Format

Send to

Choose Destination
J Am Geriatr Soc. 2009 Aug;57(8):1447-52. doi: 10.1111/j.1532-5415.2009.02345.x. Epub 2009 Jun 8.

Brain-derived neurotrophic factor predicts mortality risk in older women.

Author information

1
Center of Inflammation and Metabolism, Department of Infectious Diseases, Faculty of Health Sciences, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. karen.krabbe@dadlnet.dk

Abstract

OBJECTIVES:

To test the hypothesis that low circulating brain-derived neurotrophic factor (BDNF), a secretory member of the neurotrophin family that has a protective role in neurodegeneration and stress responses and a regulatory role in metabolism, predicts risk of all-cause mortality in 85-year-old men and women.

DESIGN:

Longitudinal study with 50- to 58-month follow-up.

SETTING:

The 1914 cohort, a population-based cohort established in 1964 by the Research Center for Prevention and Health at Glostrup Hospital.

PARTICIPANTS:

One hundred eighty-eight unselected 85-year-old Danes.

MEASUREMENTS:

BDNF was measured in plasma and serum. The Danish National Register of Patients was used to collect data on morbidity. The primary outcome in Cox regression analyses was all-cause mortality.

RESULTS:

Women with low plasma BDNF (lowest tertile) had greater all-cause mortality risk than women with high plasma BDNF (highest tertile) (hazard ratio=2.2, 95% confidence interval=1.1-4.7). Low plasma BDNF predicted mortality independently of activities of daily living; education; and a history of central nervous system disease, cerebrovascular accidents, cardiovascular disease, cancer, respiratory disease, and low-grade inflammation. No association was found between plasma BDNF and mortality in men, and serum BDNF did not influence mortality in either sex.

CONCLUSION:

Low plasma BDNF is a novel, independent, and robust biomarker of mortality risk in old women. BDNF may be a central factor in the network of multimorbidity in old populations.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center