-antichymotrypsin to ameliorate beta-amyloid (Abeta) pathology in Alzheimer's models.

Morihara T, Teter B, Yang F, Lim GP, Boudinot S, Boudinot FD, Frautschy SA, Cole GM.

Neuropsychopharmacology. 2005 Jun;30(6):1111-20.

9.

Rutin improves spatial memory in Alzheimer's disease transgenic mice by reducing Aβ oligomer level and attenuating oxidative stress and neuroinflammation.

Xu PX, Wang SW, Yu XL, Su YJ, Wang T, Zhou WW, Zhang H, Wang YJ, Liu RT.

Behav Brain Res. 2014 May 1;264:173-80. doi: 10.1016/j.bbr.2014.02.002. Epub 2014 Feb 7.

PMID:
24512768
10.

The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer's disease.

Collins JM, King AE, Woodhouse A, Kirkcaldie MT, Vickers JC.

Exp Neurol. 2015 May;267:219-29. doi: 10.1016/j.expneurol.2015.02.034. Epub 2015 Mar 4.

PMID:
25747037
11.

Nutritional antioxidants and the heme oxygenase pathway of stress tolerance: novel targets for neuroprotection in Alzheimer's disease.

Calabrese V, Butterfield DA, Stella AM.

Ital J Biochem. 2003 Dec;52(4):177-81. Review.

PMID:
15141484
12.

Decreasing oxidative stress and neuroinflammation with a multifunctional peptide rescues memory deficits in mice with Alzheimer disease.

Zhou WW, Lu S, Su YJ, Xue D, Yu XL, Wang SW, Zhang H, Xu PX, Xie XX, Liu RT.

Free Radic Biol Med. 2014 Sep;74:50-63. doi: 10.1016/j.freeradbiomed.2014.06.013. Epub 2014 Jun 21.

PMID:
24960578
13.

Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease.

Yan Q, Zhang J, Liu H, Babu-Khan S, Vassar R, Biere AL, Citron M, Landreth G.

J Neurosci. 2003 Aug 20;23(20):7504-9.

14.

Inflammatory prostaglandin E2 signaling in a mouse model of Alzheimer disease.

Shi J, Wang Q, Johansson JU, Liang X, Woodling NS, Priyam P, Loui TM, Merchant M, Breyer RM, Montine TJ, Andreasson K.

Ann Neurol. 2012 Nov;72(5):788-98. doi: 10.1002/ana.23677. Epub 2012 Aug 22.

15.

CHF5074, a novel gamma-secretase modulator, attenuates brain beta-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease.

Imbimbo BP, Hutter-Paier B, Villetti G, Facchinetti F, Cenacchi V, Volta R, Lanzillotta A, Pizzi M, Windisch M.

Br J Pharmacol. 2009 Mar;156(6):982-93. doi: 10.1111/j.1476-5381.2008.00097.x.

16.

Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice.

Sivilia S, Lorenzini L, Giuliani A, Gusciglio M, Fernandez M, Baldassarro VA, Mangano C, Ferraro L, Pietrini V, Baroc MF, Viscomi AR, Ottonello S, Villetti G, Imbimbo BP, Calzà L, Giardino L.

BMC Neurosci. 2013 Apr 5;14:44. doi: 10.1186/1471-2202-14-44.

17.

Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice.

Heneka MT, Sastre M, Dumitrescu-Ozimek L, Hanke A, Dewachter I, Kuiperi C, O'Banion K, Klockgether T, Van Leuven F, Landreth GE.

Brain. 2005 Jun;128(Pt 6):1442-53. Epub 2005 Apr 7.

PMID:
15817521
18.

Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice.

Jantzen PT, Connor KE, DiCarlo G, Wenk GL, Wallace JL, Rojiani AM, Coppola D, Morgan D, Gordon MN.

J Neurosci. 2002 Mar 15;22(6):2246-54.

19.

Age-dependent neuroplasticity mechanisms in Alzheimer Tg2576 mice following modulation of brain amyloid-β levels.

Lilja AM, Röjdner J, Mustafiz T, Thomé CM, Storelli E, Gonzalez D, Unger-Lithner C, Greig NH, Nordberg A, Marutle A.

PLoS One. 2013;8(3):e58752. doi: 10.1371/journal.pone.0058752. Epub 2013 Mar 15.

20.

Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer mice.

Nikolic WV, Hou H, Town T, Zhu Y, Giunta B, Sanberg CD, Zeng J, Luo D, Ehrhart J, Mori T, Sanberg PR, Tan J.

Stem Cells Dev. 2008 Jun;17(3):423-39. doi: 10.1089/scd.2008.0018.

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