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Association between genetic risk variants and glucose intolerance during pregnancy in north Indian women.

Arora GP, Almgren P, Brøns C, Thaman RG, Vaag AA, Groop L, Prasad RB.

BMC Med Genomics. 2018 Aug 8;11(1):64. doi: 10.1186/s12920-018-0380-8.


Genetic variants of gestational diabetes mellitus: a study of 112 SNPs among 8722 women in two independent populations.

Ding M, Chavarro J, Olsen S, Lin Y, Ley SH, Bao W, Rawal S, Grunnet LG, Thuesen ACB, Mills JL, Yeung E, Hinkle SN, Zhang W, Vaag A, Liu A, Hu FB, Zhang C.

Diabetologia. 2018 Aug;61(8):1758-1768. doi: 10.1007/s00125-018-4637-8. Epub 2018 Jun 12.


Gestational Diabetes Mellitus and Renal Function: A Prospective Study With 9- to 16-Year Follow-up After Pregnancy.

Rawal S, Olsen SF, Grunnet LG, Ma RC, Hinkle SN, Granström C, Wu J, Yeung E, Mills JL, Zhu Y, Bao W, Ley SH, Hu FB, Damm P, Vaag A, Tsai MY, Zhang C.

Diabetes Care. 2018 Jul;41(7):1378-1384. doi: 10.2337/dc17-2629. Epub 2018 May 4.


Effect of metformin on plasma metabolite profile in the Copenhagen Insulin and Metformin Therapy (CIMT) trial.

Safai N, Suvitaival T, Ali A, Spégel P, Al-Majdoub M, Carstensen B, Vestergaard H, Ridderstråle M; CIMT Trial Group.

Diabet Med. 2018 Jul;35(7):944-953. doi: 10.1111/dme.13636. Epub 2018 May 2.


Danish Centre for Strategic Research in Type 2 Diabetes (DD2) project cohort of newly diagnosed patients with type 2 diabetes: a cohort profile.

Christensen DH, Nicolaisen SK, Berencsi K, Beck-Nielsen H, Rungby J, Friborg S, Brandslund I, Christiansen JS, Vaag A, Sørensen HT, Nielsen JS, Thomsen RW.

BMJ Open. 2018 Apr 7;8(4):e017273. doi: 10.1136/bmjopen-2017-017273.


Increased expression of microRNA-15a and microRNA-15b in skeletal muscle from adult offspring of women with diabetes in pregnancy.

Houshmand-Oeregaard A, Schrölkamp M, Kelstrup L, Hansen NS, Hjort L, Thuesen ACB, Broholm C, Mathiesen ER, Clausen TD, Vaag A, Damm P.

Hum Mol Genet. 2018 May 15;27(10):1763-1771. doi: 10.1093/hmg/ddy085.


Plasma ceramide levels are altered in low and normal birth weight men in response to short-term high-fat overfeeding.

Ribel-Madsen A, Ribel-Madsen R, Nielsen KF, Brix S, Vaag AA, Brøns C.

Sci Rep. 2018 Feb 22;8(1):3452. doi: 10.1038/s41598-018-21419-5.


N1-methylnicotinamide is a signalling molecule produced in skeletal muscle coordinating energy metabolism.

Ström K, Morales-Alamo D, Ottosson F, Edlund A, Hjort L, Jörgensen SW, Almgren P, Zhou Y, Martin-Rincon M, Ekman C, Pérez-López A, Ekström O, Perez-Suarez I, Mattiasson M, de Pablos-Velasco P, Oskolkov N, Ahlqvist E, Wierup N, Eliasson L, Vaag A, Groop L, Stenkula KG, Fernandez C, Calbet JAL, Holmberg HC, Hansson O.

Sci Rep. 2018 Feb 14;8(1):3016. doi: 10.1038/s41598-018-21099-1.


Perspectives on diabetes mortality as the result of residual confounding and reverse causality by common disease.

Thuesen ACB, Vaag A.

Diabetes Obes Metab. 2018 Jun;20(6):1342-1349. doi: 10.1111/dom.13238. Epub 2018 Feb 25. Review.


MECHANISMS IN ENDOCRINOLOGY: SGLT2 inhibitors: clinical benefits by restoration of normal diurnal metabolism?

Esterline RL, Vaag A, Oscarsson J, Vora J.

Eur J Endocrinol. 2018 Apr;178(4):R113-R125. doi: 10.1530/EJE-17-0832. Epub 2018 Jan 25. Review.


Telomere length is reduced in 9- to 16-year-old girls exposed to gestational diabetes in utero.

Hjort L, Vryer R, Grunnet LG, Burgner D, Olsen SF, Saffery R, Vaag A.

Diabetologia. 2018 Apr;61(4):870-880. doi: 10.1007/s00125-018-4549-7. Epub 2018 Jan 23.


Prevalence of micro- and macrovascular diabetes complications at time of type 2 diabetes diagnosis and associated clinical characteristics: A cross-sectional baseline study of 6958 patients in the Danish DD2 cohort.

Gedebjerg A, Almdal TP, Berencsi K, Rungby J, Nielsen JS, Witte DR, Friborg S, Brandslund I, Vaag A, Beck-Nielsen H, Sørensen HT, Thomsen RW.

J Diabetes Complications. 2018 Jan;32(1):34-40. doi: 10.1016/j.jdiacomp.2017.09.010. Epub 2017 Sep 19.


Dnmt3a is an epigenetic mediator of adipose insulin resistance.

You D, Nilsson E, Tenen DE, Lyubetskaya A, Lo JC, Jiang R, Deng J, Dawes BA, Vaag A, Ling C, Rosen ED, Kang S.

Elife. 2017 Nov 1;6. pii: e30766. doi: 10.7554/eLife.30766.


DNA methylation and gene expression of TXNIP in adult offspring of women with diabetes in pregnancy.

Houshmand-Oeregaard A, Hjort L, Kelstrup L, Hansen NS, Broholm C, Gillberg L, Clausen TD, Mathiesen ER, Damm P, Vaag A.

PLoS One. 2017 Oct 27;12(10):e0187038. doi: 10.1371/journal.pone.0187038. eCollection 2017.


Escitalopram Ameliorates Hypercortisolemia and Insulin Resistance in Low Birth Weight Men With Limbic Brain Alterations.

Buhl CS, Stødkilde-Jørgensen H, Videbech P, Vaag A, Møller N, Lund S, Buhl ES.

J Clin Endocrinol Metab. 2018 Jan 1;103(1):115-124. doi: 10.1210/jc.2017-01438.


Adiposity, Dysmetabolic Traits, and Earlier Onset of Female Puberty in Adolescent Offspring of Women With Gestational Diabetes Mellitus: A Clinical Study Within the Danish National Birth Cohort.

Grunnet LG, Hansen S, Hjort L, Madsen CM, Kampmann FB, Thuesen ACB, Granstrømi C, Strøm M, Maslova E, Frikke-Schmidt R, Damm P, Chavarro JE, Hu FB, Olsen SF, Vaag A.

Diabetes Care. 2017 Dec;40(12):1746-1755. doi: 10.2337/dc17-0514. Epub 2017 Oct 16.


Effect of an Intensive Lifestyle Intervention on Glycemic Control in Patients With Type 2 Diabetes: A Randomized Clinical Trial.

Johansen MY, MacDonald CS, Hansen KB, Karstoft K, Christensen R, Pedersen M, Hansen LS, Zacho M, Wedell-Neergaard AS, Nielsen ST, Iepsen UW, Langberg H, Vaag AA, Pedersen BK, Ried-Larsen M.

JAMA. 2017 Aug 15;318(7):637-646. doi: 10.1001/jama.2017.10169.


Insulin secretion and action in North Indian women during pregnancy.

Arora GP, Almgren P, Thaman RG, Pal A, Groop L, Vaag A, Prasad RB, Brøns C.

Diabet Med. 2017 Oct;34(10):1477-1482. doi: 10.1111/dme.13428. Epub 2017 Aug 17.


Dysregulation of a novel miR-23b/27b-p53 axis impairs muscle stem cell differentiation of humans with type 2 diabetes.

Henriksen TI, Davidsen PK, Pedersen M, Schultz HS, Hansen NS, Larsen TJ, Vaag A, Pedersen BK, Nielsen S, Scheele C.

Mol Metab. 2017 Apr 27;6(7):770-779. doi: 10.1016/j.molmet.2017.04.006. eCollection 2017 Jul.


Maternal protein intake in pregnancy and offspring metabolic health at age 9-16 y: results from a Danish cohort of gestational diabetes mellitus pregnancies and controls.

Maslova E, Hansen S, Grunnet LG, Strøm M, Bjerregaard AA, Hjort L, Kampmann FB, Madsen CM, Baun Thuesen AC, Bech BH, Halldorsson TI, Vaag AA, Olsen SF.

Am J Clin Nutr. 2017 Aug;106(2):623-636. doi: 10.3945/ajcn.115.128637. Epub 2017 Jul 5.


Ponderal index at birth associates with later risk of gestational diabetes mellitus.

Crusell M, Damm P, Hansen T, Pedersen O, Glümer C, Vaag A, Lauenborg J.

Arch Gynecol Obstet. 2017 Aug;296(2):249-256. doi: 10.1007/s00404-017-4427-4. Epub 2017 Jun 17.


Complement factors C4 and C3 are down regulated in response to short term overfeeding in healthy young men.

Foghmar C, Brøns C, Pilely K, Vaag A, Garred P.

Sci Rep. 2017 Apr 27;7(1):1235. doi: 10.1038/s41598-017-01382-3.


36 h fasting of young men influences adipose tissue DNA methylation of LEP and ADIPOQ in a birth weight-dependent manner.

Hjort L, Jørgensen SW, Gillberg L, Hall E, Brøns C, Frystyk J, Vaag AA, Ling C.

Clin Epigenetics. 2017 Apr 21;9:40. doi: 10.1186/s13148-017-0340-8. eCollection 2017.


Differential adipokine DNA methylation and gene expression in subcutaneous adipose tissue from adult offspring of women with diabetes in pregnancy.

Houshmand-Oeregaard A, Hansen NS, Hjort L, Kelstrup L, Broholm C, Mathiesen ER, Clausen TD, Damm P, Vaag A.

Clin Epigenetics. 2017 Apr 13;9:37. doi: 10.1186/s13148-017-0338-2. eCollection 2017.


Long-term effect of smartphone-delivered Interval Walking Training on physical activity in patients with type 2 diabetes: protocol for a parallel group single-blinded randomised controlled trial.

Valentiner LS, Ried-Larsen M, Karstoft K, Brinkløv CF, Brøns C, Nielsen RO, Christensen R, Nielsen JS, Vaag AA, Pedersen BK, Langberg H.

BMJ Open. 2017 Apr 7;7(4):e014036. doi: 10.1136/bmjopen-2016-014036.


Childhood body mass index and development of type 2 diabetes throughout adult life-A large-scale danish cohort study.

Zimmermann E, Bjerregaard LG, Gamborg M, Vaag AA, Sørensen TIA, Baker JL.

Obesity (Silver Spring). 2017 May;25(5):965-971. doi: 10.1002/oby.21820. Epub 2017 Mar 27.


A retrospective analysis of a societal experiment among the Danish population suggests that exposure to extra doses of vitamin A during fetal development may lower type 2 diabetes mellitus (T2DM) risk later in life.

Keller A, Ängquist L, Jacobsen R, Vaag A, Heitmann BL.

Br J Nutr. 2017 Mar;117(5):731-736. doi: 10.1017/S000711451700037X. Epub 2017 Mar 27.


Abnormal epigenetic changes during differentiation of human skeletal muscle stem cells from obese subjects.

Davegårdh C, Broholm C, Perfilyev A, Henriksen T, García-Calzón S, Peijs L, Hansen NS, Volkov P, Kjøbsted R, Wojtaszewski JF, Pedersen M, Pedersen BK, Ballak DB, Dinarello CA, Heinhuis B, Joosten LA, Nilsson E, Vaag A, Scheele C, Ling C.

BMC Med. 2017 Feb 22;15(1):39. doi: 10.1186/s12916-017-0792-x.


Fetal Hyperglycemia Changes Human Preadipocyte Function in Adult Life.

Hansen NS, Strasko KS, Hjort L, Kelstrup L, Houshmand-Øregaard A, Schrölkamp M, Schultz HS, Scheele C, Pedersen BK, Ling C, Clausen TD, Damm P, Vaag A, Broholm C.

J Clin Endocrinol Metab. 2017 Apr 1;102(4):1141-1150. doi: 10.1210/jc.2016-3907.


Criterion validity and reliability of a smartphone delivered sub-maximal fitness test for people with type 2 diabetes.

Brinkløv CF, Thorsen IK, Karstoft K, Brøns C, Valentiner L, Langberg H, Vaag AA, Nielsen JS, Pedersen BK, Ried-Larsen M.

BMC Sports Sci Med Rehabil. 2016 Oct 7;8:31. doi: 10.1186/s13102-016-0056-7. eCollection 2016.


Diagnosing gestational diabetes mellitus in the Danish National Birth Cohort.

Olsen SF, Houshmand-Oeregaard A, Granström C, Langhoff-Roos J, Damm P, Bech BH, Vaag AA, Zhang C.

Acta Obstet Gynecol Scand. 2017 May;96(5):563-569. doi: 10.1111/aogs.13083. Epub 2017 Feb 9.


Plasma amino acid levels are elevated in young, healthy low birth weight men exposed to short-term high-fat overfeeding.

Ribel-Madsen A, Hellgren LI, Brøns C, Ribel-Madsen R, Newgard CB, Vaag AA.

Physiol Rep. 2016 Dec;4(23). pii: e13044.


Human adipogenesis is associated with genome-wide DNA methylation and gene-expression changes.

Broholm C, Olsson AH, Perfilyev A, Gillberg L, Hansen NS, Ali A, Mortensen B, Ling C, Vaag A.

Epigenomics. 2016 Dec;8(12):1601-1617. Epub 2016 Nov 17.


Impact of the TCF7L2 genotype on risk of hypoglycaemia and glucagon secretion during hypoglycaemia.

Kristensen PL, Pedersen-Bjergaard U, Due-Andersen R, Høi-Hansen T, Grimmeshave L, Lyssenko V, Groop L, Holst JJ, Vaag AA, Thorsteinsson B.

Endocr Connect. 2016 Nov;5(6):53-60. Epub 2016 Oct 10.


Plasma acylcarnitine profiling indicates increased fatty acid oxidation relative to tricarboxylic acid cycle capacity in young, healthy low birth weight men.

Ribel-Madsen A, Ribel-Madsen R, Brøns C, Newgard CB, Vaag AA, Hellgren LI.

Physiol Rep. 2016 Oct;4(19). pii: e12977.


Genome-wide associations for birth weight and correlations with adult disease.

Horikoshi M, Beaumont RN, Day FR, Warrington NM, Kooijman MN, Fernandez-Tajes J, Feenstra B, van Zuydam NR, Gaulton KJ, Grarup N, Bradfield JP, Strachan DP, Li-Gao R, Ahluwalia TS, Kreiner E, Rueedi R, Lyytikäinen LP, Cousminer DL, Wu Y, Thiering E, Wang CA, Have CT, Hottenga JJ, Vilor-Tejedor N, Joshi PK, Boh ETH, Ntalla I, Pitkänen N, Mahajan A, van Leeuwen EM, Joro R, Lagou V, Nodzenski M, Diver LA, Zondervan KT, Bustamante M, Marques-Vidal P, Mercader JM, Bennett AJ, Rahmioglu N, Nyholt DR, Ma RCW, Tam CHT, Tam WH; CHARGE Consortium Hematology Working Group, Ganesh SK, van Rooij FJ, Jones SE, Loh PR, Ruth KS, Tuke MA, Tyrrell J, Wood AR, Yaghootkar H, Scholtens DM, Paternoster L, Prokopenko I, Kovacs P, Atalay M, Willems SM, Panoutsopoulou K, Wang X, Carstensen L, Geller F, Schraut KE, Murcia M, van Beijsterveldt CE, Willemsen G, Appel EVR, Fonvig CE, Trier C, Tiesler CM, Standl M, Kutalik Z, Bonas-Guarch S, Hougaard DM, Sánchez F, Torrents D, Waage J, Hollegaard MV, de Haan HG, Rosendaal FR, Medina-Gomez C, Ring SM, Hemani G, McMahon G, Robertson NR, Groves CJ, Langenberg C, Luan J, Scott RA, Zhao JH, Mentch FD, MacKenzie SM, Reynolds RM; Early Growth Genetics (EGG) Consortium, Lowe WL Jr, Tönjes A, Stumvoll M, Lindi V, Lakka TA, van Duijn CM, Kiess W, Körner A, Sørensen TI, Niinikoski H, Pahkala K, Raitakari OT, Zeggini E, Dedoussis GV, Teo YY, Saw SM, Melbye M, Campbell H, Wilson JF, Vrijheid M, de Geus EJ, Boomsma DI, Kadarmideen HN, Holm JC, Hansen T, Sebert S, Hattersley AT, Beilin LJ, Newnham JP, Pennell CE, Heinrich J, Adair LS, Borja JB, Mohlke KL, Eriksson JG, Widén EE, Kähönen M, Viikari JS, Lehtimäki T, Vollenweider P, Bønnelykke K, Bisgaard H, Mook-Kanamori DO, Hofman A, Rivadeneira F, Uitterlinden AG, Pisinger C, Pedersen O, Power C, Hyppönen E, Wareham NJ, Hakonarson H, Davies E, Walker BR, Jaddoe VW, Jarvelin MR, Grant SF, Vaag AA, Lawlor DA, Frayling TM, Davey Smith G, Morris AP, Ong KK, Felix JF, Timpson NJ, Perry JR, Evans DM, McCarthy MI, Freathy RM.

Nature. 2016 Oct 13;538(7624):248-252. doi: 10.1038/nature19806. Epub 2016 Sep 28.


Epigenetic programming of adipose-derived stem cells in low birthweight individuals.

Broholm C, Olsson AH, Perfilyev A, Hansen NS, Schrölkamp M, Strasko KS, Scheele C, Ribel-Madsen R, Mortensen B, Jørgensen SW, Ling C, Vaag A.

Diabetologia. 2016 Dec;59(12):2664-2673. Epub 2016 Sep 14.


Microchimerism of male origin in a cohort of Danish girls.

Müller AC, Jakobsen MA, Barington T, Vaag AA, Grunnet LG, Olsen SF, Kamper-Jørgensen M.

Chimerism. 2015 Oct 2;6(4):65-71. doi: 10.1080/19381956.2016.1218583. Epub 2016 Aug 11.


DNA methylation and gene expression of HIF3A: cross-tissue validation and associations with BMI and insulin resistance.

Main AM, Gillberg L, Jacobsen AL, Nilsson E, Gjesing AP, Hansen T, Pedersen O, Ribel-Madsen R, Vaag A.

Clin Epigenetics. 2016 Sep 2;8:89. doi: 10.1186/s13148-016-0258-6. eCollection 2016.


Gene Expression and DNA Methylation of PPARGC1A in Muscle and Adipose Tissue From Adult Offspring of Women With Diabetes in Pregnancy.

Kelstrup L, Hjort L, Houshmand-Oeregaard A, Clausen TD, Hansen NS, Broholm C, Borch-Johnsen L, Mathiesen ER, Vaag AA, Damm P.

Diabetes. 2016 Oct;65(10):2900-10. doi: 10.2337/db16-0227. Epub 2016 Jul 7.


Implementation of interval walking training in patients with type 2 diabetes in Denmark: rationale, design, and baseline characteristics.

Ried-Larsen M, Thomsen RW, Berencsi K, Brinkløv CF, Brøns C, Valentiner LS, Karstoft K, Langberg H, Vaag AA, Pedersen BK, Nielsen JS.

Clin Epidemiol. 2016 Jun 8;8:201-9. doi: 10.2147/CLEP.S97303. eCollection 2016.


Rates of Community-based Antibiotic Prescriptions and Hospital-treated Infections in Individuals With and Without Type 2 Diabetes: A Danish Nationwide Cohort Study, 2004-2012.

Mor A, Berencsi K, Nielsen JS, Rungby J, Friborg S, Brandslund I, Christiansen JS, Vaag A, Beck-Nielsen H, Sørensen HT, Thomsen RW.

Clin Infect Dis. 2016 Aug 15;63(4):501-11. doi: 10.1093/cid/ciw345. Epub 2016 Jun 26.


A Genome-Wide mQTL Analysis in Human Adipose Tissue Identifies Genetic Variants Associated with DNA Methylation, Gene Expression and Metabolic Traits.

Volkov P, Olsson AH, Gillberg L, Jørgensen SW, Brøns C, Eriksson KF, Groop L, Jansson PA, Nilsson E, Rönn T, Vaag A, Ling C.

PLoS One. 2016 Jun 20;11(6):e0157776. doi: 10.1371/journal.pone.0157776. eCollection 2016.


Endocrine and metabolic diurnal rhythms in young adult men born small vs appropriate for gestational age.

Brøns C, Saltbæk PN, Friedrichsen M, Chen Y, Vaag A.

Eur J Endocrinol. 2016 Jul;175(1):29-40. doi: 10.1530/EJE-16-0177.


DNA methylation of loci within ABCG1 and PHOSPHO1 in blood DNA is associated with future type 2 diabetes risk.

Dayeh T, Tuomi T, Almgren P, Perfilyev A, Jansson PA, de Mello VD, Pihlajamäki J, Vaag A, Groop L, Nilsson E, Ling C.

Epigenetics. 2016 Jul 2;11(7):482-8. doi: 10.1080/15592294.2016.1178418. Epub 2016 May 5.


Vitamin D fortification and seasonality of birth in type 1 diabetic cases: D-tect study - ERRATUM.

Jacobsen R, Moldovan M, Vaag AA, Hypponen E, Heitmann BL.

J Dev Orig Health Dis. 2016 Aug;7(4):429. doi: 10.1017/S2040174416000155. Epub 2016 Apr 18. No abstract available.


A common variation of the PTEN gene is associated with peripheral insulin resistance.

Grinder-Hansen L, Ribel-Madsen R, Wojtaszewski JF, Poulsen P, Grunnet LG, Vaag A.

Diabetes Metab. 2016 Sep;42(4):280-4. doi: 10.1016/j.diabet.2016.03.003. Epub 2016 Apr 8.


Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes.

Bacos K, Gillberg L, Volkov P, Olsson AH, Hansen T, Pedersen O, Gjesing AP, Eiberg H, Tuomi T, Almgren P, Groop L, Eliasson L, Vaag A, Dayeh T, Ling C.

Nat Commun. 2016 Mar 31;7:11089. doi: 10.1038/ncomms11089.


Metabolic and Transcriptional Changes in Cultured Muscle Stem Cells from Low Birth Weight Subjects.

Hansen NS, Hjort L, Broholm C, Gillberg L, Schrölkamp M, Schultz HS, Mortensen B, Jørgensen SW, Friedrichsen M, Wojtaszewski JF, Pedersen BK, Vaag A.

J Clin Endocrinol Metab. 2016 May;101(5):2254-64. doi: 10.1210/jc.2015-4214. Epub 2016 Mar 22.


EMPA-REG: Glucose excretion and lipid mobilization - not storage - saves lives.

Jørgensen NB, Pedersen J, Vaag AA.

J Diabetes Complications. 2016 May-Jun;30(4):753. doi: 10.1016/j.jdiacomp.2016.02.015. Epub 2016 Feb 23. No abstract available.


Effects of biphasic, basal-bolus or basal insulin analogue treatments on carotid intima-media thickness in patients with type 2 diabetes mellitus: the randomised Copenhagen Insulin and Metformin Therapy (CIMT) trial.

Lundby-Christensen L, Vaag A, Tarnow L, Almdal TP, Lund SS, Wetterslev J, Gluud C, Boesgaard TW, Wiinberg N, Perrild H, Krarup T, Snorgaard O, Gade-Rasmussen B, Thorsteinsson B, Røder M, Mathiesen ER, Jensen T, Vestergaard H, Hedetoft C, Breum L, Duun E, Sneppen SB, Pedersen O, Hemmingsen B, Carstensen B, Madsbad S.

BMJ Open. 2016 Feb 25;6(2):e008377. doi: 10.1136/bmjopen-2015-008377.


Metformin versus placebo in combination with insulin analogues in patients with type 2 diabetes mellitus-the randomised, blinded Copenhagen Insulin and Metformin Therapy (CIMT) trial.

Lundby-Christensen L, Tarnow L, Boesgaard TW, Lund SS, Wiinberg N, Perrild H, Krarup T, Snorgaard O, Gade-Rasmussen B, Thorsteinsson B, Røder M, Mathiesen ER, Jensen T, Vestergaard H, Hedetoft C, Breum L, Duun E, Sneppen SB, Pedersen O, Hemmingsen B, Carstensen B, Madsbad S, Gluud C, Wetterslev J, Vaag A, Almdal TP.

BMJ Open. 2016 Feb 25;6(2):e008376. doi: 10.1136/bmjopen-2015-008376.


Growth and obesity through the first 7 y of life in association with levels of maternal glycemia during pregnancy: a prospective cohort study.

Zhu Y, Olsen SF, Mendola P, Yeung EH, Vaag A, Bowers K, Liu A, Bao W, Li S, Madsen C, Grunnet LG, Granström C, Hansen S, Martin K, Chavarro JE, Hu FB, Langhoff-Roos J, Damm P, Zhang C.

Am J Clin Nutr. 2016 Mar;103(3):794-800. doi: 10.3945/ajcn.115.121780. Epub 2016 Jan 27.


Adipose tissue transcriptomics and epigenomics in low birthweight men and controls: role of high-fat overfeeding.

Gillberg L, Perfilyev A, Brøns C, Thomasen M, Grunnet LG, Volkov P, Rosqvist F, Iggman D, Dahlman I, Risérus U, Rönn T, Nilsson E, Vaag A, Ling C.

Diabetologia. 2016 Apr;59(4):799-812. doi: 10.1007/s00125-015-3852-9. Epub 2016 Jan 11.


Parental smoking during pregnancy and the risk of gestational diabetes in the daughter.

Bao W, Michels KB, Tobias DK, Li S, Chavarro JE, Gaskins AJ, Vaag AA, Hu FB, Zhang C.

Int J Epidemiol. 2016 Feb;45(1):160-9. doi: 10.1093/ije/dyv334. Epub 2016 Jan 9.


Head-to-head comparison of intensive lifestyle intervention (U-TURN) versus conventional multifactorial care in patients with type 2 diabetes: protocol and rationale for an assessor-blinded, parallel group and randomised trial.

Ried-Larsen M, Christensen R, Hansen KB, Johansen MY, Pedersen M, Zacho M, Hansen LS, Kofoed K, Thomsen K, Jensen MS, Nielsen RO, MacDonald C, Langberg H, Vaag AA, Pedersen BK, Karstoft K.

BMJ Open. 2015 Dec 9;5(12):e009764. doi: 10.1136/bmjopen-2015-009764.


Vitamin D fortification and seasonality of birth in type 1 diabetic cases: D-tect study.

Jacobsen R, Moldovan M, Vaag AA, Hypponen E, Heitmann BL.

J Dev Orig Health Dis. 2016 Feb;7(1):114-9. doi: 10.1017/S2040174415007849. Epub 2015 Oct 27.


Association of parental history of type 2 diabetes with age, lifestyle, anthropometric factors, and clinical severity at type 2 diabetes diagnosis: results from the DD2 study.

Svensson E, Berencsi K, Sander S, Mor A, Rungby J, Nielsen JS, Friborg S, Brandslund I, Christiansen JS, Vaag A, Beck-Nielsen H, Sørensen HT, Thomsen RW.

Diabetes Metab Res Rev. 2016 Mar;32(3):308-15. doi: 10.1002/dmrr.2721. Epub 2015 Nov 6.


Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB.

Berglund LM, Lyssenko V, Ladenvall C, Kotova O, Edsfeldt A, Pilgaard K, Alkayyali S, Brøns C, Forsblom C, Jonsson A, Zetterqvist AV, Nitulescu M, McDavitt CR, Dunér P, Stancáková A, Kuusisto J, Ahlqvist E, Lajer M, Tarnow L, Madsbad S, Rossing P, Kieffer TJ, Melander O, Orho-Melander M, Nilsson P, Groop PH, Vaag A, Lindblad B, Gottsäter A, Laakso M, Goncalves I, Groop L, Gomez MF.

Diabetes. 2016 Jan;65(1):239-54. doi: 10.2337/db15-0122. Epub 2015 Sep 22.


Disproportionately increased 24-h energy expenditure and fat oxidation in young men with low birth weight during a high-fat overfeeding challenge.

Brøns C, Lilleøre SK, Astrup A, Vaag A.

Eur J Nutr. 2016 Sep;55(6):2045-52. doi: 10.1007/s00394-015-1018-7. Epub 2015 Aug 22.


WITHDRAWN: Sulphonylurea monotherapy for patients with type 2 diabetes mellitus.

Hemmingsen B, Schroll JB, Lund SS, Wetterslev J, Gluud C, Vaag A, Sonne DP, Lundstrøm LH, Almdal TP.

Cochrane Database Syst Rev. 2015 Jul 29;(7):CD009008. doi: 10.1002/14651858.CD009008.pub3. No abstract available.


WITHDRAWN: Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes mellitus.

Hemmingsen B, Lund SS, Gluud C, Vaag A, Almdal TP, Wetterslev J.

Cochrane Database Syst Rev. 2015 Jul 29;(7):CD008143. doi: 10.1002/14651858.CD008143.pub4. No abstract available.


Are hepatic and soleus lipid content, assessed by magnetic resonance spectroscopy, associated with low birth weight or insulin resistance in a rural Indian population of healthy young men?

Livingstone RS, Grunnet LG, Thomas N, Eapen A, Antonisamy B, Mohan VR, Spurgeon R, Frank ID, Bygbjerg IC, Vaag A.

Diabet Med. 2016 Mar;33(3):365-70. doi: 10.1111/dme.12852. Epub 2015 Aug 18.


Impaired cerebral blood flow and oxygenation during exercise in type 2 diabetic patients.

Kim YS, Seifert T, Brassard P, Rasmussen P, Vaag A, Nielsen HB, Secher NH, van Lieshout JJ.

Physiol Rep. 2015 Jun;3(6). pii: e12430. doi: 10.14814/phy2.12430.


No evidence of seasonality of birth in adult type 2 diabetes in Denmark.

Jensen CB, Zimmermann E, Gamborg M, Heitmann BL, Baker JL, Vaag A, Sørensen TI.

Diabetologia. 2015 Sep;58(9):2045-50. doi: 10.1007/s00125-015-3661-1. Epub 2015 Jun 16.


Prescribing practices and clinical predictors of glucose-lowering therapy within the first year in people with newly diagnosed Type 2 diabetes.

Mor A, Berencsi K, Svensson E, Rungby J, Nielsen JS, Friborg S, Brandslund I, Christiansen JS, Vaag A, Beck-Nielsen H, Sørensen HT, Thomsen RW.

Diabet Med. 2015 Dec;32(12):1546-54. doi: 10.1111/dme.12819. Epub 2015 Jul 3.


Gestational and Early Infancy Exposure to Margarine Fortified with Vitamin D through a National Danish Programme and the Risk of Type 1 Diabetes: The D-Tect Study.

Jacobsen R, Hypponen E, Sørensen TI, Vaag AA, Heitmann BL.

PLoS One. 2015 Jun 1;10(6):e0128631. doi: 10.1371/journal.pone.0128631. eCollection 2015.


Prevalence and risk factors of gestational diabetes in Punjab, North India: results from a population screening program.

Arora GP, Thaman RG, Prasad RB, Almgren P, Brøns C, Groop LC, Vaag AA.

Eur J Endocrinol. 2015 Aug;173(2):257-67. doi: 10.1530/EJE-14-0428. Epub 2015 May 26.


Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood.

Rönn T, Volkov P, Gillberg L, Kokosar M, Perfilyev A, Jacobsen AL, Jørgensen SW, Brøns C, Jansson PA, Eriksson KF, Pedersen O, Hansen T, Groop L, Stener-Victorin E, Vaag A, Nilsson E, Ling C.

Hum Mol Genet. 2015 Jul 1;24(13):3792-813. doi: 10.1093/hmg/ddv124. Epub 2015 Apr 10.


Long-term risk of type 2 diabetes mellitus in relation to BMI and weight change among women with a history of gestational diabetes mellitus: a prospective cohort study.

Bao W, Yeung E, Tobias DK, Hu FB, Vaag AA, Chavarro JE, Mills JL, Grunnet LG, Bowers K, Ley SH, Kiely M, Olsen SF, Zhang C.

Diabetologia. 2015 Jun;58(6):1212-9. doi: 10.1007/s00125-015-3537-4. Epub 2015 Mar 22.


Effects of an outdoor bicycle-based intervention in healthy rural Indian men with normal and low birth weight.

Madsen C, Mogensen P, Thomas N, Christensen DL, Bygbjerg IC, Mohan V, Inbakumari M, Nadig SV, Alex R, Geetanjali FS, Westgate K, Brage S, Vaag A, Grunnet LG.

J Dev Orig Health Dis. 2015 Feb;6(1):27-37. doi: 10.1017/S2040174414000609. Epub 2014 Dec 17.


Metformin in combination with various insulin secretagogues in type 2 diabetes and associated risk of cardiovascular morbidity and mortality--a retrospective nationwide study.

Mogensen UM, Andersson C, Fosbøl EL, Schramm TK, Vaag A, Scheller NM, Torp-Pedersen C, Gislason G, Køber L.

Diabetes Res Clin Pract. 2015 Jan;107(1):104-12. doi: 10.1016/j.diabres.2014.09.047. Epub 2014 Oct 7.


Glucose tolerance is associated with differential expression of microRNAs in skeletal muscle: results from studies of twins with and without type 2 diabetes.

Bork-Jensen J, Scheele C, Christophersen DV, Nilsson E, Friedrichsen M, Fernandez-Twinn DS, Grunnet LG, Litman T, Holmstrøm K, Vind B, Højlund K, Beck-Nielsen H, Wojtaszewski J, Ozanne SE, Pedersen BK, Poulsen P, Vaag A.

Diabetologia. 2015 Feb;58(2):363-73. doi: 10.1007/s00125-014-3434-2. Epub 2014 Nov 19.


Erratum to: Metabolic response to 36 hours of fasting in young men born small vs appropriate for gestational age.

Jørgensen SW, Brøns C, Bluck L, Hjort L, Færch K, Thankamony A, Gillberg L, Friedrichsen M, Dunger DB, Vaag AA.

Diabetologia. 2015 Jan;58(1):204. doi: 10.1007/s00125-014-3432-4. No abstract available.


Insulin is not insulin and a unit not a unit.

Vaag A.

Diabetes Obes Metab. 2015 Mar;17(3):217-8. doi: 10.1111/dom.12404. Review. No abstract available.


Sulfonylurea versus metformin monotherapy in patients with type 2 diabetes: a Cochrane systematic review and meta-analysis of randomized clinical trials and trial sequential analysis.

Hemmingsen B, Schroll JB, Wetterslev J, Gluud C, Vaag A, Sonne DP, Lundstrøm LH, Almdal T.

CMAJ Open. 2014 Jul 22;2(3):E162-75. doi: 10.9778/cmajo.20130073. eCollection 2014 Jul.


Metabolic response to 36 hours of fasting in young men born small vs appropriate for gestational age.

Jørgensen SW, Brøns C, Bluck L, Hjort L, Færch K, Thankamony A, Gillberg L, Friedrichsen M, Dunger DB, Vaag AA.

Diabetologia. 2015 Jan;58(1):178-87. doi: 10.1007/s00125-014-3406-6. Epub 2014 Oct 7. Erratum in: Diabetologia. 2015 Jan;58(1):204.


Sulfonylurea in combination with insulin is associated with increased mortality compared with a combination of insulin and metformin in a retrospective Danish nationwide study.

Mogensen UM, Andersson C, Fosbøl EL, Schramm TK, Vaag A, Scheller NM, Torp-Pedersen C, Gislason G, Køber L.

Diabetologia. 2015 Jan;58(1):50-8. doi: 10.1007/s00125-014-3372-z. Epub 2014 Sep 10.


DD2 - nye veje i behandlingen af type 2-diabetes.

Nielsen JS, Rungby J, Christiansen JS, Vaag A, Friborg S, Sørensen HT, Beck-Nielsen H.

Ugeskr Laeger. 2014 Jun 2;176(11A). pii: V66222. Danish. No abstract available.


Genetic, nongenetic and epigenetic risk determinants in developmental programming of type 2 diabetes.

Vaag A, Brøns C, Gillberg L, Hansen NS, Hjort L, Arora GP, Thomas N, Broholm C, Ribel-Madsen R, Grunnet LG.

Acta Obstet Gynecol Scand. 2014 Nov;93(11):1099-108. doi: 10.1111/aogs.12494. Epub 2014 Sep 30. Review.


Targeting intensive versus conventional glycaemic control for type 1 diabetes mellitus: a systematic review with meta-analyses and trial sequential analyses of randomised clinical trials.

Kähler P, Grevstad B, Almdal T, Gluud C, Wetterslev J, Lund SS, Vaag A, Hemmingsen B.

BMJ Open. 2014 Aug 19;4(8):e004806. doi: 10.1136/bmjopen-2014-004806. Review. Erratum in: BMJ Open. 2015;5(6):e004806corr1. Lund, Søren Søgaard [added].


Genetic versus Non-Genetic Regulation of miR-103, miR-143 and miR-483-3p Expression in Adipose Tissue and Their Metabolic Implications-A Twin Study.

Bork-Jensen J, Thuesen AC, Bang-Bertelsen CH, Grunnet LG, Pociot F, Beck-Nielsen H, Ozanne SE, Poulsen P, Vaag A.

Genes (Basel). 2014 Jul 9;5(3):508-17. doi: 10.3390/genes5030508.


CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients.

Fløyel T, Brorsson C, Nielsen LB, Miani M, Bang-Berthelsen CH, Friedrichsen M, Overgaard AJ, Berchtold LA, Wiberg A, Poulsen P, Hansen L, Rosinger S, Boehm BO, Ram R, Nguyen Q, Mehta M, Morahan G, Concannon P, Bergholdt R, Nielsen JH, Reinheckel T, von Herrath M, Vaag A, Eizirik DL, Mortensen HB, Størling J, Pociot F.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10305-10. doi: 10.1073/pnas.1402571111. Epub 2014 Jun 30.


Association of heart failure severity with risk of diabetes: a Danish nationwide cohort study.

Demant MN, Gislason GH, Køber L, Vaag A, Torp-Pedersen C, Andersson C.

Diabetologia. 2014 Aug;57(8):1595-600. doi: 10.1007/s00125-014-3259-z. Epub 2014 May 22.


Physical activity and sedentary behaviors associated with risk of progression from gestational diabetes mellitus to type 2 diabetes mellitus: a prospective cohort study.

Bao W, Tobias DK, Bowers K, Chavarro J, Vaag A, Grunnet LG, Strøm M, Mills J, Liu A, Kiely M, Zhang C.

JAMA Intern Med. 2014 Jul;174(7):1047-55. doi: 10.1001/jamainternmed.2014.1795.


Rationale, design, and method of the Diabetes & Women's Health study--a study of long-term health implications of glucose intolerance in pregnancy and their determinants.

Zhang C, Hu FB, Olsen SF, Vaag A, Gore-Langton R, Chavarro JE, Bao W, Yeung E, Bowers K, Grunnet LG, Sherman S, Kiely M, Strøm M, Hansen S, Liu A, Mills J, Fan R; DWH study team.

Acta Obstet Gynecol Scand. 2014 Nov;93(11):1123-30. doi: 10.1111/aogs.12425. Epub 2014 Jun 9.


Cardiovascular safety of combination therapies with incretin-based drugs and metformin compared with a combination of metformin and sulphonylurea in type 2 diabetes mellitus--a retrospective nationwide study.

Mogensen UM, Andersson C, Fosbøl EL, Schramm TK, Vaag A, Scheller NM, Torp-Pedersen C, Gislason G, Køber L.

Diabetes Obes Metab. 2014 Oct;16(10):1001-8. doi: 10.1111/dom.12314. Epub 2014 Jun 9.


Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes.

Nilsson E, Jansson PA, Perfilyev A, Volkov P, Pedersen M, Svensson MK, Poulsen P, Ribel-Madsen R, Pedersen NL, Almgren P, Fadista J, Rönn T, Klarlund Pedersen B, Scheele C, Vaag A, Ling C.

Diabetes. 2014 Sep;63(9):2962-76. doi: 10.2337/db13-1459. Epub 2014 May 8.


Prepregnancy low-carbohydrate dietary pattern and risk of gestational diabetes mellitus: a prospective cohort study.

Bao W, Bowers K, Tobias DK, Olsen SF, Chavarro J, Vaag A, Kiely M, Zhang C.

Am J Clin Nutr. 2014 Jun;99(6):1378-84. doi: 10.3945/ajcn.113.082966. Epub 2014 Apr 9.


Carotid intima-media thickness is reduced 12 months after gastric bypass surgery in obese patients with type 2 diabetes or impaired glucose tolerance.

Lundby-Christensen L, Tarnow L, Hansen DL, Worm D, Naver LS, Hvolris LE, Wiinberg N, Vaag A, Almdal TP.

J Diabetes Complications. 2014 Jul-Aug;28(4):517-22. doi: 10.1016/j.jdiacomp.2014.03.005. Epub 2014 Mar 12.


Low circulating levels of IGF-1 in healthy adults are associated with reduced β-cell function, increased intramyocellular lipid, and enhanced fat utilization during fasting.

Thankamony A, Capalbo D, Marcovecchio ML, Sleigh A, Jørgensen SW, Hill NR, Mooslehner K, Yeo GS, Bluck L, Juul A, Vaag A, Dunger DB.

J Clin Endocrinol Metab. 2014 Jun;99(6):2198-207. doi: 10.1210/jc.2013-4542. Epub 2014 Mar 11.


Young men with low birthweight exhibit decreased plasticity of genome-wide muscle DNA methylation by high-fat overfeeding.

Jacobsen SC, Gillberg L, Bork-Jensen J, Ribel-Madsen R, Lara E, Calvanese V, Ling C, Fernandez AF, Fraga MF, Poulsen P, Brøns C, Vaag A.

Diabetologia. 2014 Jun;57(6):1154-8. doi: 10.1007/s00125-014-3198-8. Epub 2014 Feb 26.


Pre-natal undernutrition and post-natal overnutrition are associated with permanent changes in hepatic metabolism markers and fatty acid composition in sheep.

Hou L, Hellgren LI, Kongsted AH, Vaag A, Nielsen MO.

Acta Physiol (Oxf). 2014 Feb;210(2):317-29. doi: 10.1111/apha.12211. Epub 2013 Dec 27.


PPARGC1A DNA methylation in subcutaneous adipose tissue in low birth weight subjects--impact of 5 days of high-fat overfeeding.

Gillberg L, Jacobsen SC, Rönn T, Brøns C, Vaag A.

Metabolism. 2014 Feb;63(2):263-71. doi: 10.1016/j.metabol.2013.10.003. Epub 2013 Oct 23.


Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes mellitus.

Hemmingsen B, Lund SS, Gluud C, Vaag A, Almdal TP, Hemmingsen C, Wetterslev J.

Cochrane Database Syst Rev. 2013 Nov 11;(11):CD008143. doi: 10.1002/14651858.CD008143.pub3. Review. Update in: Cochrane Database Syst Rev. 2015;(7):CD008143.


Subclinical inflammation during third trimester of pregnancy was not associated with markers of the metabolic syndrome in young adult offspring.

Danielsen I, Granström C, Rytter D, Halldorsson TI, Bech BH, Henriksen TB, Stehouwer CD, Schalkwijk CG, Vaag AA, Olsen SF.

Obesity (Silver Spring). 2014 May;22(5):1351-8. doi: 10.1002/oby.20650. Epub 2013 Dec 5.


Physical inactivity affects skeletal muscle insulin signaling in a birth weight-dependent manner.

Mortensen B, Friedrichsen M, Andersen NR, Alibegovic AC, Højbjerre L, Sonne MP, Stallknecht B, Dela F, Wojtaszewski JF, Vaag A.

J Diabetes Complications. 2014 Jan-Feb;28(1):71-8. doi: 10.1016/j.jdiacomp.2013.09.002. Epub 2013 Oct 10.


Treating allergic rhinitis with depot-steroid injections increase risk of osteoporosis and diabetes.

Aasbjerg K, Torp-Pedersen C, Vaag A, Backer V.

Respir Med. 2013 Dec;107(12):1852-8. doi: 10.1016/j.rmed.2013.09.007. Epub 2013 Sep 20.


Impaired leptin gene expression and release in cultured preadipocytes isolated from individuals born with low birth weight.

Schultz NS, Broholm C, Gillberg L, Mortensen B, Jørgensen SW, Schultz HS, Scheele C, Wojtaszewski JF, Pedersen BK, Vaag A.

Diabetes. 2014 Jan;63(1):111-21. doi: 10.2337/db13-0621. Epub 2013 Sep 23.


All-cause mortality and cardiovascular effects associated with the DPP-IV inhibitor sitagliptin compared with metformin, a retrospective cohort study on the Danish population.

Scheller NM, Mogensen UM, Andersson C, Vaag A, Torp-Pedersen C.

Diabetes Obes Metab. 2014 Mar;16(3):231-6. doi: 10.1111/dom.12197. Epub 2013 Sep 10.


Insulin resistance and impaired pancreatic β-cell function in adult offspring of women with diabetes in pregnancy.

Kelstrup L, Damm P, Mathiesen ER, Hansen T, Vaag AA, Pedersen O, Clausen TD.

J Clin Endocrinol Metab. 2013 Sep;98(9):3793-801. doi: 10.1210/jc.2013-1536. Epub 2013 Jun 24.


Pre- and early-postnatal nutrition modify gene and protein expressions of muscle energy metabolism markers and phospholipid Fatty Acid composition in a muscle type specific manner in sheep.

Hou L, Kongsted AH, Ghoreishi SM, Takhtsabzy TK, Friedrichsen M, Hellgren LI, Kadarmideen HN, Vaag A, Nielsen MO.

PLoS One. 2013 Jun 6;8(6):e65452. doi: 10.1371/journal.pone.0065452. Print 2013.


Dietary glycemic index during pregnancy is associated with biomarkers of the metabolic syndrome in offspring at age 20 years.

Danielsen I, Granström C, Haldorsson T, Rytter D, Hammer Bech B, Henriksen TB, Vaag AA, Olsen SF.

PLoS One. 2013 May 31;8(5):e64887. doi: 10.1371/journal.pone.0064887. Print 2013.


The influence of early exposure to vitamin D for development of diseases later in life.

Jacobsen R, Abrahamsen B, Bauerek M, Holst C, Jensen CB, Knop J, Raymond K, Rasmussen LB, Stougaard M, Sørensen TI, Vaag AA, Heitmann BL.

BMC Public Health. 2013 May 28;13:515. doi: 10.1186/1471-2458-13-515.


Does physical activity during pregnancy adversely influence markers of the metabolic syndrome in adult offspring? A prospective study over two decades.

Danielsen I, Granström C, Rytter D, Hammer Bech B, Brink Henriksen T, Vaag AA, Olsen SF.

J Epidemiol Community Health. 2013 Aug;67(8):648-54. doi: 10.1136/jech-2012-202017. Epub 2013 May 16.


Sulphonylurea monotherapy for patients with type 2 diabetes mellitus.

Hemmingsen B, Schroll JB, Lund SS, Wetterslev J, Gluud C, Vaag A, Sonne DP, Lundstrøm LH, Almdal T.

Cochrane Database Syst Rev. 2013 Apr 30;(4):CD009008. doi: 10.1002/14651858.CD009008.pub2. Review. Update in: Cochrane Database Syst Rev. 2015;(7):CD009008.


Effect of birth weight and 12 weeks of exercise training on exercise-induced AMPK signaling in human skeletal muscle.

Mortensen B, Hingst JR, Frederiksen N, Hansen RW, Christiansen CS, Iversen N, Friedrichsen M, Birk JB, Pilegaard H, Hellsten Y, Vaag A, Wojtaszewski JF.

Am J Physiol Endocrinol Metab. 2013 Jun 15;304(12):E1379-90. doi: 10.1152/ajpendo.00295.2012. Epub 2013 Apr 23.


Does DNA methylation of PPARGC1A influence insulin action in first degree relatives of patients with type 2 diabetes?

Gillberg L, Jacobsen SC, Ribel-Madsen R, Gjesing AP, Boesgaard TW, Ling C, Pedersen O, Hansen T, Vaag A.

PLoS One. 2013;8(3):e58384. doi: 10.1371/journal.pone.0058384. Epub 2013 Mar 7. Erratum in: PLoS One. 2013;8(6). doi:10.1371/annotation/5c3cf392-57b5-4e80-9a66-4997d10200ae. Jacobsen, Stine [corrected to Jacobsen, Stine C].


Carboxylesterase 1 gene duplication and mRNA expression in adipose tissue are linked to obesity and metabolic function.

Friedrichsen M, Poulsen P, Wojtaszewski J, Hansen PR, Vaag A, Rasmussen HB.

PLoS One. 2013;8(2):e56861. doi: 10.1371/journal.pone.0056861. Epub 2013 Feb 28.


Link between GIP and osteopontin in adipose tissue and insulin resistance.

Ahlqvist E, Osmark P, Kuulasmaa T, Pilgaard K, Omar B, Brøns C, Kotova O, Zetterqvist AV, Stancáková A, Jonsson A, Hansson O, Kuusisto J, Kieffer TJ, Tuomi T, Isomaa B, Madsbad S, Gomez MF, Poulsen P, Laakso M, Degerman E, Pihlajamäki J, Wierup N, Vaag A, Groop L, Lyssenko V.

Diabetes. 2013 Jun;62(6):2088-94. doi: 10.2337/db12-0976. Epub 2013 Jan 24.


Increased nocturnal fat oxidation in young healthy men with low birth weight: results from 24-h whole-body respiratory chamber measurements.

Brøns C, Lilleøre SK, Jensen CB, Toubro S, Vaag A, Astrup A.

Metabolism. 2013 May;62(5):709-16. doi: 10.1016/j.metabol.2012.12.002. Epub 2013 Jan 18.


Akt2 influences glycogen synthase activity in human skeletal muscle through regulation of NH₂-terminal (sites 2 + 2a) phosphorylation.

Friedrichsen M, Birk JB, Richter EA, Ribel-Madsen R, Pehmøller C, Hansen BF, Beck-Nielsen H, Hirshman MF, Goodyear LJ, Vaag A, Poulsen P, Wojtaszewski JF.

Am J Physiol Endocrinol Metab. 2013 Mar 15;304(6):E631-9. doi: 10.1152/ajpendo.00494.2012. Epub 2013 Jan 15.


Genome-wide analysis of DNA methylation differences in muscle and fat from monozygotic twins discordant for type 2 diabetes.

Ribel-Madsen R, Fraga MF, Jacobsen S, Bork-Jensen J, Lara E, Calvanese V, Fernandez AF, Friedrichsen M, Vind BF, Højlund K, Beck-Nielsen H, Esteller M, Vaag A, Poulsen P.

PLoS One. 2012;7(12):e51302. doi: 10.1371/journal.pone.0051302. Epub 2012 Dec 10.


New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.

Horikoshi M, Yaghootkar H, Mook-Kanamori DO, Sovio U, Taal HR, Hennig BJ, Bradfield JP, St Pourcain B, Evans DM, Charoen P, Kaakinen M, Cousminer DL, Lehtimäki T, Kreiner-Møller E, Warrington NM, Bustamante M, Feenstra B, Berry DJ, Thiering E, Pfab T, Barton SJ, Shields BM, Kerkhof M, van Leeuwen EM, Fulford AJ, Kutalik Z, Zhao JH, den Hoed M, Mahajan A, Lindi V, Goh LK, Hottenga JJ, Wu Y, Raitakari OT, Harder MN, Meirhaeghe A, Ntalla I, Salem RM, Jameson KA, Zhou K, Monies DM, Lagou V, Kirin M, Heikkinen J, Adair LS, Alkuraya FS, Al-Odaib A, Amouyel P, Andersson EA, Bennett AJ, Blakemore AI, Buxton JL, Dallongeville J, Das S, de Geus EJ, Estivill X, Flexeder C, Froguel P, Geller F, Godfrey KM, Gottrand F, Groves CJ, Hansen T, Hirschhorn JN, Hofman A, Hollegaard MV, Hougaard DM, Hyppönen E, Inskip HM, Isaacs A, Jørgensen T, Kanaka-Gantenbein C, Kemp JP, Kiess W, Kilpeläinen TO, Klopp N, Knight BA, Kuzawa CW, McMahon G, Newnham JP, Niinikoski H, Oostra BA, Pedersen L, Postma DS, Ring SM, Rivadeneira F, Robertson NR, Sebert S, Simell O, Slowinski T, Tiesler CM, Tönjes A, Vaag A, Viikari JS, Vink JM, Vissing NH, Wareham NJ, Willemsen G, Witte DR, Zhang H, Zhao J; Meta-Analyses of Glucose- and Insulin-related traits Consortium (MAGIC), Wilson JF, Stumvoll M, Prentice AM, Meyer BF, Pearson ER, Boreham CA, Cooper C, Gillman MW, Dedoussis GV, Moreno LA, Pedersen O, Saarinen M, Mohlke KL, Boomsma DI, Saw SM, Lakka TA, Körner A, Loos RJ, Ong KK, Vollenweider P, van Duijn CM, Koppelman GH, Hattersley AT, Holloway JW, Hocher B, Heinrich J, Power C, Melbye M, Guxens M, Pennell CE, Bønnelykke K, Bisgaard H, Eriksson JG, Widén E, Hakonarson H, Uitterlinden AG, Pouta A, Lawlor DA, Smith GD, Frayling TM, McCarthy MI, Grant SF, Jaddoe VW, Jarvelin MR, Timpson NJ, Prokopenko I, Freathy RM; Early Growth Genetics (EGG) Consortium.

Nat Genet. 2013 Jan;45(1):76-82. doi: 10.1038/ng.2477. Epub 2012 Dec 2.


The Danish national type 2 diabetes cohort - the DD2 study.

Sørensen HT, Friborg S, Rungby J, Christensen JS, Vaag A, Beck-Nielsen H.

Clin Epidemiol. 2012;4(Suppl 1):1-5. doi: 10.2147/CLEP.S31104. Epub 2012 Sep 21. No abstract available. Erratum in: Clin Epidemiol. 2012;4:49.


The Danish Centre for Strategic Research in Type 2 Diabetes (DD2) study: expected outcome from the DD2 project and two intervention studies.

Beck-Nielsen H, Solomon TP, Lauridsen J, Karstoft K, Pedersen BK, Johnsen SP, Nielsen JS, Kryger TB, Sortsø C, Vaag A.

Clin Epidemiol. 2012;4(Suppl 1):21-6. doi: 10.2147/CLEP.S30655. Epub 2012 Sep 21.


The Danish Centre for Strategic Research in Type 2 Diabetes (DD2) Project: rationale and planned nationwide studies of genetic predictors, physical exercise, and individualized pharmacological treatment.

Steffensen C, Thomsen RW, Vaag A, Beck-Nielsen H, Christiansen JS, Hansen T, Pedersen O, Rungby J.

Clin Epidemiol. 2012;4(Suppl 1):7-13. doi: 10.2147/CLEP.S30188. Epub 2012 Sep 21.


The triglyceride content in skeletal muscle is associated with hepatic but not peripheral insulin resistance in elderly twins.

Grunnet LG, Laurila E, Hansson O, Almgren P, Groop L, Brøns C, Poulsen P, Vaag A.

J Clin Endocrinol Metab. 2012 Dec;97(12):4571-7. doi: 10.1210/jc.2012-2061. Epub 2012 Oct 9.


Effects of 12 weeks' treatment with a proton pump inhibitor on insulin secretion, glucose metabolism and markers of cardiovascular risk in patients with type 2 diabetes: a randomised double-blind prospective placebo-controlled study.

Hove KD, Brøns C, Færch K, Lund SS, Petersen JS, Karlsen AE, Rossing P, Rehfeld JF, Vaag A.

Diabetologia. 2013 Jan;56(1):22-30. doi: 10.1007/s00125-012-2714-y. Epub 2012 Sep 26.


[Type 2 diabetes--a heterogeneous disease with a foetal predisposition].

Vaag A.

Ugeskr Laeger. 2012 Sep 10;174(37):2138-42. Danish.


Muscle inflammatory signaling in response to 9 days of physical inactivity in young men with low compared with normal birth weight.

Friedrichsen M, Ribel-Madsen R, Mortensen B, Hansen CN, Alibegovic AC, Højbjerre L, Sonne MP, Wojtaszewski JF, Stallknecht B, Dela F, Vaag A.

Eur J Endocrinol. 2012 Dec;167(6):829-38. doi: 10.1530/EJE-12-0498. Epub 2012 Sep 11.


Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skeletal muscle of healthy young men.

Jacobsen SC, Brøns C, Bork-Jensen J, Ribel-Madsen R, Yang B, Lara E, Hall E, Calvanese V, Nilsson E, Jørgensen SW, Mandrup S, Ling C, Fernandez AF, Fraga MF, Poulsen P, Vaag A.

Diabetologia. 2012 Dec;55(12):3341-9. doi: 10.1007/s00125-012-2717-8. Epub 2012 Sep 8.


The PNPLA3 rs738409 G-allele associates with reduced fasting serum triglyceride and serum cholesterol in Danes with impaired glucose regulation.

Krarup NT, Grarup N, Banasik K, Friedrichsen M, Færch K, Sandholt CH, Jørgensen T, Poulsen P, Witte DR, Vaag A, Sørensen T, Pedersen O, Hansen T.

PLoS One. 2012;7(7):e40376. doi: 10.1371/journal.pone.0040376. Epub 2012 Jul 5.


Increased serum concentrations of persistent organic pollutants among prediabetic individuals: potential role of altered substrate oxidation patterns.

Færch K, Højlund K, Vind BF, Vaag A, Dalgård C, Nielsen F, Grandjean P.

J Clin Endocrinol Metab. 2012 Sep;97(9):E1705-13. doi: 10.1210/jc.2012-1342. Epub 2012 Jun 26.


Risk of cancer in patients using glucose-lowering agents: a nationwide cohort study of 3.6 million people.

Andersson C, Vaag A, Selmer C, Schmiegelow M, Sørensen R, Lindhardsen J, Gislason GH, Køber L, Torp-Pedersen C.

BMJ Open. 2012 Jun 8;2(3). pii: e000433. doi: 10.1136/bmjopen-2011-000433. Print 2012.


Comparison of a soluble co-formulation of insulin degludec/insulin aspart vs biphasic insulin aspart 30 in type 2 diabetes: a randomised trial.

Niskanen L, Leiter LA, Franek E, Weng J, Damci T, Muñoz-Torres M, Donnet JP, Endahl L, Skjøth TV, Vaag A.

Eur J Endocrinol. 2012 Aug;167(2):287-94. doi: 10.1530/EJE-12-0293. Epub 2012 Jun 1. Erratum in: Eur J Endocrinol. 2012 Sep;167(3):453.


The thrifty phenotype hypothesis revisited.

Vaag AA, Grunnet LG, Arora GP, Brøns C.

Diabetologia. 2012 Aug;55(8):2085-8. doi: 10.1007/s00125-012-2589-y. Epub 2012 May 30.


Impact of short-term high-fat feeding and insulin-stimulated FGF21 levels in subjects with low birth weight and controls.

Vienberg SG, Brøns C, Nilsson E, Astrup A, Vaag A, Andersen B.

Eur J Endocrinol. 2012 Jul;167(1):49-57. doi: 10.1530/EJE-12-0039. Epub 2012 Apr 23.


Comparison of metformin and insulin versus insulin alone for type 2 diabetes: systematic review of randomised clinical trials with meta-analyses and trial sequential analyses.

Hemmingsen B, Christensen LL, Wetterslev J, Vaag A, Gluud C, Lund SS, Almdal T.

BMJ. 2012 Apr 19;344:e1771. doi: 10.1136/bmj.e1771. Review.


Timing of inter-generational prevention of adiposity and type 2 diabetes.

Vaag A, Arora GP, Thaman RG.

J Physiol. 2012 Mar 1;590(5):1021-2. doi: 10.1113/jphysiol.2012.227371. No abstract available.


Born with low birth weight in rural Southern India: what are the metabolic consequences 20 years later?

Thomas N, Grunnet LG, Poulsen P, Christopher S, Spurgeon R, Inbakumari M, Livingstone R, Alex R, Mohan VR, Antonisamy B, Geethanjali FS, Karol R, Vaag A, Bygbjerg IC.

Eur J Endocrinol. 2012 Apr;166(4):647-55. doi: 10.1530/EJE-11-0870. Epub 2012 Jan 16.


Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes.

Ferland-McCollough D, Fernandez-Twinn DS, Cannell IG, David H, Warner M, Vaag AA, Bork-Jensen J, Brøns C, Gant TW, Willis AE, Siddle K, Bushell M, Ozanne SE.

Cell Death Differ. 2012 Jun;19(6):1003-12. doi: 10.1038/cdd.2011.183. Epub 2012 Jan 6.


Impact of circulating vaspin levels on metabolic variables in elderly twins.

Hida K, Poulsen P, Teshigawara S, Nilsson E, Friedrichsen M, Ribel-Madsen R, Grunnet L, Lund SS, Wada J, Vaag A.

Diabetologia. 2012 Feb;55(2):530-2. doi: 10.1007/s00125-011-2385-0. Epub 2011 Nov 25. No abstract available.


Intensive glycaemic control for patients with type 2 diabetes: systematic review with meta-analysis and trial sequential analysis of randomised clinical trials.

Hemmingsen B, Lund SS, Gluud C, Vaag A, Almdal T, Hemmingsen C, Wetterslev J.

BMJ. 2011 Nov 24;343:d6898. doi: 10.1136/bmj.d6898. Review.


The birth weight lowering C-allele of rs900400 near LEKR1 and CCNL1 associates with elevated insulin release following an oral glucose challenge.

Andersson EA, Harder MN, Pilgaard K, Pisinger C, Stančáková A, Kuusisto J, Grarup N, Færch K, Poulsen P, Witte DR, Jørgensen T, Vaag A, Laakso M, Pedersen O, Hansen T.

PLoS One. 2011;6(11):e27096. doi: 10.1371/journal.pone.0027096. Epub 2011 Nov 4.


Insulin initiation in patients with type 2 diabetes mellitus: treatment guidelines, clinical evidence and patterns of use of basal vs premixed insulin analogues.

Vaag A, Lund SS.

Eur J Endocrinol. 2012 Feb;166(2):159-70. doi: 10.1530/EJE-11-0022. Epub 2011 Sep 19. Review. Erratum in: Eur J Endocrinol. 2012 Mar;166(3):565. Lund, Sørens [corrected to Lund, Søren S].


Effects of high-fat overfeeding on mitochondrial function, glucose and fat metabolism, and adipokine levels in low-birth-weight subjects.

Brøns C, Jacobsen S, Hiscock N, White A, Nilsson E, Dunger D, Astrup A, Quistorff B, Vaag A.

Am J Physiol Endocrinol Metab. 2012 Jan 1;302(1):E43-51. doi: 10.1152/ajpendo.00095.2011. Epub 2011 Sep 13.


Increased lipolysis but diminished gene expression of lipases in subcutaneous adipose tissue of healthy young males with intrauterine growth retardation.

Højbjerre L, Alibegovic AC, Sonne MP, Dela F, Vaag A, Bruun JM, Stallknecht B.

J Appl Physiol (1985). 2011 Dec;111(6):1863-70. doi: 10.1152/japplphysiol.00960.2011. Epub 2011 Sep 8.


Impact of physical inactivity on adipose tissue low-grade inflammation in first-degree relatives of type 2 diabetic patients.

Højbjerre L, Sonne MP, Alibegovic AC, Nielsen NB, Dela F, Vaag A, Bruun JM, Stallknecht B.

Diabetes Care. 2011 Oct;34(10):2265-72. doi: 10.2337/dc11-0631. Epub 2011 Aug 11.


Comparable long-term mortality risk associated with individual sulfonylureas in diabetes patients with heart failure.

Andersson C, Gislason GH, Jørgensen CH, Hansen PR, Vaag A, Sørensen R, Mérie C, Olesen JB, Weeke P, Schmiegelow M, Norgaard ML, Køber L, Torp-Pedersen C.

Diabetes Res Clin Pract. 2011 Oct;94(1):119-25. doi: 10.1016/j.diabres.2011.07.011. Epub 2011 Aug 9.


Pleiotropic effects of GIP on islet function involve osteopontin.

Lyssenko V, Eliasson L, Kotova O, Pilgaard K, Wierup N, Salehi A, Wendt A, Jonsson A, De Marinis YZ, Berglund LM, Taneera J, Balhuizen A, Hansson O, Osmark P, Dunér P, Brøns C, Stancáková A, Kuusisto J, Bugliani M, Saxena R, Ahlqvist E, Kieffer TJ, Tuomi T, Isomaa B, Melander O, Sonestedt E, Orho-Melander M, Nilsson P, Bonetti S, Bonadonna R, Miccoli R, Delprato S, Marchetti P, Madsbad S, Poulsen P, Vaag A, Laakso M, Gomez MF, Groop L.

Diabetes. 2011 Sep;60(9):2424-33. doi: 10.2337/db10-1532. Epub 2011 Aug 1. Erratum in: Diabetes. 2012 Jun;61(6):1648.


Differential nongenetic impact of birth weight versus third-trimester growth velocity on glucose metabolism and magnetic resonance imaging abdominal obesity in young healthy twins.

Pilgaard K, Hammershaimb Mosbech T, Grunnet L, Eiberg H, Van Hall G, Fallentin E, Larsen T, Larsen R, Poulsen P, Vaag A.

J Clin Endocrinol Metab. 2011 Sep;96(9):2835-43. doi: 10.1210/jc.2011-0577. Epub 2011 Jul 6.


Endothelial function after 10 days of bed rest in individuals at risk for type 2 diabetes and cardiovascular disease.

Sonne MP, Højbjerre L, Alibegovic AC, Nielsen LB, Stallknecht B, Vaag AA, Dela F.

Exp Physiol. 2011 Oct;96(10):1000-9. doi: 10.1113/expphysiol.2011.058511. Epub 2011 Jul 1.


Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes mellitus.

Hemmingsen B, Lund SS, Gluud C, Vaag A, Almdal T, Hemmingsen C, Wetterslev J.

Cochrane Database Syst Rev. 2011 Jun 15;(6):CD008143. doi: 10.1002/14651858.CD008143.pub2. Review. Update in: Cochrane Database Syst Rev. 2013;11:CD008143.


Impact of birth weight and early infant weight gain on insulin resistance and associated cardiovascular risk factors in adolescence.

Fabricius-Bjerre S, Jensen RB, Færch K, Larsen T, Mølgaard C, Michaelsen KF, Vaag A, Greisen G.

PLoS One. 2011;6(6):e20595. doi: 10.1371/journal.pone.0020595. Epub 2011 Jun 2.


Mortality and cardiovascular risk associated with different insulin secretagogues compared with metformin in type 2 diabetes, with or without a previous myocardial infarction: a nationwide study.

Schramm TK, Gislason GH, Vaag A, Rasmussen JN, Folke F, Hansen ML, Fosbøl EL, Køber L, Norgaard ML, Madsen M, Hansen PR, Torp-Pedersen C.

Eur Heart J. 2011 Aug;32(15):1900-8. doi: 10.1093/eurheartj/ehr077. Epub 2011 Apr 6. Erratum in: Eur Heart J. 2012 May;33(10):1183.


The expression of myosin heavy chain (MHC) genes in human skeletal muscle is related to metabolic characteristics involved in the pathogenesis of type 2 diabetes.

Olsson AH, Rönn T, Elgzyri T, Hansson O, Eriksson KF, Groop L, Vaag A, Poulsen P, Ling C.

Mol Genet Metab. 2011 Jul;103(3):275-81. doi: 10.1016/j.ymgme.2011.03.017. Epub 2011 Mar 21.


Genetic and environmental influences on oxidative damage assessed in elderly Danish twins.

Broedbaek K, Ribel-Madsen R, Henriksen T, Weimann A, Petersen M, Andersen JT, Afzal S, Hjelvang B, Roberts LJ 2nd, Vaag A, Poulsen P, Poulsen HE.

Free Radic Biol Med. 2011 Jun 1;50(11):1488-91. doi: 10.1016/j.freeradbiomed.2011.02.017. Epub 2011 Feb 24.


Temporal trends in the initiation of glucose-lowering medications after a first-time myocardial infarction - a nationwide study between 1997 and 2006.

Norgaard ML, Andersson C, Hansen PR, Andersen SS, Vaag A, Schramm TK, Folke F, Køber L, Torp-Pedersen C, Gislason GH.

Cardiovasc Diabetol. 2011 Jan 19;10:5. doi: 10.1186/1475-2840-10-5.


Metabolic inflexibility is a common feature of impaired fasting glycaemia and impaired glucose tolerance.

Færch K, Vaag A.

Acta Diabetol. 2011 Dec;48(4):349-353. doi: 10.1007/s00592-010-0245-x. Epub 2011 Jan 5.


Improved glycemic control induced by both metformin and repaglinide is associated with a reduction in blood levels of 3-deoxyglucosone in nonobese patients with type 2 diabetes.

Engelen L, Lund SS, Ferreira I, Tarnow L, Parving HH, Gram J, Winther K, Pedersen O, Teerlink T, Barto R, Stehouwer CD, Vaag AA, Schalkwijk CG.

Eur J Endocrinol. 2011 Mar;164(3):371-9. doi: 10.1530/EJE-10-0851. Epub 2011 Jan 4.


A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes.

Koeck T, Olsson AH, Nitert MD, Sharoyko VV, Ladenvall C, Kotova O, Reiling E, Rönn T, Parikh H, Taneera J, Eriksson JG, Metodiev MD, Larsson NG, Balhuizen A, Luthman H, Stančáková A, Kuusisto J, Laakso M, Poulsen P, Vaag A, Groop L, Lyssenko V, Mulder H, Ling C.

Cell Metab. 2011 Jan 5;13(1):80-91. doi: 10.1016/j.cmet.2010.12.007.


Retinol-binding protein 4 in young men with low versus normal birth weight: physiological response to short-term overfeeding.

Ribel-Madsen R, Brøns C, Friedrichsen M, Poulsen P, Vaag A.

Obesity (Silver Spring). 2011 Jun;19(6):1304-6. doi: 10.1038/oby.2010.311. Epub 2010 Dec 16.


Do gene variants influencing adult adiposity affect birth weight? A population-based study of 24 loci in 4,744 Danish individuals.

Andersson EA, Pilgaard K, Pisinger C, Harder MN, Grarup N, Færch K, Sandholt C, Poulsen P, Witte DR, Jørgensen T, Vaag A, Pedersen O, Hansen T.

PLoS One. 2010 Dec 1;5(12):e14190. doi: 10.1371/journal.pone.0014190.


Agreement between fasting and postprandial LDL cholesterol measured with 3 methods in patients with type 2 diabetes mellitus.

Lund SS, Petersen M, Frandsen M, Smidt UM, Parving HH, Vaag AA, Jensen T.

Clin Chem. 2011 Feb;57(2):298-308. doi: 10.1373/clinchem.2009.133868. Epub 2010 Oct 14. Erratum in: Clin Chem. 2011 May;57(5):782.


Treatment with a proton pump inhibitor improves glycaemic control in type 2 diabetic patients - a retrospective analysis.

Hove KD, Færch K, Bödvarsdóttir TB, Karlsen AE, Petersen JS, Vaag A.

Diabetes Res Clin Pract. 2010 Dec;90(3):e72-4. doi: 10.1016/j.diabres.2010.09.007.


The FOXO3A rs2802292 G-allele associates with improved peripheral and hepatic insulin sensitivity and increased skeletal muscle-FOXO3A mRNA expression in twins.

Banasik K, Ribel-Madsen R, Gjesing AP, Wegner L, Andersson A, Poulsen P, Borglykke A, Witte DR, Pedersen O, Hansen T, Vaag A.

J Clin Endocrinol Metab. 2011 Jan;96(1):E119-24. doi: 10.1210/jc.2010-0881. Epub 2010 Sep 29.


Impact of size at birth and prematurity on adult anthropometry in 4744 middle-aged Danes - The Inter99 study.

Pilgaard K, Færch K, Poulsen P, Larsen C, Andersson EA, Pisinger C, Toft U, Aadahl M, Pedersen O, Hansen T, Borch-Johnsen K, Vaag A, Jørgensen T.

J Dev Orig Health Dis. 2010 Oct;1(5):319-28. doi: 10.1017/S2040174410000413.


Heart failure severity, as determined by loop diuretic dosages, predicts the risk of developing diabetes after myocardial infarction: a nationwide cohort study.

Andersson C, Norgaard ML, Hansen PR, Fosbøl EL, Schmiegelow M, Weeke P, Olesen JB, Raunsø J, Jørgensen CH, Vaag A, Køber L, Torp-Pedersen C, Gislason GH.

Eur J Heart Fail. 2010 Dec;12(12):1333-8. doi: 10.1093/eurjhf/hfq160. Epub 2010 Sep 23.


Low birthweight and premature birth are both associated with type 2 diabetes in a random sample of middle-aged Danes.

Pilgaard K, Færch K, Carstensen B, Poulsen P, Pisinger C, Pedersen O, Witte DR, Hansen T, Jørgensen T, Vaag A.

Diabetologia. 2010 Dec;53(12):2526-30. doi: 10.1007/s00125-010-1917-3. Epub 2010 Sep 22.


Effects of oral glucose-lowering drugs on long term outcomes in patients with diabetes mellitus following myocardial infarction not treated with emergent percutaneous coronary intervention--a retrospective nationwide cohort study.

Jørgensen CH, Gislason GH, Andersson C, Ahlehoff O, Charlot M, Schramm TK, Vaag A, Abildstrøm SZ, Torp-Pedersen C, Hansen PR.

Cardiovasc Diabetol. 2010 Sep 16;9:54. doi: 10.1186/1475-2840-9-54.


Metformin treatment is associated with a low risk of mortality in diabetic patients with heart failure: a retrospective nationwide cohort study.

Andersson C, Olesen JB, Hansen PR, Weeke P, Norgaard ML, Jørgensen CH, Lange T, Abildstrøm SZ, Schramm TK, Vaag A, Køber L, Torp-Pedersen C, Gislason GH.

Diabetologia. 2010 Dec;53(12):2546-53. doi: 10.1007/s00125-010-1906-6. Epub 2010 Sep 14.


[Reporting adverse reactions and events in randomised clinical trials].

Hemmingsen B, Støy L, Wetterslev J, Tarnow L, Friis KB, Christensen LL, Sales N, Gluud C; Copenhagen Insulin Metformin Therapy Trial-Gruppen.

Ugeskr Laeger. 2010 Aug 30;172(35):2381-4. Danish.


Impact of physical inactivity on subcutaneous adipose tissue metabolism in healthy young male offspring of patients with type 2 diabetes.

Højbjerre L, Sonne MP, Alibegovic AC, Dela F, Vaag A, Meldgaard JB, Christensen KB, Stallknecht B.

Diabetes. 2010 Nov;59(11):2790-8. doi: 10.2337/db10-0320. Epub 2010 Sep 7.


Insulin resistance induced by physical inactivity is associated with multiple transcriptional changes in skeletal muscle in young men.

Alibegovic AC, Sonne MP, Højbjerre L, Bork-Jensen J, Jacobsen S, Nilsson E, Faerch K, Hiscock N, Mortensen B, Friedrichsen M, Stallknecht B, Dela F, Vaag A.

Am J Physiol Endocrinol Metab. 2010 Nov;299(5):E752-63. doi: 10.1152/ajpendo.00590.2009. Epub 2010 Aug 24.


Metformin is associated with improved left ventricular diastolic function measured by tissue Doppler imaging in patients with diabetes.

Andersson C, Søgaard P, Hoffmann S, Hansen PR, Vaag A, Major-Pedersen A, Hansen TF, Bech J, Køber L, Torp-Pedersen C, Gislason GH.

Eur J Endocrinol. 2010 Oct;163(4):593-9. doi: 10.1530/EJE-10-0624. Epub 2010 Aug 2.


Treatment with a proton pump inhibitor improves glycaemic control in Psammomys obesus, a model of type 2 diabetes.

Bödvarsdóttir TB, Hove KD, Gotfredsen CF, Pridal L, Vaag A, Karlsen AE, Petersen JS.

Diabetologia. 2010 Oct;53(10):2220-3. doi: 10.1007/s00125-010-1825-6. Epub 2010 Jun 30.


Differential aetiology and impact of phosphoinositide 3-kinase (PI3K) and Akt signalling in skeletal muscle on in vivo insulin action.

Friedrichsen M, Poulsen P, Richter EA, Hansen BF, Birk JB, Ribel-Madsen R, Stender-Petersen K, Nilsson E, Beck-Nielsen H, Vaag A, Wojtaszewski JF.

Diabetologia. 2010 Sep;53(9):1998-2007. doi: 10.1007/s00125-010-1795-8. Epub 2010 May 29.


LMNA rs4641 and the muscle lamin A and C isoforms in twins--metabolic implications and transcriptional regulation.

Wegner L, Anthonsen S, Bork-Jensen J, Dalgaard L, Hansen T, Pedersen O, Poulsen P, Vaag A.

J Clin Endocrinol Metab. 2010 Aug;95(8):3884-92. doi: 10.1210/jc.2009-2675. Epub 2010 May 25.


Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight.

Andersson EA, Pilgaard K, Pisinger C, Harder MN, Grarup N, Faerch K, Poulsen P, Witte DR, Jørgensen T, Vaag A, Hansen T, Pedersen O.

Diabetologia. 2010 Sep;53(9):1908-16. doi: 10.1007/s00125-010-1790-0. Epub 2010 May 20.


Changes in short- and long-term cardiovascular risk of incident diabetes and incident myocardial infarction--a nationwide study.

Norgaard ML, Andersen SS, Schramm TK, Folke F, Jørgensen CH, Hansen ML, Andersson C, Bretler DM, Vaag A, Køber L, Torp-Pedersen C, Gislason GH.

Diabetologia. 2010 Aug;53(8):1612-9. doi: 10.1007/s00125-010-1783-z. Epub 2010 May 9.


Deoxyribonucleic acid methylation and gene expression of PPARGC1A in human muscle is influenced by high-fat overfeeding in a birth-weight-dependent manner.

Brøns C, Jacobsen S, Nilsson E, Rönn T, Jensen CB, Storgaard H, Poulsen P, Groop L, Ling C, Astrup A, Vaag A.

J Clin Endocrinol Metab. 2010 Jun;95(6):3048-56. doi: 10.1210/jc.2009-2413. Epub 2010 Apr 21.


Insulin regimens in type 2 diabetes.

Lund SS, Vaag AA.

N Engl J Med. 2010 Mar 11;362(10):959; author reply 960. doi: 10.1056/NEJMc0911551. No abstract available.


Sex differences in glucose levels: a consequence of physiology or methodological convenience? The Inter99 study.

Faerch K, Borch-Johnsen K, Vaag A, Jørgensen T, Witte DR.

Diabetologia. 2010 May;53(5):858-65. doi: 10.1007/s00125-010-1673-4. Epub 2010 Feb 25.


Effect of 10 days of bedrest on metabolic and vascular insulin action: a study in individuals at risk for type 2 diabetes.

Sonne MP, Alibegovic AC, Højbjerre L, Vaag A, Stallknecht B, Dela F.

J Appl Physiol (1985). 2010 Apr;108(4):830-7. doi: 10.1152/japplphysiol.00545.2009. Epub 2010 Jan 28.


The T-allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest.

Alibegovic AC, Sonne MP, Højbjerre L, Hansen T, Pedersen O, van Hall G, Holst JJ, Stallknecht B, Dela F, Vaag A.

Diabetes. 2010 Apr;59(4):836-43. doi: 10.2337/db09-0918. Epub 2010 Jan 27.


Impact of rs361072 in the phosphoinositide 3-kinase p110beta gene on whole-body glucose metabolism and subunit protein expression in skeletal muscle.

Ribel-Madsen R, Poulsen P, Holmkvist J, Mortensen B, Grarup N, Friedrichsen M, Jørgensen T, Lauritzen T, Wojtaszewski JF, Pedersen O, Hansen T, Vaag A.

Diabetes. 2010 Apr;59(4):1108-12. doi: 10.2337/db09-1359. Epub 2010 Jan 27.


The disposition index: adjustment for peripheral vs. hepatic insulin sensitivity?

Faerch K, Brøns C, Alibegovic AC, Vaag A.

J Physiol. 2010 Mar 1;588(Pt 5):759-64. doi: 10.1113/jphysiol.2009.184028. Epub 2010 Jan 25. Review.


Functional variant disrupts insulin induction of USF1: mechanism for USF1-associated dyslipidemias.

Naukkarinen J, Nilsson E, Koistinen HA, Söderlund S, Lyssenko V, Vaag A, Poulsen P, Groop L, Taskinen MR, Peltonen L.

Circ Cardiovasc Genet. 2009 Oct;2(5):522-9. doi: 10.1161/CIRCGENETICS.108.840421. Epub 2009 Jun 12.


Desaturation of excess intramyocellular triacylglycerol in obesity: implications for glycemic control.

Haugaard SB, Madsbad S, Mu H, Vaag A.

Int J Obes (Lond). 2010 Mar;34(3):500-10. doi: 10.1038/ijo.2009.264. Epub 2009 Dec 22.


Increased rate of whole body lipolysis before and after 9 days of bed rest in healthy young men born with low birth weight.

Alibegovic AC, Højbjerre L, Sonne MP, van Hall G, Alsted TJ, Kiens B, Stallknecht B, Dela F, Vaag A.

Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E555-64. doi: 10.1152/ajpendo.00223.2009. Epub 2009 Dec 8.


Adding liraglutide to oral antidiabetic drug therapy: onset of treatment effects over time.

Gallwitz B, Vaag A, Falahati A, Madsbad S.

Int J Clin Pract. 2010 Jan;64(2):267-76. doi: 10.1111/j.1742-1241.2009.02265.x. Epub 2009 Nov 17.


Combining insulin with metformin or an insulin secretagogue in non-obese patients with type 2 diabetes: 12 month, randomised, double blind trial.

Lund SS, Tarnow L, Frandsen M, Nielsen BB, Hansen BV, Pedersen O, Parving HH, Vaag AA.

BMJ. 2009 Nov 9;339:b4324. doi: 10.1136/bmj.b4324.


Dissociation between skeletal muscle inhibitor-kappaB kinase/nuclear factor-kappaB pathway activity and insulin sensitivity in nondiabetic twins.

Friedrichsen M, Ribel-Madsen R, Wojtaszewski J, Grunnet L, Richter EA, Billestrup N, Ploug T, Vaag A, Poulsen P.

J Clin Endocrinol Metab. 2010 Jan;95(1):414-21. doi: 10.1210/jc.2009-1147. Epub 2009 Oct 29.


Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.

Rung J, Cauchi S, Albrechtsen A, Shen L, Rocheleau G, Cavalcanti-Proença C, Bacot F, Balkau B, Belisle A, Borch-Johnsen K, Charpentier G, Dina C, Durand E, Elliott P, Hadjadj S, Järvelin MR, Laitinen J, Lauritzen T, Marre M, Mazur A, Meyre D, Montpetit A, Pisinger C, Posner B, Poulsen P, Pouta A, Prentki M, Ribel-Madsen R, Ruokonen A, Sandbaek A, Serre D, Tichet J, Vaxillaire M, Wojtaszewski JF, Vaag A, Hansen T, Polychronakos C, Pedersen O, Froguel P, Sladek R.

Nat Genet. 2009 Oct;41(10):1110-5. doi: 10.1038/ng.443. Epub 2009 Sep 6. Erratum in: Nat Genet. 2009 Oct;41(10):1156.


Diminished insulin-mediated forearm blood flow and muscle glucose uptake in young men with low birth weight.

Sonne MP, Højbjerre L, Alibegovic AC, Vaag A, Stallknecht B, Dela F.

J Vasc Res. 2010;47(2):139-47. doi: 10.1159/000235968. Epub 2009 Sep 4.


Impact of 9 days of bed rest on hepatic and peripheral insulin action, insulin secretion, and whole-body lipolysis in healthy young male offspring of patients with type 2 diabetes.

Alibegovic AC, Højbjerre L, Sonne MP, van Hall G, Stallknecht B, Dela F, Vaag A.

Diabetes. 2009 Dec;58(12):2749-56. doi: 10.2337/db09-0369. Epub 2009 Aug 31.


Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial.

Russell-Jones D, Vaag A, Schmitz O, Sethi BK, Lalic N, Antic S, Zdravkovic M, Ravn GM, Simó R; Liraglutide Effect and Action in Diabetes 5 (LEAD-5) met+SU Study Group.

Diabetologia. 2009 Oct;52(10):2046-55. doi: 10.1007/s00125-009-1472-y. Epub 2009 Aug 14.


Skeletal muscle lipotoxicity in insulin resistance and type 2 diabetes.

Brøns C, Vaag A.

J Physiol. 2009 Aug 15;587(Pt 16):3977-8. doi: 10.1113/jphysiol.2009.177758. No abstract available.


Skeletal muscle structural lipids improve during weight-maintenance after a very low calorie dietary intervention.

Haugaard SB, Vaag A, Mu H, Madsbad S.

Lipids Health Dis. 2009 Aug 13;8:34. doi: 10.1186/1476-511X-8-34.


Genetic and metabolic effects on skeletal muscle AMPK in young and older twins.

Mortensen B, Poulsen P, Wegner L, Stender-Petersen KL, Ribel-Madsen R, Friedrichsen M, Birk JB, Vaag A, Wojtaszewski JF.

Am J Physiol Endocrinol Metab. 2009 Oct;297(4):E956-64. doi: 10.1152/ajpendo.00058.2009. Epub 2009 Aug 11.


A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads.

Rose CS, Grarup N, Krarup NT, Poulsen P, Wegner L, Nielsen T, Banasik K, Faerch K, Andersen G, Albrechtsen A, Borch-Johnsen K, Clausen JO, Jørgensen T, Vaag A, Pedersen O, Hansen T.

Diabetologia. 2009 Oct;52(10):2122-9. doi: 10.1007/s00125-009-1463-z. Epub 2009 Aug 8.


Gene expression in skeletal muscle biopsies from people with type 2 diabetes and relatives: differential regulation of insulin signaling pathways.

Palsgaard J, Brøns C, Friedrichsen M, Dominguez H, Jensen M, Storgaard H, Spohr C, Torp-Pedersen C, Borup R, De Meyts P, Vaag A.

PLoS One. 2009 Aug 11;4(8):e6575. doi: 10.1371/journal.pone.0006575.


Pathophysiology and aetiology of impaired fasting glycaemia and impaired glucose tolerance: does it matter for prevention and treatment of type 2 diabetes?

Faerch K, Borch-Johnsen K, Holst JJ, Vaag A.

Diabetologia. 2009 Sep;52(9):1714-23. doi: 10.1007/s00125-009-1443-3. Epub 2009 Jul 10.


Regulation and function of FTO mRNA expression in human skeletal muscle and subcutaneous adipose tissue.

Grunnet LG, Nilsson E, Ling C, Hansen T, Pedersen O, Groop L, Vaag A, Poulsen P.

Diabetes. 2009 Oct;58(10):2402-8. doi: 10.2337/db09-0205. Epub 2009 Jul 8.


Effect of adjunct metformin treatment on levels of plasma lipids in patients with type 1 diabetes.

Lund SS, Tarnow L, Astrup AS, Hovind P, Jacobsen PK, Alibegovic AC, Parving I, Pietraszek L, Frandsen M, Rossing P, Parving HH, Vaag AA.

Diabetes Obes Metab. 2009 Oct;11(10):966-77. doi: 10.1111/j.1463-1326.2009.01079.x. Epub 2009 Jun 25.


Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes.

Larsen CM, Faulenbach M, Vaag A, Ehses JA, Donath MY, Mandrup-Poulsen T.

Diabetes Care. 2009 Sep;32(9):1663-8. doi: 10.2337/dc09-0533. Epub 2009 Jun 19.


IL-1 receptor antagonism and muscle gene expression in patients with type 2 diabetes.

Berchtold LA, Larsen CM, Vaag A, Faulenbach M, Workman CT, Kruhøffer M, Donath M, Mandrup-Poulsen T.

Eur Cytokine Netw. 2009 Jun;20(2):81-7. doi: 10.1684/ecn.2009.0152.

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