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Items: 1 to 200 of 404

1.

Automatic electrocardiographic algorithm for assessing severity of ischemia in ST-segment elevation myocardial infarction.

Fakhri Y, Melgaard J, Andersson HB, Schoos MM, Birnbaum Y, Graff C, Sejersten M, Kastrup J, Clemmensen P.

Int J Cardiol. 2018 Oct 1;268:18-22. doi: 10.1016/j.ijcard.2018.04.057.

PMID:
30041784
2.

Protein biomarkers and coronary microvascular dilatation assessed by rubidium-82 PET in women with angina pectoris and no obstructive coronary artery disease.

Schroder J, Zethner-Moller R, Bové KB, Mygind ND, Hasbak P, Michelsen MM, Gustafsson I, Kastrup J, Prescott E.

Atherosclerosis. 2018 Jun 19;275:319-327. doi: 10.1016/j.atherosclerosis.2018.06.864. [Epub ahead of print]

PMID:
29981522
3.

Enhancing Action of Positive Allosteric Modulators through the Design of Dimeric Compounds.

Drapier T, Geubelle P, Bouckaert C, Nielsen L, Laulumaa S, Goffin E, Dilly S, Francotte P, Hanson J, Pochet L, Kastrup JS, Pirotte B.

J Med Chem. 2018 Jun 28;61(12):5279-5291. doi: 10.1021/acs.jmedchem.8b00250. Epub 2018 Jun 8.

PMID:
29775064
4.

Angiogenesis PET Tracer Uptake (68Ga-NODAGA-E[(cRGDyK)]₂) in Induced Myocardial Infarction and Stromal Cell Treatment in Minipigs.

Rasmussen T, Follin B, Kastrup J, Brandt-Larsen M, Madsen J, Emil Christensen T, Juhl M, Cohen S, Pharao Hammelev K, Holdflod Møller C, Peter Goetze J, Hasbak P, Kjær A.

Diagnostics (Basel). 2018 May 16;8(2). pii: E33. doi: 10.3390/diagnostics8020033.

5.

Retention and Functional Effect of Adipose-Derived Stromal Cells Administered in Alginate Hydrogel in a Rat Model of Acute Myocardial Infarction.

Follin B, Ghotbi AA, Clemmensen AE, Bentsen S, Juhl M, Søndergaard RH, Lund LD, Haack-Sørensen M, Hasbak P, Cohen S, Ripa RS, Kastrup J, Ekblond A, Kjær A.

Stem Cells Int. 2018 Mar 26;2018:7821461. doi: 10.1155/2018/7821461. eCollection 2018.

6.

10-Year Associations Between Tumor Necrosis Factor Receptors 1 and 2 and Cardiovascular Events in Patients With Stable Coronary Heart Disease: A CLARICOR (Effect of Clarithromycin on Mortality and Morbidity in Patients With Ischemic Heart Disease) Trial Substudy.

Carlsson AC, Ruge T, Kjøller E, Hilden J, Kolmos HJ, Sajadieh A, Kastrup J, Jensen GB, Larsson A, Nowak C, Jakobsen JC, Winkel P, Gluud C, Ärnlöv J.

J Am Heart Assoc. 2018 Apr 23;7(9). pii: e008299. doi: 10.1161/JAHA.117.008299.

7.

Development of large-scale manufacturing of adipose-derived stromal cells for clinical applications using bioreactors and human platelet lysate.

Haack-Sørensen M, Juhl M, Follin B, Harary Søndergaard R, Kirchhoff M, Kastrup J, Ekblond A.

Scand J Clin Lab Invest. 2018 Jul;78(4):293-300. doi: 10.1080/00365513.2018.1462082. Epub 2018 Apr 17.

PMID:
29661028
8.

( S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements and Structural and Biological Investigation.

Brogi S, Brindisi M, Butini S, Kshirsagar GU, Maramai S, Chemi G, Gemma S, Campiani G, Novellino E, Fiorenzani P, Pinassi J, Aloisi AM, Gynther M, Venskutonytė R, Han L, Frydenvang K, Kastrup JS, Pickering DS.

J Med Chem. 2018 Mar 8;61(5):2124-2130. doi: 10.1021/acs.jmedchem.8b00099. Epub 2018 Feb 26.

PMID:
29451794
9.

Accelerated collagen turnover in women with angina pectoris without obstructive coronary artery disease: An iPOWER substudy.

Nielsen SH, Mygind ND, Michelsen MM, Bechsgaard DF, Suhrs HE, Genovese F, Nielsen HB, Brix S, Karsdal M, Prescott E, Kastrup J.

Eur J Prev Cardiol. 2018 May;25(7):719-727. doi: 10.1177/2047487318758750. Epub 2018 Feb 13.

PMID:
29436257
10.

YKL-40 in patients with end-stage renal disease receiving haemodialysis.

Nielsen TL, Plesner LL, Warming PE, Pallisgaard JL, Dalsgaard M, Schou M, Høst U, Rydahl C, Brandi L, Køber L, Johansen JS, Kastrup J, Iversen KK.

Biomarkers. 2018 May - Jun;23(4):357-363. doi: 10.1080/1354750X.2018.1428359. Epub 2018 Mar 8.

PMID:
29357700
11.

Global Overview of the Transnational Alliance for Regenerative Therapies in Cardiovascular Syndromes (TACTICS) Recommendations: A Comprehensive Series of Challenges and Priorities of Cardiovascular Regenerative Medicine.

Fernández-Avilés F, Sanz-Ruiz R, Climent AM, Badimon L, Bolli R, Charron D, Fuster V, Janssens S, Kastrup J, Kim HS, Lüscher TF, Martin JF, Menasché P, Pinto FJ, Simari RD, Stone GW, Terzic A, Willerson JT, Wu JC; TACTICS Writing Group.

Circ Res. 2018 Jan 19;122(2):199-201. doi: 10.1161/CIRCRESAHA.117.312099. No abstract available.

PMID:
29348246
12.

Adipose-Derived Stromal Cells for Treatment of Patients with Chronic Ischemic Heart Disease (MyStromalCell Trial): A Randomized Placebo-Controlled Study.

Qayyum AA, Mathiasen AB, Mygind ND, Kühl JT, Jørgensen E, Helqvist S, Elberg JJ, Kofoed KF, Vejlstrup NG, Fischer-Nielsen A, Haack-Sørensen M, Ekblond A, Kastrup J.

Stem Cells Int. 2017;2017:5237063. doi: 10.1155/2017/5237063. Epub 2017 Dec 3.

13.

7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency.

Goffin E, Drapier T, Larsen AP, Geubelle P, Ptak CP, Laulumaa S, Rovinskaja K, Gilissen J, Tullio P, Olsen L, Frydenvang K, Pirotte B, Hanson J, Oswald RE, Kastrup JS, Francotte P.

J Med Chem. 2018 Jan 11;61(1):251-264. doi: 10.1021/acs.jmedchem.7b01323. Epub 2017 Dec 19.

14.

Coronary microvascular dysfunction and myocardial contractile reserve in women with angina and no obstructive coronary artery disease.

Michelsen MM, Pena A, Mygind ND, Bech J, Gustafsson I, Kastrup J, Hansen HS, Høst N, Hansen PR, Prescott E.

Echocardiography. 2018 Feb;35(2):196-203. doi: 10.1111/echo.13767. Epub 2017 Dec 8.

PMID:
29222822
15.

Invisible detergents for structure determination of membrane proteins by small-angle neutron scattering.

Midtgaard SR, Darwish TA, Pedersen MC, Huda P, Larsen AH, Jensen GV, Kynde SAR, Skar-Gislinge N, Nielsen AJZ, Olesen C, Blaise M, Dorosz JJ, Thorsen TS, Venskutonytė R, Krintel C, Møller JV, Frielinghaus H, Gilbert EP, Martel A, Kastrup JS, Jensen PE, Nissen P, Arleth L.

FEBS J. 2018 Jan;285(2):357-371. doi: 10.1111/febs.14345. Epub 2017 Dec 30.

PMID:
29178440
16.

Electrocardiographic scores of severity and acuteness of myocardial ischemia predict myocardial salvage in patients with anterior ST-segment elevation myocardial infarction.

Fakhri Y, Sejersten M, Schoos MM, Hansen HS, Dubois-Rande JL, Hall TS, Larsen AI, Jensen SE, Engblom H, Arheden H, Kastrup J, Atar D, Clemmensen P.

J Electrocardiol. 2018 Mar - Apr;51(2):195-202. doi: 10.1016/j.jelectrocard.2017.11.002. Epub 2017 Nov 13.

PMID:
29174706
17.

Rationale and Design of the First Double-Blind, Placebo-Controlled Trial with Allogeneic Adipose Tissue-Derived Stromal Cell Therapy in Patients with Ischemic Heart Failure: A Phase II Danish Multicentre Study.

Kastrup J, Schou M, Gustafsson I, Nielsen OW, Møgelvang R, Kofoed KF, Kragelund C, Hove JD, Fabricius-Bjerre A, Heitman M, Haack-Sørensen M, Lund LD, Johansen EM, Qayyum AA, Mathiasen AB, Ekblond A.

Stem Cells Int. 2017;2017:8506370. doi: 10.1155/2017/8506370. Epub 2017 Sep 19.

18.

The effect of intracoronary infusion of bone marrow-derived mononuclear cells on all-cause mortality in acute myocardial infarction: rationale and design of the BAMI trial.

Mathur A, Arnold R, Assmus B, Bartunek J, Belmans A, Bönig H, Crea F, Dimmeler S, Dowlut S, Fernández-Avilés F, Galiñanes M, Garcia-Dorado D, Hartikainen J, Hill J, Hogardt-Noll A, Homsy C, Janssens S, Kala P, Kastrup J, Martin J, Menasche P, Miklik R, Mozid A, San Román JA, Sanz-Ruiz R, Tendera M, Wojakowski W, Ylä-Herttuala S, Zeiher A.

Eur J Heart Fail. 2017 Nov;19(11):1545-1550. doi: 10.1002/ejhf.829. Epub 2017 Sep 25.

PMID:
28948706
19.

Ventricular repolarization alterations in women with angina pectoris and suspected coronary microvascular dysfunction.

Dose N, Michelsen MM, Mygind ND, Pena A, Ellervik C, Hansen PR, Kanters JK, Prescott E; Steering Committee of the iPOWER study, Kastrup J, Gustafsson I, Hansen HS.

J Electrocardiol. 2018 Jan - Feb;51(1):15-20. doi: 10.1016/j.jelectrocard.2017.08.017. Epub 2017 Aug 17.

PMID:
28939174
20.

Cryopreserved Off-the-Shelf Allogeneic Adipose-Derived Stromal Cells for Therapy in Patients with Ischemic Heart Disease and Heart Failure-A Safety Study.

Kastrup J, Haack-Sørensen M, Juhl M, Harary Søndergaard R, Follin B, Drozd Lund L, Mønsted Johansen E, Ali Qayyum A, Bruun Mathiasen A, Jørgensen E, Helqvist S, Jørgen Elberg J, Bruunsgaard H, Ekblond A.

Stem Cells Transl Med. 2017 Nov;6(11):1963-1971. doi: 10.1002/sctm.17-0040. Epub 2017 Sep 7.

21.

Influence of patient related factors on number of mesenchymal stromal cells reached after in vitro culture expansion for clinical treatment.

Qayyum AA, Kaur KP, Mathiasen AB, Haack-Sørensen M, Ekblond A, Kastrup J.

Scand J Clin Lab Invest. 2017 Nov;77(7):541-548. doi: 10.1080/00365513.2017.1354258. Epub 2017 Jul 24.

PMID:
28737959
22.

Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and Kainate Receptors.

Møllerud S, Pinto A, Marconi L, Frydenvang K, Thorsen TS, Laulumaa S, Venskutonytė R, Winther S, Moral AMC, Tamborini L, Conti P, Pickering DS, Kastrup JS.

ACS Chem Neurosci. 2017 Sep 20;8(9):2056-2064. doi: 10.1021/acschemneuro.7b00201. Epub 2017 Jul 21.

PMID:
28691798
23.

Global position paper on cardiovascular regenerative medicine.

Fernández-Avilés F, Sanz-Ruiz R, Climent AM, Badimon L, Bolli R, Charron D, Fuster V, Janssens S, Kastrup J, Kim HS, Lüscher TF, Martin JF, Menasché P, Simari RD, Stone GW, Terzic A, Willerson JT, Wu JC; TACTICS (Transnational Alliance for Regenerative Therapies in Cardiovascular Syndromes) Writing Group; Authors/Task Force Members. Chairpersons; Basic Research Subcommittee; Translational Research Subcommittee; Challenges of Cardiovascular Regenerative Medicine Subcommittee; Tissue Engineering Subcommittee; Delivery, Navigation, Tracking and Assessment Subcommittee; Clinical Trials Subcommittee; Regulatory and funding strategies subcommittee; Delivery, Navigation, Tracking and Assessment Subcommittee.

Eur Heart J. 2017 Sep 1;38(33):2532-2546. doi: 10.1093/eurheartj/ehx248. No abstract available.

24.

The inflammatory biomarker YKL-40 decreases stepwise after exercise stress test.

Dam Mygind N, Axelsson A, Ruwald MH, Dalsgaard M, Steffensen R, Iversen K, Johansen JS, Kastrup J.

Cardiovasc Endocrinol. 2016 Mar;5(1):21-27. doi: 10.1097/XCE.0000000000000073. Epub 2016 Jan 4.

25.

The low binding affinity of D-serine at the ionotropic glutamate receptor GluD2 can be attributed to the hinge region.

Tapken D, Steffensen TB, Leth R, Kristensen LB, Gerbola A, Gajhede M, Jørgensen FS, Olsen L, Kastrup JS.

Sci Rep. 2017 Apr 7;7:46145. doi: 10.1038/srep46145.

26.

Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors.

Larsen AP, Fièvre S, Frydenvang K, Francotte P, Pirotte B, Kastrup JS, Mulle C.

Mol Pharmacol. 2017 Jun;91(6):576-585. doi: 10.1124/mol.116.107599. Epub 2017 Mar 30.

27.

Design and Synthesis of a Series of l-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid.

Krogsgaard-Larsen N, Delgar CG, Koch K, Brown PM, Møller C, Han L, Huynh TH, Hansen SW, Nielsen B, Bowie D, Pickering DS, Kastrup JS, Frydenvang K, Bunch L.

J Med Chem. 2017 Jan 12;60(1):441-457. doi: 10.1021/acs.jmedchem.6b01516. Epub 2016 Dec 22.

PMID:
28005385
28.

The structure of the mite allergen Blo t 1 explains the limited antibody cross-reactivity to Der p 1.

Meno KH, Kastrup JS, Kuo IC, Chua KY, Gajhede M.

Allergy. 2017 Apr;72(4):665-670. doi: 10.1111/all.13111. Epub 2017 Jan 19.

PMID:
27997997
29.

Algorithm for the automatic computation of the modified Anderson-Wilkins acuteness score of ischemia from the pre-hospital ECG in ST-segment elevation myocardial infarction.

Fakhri Y, Sejersten M, Schoos MM, Melgaard J, Graff C, Wagner GS, Clemmensen P, Kastrup J.

J Electrocardiol. 2017 Jan - Feb;50(1):97-101. doi: 10.1016/j.jelectrocard.2016.11.005. Epub 2016 Nov 10.

PMID:
27889057
30.

Prehospital electrocardiographic acuteness score of ischemia is inversely associated with neurohormonal activation in STEMI patients with severe ischemia.

Fakhri Y, Schoos MM, Sejersten M, Ersbøll M, Valeur N, Køber L, Hassager C, Wagner GS, Kastrup J, Clemmensen P.

J Electrocardiol. 2017 Jan - Feb;50(1):90-96. doi: 10.1016/j.jelectrocard.2016.11.002. Epub 2016 Nov 10.

PMID:
27887720
31.

Transthoracic Doppler echocardiography compared with positron emission tomography for assessment of coronary microvascular dysfunction: The iPOWER study.

Michelsen MM, Mygind ND, Pena A, Olsen RH, Christensen TE, Ghotbi AA, Hasbak P, Kjaer A, Gustafsson I, Hansen PR, Hansen HS, Høst N, Kastrup J, Prescott E.

Int J Cardiol. 2017 Feb 1;228:435-443. doi: 10.1016/j.ijcard.2016.11.004. Epub 2016 Nov 7.

PMID:
27870973
32.

Comparison of rest and adenosine stress quantitative and semi-quantitative myocardial perfusion using magnetic resonance in patients with ischemic heart disease.

Qayyum AA, Qayyum F, Larsson HB, Kjaer A, Hasbak P, Vejlstrup NG, Kastrup J.

Clin Imaging. 2017 Jan - Feb;41:149-156. doi: 10.1016/j.clinimag.2016.11.001. Epub 2016 Nov 5.

PMID:
27855349
33.

Culture expansion of adipose derived stromal cells. A closed automated Quantum Cell Expansion System compared with manual flask-based culture.

Haack-Sørensen M, Follin B, Juhl M, Brorsen SK, Søndergaard RH, Kastrup J, Ekblond A.

J Transl Med. 2016 Nov 16;14(1):319.

34.

Coronary microvascular function and myocardial fibrosis in women with angina pectoris and no obstructive coronary artery disease: the iPOWER study.

Mygind ND, Michelsen MM, Pena A, Qayyum AA, Frestad D, Christensen TE, Ghotbi AA, Dose N, Faber R, Vejlstrup N, Hasbak P, Kjaer A, Prescott E, Kastrup J; steering committee of the iPower study.

J Cardiovasc Magn Reson. 2016 Nov 4;18(1):76.

35.

Senescence and quiescence in adipose-derived stromal cells: Effects of human platelet lysate, fetal bovine serum and hypoxia.

Søndergaard RH, Follin B, Lund LD, Juhl M, Ekblond A, Kastrup J, Haack-Sørensen M.

Cytotherapy. 2017 Jan;19(1):95-106. doi: 10.1016/j.jcyt.2016.09.006. Epub 2016 Oct 19.

36.

Lessons from crystal structures of kainate receptors.

Møllerud S, Frydenvang K, Pickering DS, Kastrup JS.

Neuropharmacology. 2017 Jan;112(Pt A):16-28. doi: 10.1016/j.neuropharm.2016.05.014. Epub 2016 May 26. Review.

PMID:
27236079
37.

The Structure of a High-Affinity Kainate Receptor: GluK4 Ligand-Binding Domain Crystallized with Kainate.

Kristensen O, Kristensen LB, Møllerud S, Frydenvang K, Pickering DS, Kastrup JS.

Structure. 2016 Sep 6;24(9):1582-9. doi: 10.1016/j.str.2016.06.019. Epub 2016 Aug 11.

38.

A parallel panning scheme used for selection of a GluA4-specific Fab targeting the ligand-binding domain.

Clausen RP, Mohr AØ, Riise E, Jensen AA, Gill A, Madden DR, Kastrup JS, Skottrup PD.

Int J Biol Macromol. 2016 Nov;92:779-787. doi: 10.1016/j.ijbiomac.2016.07.026. Epub 2016 Jul 8.

39.

Mesenchymal stromal cell therapy in ischemic heart disease.

Kastrup J, Mygind ND, Qayyum AA, Mathiasen AB, Haack-Sørensen M, Ekblond A.

Scand Cardiovasc J. 2016 Oct - Dec;50(5-6):293-299. Epub 2016 Sep 22. Review.

PMID:
27380735
40.

A pharmacological profile of the high-affinity GluK5 kainate receptor.

Møllerud S, Kastrup JS, Pickering DS.

Eur J Pharmacol. 2016 Oct 5;788:315-320. doi: 10.1016/j.ejphar.2016.06.049. Epub 2016 Jun 29.

PMID:
27373850
41.

Angiogenesis PET Tracer Uptake ((68)Ga-NODAGA-E[(cRGDyK)]₂) in Induced Myocardial Infarction in Minipigs.

Rasmussen T, Follin B, Kastrup J, Brandt-Larsen M, Madsen J, Emil Christensen T, Pharao Hammelev K, Hasbak P, Kjær A.

Diagnostics (Basel). 2016 Jun 17;6(2). pii: E26. doi: 10.3390/diagnostics6020026.

42.

Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2.

Krintel C, Francotte P, Pickering DS, Juknaitė L, Pøhlsgaard J, Olsen L, Frydenvang K, Goffin E, Pirotte B, Kastrup JS.

Biophys J. 2016 Jun 7;110(11):2397-2406. doi: 10.1016/j.bpj.2016.04.032.

43.

Cryopreservation and Revival of Human Mesenchymal Stromal Cells.

Haack-Sørensen M, Ekblond A, Kastrup J.

Methods Mol Biol. 2016;1416:357-74. doi: 10.1007/978-1-4939-3584-0_21.

PMID:
27236683
44.

Meta-Analyses of Human Cell-Based Cardiac Regeneration Therapies: Controversies in Meta-Analyses Results on Cardiac Cell-Based Regenerative Studies.

Gyöngyösi M, Wojakowski W, Navarese EP, Moye LÀ; ACCRUE Investigators.

Circ Res. 2016 Apr 15;118(8):1254-63. doi: 10.1161/CIRCRESAHA.115.307347.

45.

Coronary Microvascular Function and Cardiovascular Risk Factors in Women With Angina Pectoris and No Obstructive Coronary Artery Disease: The iPOWER Study.

Mygind ND, Michelsen MM, Pena A, Frestad D, Dose N, Aziz A, Faber R, Høst N, Gustafsson I, Hansen PR, Hansen HS, Bairey Merz CN, Kastrup J, Prescott E.

J Am Heart Assoc. 2016 Mar 15;5(3):e003064. doi: 10.1161/JAHA.115.003064.

46.

Coronary Flow Velocity Reserve Assessed by Transthoracic Doppler: The iPOWER Study: Factors Influencing Feasibility and Quality.

Michelsen MM, Pena A, Mygind ND, Frestad D, Gustafsson I, Hansen HS, Kastrup J, Bech J, Høst N, Prescott E.

J Am Soc Echocardiogr. 2016 Jul;29(7):709-16. doi: 10.1016/j.echo.2016.02.011. Epub 2016 Mar 31.

PMID:
27038514
47.

Pre-hospital electrocardiographic severity and acuteness scores predict left ventricular function in patients with ST elevation myocardial infarction.

Fakhri Y, Ersbøll M, Køber L, Hassager C, Hesselfeldt R, Steinmetz J, Wagner GS, Sejersten M, Kastrup J, Clemmensen P, Schoos MM.

J Electrocardiol. 2016 May-Jun;49(3):284-91. doi: 10.1016/j.jelectrocard.2016.02.012. Epub 2016 Feb 21.

PMID:
26962019
48.

Evaluation of acute ischemia in pre-procedure ECG predicts myocardial salvage after primary PCI in STEMI patients with symptoms >12hours.

Fakhri Y, Busk M, Schoos MM, Terkelsen CJ, Kristensen SD, Wagner GS, Sejersten M, Clemmensen P, Kastrup J.

J Electrocardiol. 2016 May-Jun;49(3):278-83. doi: 10.1016/j.jelectrocard.2016.02.009. Epub 2016 Feb 10.

PMID:
26949016
49.

Myocardial perfusion of infarcted and normal myocardium in propofol-anesthetized minipigs using (82)Rubidium PET.

Rasmussen T, Follin B, Kastrup J, Christensen TE, Hammelev KP, Kjær A, Hasbak P.

J Nucl Cardiol. 2016 Jun;23(3):599-603. doi: 10.1007/s12350-016-0453-z. Epub 2016 Mar 1.

PMID:
26931633
50.

Experimental myocardial stem cell therapy for ST-elevation myocardial infarction: rationale and level of evidence.

Kastrup J, Mygind ND, Qayyum AA, Mathiasen AB.

Minerva Cardioangiol. 2016 Jun;64(3):322-9. Epub 2016 Feb 19. Review.

PMID:
26899403
51.

Comparison of clinical grade human platelet lysates for cultivation of mesenchymal stromal cells from bone marrow and adipose tissue.

Juhl M, Tratwal J, Follin B, Søndergaard RH, Kirchhoff M, Ekblond A, Kastrup J, Haack-Sørensen M.

Scand J Clin Lab Invest. 2016;76(2):93-104. doi: 10.3109/00365513.2015.1099723. Epub 2016 Jan 11.

PMID:
26878874
52.

Long-term outcome of FFR-guided PCI for stable coronary artery disease in daily clinical practice: a propensity score-matched landmark analysis.

De Backer O, Biasco L, Lønborg J, Pedersen F, Holmvang L, Kelbaek H, Arnous S, Saunamäki K, Helqvist S, Kastrup J, Jørgensen E, Engstrøm T.

EuroIntervention. 2016 Feb;11(11):e1257-66. doi: 10.4244/EIJV11I11A247.

53.

Tweaking Subtype Selectivity and Agonist Efficacy at (S)-2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) Receptors in a Small Series of BnTetAMPA Analogues.

Wang SY, Larsen Y, Navarrete CV, Jensen AA, Nielsen B, Al-Musaed A, Frydenvang K, Kastrup JS, Pickering DS, Clausen RP.

J Med Chem. 2016 Mar 10;59(5):2244-54. doi: 10.1021/acs.jmedchem.5b01982. Epub 2016 Feb 22.

PMID:
26862980
54.

Increased Paracrine Immunomodulatory Potential of Mesenchymal Stromal Cells in Three-Dimensional Culture.

Follin B, Juhl M, Cohen S, Perdersen AE, Kastrup J, Ekblond A.

Tissue Eng Part B Rev. 2016 Aug;22(4):322-9. doi: 10.1089/ten.TEB.2015.0532. Epub 2016 Mar 16. Review.

55.

Cardiovascular magnetic resonance imaging of myocardial oedema following acute myocardial infarction: Is whole heart coverage necessary?

Hamshere S, Jones DA, Pellaton C, Longchamp D, Burchell T, Mohiddin S, Moon JC, Kastrup J, Locca D, Petersen SE, Westwood M, Mathur A.

J Cardiovasc Magn Reson. 2016 Jan 23;18:7. doi: 10.1186/s12968-016-0226-5.

56.

Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure-Activity Relationship at AMPA Receptors.

Larsen AP, Francotte P, Frydenvang K, Tapken D, Goffin E, Fraikin P, Caignard DH, Lestage P, Danober L, Pirotte B, Kastrup JS.

ACS Chem Neurosci. 2016 Mar 16;7(3):378-90. doi: 10.1021/acschemneuro.5b00318. Epub 2016 Feb 1.

PMID:
26771108
57.

Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors.

Kristensen AS, Hansen KB, Naur P, Olsen L, Kurtkaya NL, Dravid SM, Kvist T, Yi F, Pøhlsgaard J, Clausen RP, Gajhede M, Kastrup JS, Traynelis SF.

Mol Pharmacol. 2016 Feb;89(2):253-62. doi: 10.1124/mol.115.100909. Epub 2015 Dec 10.

58.

Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors.

Szymanska E, Frydenvang K, Pickering DS, Krintel C, Nielsen B, Kooshki A, Zachariassen LG, Olsen L, Kastrup JS, Johansen TN.

J Med Chem. 2016 Jan 14;59(1):448-61. doi: 10.1021/acs.jmedchem.5b01666. Epub 2015 Dec 22.

PMID:
26653877
59.

Semi-quantitative myocardial perfusion measured by computed tomography in patients with refractory angina: a head-to-head comparison with quantitative rubidium-82 positron emission tomography as reference.

Qayyum AA, Kühl JT, Kjaer A, Hasbak P, Kofoed KF, Kastrup J.

Clin Physiol Funct Imaging. 2017 Sep;37(5):481-488. doi: 10.1111/cpf.12322. Epub 2015 Dec 2.

PMID:
26625937
60.

Structural Studies of Nicotinic Acetylcholine Receptors: Using Acetylcholine-Binding Protein as a Structural Surrogate.

Shahsavar A, Gajhede M, Kastrup JS, Balle T.

Basic Clin Pharmacol Toxicol. 2016 Jun;118(6):399-407. doi: 10.1111/bcpt.12528. Epub 2016 Jan 14. Review.

61.

A novel dualistic profile of an allosteric AMPA receptor modulator identified through studies on recombinant receptors, mouse hippocampal synapses and crystal structures.

Christiansen GB, Harbak B, Hede SE, Gouliaev AH, Olsen L, Frydenvang K, Egebjerg J, Kastrup JS, Holm MM.

Neuroscience. 2015 Dec 3;310:709-22. doi: 10.1016/j.neuroscience.2015.09.073. Epub 2015 Oct 9.

PMID:
26450748
62.

Revival of cytokine therapy in heart failure?

Kastrup J.

Eur Heart J. 2015 Nov 21;36(44):3070-3. doi: 10.1093/eurheartj/ehv515. Epub 2015 Sep 28. No abstract available.

PMID:
26419622
63.

A randomized double-blind control study of early intra-coronary autologous bone marrow cell infusion in acute myocardial infarction: the REGENERATE-AMI clinical trial†.

Choudry F, Hamshere S, Saunders N, Veerapen J, Bavnbek K, Knight C, Pellerin D, Locca D, Westwood M, Rakhit R, Crake T, Kastrup J, Parmar M, Agrawal S, Jones D, Martin J, Mathur A.

Eur Heart J. 2016 Jan 14;37(3):256-63. doi: 10.1093/eurheartj/ehv493. Epub 2015 Sep 23.

64.

Structure-Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid.

Krogsgaard-Larsen N, Storgaard M, Møller C, Demmer CS, Hansen J, Han L, Monrad RN, Nielsen B, Tapken D, Pickering DS, Kastrup JS, Frydenvang K, Bunch L.

J Med Chem. 2015 Aug 13;58(15):6131-50. doi: 10.1021/acs.jmedchem.5b00750. Epub 2015 Jul 22.

PMID:
26200741
65.

Acetylcholine-Binding Protein Engineered to Mimic the α4-α4 Binding Pocket in α4β2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity.

Shahsavar A, Ahring PK, Olsen JA, Krintel C, Kastrup JS, Balle T, Gajhede M.

Mol Pharmacol. 2015 Oct;88(4):697-707. doi: 10.1124/mol.115.098061. Epub 2015 Jul 15.

66.

Human adipose-derived stromal cells in a clinically applicable injectable alginate hydrogel: Phenotypic and immunomodulatory evaluation.

Follin B, Juhl M, Cohen S, Pedersen AE, Gad M, Kastrup J, Ekblond A.

Cytotherapy. 2015 Aug;17(8):1104-18. doi: 10.1016/j.jcyt.2015.04.008. Epub 2015 May 29.

PMID:
26031743
67.

Bone marrow-derived mesenchymal stromal cell treatment in patients with severe ischaemic heart failure: a randomized placebo-controlled trial (MSC-HF trial).

Mathiasen AB, Qayyum AA, Jørgensen E, Helqvist S, Fischer-Nielsen A, Kofoed KF, Haack-Sørensen M, Ekblond A, Kastrup J.

Eur Heart J. 2015 Jul 14;36(27):1744-53. doi: 10.1093/eurheartj/ehv136. Epub 2015 Apr 29.

PMID:
25926562
68.

Influence of vascular endothelial growth factor stimulation and serum deprivation on gene activation patterns of human adipose tissue-derived stromal cells.

Tratwal J, Mathiasen AB, Juhl M, Brorsen SK, Kastrup J, Ekblond A.

Stem Cell Res Ther. 2015 Apr 13;6:62. doi: 10.1186/s13287-015-0062-9.

69.

Binding mode of an α-amino acid-linked quinoxaline-2,3-dione analogue at glutamate receptor subtype GluK1.

Demmer CS, Møller C, Brown PM, Han L, Pickering DS, Nielsen B, Bowie D, Frydenvang K, Kastrup JS, Bunch L.

ACS Chem Neurosci. 2015 Jun 17;6(6):845-54. doi: 10.1021/acschemneuro.5b00038. Epub 2015 Apr 9.

PMID:
25856736
70.

Meta-Analysis of Cell-based CaRdiac stUdiEs (ACCRUE) in patients with acute myocardial infarction based on individual patient data.

Gyöngyösi M, Wojakowski W, Lemarchand P, Lunde K, Tendera M, Bartunek J, Marban E, Assmus B, Henry TD, Traverse JH, Moyé LA, Sürder D, Corti R, Huikuri H, Miettinen J, Wöhrle J, Obradovic S, Roncalli J, Malliaras K, Pokushalov E, Romanov A, Kastrup J, Bergmann MW, Atsma DE, Diederichsen A, Edes I, Benedek I, Benedek T, Pejkov H, Nyolczas N, Pavo N, Bergler-Klein J, Pavo IJ, Sylven C, Berti S, Navarese EP, Maurer G; ACCRUE Investigators.

Circ Res. 2015 Apr 10;116(8):1346-60. doi: 10.1161/CIRCRESAHA.116.304346. Epub 2015 Feb 19.

71.

[Effect of cell therapy in patients with chronic ischaemic heart disease--a survey of a Cochrane review].

Mathiasen AB, Qayyum AA, Kastrup J.

Ugeskr Laeger. 2015 Feb 9;177(7). pii: V08140433. Danish.

PMID:
25697069
72.

Measuring myocardial perfusion: the role of PET, MRI and CT.

Qayyum AA, Kastrup J.

Clin Radiol. 2015 Jun;70(6):576-84. doi: 10.1016/j.crad.2014.12.017. Epub 2015 Jan 30. Review.

PMID:
25649865
73.

Clarithromycin for stable coronary heart disease increases all-cause and cardiovascular mortality and cerebrovascular morbidity over 10years in the CLARICOR randomised, blinded clinical trial.

Winkel P, Hilden J, Hansen JF, Kastrup J, Kolmos HJ, Kjøller E, Jensen GB, Skoog M, Lindschou J, Gluud C; CLARICOR trial group.

Int J Cardiol. 2015 Mar 1;182:459-65. doi: 10.1016/j.ijcard.2015.01.020. Epub 2015 Jan 6.

PMID:
25602299
74.

Cutting Edge: identification of neutrophil PGLYRP1 as a ligand for TREM-1.

Read CB, Kuijper JL, Hjorth SA, Heipel MD, Tang X, Fleetwood AJ, Dantzler JL, Grell SN, Kastrup J, Wang C, Brandt CS, Hansen AJ, Wagtmann NR, Xu W, Stennicke VW.

J Immunol. 2015 Feb 15;194(4):1417-21. doi: 10.4049/jimmunol.1402303. Epub 2015 Jan 16.

75.

Engineered α4β2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity α4-α4 interface.

Ahring PK, Olsen JA, Nielsen EØ, Peters D, Pedersen MH, Rohde LA, Kastrup JS, Shahsavar A, Indurthi DC, Chebib M, Gajhede M, Balle T.

Neuropharmacology. 2015 May;92:135-45. doi: 10.1016/j.neuropharm.2014.12.035. Epub 2015 Jan 13.

PMID:
25595102
76.

Short- and long-term cause of death in patients treated with primary PCI for STEMI.

Pedersen F, Butrymovich V, Kelbæk H, Wachtell K, Helqvist S, Kastrup J, Holmvang L, Clemmensen P, Engstrøm T, Grande P, Saunamäki K, Jørgensen E.

J Am Coll Cardiol. 2014 Nov 18-25;64(20):2101-8. doi: 10.1016/j.jacc.2014.08.037. Epub 2014 Nov 10.

77.

Optimal catchment area and primary PCI centre volume revisited: a single-centre experience in transition from high-volume centre to "mega centre" for patients with ST-segment elevation myocardial infarction.

Schoos MM, Pedersen F, Holmvang L, Engstrøm T, Saunamaki K, Helqvist S, Kastrup J, Mehran R, Dangas G, Jørgensen E, Kelbæk H, Clemmensen P.

EuroIntervention. 2015 Sep;11(5):503-10. doi: 10.4244/EIJY14M11_07.

78.

Thermodynamic characterization of new positive allosteric modulators binding to the glutamate receptor A2 ligand-binding domain: combining experimental and computational methods unravels differences in driving forces.

Nørholm AB, Francotte P, Goffin E, Botez I, Danober L, Lestage P, Pirotte B, Kastrup JS, Olsen L, Oostenbrink C.

J Chem Inf Model. 2014 Dec 22;54(12):3404-16. doi: 10.1021/ci500559b. Epub 2014 Dec 9.

PMID:
25420075
79.

Positive allosteric modulators of 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors belonging to 4-cyclopropyl-3,4-dihydro-2h-1,2,4-pyridothiadiazine dioxides and diversely chloro-substituted 4-cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides.

Francotte P, Nørholm AB, Deva T, Olsen L, Frydenvang K, Goffin E, Fraikin P, de Tullio P, Challal S, Thomas JY, Iop F, Louis C, Botez-Pop I, Lestage P, Danober L, Kastrup JS, Pirotte B.

J Med Chem. 2014 Nov 26;57(22):9539-53. doi: 10.1021/jm501268r. Epub 2014 Nov 17.

PMID:
25375781
80.

Stem cell therapy to treat heart ischaemia: implications for diabetes cardiovascular complications.

Qayyum AA, Mathiasen AB, Kastrup J.

Curr Diab Rep. 2014 Dec;14(12):554. doi: 10.1007/s11892-014-0554-5. Review.

PMID:
25344789
81.

Serum YKL-40 for monitoring myocardial ischemia after revascularization in patients with stable coronary artery disease.

Harutyunyan M, Johansen JS, Mygind ND, Reuter SB, Kastrup J.

Biomark Med. 2014;8(8):977-87. doi: 10.2217/bmm.14.20.

PMID:
25343670
82.

Agreement between public register and adjudication committee outcome in a cardiovascular randomized clinical trial.

Kjøller E, Hilden J, Winkel P, Galatius S, Frandsen NJ, Jensen GB, Fischer Hansen J, Kastrup J, Jespersen CM, Hildebrandt P, Kolmos HJ, Gluud C; CLARICOR Trial Group.

Am Heart J. 2014 Aug;168(2):197-204.e1-4. doi: 10.1016/j.ahj.2013.12.032. Epub 2014 May 4.

PMID:
25066559
83.

Molecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand binding domain.

Venskutonytė R, Larsen AP, Frydenvang K, Gajhede M, Sagot E, Assaf Z, Gefflaut T, Pickering DS, Bunch L, Kastrup JS.

ChemMedChem. 2014 Oct;9(10):2254-9. doi: 10.1002/cmdc.201402204. Epub 2014 Jul 8.

PMID:
25044437
84.

Osteoprotegerin independently predicts mortality in patients with stable coronary artery disease: the CLARICOR trial.

Bjerre M, Hilden J, Kastrup J, Skoog M, Hansen JF, Kolmos HJ, Jensen GB, Kjøller E, Winkel P, Flyvbjerg A, Gluud C; Claricor Trial Group.

Scand J Clin Lab Invest. 2014 Nov;74(8):657-64. doi: 10.3109/00365513.2014.930510. Epub 2014 Jul 15.

PMID:
25026506
85.

Structural and functional studies of the modulator NS9283 reveal agonist-like mechanism of action at α4β2 nicotinic acetylcholine receptors.

Olsen JA, Ahring PK, Kastrup JS, Gajhede M, Balle T.

J Biol Chem. 2014 Sep 5;289(36):24911-21. doi: 10.1074/jbc.M114.568097. Epub 2014 Jun 30.

86.

Adipose-derived regenerative cells in patients with ischemic cardiomyopathy: The PRECISE Trial.

Perin EC, Sanz-Ruiz R, Sánchez PL, Lasso J, Pérez-Cano R, Alonso-Farto JC, Pérez-David E, Fernández-Santos ME, Serruys PW, Duckers HJ, Kastrup J, Chamuleau S, Zheng Y, Silva GV, Willerson JT, Fernández-Avilés F.

Am Heart J. 2014 Jul;168(1):88-95.e2. doi: 10.1016/j.ahj.2014.03.022. Epub 2014 Apr 5.

PMID:
24952864
87.

The influence of contrast media on kidney function in patients with stable coronary artery disease.

Reuter SB, Harutyunyan M, Mygind ND, Jørgensen E, Kastrup J.

Scand Cardiovasc J. 2014 Aug;48(4):234-40. doi: 10.3109/14017431.2014.934713. Epub 2014 Jul 18.

PMID:
24941300
88.

Identification of a common reference gene pair for qPCR in human mesenchymal stromal cells from different tissue sources treated with VEGF.

Tratwal J, Follin B, Ekblond A, Kastrup J, Haack-Sørensen M.

BMC Mol Biol. 2014 May 28;15:11. doi: 10.1186/1471-2199-15-11.

89.

Quantification of myocardial perfusion using cardiac magnetic resonance imaging correlates significantly to rubidium-82 positron emission tomography in patients with severe coronary artery disease: a preliminary study.

Qayyum AA, Hasbak P, Larsson HBW, Christensen TE, Ghotbi AA, Mathiasen AB, Vejlstrup NG, Kjaer A, Kastrup J.

Eur J Radiol. 2014 Jul;83(7):1120-1128. doi: 10.1016/j.ejrad.2014.04.004. Epub 2014 Apr 16.

PMID:
24815746
90.

Ultrastructural characterization of mesenchymal stromal cells labeled with ultrasmall superparamagnetic iron-oxide nanoparticles for clinical tracking studies.

Hansen L, Hansen AB, Mathiasen AB, Ng M, Bhakoo K, Ekblond A, Kastrup J, Friis T.

Scand J Clin Lab Invest. 2014 Aug;74(5):437-46. doi: 10.3109/00365513.2014.900698. Epub 2014 Apr 15.

PMID:
24734781
91.

L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain.

Krintel C, Frydenvang K, Ceravalls de Rabassa A, Kaern AM, Gajhede M, Pickering DS, Kastrup JS.

FEBS J. 2014 May;281(10):2422-30. doi: 10.1111/febs.12795. Epub 2014 Apr 17.

92.

Improving diagnosis and treatment of women with angina pectoris and microvascular disease: the iPOWER study design and rationale.

Prescott E, Abildstrøm SZ, Aziz A, Merz NB, Gustafsson I, Halcox J, Hansen HS, Hansen PR, Kastrup J, Michelsen M, Mygind ND, Ong P, Pena A, Rosengren A, Sechtem U, Søgaard P.

Am Heart J. 2014 Apr;167(4):452-8. doi: 10.1016/j.ahj.2014.01.003. Epub 2014 Jan 15. Review.

PMID:
24655692
93.

Molecular recognition of the neurotransmitter acetylcholine by an acetylcholine binding protein reveals determinants of binding to nicotinic acetylcholine receptors.

Olsen JA, Balle T, Gajhede M, Ahring PK, Kastrup JS.

PLoS One. 2014 Mar 17;9(3):e91232. doi: 10.1371/journal.pone.0091232. eCollection 2014.

94.

Levels of soluble osteoclast-associated receptor (sOSCAR) in rheumatoid arthritis: link to disease severity and cardiovascular risk.

Ndongo-Thiam N, de Sallmard G, Kastrup J, Miossec P.

Ann Rheum Dis. 2014 Jun;73(6):1276-7. doi: 10.1136/annrheumdis-2013-204886. Epub 2014 Jan 21. No abstract available.

PMID:
24448348
95.

Autotransplantation of mesenchymal stromal cells from bone-marrow to heart in patients with severe stable coronary artery disease and refractory angina--final 3-year follow-up.

Mathiasen AB, Haack-Sørensen M, Jørgensen E, Kastrup J.

Int J Cardiol. 2013 Dec 10;170(2):246-51. doi: 10.1016/j.ijcard.2013.10.079. Epub 2013 Oct 28.

PMID:
24211066
96.

Two distinct allosteric binding sites at α4β2 nicotinic acetylcholine receptors revealed by NS206 and NS9283 give unique insights to binding activity-associated linkage at Cys-loop receptors.

Olsen JA, Kastrup JS, Peters D, Gajhede M, Balle T, Ahring PK.

J Biol Chem. 2013 Dec 13;288(50):35997-6006. doi: 10.1074/jbc.M113.498618. Epub 2013 Oct 29.

97.

Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold.

Nørholm AB, Francotte P, Olsen L, Krintel C, Frydenvang K, Goffin E, Challal S, Danober L, Botez-Pop I, Lestage P, Pirotte B, Kastrup JS.

J Med Chem. 2013 Nov 14;56(21):8736-45. doi: 10.1021/jm4012092. Epub 2013 Nov 5.

PMID:
24131202
98.

The origin of human mesenchymal stromal cells dictates their reparative properties.

Naftali-Shani N, Itzhaki-Alfia A, Landa-Rouben N, Kain D, Holbova R, Adutler-Lieber S, Molotski N, Asher E, Grupper A, Millet E, Tessone A, Winkler E, Kastrup J, Feinberg MS, Zipori D, Pevsner-Fischer M, Raanani E, Leor J.

J Am Heart Assoc. 2013 Sep 30;2(5):e000253. doi: 10.1161/JAHA.113.000253.

99.

Enrichment of autologous fat grafts with ex-vivo expanded adipose tissue-derived stem cells for graft survival: a randomised placebo-controlled trial.

Kølle SF, Fischer-Nielsen A, Mathiasen AB, Elberg JJ, Oliveri RS, Glovinski PV, Kastrup J, Kirchhoff M, Rasmussen BS, Talman ML, Thomsen C, Dickmeiss E, Drzewiecki KT.

Lancet. 2013 Sep 28;382(9898):1113-20. doi: 10.1016/S0140-6736(13)61410-5.

PMID:
24075051
100.

Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site.

Kvist T, Steffensen TB, Greenwood JR, Mehrzad Tabrizi F, Hansen KB, Gajhede M, Pickering DS, Traynelis SF, Kastrup JS, Bräuner-Osborne H.

J Biol Chem. 2013 Nov 15;288(46):33124-35. doi: 10.1074/jbc.M113.480210. Epub 2013 Sep 26.

101.

Identical effects of VEGF and serum-deprivation on phenotype and function of adipose-derived stromal cells from healthy donors and patients with ischemic heart disease.

Follin B, Tratwal J, Haack-Sørensen M, Elberg JJ, Kastrup J, Ekblond A.

J Transl Med. 2013 Sep 18;11:219. doi: 10.1186/1479-5876-11-219.

102.

Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain.

Krintel C, Harpsøe K, Zachariassen LG, Peters D, Frydenvang K, Pickering DS, Gajhede M, Kastrup JS.

Acta Crystallogr D Biol Crystallogr. 2013 Sep;69(Pt 9):1645-52. doi: 10.1107/S0907444913011839. Epub 2013 Aug 15.

PMID:
23999288
103.

Non-invasive in-vivo imaging of stem cells after transplantation in cardiovascular tissue.

Mathiasen AB, Kastrup J.

Theranostics. 2013 Jul 20;3(8):561-72. doi: 10.7150/thno.5787. eCollection 2013. Review.

104.

Risk stratification in stable coronary artery disease is possible at cardiac troponin levels below conventional detection and is improved by use of N-terminal pro-B-type natriuretic peptide.

Lyngbæk S, Winkel P, Gøtze JP, Kastrup J, Gluud C, Kolmos HJ, Kjøller E, Jensen GB, Hansen JF, Hildebrandt P, Hilden J; CLARICOR Trial Group.

Eur J Prev Cardiol. 2014 Oct;21(10):1275-84. doi: 10.1177/2047487313492099. Epub 2013 May 30.

PMID:
23723326
105.

Value of cardiac 320-multidetector computed tomography and cardiac magnetic resonance imaging for assessment of myocardial perfusion defects in patients with known chronic ischemic heart disease.

Qayyum AA, Kühl JT, Mathiasen AB, Ahtarovski KA, Vejlstrup NG, Kofoed KF, Kastrup J.

Int J Cardiovasc Imaging. 2013 Oct;29(7):1585-93. doi: 10.1007/s10554-013-0234-6. Epub 2013 May 8.

PMID:
23653247
106.

Optimal labeling dose, labeling time, and magnetic resonance imaging detection limits of ultrasmall superparamagnetic iron-oxide nanoparticle labeled mesenchymal stromal cells.

Mathiasen AB, Hansen L, Friis T, Thomsen C, Bhakoo K, Kastrup J.

Stem Cells Int. 2013;2013:353105. doi: 10.1155/2013/353105. Epub 2013 Mar 19.

107.

Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy.

Fiorentini M, Bach A, Strømgaard K, Kastrup JS, Gajhede M.

Acta Crystallogr D Biol Crystallogr. 2013 Apr;69(Pt 4):587-94. doi: 10.1107/S0907444912051839. Epub 2013 Mar 14.

PMID:
23519667
108.

Studies on an (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist IKM-159: asymmetric synthesis, neuroactivity, and structural characterization.

Juknaitė L, Sugamata Y, Tokiwa K, Ishikawa Y, Takamizawa S, Eng A, Sakai R, Pickering DS, Frydenvang K, Swanson GT, Kastrup JS, Oikawa M.

J Med Chem. 2013 Mar 28;56(6):2283-93. doi: 10.1021/jm301590z. Epub 2013 Mar 13.

109.

Chemoenzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters.

Assaf Z, Larsen AP, Venskutonytė R, Han L, Abrahamsen B, Nielsen B, Gajhede M, Kastrup JS, Jensen AA, Pickering DS, Frydenvang K, Gefflaut T, Bunch L.

J Med Chem. 2013 Feb 28;56(4):1614-28. doi: 10.1021/jm301433m. Epub 2013 Feb 15. Erratum in: J Med Chem. 2013 Jul 25;56(14):5985.

PMID:
23414088
110.

Association between lectin complement pathway initiators, C-reactive protein and left ventricular remodeling in myocardial infarction-a magnetic resonance study.

Schoos MM, Munthe-Fog L, Skjoedt MO, Ripa RS, Lønborg J, Kastrup J, Kelbæk H, Clemmensen P, Garred P.

Mol Immunol. 2013 Jul;54(3-4):408-14. doi: 10.1016/j.molimm.2013.01.008. Epub 2013 Feb 11.

PMID:
23399387
111.

Serum YKL-40 predicts long-term mortality in patients with stable coronary disease: a prognostic study within the CLARICOR trial.

Harutyunyan M, Gøtze JP, Winkel P, Johansen JS, Hansen JF, Jensen GB, Hilden J, Kjøller E, Kolmos HJ, Gluud C, Kastrup J.

Immunobiology. 2013 Jul;218(7):945-51. doi: 10.1016/j.imbio.2012.10.015. Epub 2012 Nov 7.

PMID:
23294528
112.

Clinical outcome after stem cell mobilization with granulocyte-colony-stimulating factor after acute ST-elevation myocardial infarction: 5-year results of the STEMMI trial.

Ripa RS, Jørgensen E, Kastrup J.

Scand J Clin Lab Invest. 2013 Mar;73(2):125-9. doi: 10.3109/00365513.2012.750010. Epub 2013 Jan 3.

PMID:
23281844
113.

Synthesis, pharmacology, and biostructural characterization of novel α4β2 nicotinic acetylcholine receptor agonists.

Ussing CA, Hansen CP, Petersen JG, Jensen AA, Rohde LA, Ahring PK, Nielsen EØ, Kastrup JS, Gajhede M, Frølund B, Balle T.

J Med Chem. 2013 Feb 14;56(3):940-51. doi: 10.1021/jm301409f. Epub 2013 Jan 22.

PMID:
23256554
114.

Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors.

Harpsøe K, Hald H, Timmermann DB, Jensen ML, Dyhring T, Nielsen EØ, Peters D, Balle T, Gajhede M, Kastrup JS, Ahring PK.

J Biol Chem. 2013 Jan 25;288(4):2559-70. doi: 10.1074/jbc.M112.436337. Epub 2012 Dec 10.

115.

Comparison of human adipose-derived stem cells and bone marrow-derived stem cells in a myocardial infarction model.

Rasmussen JG, Frøbert O, Holst-Hansen C, Kastrup J, Baandrup U, Zachar V, Fink T, Simonsen U.

Cell Transplant. 2014 Feb;23(2):195-206. doi: 10.3727/096368912X659871. Epub 2012 Dec 4.

PMID:
23211469
116.

The inflammatory biomarker YKL-40 at admission is a strong predictor of overall mortality.

Mygind ND, Iversen K, Køber L, Goetze JP, Nielsen H, Boesgaard S, Bay M, Johansen JS, Nielsen OW, Kirk V, Kastrup J.

J Intern Med. 2013 Feb;273(2):205-16. doi: 10.1111/joim.12006. Epub 2012 Dec 31.

117.

Activation of protease-activated receptor 2 induces VEGF independently of HIF-1.

Rasmussen JG, Riis SE, Frøbert O, Yang S, Kastrup J, Zachar V, Simonsen U, Fink T.

PLoS One. 2012;7(9):e46087. doi: 10.1371/journal.pone.0046087. Epub 2012 Sep 25.

118.

Angiographic features and cardiovascular risk factors in human immunodeficiency virus-infected patients with first-time acute coronary syndrome.

Knudsen A, Mathiasen AB, Worck RH, Kastrup J, Gerstoft J, Katzenstein TL, Kjaer A, Lebech AM.

Am J Cardiol. 2013 Jan 1;111(1):63-7. doi: 10.1016/j.amjcard.2012.08.047. Epub 2012 Oct 2.

PMID:
23040592
119.

Rationale and design of the first randomized, double-blind, placebo-controlled trial of intramyocardial injection of autologous bone-marrow derived Mesenchymal Stromal Cells in chronic ischemic Heart Failure (MSC-HF Trial).

Mathiasen AB, Jørgensen E, Qayyum AA, Haack-Sørensen M, Ekblond A, Kastrup J.

Am Heart J. 2012 Sep;164(3):285-91. doi: 10.1016/j.ahj.2012.05.026.

PMID:
22980293
120.

Crystal structure of Lymnaea stagnalis AChBP complexed with the potent nAChR antagonist DHβE suggests a unique mode of antagonism.

Shahsavar A, Kastrup JS, Nielsen EØ, Kristensen JL, Gajhede M, Balle T.

PLoS One. 2012;7(8):e40757. doi: 10.1371/journal.pone.0040757. Epub 2012 Aug 22.

121.

Cysteinyl leukotriene signaling aggravates myocardial hypoxia in experimental atherosclerotic heart disease.

Nobili E, Salvado MD, Folkersen L, Castiglioni L, Kastrup J, Wetterholm A, Tremoli E, Hansson GK, Sironi L, Haeggström JZ, Gabrielsen A.

PLoS One. 2012;7(7):e41786. doi: 10.1371/journal.pone.0041786. Epub 2012 Jul 25.

122.

Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors.

Juknaitė L, Venskutonytė R, Assaf Z, Faure S, Gefflaut T, Aitken DJ, Nielsen B, Gajhede M, Kastrup JS, Bunch L, Frydenvang K, Pickering DS.

J Struct Biol. 2012 Oct;180(1):39-46. doi: 10.1016/j.jsb.2012.07.001. Epub 2012 Jul 9.

PMID:
22789682
123.

Mesenchymal stromal cell phenotype is not influenced by confluence during culture expansion.

Haack-Sørensen M, Hansen SK, Hansen L, Gaster M, Hyttel P, Ekblond A, Kastrup J.

Stem Cell Rev. 2013 Feb;9(1):44-58. doi: 10.1007/s12015-012-9386-3.

PMID:
22644809
124.

Adipose-derived mesenchymal stromal cells for chronic myocardial ischemia (MyStromalCell Trial): study design.

Qayyum AA, Haack-Sørensen M, Mathiasen AB, Jørgensen E, Ekblond A, Kastrup J.

Regen Med. 2012 May;7(3):421-8. doi: 10.2217/rme.12.17. Review.

125.

Coronary artery stent mimicking intracardiac thrombus on cardiac magnetic resonance imaging due to signal loss: case report.

Qayyum AA, Vejlstrup NG, Ahtarovski KA, Kofoed KF, Kastrup J.

Magn Reson Imaging. 2012 Jul;30(6):889-92. doi: 10.1016/j.mri.2012.02.023. Epub 2012 Apr 9.

PMID:
22495236
126.

Direct intramyocardial mesenchymal stromal cell injections in patients with severe refractory angina: one-year follow-up.

Haack-Sørensen M, Friis T, Mathiasen AB, Jørgensen E, Hansen L, Dickmeiss E, Ekblond A, Kastrup J.

Cell Transplant. 2013;22(3):521-8. doi: 10.3727/096368912X636830. Epub 2012 Apr 2.

PMID:
22472086
127.

Kainate induces various domain closures in AMPA and kainate receptors.

Venskutonytė R, Frydenvang K, Hald H, Rabassa AC, Gajhede M, Ahring PK, Kastrup JS.

Neurochem Int. 2012 Sep;61(4):536-45. doi: 10.1016/j.neuint.2012.02.016. Epub 2012 Mar 7.

PMID:
22425692
128.

Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor.

Kristensen LH, Nielsen AL, Helgstrand C, Lees M, Cloos P, Kastrup JS, Helin K, Olsen L, Gajhede M.

FEBS J. 2012 Jun;279(11):1905-14. doi: 10.1111/j.1742-4658.2012.08567.x. Epub 2012 May 2.

129.

Structural and pharmacological characterization of phenylalanine-based AMPA receptor antagonists at kainate receptors.

Venskutonytė R, Frydenvang K, Valadés EA, Szymańska E, Johansen TN, Kastrup JS, Pickering DS.

ChemMedChem. 2012 Oct;7(10):1793-8. doi: 10.1002/cmdc.201100599. Epub 2012 Mar 7.

PMID:
22407805
130.

A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage.

Bach A, Clausen BH, Møller M, Vestergaard B, Chi CN, Round A, Sørensen PL, Nissen KB, Kastrup JS, Gajhede M, Jemth P, Kristensen AS, Lundström P, Lambertsen KL, Strømgaard K.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3317-22. doi: 10.1073/pnas.1113761109. Epub 2012 Feb 17.

131.

Good interobserver agreement was attainable on outcome adjudication in patients with stable coronary heart disease.

Kjoller E, Hilden J, Winkel P, Frandsen NJ, Galatius S, Jensen G, Kastrup J, Hansen JF, Kolmos HJ, Jespersen CM, Hildebrandt P, Gluud C; CLARICOR Trial Group.

J Clin Epidemiol. 2012 Apr;65(4):444-53. doi: 10.1016/j.jclinepi.2011.09.011. Epub 2012 Jan 17.

PMID:
22257841
132.

The inflammatory biomarker YKL-40 as a new prognostic marker for all-cause mortality in patients with heart failure.

Harutyunyan M, Christiansen M, Johansen JS, Køber L, Torp-Petersen C, Kastrup J.

Immunobiology. 2012 Jun;217(6):652-6. doi: 10.1016/j.imbio.2011.11.003. Epub 2011 Nov 18.

PMID:
22209156
133.

Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine α4β2 receptors: unique role of halogen bonding revealed.

Rohde LA, Ahring PK, Jensen ML, Nielsen EØ, Peters D, Helgstrand C, Krintel C, Harpsøe K, Gajhede M, Kastrup JS, Balle T.

J Biol Chem. 2012 Feb 3;287(6):4248-59. doi: 10.1074/jbc.M111.292243. Epub 2011 Dec 13.

134.

A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure: synthesis, resolution, pharmacology, and crystal structure.

Szymańska E, Frydenvang K, Contreras-Sanz A, Pickering DS, Frola E, Serafimoska Z, Nielsen B, Kastrup JS, Johansen TN.

J Med Chem. 2011 Oct 27;54(20):7289-98. doi: 10.1021/jm200862h. Epub 2011 Oct 4.

PMID:
21923187
135.

Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate.

Venskutonytė R, Frydenvang K, Gajhede M, Bunch L, Pickering DS, Kastrup JS.

J Struct Biol. 2011 Dec;176(3):307-14. doi: 10.1016/j.jsb.2011.08.014. Epub 2011 Sep 1. Erratum in: J Struct Biol. 2013 Nov;184(2):381.

PMID:
21907808
136.

Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2.

Krintel C, Frydenvang K, Olsen L, Kristensen MT, de Barrios O, Naur P, Francotte P, Pirotte B, Gajhede M, Kastrup JS.

Biochem J. 2012 Jan 1;441(1):173-8. doi: 10.1042/BJ20111221.

PMID:
21895609
137.

Plasma YKL-40 in relation to the degree of coronary artery disease in patients with stable ischemic heart disease.

Mathiasen AB, Harutyunyan MJ, Jørgensen E, Helqvist S, Ripa R, Gøtze JP, Johansen JS, Kastrup J.

Scand J Clin Lab Invest. 2011 Sep;71(5):439-47. doi: 10.3109/00365513.2011.586470.

PMID:
21827355
138.

Selective kainate receptor (GluK1) ligands structurally based upon 1H-cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization.

Venskutonyte R, Butini S, Coccone SS, Gemma S, Brindisi M, Kumar V, Guarino E, Maramai S, Valenti S, Amir A, Valadés EA, Frydenvang K, Kastrup JS, Novellino E, Campiani G, Pickering DS.

J Med Chem. 2011 Jul 14;54(13):4793-805. doi: 10.1021/jm2004078. Epub 2011 Jun 13.

PMID:
21619066
139.

Can YKL-40 be a new inflammatory biomarker in cardiovascular disease?

Kastrup J.

Immunobiology. 2012 May;217(5):483-91. doi: 10.1016/j.imbio.2011.04.007. Epub 2011 Apr 30. Review.

PMID:
21601307
140.

Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: towards understanding selectivity of inhibitors targeting oncogenic histone demethylases.

Kristensen JB, Nielsen AL, Jørgensen L, Kristensen LH, Helgstrand C, Juknaite L, Kristensen JL, Kastrup JS, Clausen RP, Olsen L, Gajhede M.

FEBS Lett. 2011 Jun 23;585(12):1951-6. doi: 10.1016/j.febslet.2011.05.023. Epub 2011 May 12. Erratum in: FEBS Lett. 2011 Nov 16;585(22):3600.

141.

Mesenchymal stromal cell derived endothelial progenitor treatment in patients with refractory angina.

Friis T, Haack-Sørensen M, Mathiasen AB, Ripa RS, Kristoffersen US, Jørgensen E, Hansen L, Bindslev L, Kjær A, Hesse B, Dickmeiss E, Kastrup J.

Scand Cardiovasc J. 2011 Jun;45(3):161-8. doi: 10.3109/14017431.2011.569571. Epub 2011 Apr 12.

PMID:
21486102
142.

Excess sudden cardiac deaths after short-term clarithromycin administration in the CLARICOR trial: why is this so, and why are statins protective?

Winkel P, Hilden J, Fischer Hansen J, Hildebrandt P, Kastrup J, Kolmos HJ, Kjøller E, Jespersen CM, Gluud C, Jensen GB; CLARICOR Trial Group.

Cardiology. 2011;118(1):63-7. doi: 10.1159/000324533. Epub 2011 Mar 26.

PMID:
21447948
143.

Cryopreservation and revival of mesenchymal stromal cells.

Haack-Sørensen M, Kastrup J.

Methods Mol Biol. 2011;698:161-74. doi: 10.1007/978-1-60761-999-4_13.

PMID:
21431518
144.

Historical perspectives and the future of adverse reactions associated with haemopoietic stem cells cryopreserved with dimethyl sulfoxide.

Cox MA, Kastrup J, Hrubiško M.

Cell Tissue Bank. 2012 Jun;13(2):203-15. doi: 10.1007/s10561-011-9248-2. Epub 2011 Mar 11. Review.

PMID:
21394484
145.

Stem cells therapy for cardiovascular repair in ischemic heart disease: How to predict and secure optimal outcome?

Kastrup J.

EPMA J. 2011 Mar;2(1):107-17. doi: 10.1007/s13167-011-0062-5. Epub 2011 Feb 8.

146.

Structural model and trans-interaction of the entire ectodomain of the olfactory cell adhesion molecule.

Kulahin N, Kristensen O, Rasmussen KK, Olsen L, Rydberg P, Vestergaard B, Kastrup JS, Berezin V, Bock E, Walmod PS, Gajhede M.

Structure. 2011 Feb 9;19(2):203-11. doi: 10.1016/j.str.2010.12.014.

147.

A randomised, double-blind, placebo-controlled, multicentre study of the safety and efficacy of BIOBYPASS (AdGVVEGF121.10NH) gene therapy in patients with refractory advanced coronary artery disease: the NOVA trial.

Kastrup J, Jørgensen E, Fuchs S, Nikol S, Bøtker HE, Gyöngyösi M, Glogar D, Kornowski R.

EuroIntervention. 2011 Feb;6(7):813-8. doi: 10.4244/EIJV6I7A140.

148.

Comparison of mesenchymal stromal cells from young healthy donors and patients with severe chronic coronary artery disease.

Friis T, Haack-Sørensen M, Hansen SK, Hansen L, Bindslev L, Kastrup J.

Scand J Clin Lab Invest. 2011 May;71(3):193-202. doi: 10.3109/00365513.2010.550310. Epub 2011 Jan 11.

PMID:
21222501
149.

High-sensitivity C-reactive protein and N-terminal pro-B-type natriuretic peptide in patients with stable coronary artery disease: a prognostic study within the CLARICOR trial.

Harutyunyan MJ, Mathiasen AB, Winkel P, Gøtze JP, Hansen JF, Hildebrandt P, Jensen GB, Hilden J, Jespersen CM, Kjøller E, Kolmos HJ, Gluud C, Kastrup J; CLARICOR Trial Group.

Scand J Clin Lab Invest. 2011 Feb;71(1):52-62. doi: 10.3109/00365513.2010.538081. Epub 2010 Nov 25.

PMID:
21108561
150.

Pregnancy associated plasma protein-A as a marker for myocardial infarction and death in patients with stable coronary artery disease: a prognostic study within the CLARICOR Trial.

Iversen KK, Teisner B, Winkel P, Gluud C, Kjøller E, Kolmos HJ, Hildebrandt PR, Hilden J, Kastrup J; CLARICOR Trial Group.

Atherosclerosis. 2011 Jan;214(1):203-8. doi: 10.1016/j.atherosclerosis.2010.10.025. Epub 2010 Nov 3.

PMID:
21093861
151.

Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid.

Frydenvang K, Pickering DS, Greenwood JR, Krogsgaard-Larsen N, Brehm L, Nielsen B, Vogensen SB, Hald H, Kastrup JS, Krogsgaard-Larsen P, Clausen RP.

J Med Chem. 2010 Dec 9;53(23):8354-61. doi: 10.1021/jm101218a. Epub 2010 Nov 10.

PMID:
21067182
152.

The influence of statin treatment on the inflammatory biomarkers YKL-40 and HsCRP in patients with stable coronary artery disease.

Mygind ND, Harutyunyan MJ, Mathiasen AB, Ripa RS, Thune JJ, Gøtze JP, Johansen JS, Kastrup J; CLARICOR Trial Group.

Inflamm Res. 2011 Mar;60(3):281-7. doi: 10.1007/s00011-010-0266-5. Epub 2010 Oct 23.

PMID:
20972697
153.

[Cardiovascular regeneration using mesenchymal stem cells].

Mathiasen AB, Sørensen MH, Jørgensen E, Ekblond A, Kastrup J.

Ugeskr Laeger. 2010 Sep 20;172(38):2613-6. Review. Danish.

PMID:
20920406
154.

Prolonged hypoxic culture and trypsinization increase the pro-angiogenic potential of human adipose tissue-derived stem cells.

Rasmussen JG, Frøbert O, Pilgaard L, Kastrup J, Simonsen U, Zachar V, Fink T.

Cytotherapy. 2011 Mar;13(3):318-28. doi: 10.3109/14653249.2010.506505. Epub 2010 Aug 26.

PMID:
20795759
155.

Lessons from more than 80 structures of the GluA2 ligand-binding domain in complex with agonists, antagonists and allosteric modulators.

Pøhlsgaard J, Frydenvang K, Madsen U, Kastrup JS.

Neuropharmacology. 2011 Jan;60(1):135-50. doi: 10.1016/j.neuropharm.2010.08.004. Epub 2010 Aug 14. Review.

PMID:
20713069
156.

YKL-40: a new biomarker in cardiovascular disease?

Mathiasen AB, Henningsen KM, Harutyunyan MJ, Mygind ND, Kastrup J.

Biomark Med. 2010 Aug;4(4):591-600. doi: 10.2217/bmm.10.58. Review.

PMID:
20701447
157.

Gene therapy and angiogenesis in patients with coronary artery disease.

Kastrup J.

Expert Rev Cardiovasc Ther. 2010 Aug;8(8):1127-38. doi: 10.1586/erc.10.95. Review.

PMID:
20670190
158.

Chlamydia pneumoniae IgG and IgA antibody titers and prognosis in patients with coronary heart disease: results from the CLARICOR trial.

Hilden J, Lind I, Kolmos HJ, Als-Nielsen B, Damgaard M, Hansen JF, Hansen S, Helø OH, Hildebrandt P, Jensen GB, Kastrup J, Kjøller E, Nielsen H, Petersen L, Jespersen CM, Gluud C; CLARICOR Trial Group.

Diagn Microbiol Infect Dis. 2010 Apr;66(4):385-92. doi: 10.1016/j.diagmicrobio.2009.11.011.

PMID:
20226329
159.

Plasma YKL-40 and recovery of left ventricular function after acute myocardial infarction.

Hedegaard A, Ripa RS, Johansen JS, Jørgensen E, Kastrup J.

Scand J Clin Lab Invest. 2010 Apr;70(2):80-6. doi: 10.3109/00365510903518191.

PMID:
20102300
160.

Over-expression, purification and characterization of an Asc-1 homologue from Gloeobacter violaceus.

Wang X, Hald H, Ernst HA, Egebjerg J, Christensen KV, Gajhede M, Kastrup JS, Mirza O.

Protein Expr Purif. 2010 Jun;71(2):179-83. doi: 10.1016/j.pep.2010.01.011. Epub 2010 Jan 13.

PMID:
20074644
161.

Structure of the first PDZ domain of human PSD-93.

Fiorentini M, Nielsen AK, Kristensen O, Kastrup JS, Gajhede M.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Dec 1;65(Pt 12):1254-7. doi: 10.1107/S1744309109043267. Epub 2009 Nov 27.

162.

The apo structure of sucrose hydrolase from Xanthomonas campestris pv. campestris shows an open active-site groove.

Champion E, Remaud-Simeon M, Skov LK, Kastrup JS, Gajhede M, Mirza O.

Acta Crystallogr D Biol Crystallogr. 2009 Dec;65(Pt 12):1309-14. doi: 10.1107/S0907444909040311. Epub 2009 Nov 17.

PMID:
19966417
163.

Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor.

Owczarek S, Kiryushko D, Larsen MH, Kastrup JS, Gajhede M, Sandi C, Berezin V, Bock E, Soroka V.

FASEB J. 2010 Apr;24(4):1139-50. doi: 10.1096/fj.09-140509. Epub 2009 Dec 1.

PMID:
19952283
164.

Serial in vivo imaging of the porcine heart after percutaneous, intramyocardially injected 111In-labeled human mesenchymal stromal cells.

Lyngbaek S, Ripa RS, Haack-Sørensen M, Cortsen A, Kragh L, Andersen CB, Jørgensen E, Kjaer A, Kastrup J, Hesse B.

Int J Cardiovasc Imaging. 2010 Mar;26(3):273-84. doi: 10.1007/s10554-009-9532-4. Epub 2009 Nov 18.

PMID:
19921546
165.

Statin treatment prevents increased cardiovascular and all-cause mortality associated with clarithromycin in patients with stable coronary heart disease.

Jensen GB, Hilden J, Als-Nielsen B, Damgaard M, Hansen JF, Hansen S, Helø OH, Hildebrandt P, Kastrup J, Kolmos HJ, Kjøller E, Lind I, Nielsen H, Petersen L, Jespersen CM, Gluud C; CLARICOR Trial Group.

J Cardiovasc Pharmacol. 2010 Feb;55(2):123-8. doi: 10.1097/FJC.0b013e3181c87e37.

PMID:
19920766
166.

Mesenchymal stromal cells for cardiovascular repair: current status and future challenges.

Mathiasen AB, Haack-Sørensen M, Kastrup J.

Future Cardiol. 2009 Nov;5(6):605-17. doi: 10.2217/fca.09.42. Review.

PMID:
19886787
167.

Mesenchymal stromal cell and mononuclear cell therapy in heart disease.

Haack-Sorensen M, Friis T, Kastrup J.

Future Cardiol. 2008 Sep;4(5):481-94. doi: 10.2217/14796678.4.5.481.

PMID:
19804342
168.

Ligand binding analyses of the putative peptide transporter YjdL from E. coli display a significant selectivity towards dipeptides.

Ernst HA, Pham A, Hald H, Kastrup JS, Rahman M, Mirza O.

Biochem Biophys Res Commun. 2009 Nov 6;389(1):112-6. doi: 10.1016/j.bbrc.2009.08.098. Epub 2009 Aug 22.

PMID:
19703419
169.

Stem cells: REGENT trial-the end of cell therapy for MI?

Ripa RS, Kastrup J.

Nat Rev Cardiol. 2009 Sep;6(9):567-8. doi: 10.1038/nrcardio.2009.137. No abstract available.

PMID:
19696777
170.

Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2.

Hald H, Ahring PK, Timmermann DB, Liljefors T, Gajhede M, Kastrup JS.

J Mol Biol. 2009 Sep 4;391(5):906-17. doi: 10.1016/j.jmb.2009.07.002. Epub 2009 Jul 8.

PMID:
19591837
171.

The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization.

Clausen RP, Naur P, Kristensen AS, Greenwood JR, Strange M, Bräuner-Osborne H, Jensen AA, Nielsen AS, Geneser U, Ringgaard LM, Nielsen B, Pickering DS, Brehm L, Gajhede M, Krogsgaard-Larsen P, Kastrup JS.

J Med Chem. 2009 Aug 13;52(15):4911-22. doi: 10.1021/jm900565c.

PMID:
19588945
172.

The influence of genotype on vascular endothelial growth factor and regulation of myocardial collateral blood flow in patients with acute and chronic coronary heart disease.

Ripa RS, Jørgensen E, Baldazzi F, Frikke-Schmidt R, Wang Y, Tybjaerg-Hansen A, Kastrup J.

Scand J Clin Lab Invest. 2009;69(6):722-8. doi: 10.3109/00365510903078803.

PMID:
19544222
173.

Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine.

Frydenvang K, Lash LL, Naur P, Postila PA, Pickering DS, Smith CM, Gajhede M, Sasaki M, Sakai R, Pentikaïnen OT, Swanson GT, Kastrup JS.

J Biol Chem. 2009 May 22;284(21):14219-29. doi: 10.1074/jbc.M808547200. Epub 2009 Mar 18.

174.

High serum YKL-40 concentration is associated with cardiovascular and all-cause mortality in patients with stable coronary artery disease.

Kastrup J, Johansen JS, Winkel P, Hansen JF, Hildebrandt P, Jensen GB, Jespersen CM, Kjøller E, Kolmos HJ, Lind I, Nielsen H, Gluud C; CLARICOR Trial Group.

Eur Heart J. 2009 May;30(9):1066-72. doi: 10.1093/eurheartj/ehp049. Epub 2009 Mar 6.

PMID:
19270316
175.

Modulation of the dimer interface at ionotropic glutamate-like receptor delta2 by D-serine and extracellular calcium.

Hansen KB, Naur P, Kurtkaya NL, Kristensen AS, Gajhede M, Kastrup JS, Traynelis SF.

J Neurosci. 2009 Jan 28;29(4):907-17. doi: 10.1523/JNEUROSCI.4081-08.2009.

176.

Fractional flow reserve versus angiography for guiding percutaneous coronary intervention.

Tonino PA, De Bruyne B, Pijls NH, Siebert U, Ikeno F, van' t Veer M, Klauss V, Manoharan G, Engstrøm T, Oldroyd KG, Ver Lee PN, MacCarthy PA, Fearon WF; FAME Study Investigators.

N Engl J Med. 2009 Jan 15;360(3):213-24. doi: 10.1056/NEJMoa0807611.

177.

Timing of granulocyte-colony stimulating factor treatment after acute myocardial infarction and recovery of left ventricular function: results from the STEMMI trial.

Overgaard M, Ripa RS, Wang Y, Jørgensen E, Kastrup J.

Int J Cardiol. 2010 Apr 30;140(3):351-5. doi: 10.1016/j.ijcard.2008.11.120. Epub 2009 Jan 7.

PMID:
19131132
178.

Instent neointimal hyperplasia after percutaneous intervention for ST-elevation myocardial infarction and treatment with granulocyte-colony stimulating factor. Results from the stem cells in myocardial infarction (STEMMI) trial.

Jørgensen E, Baldazzi F, Ripa RS, Friis T, Wang Y, Helqvist S, Kastrup J.

Int J Cardiol. 2010 Mar 18;139(3):269-75. doi: 10.1016/j.ijcard.2008.10.029. Epub 2008 Dec 3.

PMID:
19056135
179.

Restenosis in coronary bare metal stents. Importance of time to follow-up: a comparison of coronary angiograms 6 months and 4 years after implantation.

Jørgensen E, Helqvist S, Kløvgaard L, Kastrup J, Clemmensen P, Holmvang L, Engstrøm T, Saunamaki K, Kelbaek H.

Scand Cardiovasc J. 2009 Apr;43(2):87-93. doi: 10.1080/14017430802582602.

PMID:
19031301
180.

Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4.

Kasper C, Frydenvang K, Naur P, Gajhede M, Pickering DS, Kastrup JS.

FEBS Lett. 2008 Dec 10;582(29):4089-94. doi: 10.1016/j.febslet.2008.11.005. Epub 2008 Nov 18.

181.

Comparison of infarct size changes with delayed contrast-enhanced magnetic resonance imaging and electrocardiogram QRS scoring during the 6 months after acutely reperfused myocardial infarction.

Bang LE, Ripa RS, Grande P, Kastrup J, Clemmensen PM, Wagner GS.

J Electrocardiol. 2008 Nov-Dec;41(6):609-13. doi: 10.1016/j.jelectrocard.2008.06.011. Epub 2008 Sep 14.

PMID:
18790502
182.

Drug-eluting versus bare metal stents in patients with st-segment-elevation myocardial infarction: eight-month follow-up in the Drug Elution and Distal Protection in Acute Myocardial Infarction (DEDICATION) trial.

Kelbaek H, Thuesen L, Helqvist S, Clemmensen P, Kløvgaard L, Kaltoft A, Andersen B, Thuesen H, Engstrøm T, Bøtker HE, Saunamäki K, Krusell LR, Jørgensen E, Hansen HH, Christiansen EH, Ravkilde J, Køber L, Kofoed KF, Terkelsen CJ, Lassen JF; DEDICATION Investigators.

Circulation. 2008 Sep 9;118(11):1155-62. doi: 10.1161/CIRCULATIONAHA.107.758698. Epub 2008 Aug 25.

PMID:
18725489
183.

Crystal structure of the Ig1 domain of the neural cell adhesion molecule NCAM2 displays domain swapping.

Rasmussen KK, Kulahin N, Kristensen O, Poulsen JC, Sigurskjold BW, Kastrup JS, Berezin V, Bock E, Walmod PS, Gajhede M.

J Mol Biol. 2008 Oct 24;382(5):1113-20. doi: 10.1016/j.jmb.2008.07.084. Epub 2008 Aug 6.

PMID:
18706912
184.

YKL-40 a new biomarker in patients with acute coronary syndrome or stable coronary artery disease.

Wang Y, Ripa RS, Johansen JS, Gabrielsen A, Steinbruchel DA, Friis T, Bindslev L, Haack-Sørensen M, Jørgensen E, Kastrup J.

Scand Cardiovasc J. 2008 Oct;42(5):295-302. doi: 10.1080/14017430802220567.

PMID:
18615353
185.

Refractory angina pectoris carries a favourable prognosis: a three-year follow-up of 150 patients.

Rück A, Sylvén C; EUROINJECT ONE study group.

Scand Cardiovasc J. 2008 Oct;42(5):291-4. doi: 10.1080/14017430802084997.

PMID:
18609054
186.

The structure of the complex between a branched pentasaccharide and Thermobacillus xylanilyticus GH-51 arabinofuranosidase reveals xylan-binding determinants and induced fit.

Paës G, Skov LK, O'Donohue MJ, Rémond C, Kastrup JS, Gajhede M, Mirza O.

Biochemistry. 2008 Jul 15;47(28):7441-51. doi: 10.1021/bi800424e. Epub 2008 Jun 19.

PMID:
18563919
187.

Structure of a SARS coronavirus-derived peptide bound to the human major histocompatibility complex class I molecule HLA-B*1501.

Røder G, Kristensen O, Kastrup JS, Buus S, Gajhede M.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jun 1;64(Pt 6):459-62. doi: 10.1107/S1744309108012396. Epub 2008 May 17.

188.

Dimerization effect of sucrose octasulfate on rat FGF1.

Kulahin N, Kiselyov V, Kochoyan A, Kristensen O, Kastrup JS, Berezin V, Bock E, Gajhede M.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jun 1;64(Pt 6):448-52. doi: 10.1107/S174430910801066X. Epub 2008 May 16.

189.

Release of biomarkers of myocardial damage after direct intramyocardial injection of genes and stem cells via the percutaneous transluminal route.

Baldazzi F, Jørgensen E, Ripa RS, Kastrup J.

Eur Heart J. 2008 Aug;29(15):1819-26. doi: 10.1093/eurheartj/ehn233. Epub 2008 Jun 4.

PMID:
18524811
190.

Clarithromycin for 2 weeks for stable coronary heart disease: 6-year follow-up of the CLARICOR randomized trial and updated meta-analysis of antibiotics for coronary heart disease.

Gluud C, Als-Nielsen B, Damgaard M, Fischer Hansen J, Hansen S, Helø OH, Hildebrandt P, Hilden J, Jensen GB, Kastrup J, Kolmos HJ, Kjøller E, Lind I, Nielsen H, Petersen L, Jespersen CM; CLARICOR Trial Group.

Cardiology. 2008;111(4):280-7. doi: 10.1159/000128994. Epub 2008 May 2.

191.

Stem cell mobilization by granulocyte colony-stimulating factor for myocardial recovery after acute myocardial infarction: a meta-analysis.

Zohlnhöfer D, Dibra A, Koppara T, de Waha A, Ripa RS, Kastrup J, Valgimigli M, Schömig A, Kastrati A.

J Am Coll Cardiol. 2008 Apr 15;51(15):1429-37. doi: 10.1016/j.jacc.2007.11.073.

192.

Small angle X-ray studies reveal that Aspergillus niger glucoamylase has a defined extended conformation and can form dimers in solution.

Jørgensen AD, Nøhr J, Kastrup JS, Gajhede M, Sigurskjold BW, Sauer J, Svergun DI, Svensson B, Vestergaard B.

J Biol Chem. 2008 May 23;283(21):14772-80. doi: 10.1074/jbc.M801709200. Epub 2008 Mar 31.

193.

G-CSF therapy with mobilization of bone marrow stem cells for myocardial recovery after acute myocardial infarction--a relevant treatment?

Ripa RS, Kastrup J.

Exp Hematol. 2008 Jun;36(6):681-6. doi: 10.1016/j.exphem.2008.01.010. Epub 2008 Mar 20. Review.

PMID:
18358590
194.

Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency.

Beich-Frandsen M, Pickering DS, Mirza O, Johansen TN, Greenwood J, Vestergaard B, Schousboe A, Gajhede M, Liljefors T, Kastrup JS.

J Med Chem. 2008 Mar 13;51(5):1459-63. doi: 10.1021/jm701126w. Epub 2008 Feb 13.

PMID:
18269227
195.

Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites.

Kaae BH, Harpsøe K, Kastrup JS, Sanz AC, Pickering DS, Metzler B, Clausen RP, Gajhede M, Sauerberg P, Liljefors T, Madsen U.

Chem Biol. 2007 Nov;14(11):1294-303.

196.

Predictors of mortality in patients with type 2 diabetes with or without diabetic nephropathy: a follow-up study.

Astrup AS, Nielsen FS, Rossing P, Ali S, Kastrup J, Smidt UM, Parving HH.

J Hypertens. 2007 Dec;25(12):2479-85.

PMID:
17984670
197.
199.

Comparison of different culture conditions for human mesenchymal stromal cells for clinical stem cell therapy.

Haack-Sorensen M, Friis T, Bindslev L, Mortensen S, Johnsen HE, Kastrup J.

Scand J Clin Lab Invest. 2008;68(3):192-203.

PMID:
17852829
200.

Bone marrow derived mesenchymal cell mobilization by granulocyte-colony stimulating factor after acute myocardial infarction: results from the Stem Cells in Myocardial Infarction (STEMMI) trial.

Ripa RS, Haack-Sørensen M, Wang Y, Jørgensen E, Mortensen S, Bindslev L, Friis T, Kastrup J.

Circulation. 2007 Sep 11;116(11 Suppl):I24-30.

PMID:
17846310

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