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Items: 1 to 20 of 97


Restoration of lymphocyte function in Janus kinase 3-deficient mice by retroviral-mediated gene transfer.

Bunting KD, Sangster MY, Ihle JN, Sorrentino BP.

Nat Med. 1998 Jan;4(1):58-64.


Virus-specific immunity after gene therapy in a murine model of severe combined immunodeficiency.

Bunting KD, Flynn KJ, Riberdy JM, Doherty PC, Sorrentino BP.

Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):232-7.


In vitro correction of JAK3-deficient severe combined immunodeficiency by retroviral-mediated gene transduction.

Candotti F, Oakes SA, Johnston JA, Notarangelo LD, O'Shea JJ, Blaese RM.

J Exp Med. 1996 Jun 1;183(6):2687-92.


Reconstitution of lymphoid development and function in ZAP-70-deficient mice following gene transfer into bone marrow cells.

Otsu M, Steinberg M, Ferrand C, Merida P, Rebouissou C, Tiberghien P, Taylor N, Candotti F, Noraz N.

Blood. 2002 Aug 15;100(4):1248-56.


In vivo retroviral gene transfer by direct intrafemoral injection results in correction of the SCID phenotype in Jak3 knock-out animals.

McCauslin CS, Wine J, Cheng L, Klarmann KD, Candotti F, Clausen PA, Spence SE, Keller JR.

Blood. 2003 Aug 1;102(3):843-8. Epub 2003 Apr 10.


Reconstitution of early lymphoid proliferation and immune function in Jak3-deficient mice by interleukin-3.

Brown MP, Nosaka T, Tripp RA, Brooks J, van Deursen JM, Brenner MK, Doherty PC, Ihle JN.

Blood. 1999 Sep 15;94(6):1906-14.


Development of autologous, oligoclonal, poorly functioning T lymphocytes in a patient with autosomal recessive severe combined immunodeficiency caused by defects of the Jak3 tyrosine kinase.

Brugnoni D, Notarangelo LD, Sottini A, Airò P, Pennacchio M, Mazzolari E, Signorini S, Candotti F, Villa A, Mella P, Vezzoni P, Cattaneo R, Ugazio AG, Imberti L.

Blood. 1998 Feb 1;91(3):949-55.


Comparison of five retrovirus vectors containing the human IL-2 receptor gamma chain gene for their ability to restore T and B lymphocytes in the X-linked severe combined immunodeficiency mouse model.

Avilés Mendoza GJ, Seidel NE, Otsu M, Anderson SM, Simon-Stoos K, Herrera A, Hoogstraten-Miller S, Malech HL, Candotti F, Puck JM, Bodine DM.

Mol Ther. 2001 Apr;3(4):565-73.


A new chance for SCID gene therapy.

Bordignon C.

Nat Med. 1998 Jan;4(1):19-20. No abstract available.


Unexpected and variable phenotypes in a family with JAK3 deficiency.

Frucht DM, Gadina M, Jagadeesh GJ, Aksentijevich I, Takada K, Bleesing JJ, Nelson J, Muul LM, Perham G, Morgan G, Gerritsen EJ, Schumacher RF, Mella P, Veys PA, Fleisher TA, Kaminski ER, Notarangelo LD, O'Shea JJ, Candotti F.

Genes Immun. 2001 Dec;2(8):422-32.


Developmental defects of lymphoid cells in Jak3 kinase-deficient mice.

Park SY, Saijo K, Takahashi T, Osawa M, Arase H, Hirayama N, Miyake K, Nakauchi H, Shirasawa T, Saito T.

Immunity. 1995 Dec;3(6):771-82.


Jak3 and the pathogenesis of severe combined immunodeficiency.

O'Shea JJ, Husa M, Li D, Hofmann SR, Watford W, Roberts JL, Buckley RH, Changelian P, Candotti F.

Mol Immunol. 2004 Jul;41(6-7):727-37. Review.


T cells from Jak3-deficient mice have intact TCR signaling, but increased apoptosis.

Thomis DC, Lee W, Berg LJ.

J Immunol. 1997 Nov 15;159(10):4708-19.


[Long-term expansion of T cell progenitors by JAK3 gene transduced primitive hematopoietic cells in vitro].

Zhao SM, Gu XC, Chang NB, Xu XD, Peng MT.

Zhonghua Yi Xue Za Zhi. 2006 Jun 27;86(24):1701-5. Chinese.


In vivo correction of ZAP-70 immunodeficiency by intrathymic gene transfer.

Adjali O, Marodon G, Steinberg M, Mongellaz C, Thomas-Vaslin V, Jacquet C, Taylor N, Klatzmann D.

J Clin Invest. 2005 Aug;115(8):2287-95.


Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development.

Russell SM, Tayebi N, Nakajima H, Riedy MC, Roberts JL, Aman MJ, Migone TS, Noguchi M, Markert ML, Buckley RH, O'Shea JJ, Leonard WJ.

Science. 1995 Nov 3;270(5237):797-800.


Retroviral-mediated gene correction for X-linked severe combined immunodeficiency.

Candotti F, Johnston JA, Puck JM, Sugamura K, O'Shea JJ, Blaese RM.

Blood. 1996 Apr 15;87(8):3097-102.


Gene therapy of RAG-2-/- mice: sustained correction of the immunodeficiency.

Yates F, Malassis-Séris M, Stockholm D, Bouneaud C, Larousserie F, Noguiez-Hellin P, Danos O, Kohn DB, Fischer A, de Villartay JP, Cavazzana-Calvo M.

Blood. 2002 Dec 1;100(12):3942-9. Epub 2002 Aug 22.

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