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Crystal structure of PBP2x from a highly penicillin-resistant Streptococcus pneumoniae clinical isolate: a mosaic framework containing 83 mutations.

Dessen A, Mouz N, Gordon E, Hopkins J, Dideberg O.

J Biol Chem. 2001 Nov 30;276(48):45106-12. Epub 2001 Sep 11.


A PBP2x from a clinical isolate of Streptococcus pneumoniae exhibits an alternative mechanism for reduction of susceptibility to beta-lactam antibiotics.

Pernot L, Chesnel L, Le Gouellec A, Croizé J, Vernet T, Dideberg O, Dessen A.

J Biol Chem. 2004 Apr 16;279(16):16463-70. Epub 2004 Jan 20.


Crystal structure of penicillin-binding protein 1a (PBP1a) reveals a mutational hotspot implicated in beta-lactam resistance in Streptococcus pneumoniae.

Contreras-Martel C, Job V, Di Guilmi AM, Vernet T, Dideberg O, Dessen A.

J Mol Biol. 2006 Jan 27;355(4):684-96. Epub 2005 Nov 9.


The structural modifications induced by the M339F substitution in PBP2x from Streptococcus pneumoniae further decreases the susceptibility to beta-lactams of resistant strains.

Chesnel L, Pernot L, Lemaire D, Champelovier D, Croizé J, Dideberg O, Vernet T, Zapun A.

J Biol Chem. 2003 Nov 7;278(45):44448-56. Epub 2003 Aug 15.


PBP active site flexibility as the key mechanism for beta-lactam resistance in pneumococci.

Contreras-Martel C, Dahout-Gonzalez C, Martins Ados S, Kotnik M, Dessen A.

J Mol Biol. 2009 Apr 10;387(4):899-909. doi: 10.1016/j.jmb.2009.02.024. Epub 2009 Feb 20.


Mutations in the active site of penicillin-binding protein PBP2x from Streptococcus pneumoniae. Role in the specificity for beta-lactam antibiotics.

Mouz N, Di Guilmi AM, Gordon E, Hakenbeck R, Dideberg O, Vernet T.

J Biol Chem. 1999 Jul 2;274(27):19175-80.


Mosaic pbpX genes of major clones of penicillin-resistant Streptococcus pneumoniae have evolved from pbpX genes of a penicillin-sensitive Streptococcus oralis.

Sibold C, Henrichsen J, König A, Martin C, Chalkley L, Hakenbeck R.

Mol Microbiol. 1994 Jun;12(6):1013-23.


Identification of a structural determinant for resistance to beta-lactam antibiotics in Gram-positive bacteria.

Mouz N, Gordon E, Di Guilmi AM, Petit I, Pétillot Y, Dupont Y, Hakenbeck R, Vernet T, Dideberg O.

Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13403-6.


X-ray structure of Streptococcus pneumoniae PBP2x, a primary penicillin target enzyme.

Pares S, Mouz N, Pétillot Y, Hakenbeck R, Dideberg O.

Nat Struct Biol. 1996 Mar;3(3):284-9.


Active site restructuring regulates ligand recognition in class A penicillin-binding proteins.

Macheboeuf P, Di Guilmi AM, Job V, Vernet T, Dideberg O, Dessen A.

Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):577-82. Epub 2005 Jan 6.


Complete sequences of six penicillin-binding protein genes from 40 Streptococcus pneumoniae clinical isolates collected in Japan.

Sanbongi Y, Ida T, Ishikawa M, Osaki Y, Kataoka H, Suzuki T, Kondo K, Ohsawa F, Yonezawa M.

Antimicrob Agents Chemother. 2004 Jun;48(6):2244-50.


The 2.4-A crystal structure of the penicillin-resistant penicillin-binding protein PBP5fm from Enterococcus faecium in complex with benzylpenicillin.

Sauvage E, Kerff F, Fonzé E, Herman R, Schoot B, Marquette JP, Taburet Y, Prevost D, Dumas J, Leonard G, Stefanic P, Coyette J, Charlier P.

Cell Mol Life Sci. 2002 Jul;59(7):1223-32.


Structures of two kinetic intermediates reveal species specificity of penicillin-binding proteins.

McDonough MA, Anderson JW, Silvaggi NR, Pratt RF, Knox JR, Kelly JA.

J Mol Biol. 2002 Sep 6;322(1):111-22.


Trapping of an acyl-enzyme intermediate in a penicillin-binding protein (PBP)-catalyzed reaction.

Macheboeuf P, Lemaire D, Teller N, Martins Ados S, Luxen A, Dideberg O, Jamin M, Dessen A.

J Mol Biol. 2008 Feb 15;376(2):405-13. Epub 2007 Nov 1. Erratum in: J Mol Biol. 2008 Aug 1;381(1):248. Teller, Nathalie [added]; Luxen, André [added].


Penicillin-binding protein 2x of Streptococcus pneumoniae: three new mutational pathways for remodelling an essential enzyme into a resistance determinant.

Maurer P, Koch B, Zerfass I, Krauss J, van der Linden M, Frère JM, Contreras-Martel C, Hakenbeck R.

J Mol Biol. 2008 Mar 7;376(5):1403-16. doi: 10.1016/j.jmb.2007.12.058. Epub 2008 Jan 4.


Biochemical characterization of Streptococcus pneumoniae penicillin-binding protein 2b and its implication in beta-lactam resistance.

Pagliero E, Chesnel L, Hopkins J, Croizé J, Dideberg O, Vernet T, Di Guilmi AM.

Antimicrob Agents Chemother. 2004 May;48(5):1848-55.

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