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Items: 1 to 20 of 775

1.

[Gene expression of down-regulation of lysyl oxidases family in keratoconus corneal fibroblasts induced by combination of mechanical stretching and prostaglandin E 2].

Lan W, Li X, Chen W, Liu C, Rong S, He R.

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2017 Apr 1;34(2):239-245. doi: 10.7507/1001-5515.201608052. Chinese.

PMID:
29745580
2.

Prostaglandin E2 Inhibits Group 2 Innate Lymphoid Cell Activation and Allergic Airway Inflammation Through E-Prostanoid 4-Cyclic Adenosine Monophosphate Signaling.

Zhou Y, Wang W, Zhao C, Wang Y, Wu H, Sun X, Guan Y, Zhang Y.

Front Immunol. 2018 Mar 12;9:501. doi: 10.3389/fimmu.2018.00501. eCollection 2018.

3.

Alleviating CYP and hERG liabilities by structure optimization of dihydrofuran-fused tricyclic benzo[d]imidazole series - Potent, selective and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-2.

Muthukaman N, Deshmukh S, Tambe M, Pisal D, Tondlekar S, Shaikh M, Sarode N, Kattige VG, Sawant P, Pisat M, Karande V, Honnegowda S, Kulkarni A, Behera D, Jadhav SB, Sangana RR, Gudi GS, Khairatkar-Joshi N, Gharat LA.

Bioorg Med Chem Lett. 2018 Apr 15;28(7):1211-1218. doi: 10.1016/j.bmcl.2018.02.048. Epub 2018 Feb 28.

PMID:
29519738
4.

Identification and Mitigation of Reactive Metabolites of 2-Aminoimidazole-Containing Microsomal Prostaglandin E Synthase-1 Inhibitors Terminated Due to Clinical Drug-Induced Liver Injury.

Norman BH, Fisher MJ, Schiffler MA, Kuklish SL, Hughes NE, Czeskis BA, Cassidy KC, Abraham TL, Alberts JJ, Luffer-Atlas D.

J Med Chem. 2018 Mar 8;61(5):2041-2051. doi: 10.1021/acs.jmedchem.7b01806. Epub 2018 Feb 15.

PMID:
29425457
5.

Corrigendum to ' Rosuvastatin inhibits pressure-induced fibrotic responses via the expression regulation of prostacyclin and prostaglandin E 2 in rat renal tubular cells.': [European Journal of Pharmacology 700 (2013) 65-73].

Chen CH, Cheng CY, Chen YC, Sue YM, Hsu YH, Tsai WL, Chen TH.

Eur J Pharmacol. 2018 Jan 15;819:290. doi: 10.1016/j.ejphar.2017.12.044. No abstract available.

PMID:
29325908
7.

Prostaglandin E2 restrains human Treg cell differentiation via E prostanoid receptor 2-protein kinase A signaling.

Li H, Chen HY, Liu WX, Jia XX, Zhang JG, Ma CL, Zhang XJ, Yu F, Cong B.

Immunol Lett. 2017 Nov;191:63-72. doi: 10.1016/j.imlet.2017.09.009. Epub 2017 Sep 28.

PMID:
28963072
8.

Endogenous prostaglandin E2 amplifies IL-33 production by macrophages through an E prostanoid (EP)2/EP4-cAMP-EPAC-dependent pathway.

Samuchiwal SK, Balestrieri B, Raff H, Boyce JA.

J Biol Chem. 2017 May 19;292(20):8195-8206. doi: 10.1074/jbc.M116.769422. Epub 2017 Mar 24.

9.

Host knockout of E-prostanoid 2 receptors reduces tumor growth and causes major alterations of gene expression in prostaglandin E2-producing tumors.

Asting AG, Iresjö BM, Nilsberth C, Smedh U, Lundholm K.

Oncol Lett. 2017 Jan;13(1):476-482. doi: 10.3892/ol.2016.5448. Epub 2016 Nov 30.

10.

Bone marrow stromal cells attenuate LPS-induced mouse acute liver injury via the prostaglandin E 2-dependent repression of the NLRP3 inflammasome in Kupffer cells.

Miao CM, Jiang XW, He K, Li PZ, Liu ZJ, Cao D, Ou ZB, Gong JP, Liu CA, Cheng Y.

Immunol Lett. 2016 Nov;179:102-113. doi: 10.1016/j.imlet.2016.09.009. Epub 2016 Sep 22.

PMID:
27666012
11.

Linking microsomal prostaglandin E Synthase-1/PGE-2 pathway with miR-15a and -186 expression: Novel mechanism of VEGF modulation in prostate cancer.

Terzuoli E, Donnini S, Finetti F, Nesi G, Villari D, Hanaka H, Radmark O, Giachetti A, Ziche M.

Oncotarget. 2016 Jul 12;7(28):44350-44364. doi: 10.18632/oncotarget.10051.

12.

Importance of adipocyte cyclooxygenase-2 and prostaglandin E2-prostaglandin E receptor 3 signaling in the development of obesity-induced adipose tissue inflammation and insulin resistance.

Chan PC, Hsiao FC, Chang HM, Wabitsch M, Hsieh PS.

FASEB J. 2016 Jun;30(6):2282-97. doi: 10.1096/fj.201500127. Epub 2016 Mar 1.

PMID:
26932930
13.

CCR7 Receptor Expression in Mono-MAC-1 Cells: Modulation by Liver X Receptor α Activation and Prostaglandin E 2.

Tanné B, Bernier S, Dumais N.

Int J Inflam. 2015;2015:201571. doi: 10.1155/2015/201571. Epub 2015 Dec 6.

14.

Anti-inflammatory effects of the butanolic fraction of Byrsonima verbascifolia leaves: Mechanisms involving inhibition of tumor necrosis factor alpha, prostaglandin E(2) production and migration of polymorphonuclear leucocyte in vivo experimentation.

Saldanha AA, de Siqueira JM, Castro AH, de Azambuja Ribeiro RI, de Oliveira FM, de Oliveira Lopes D, Pinto FC, Silva DB, Soares AC.

Int Immunopharmacol. 2016 Feb;31:123-31. doi: 10.1016/j.intimp.2015.12.031. Epub 2015 Dec 24.

PMID:
26724477
15.

The Role of Prostaglandin E(2) in Tumor-Associated Immunosuppression.

Wang D, DuBois RN.

Trends Mol Med. 2016 Jan;22(1):1-3. doi: 10.1016/j.molmed.2015.11.003. Epub 2015 Dec 17.

16.

Tryptophan-2,3-dioxygenase is regulated by prostaglandin E2 in malignant glioma via a positive signaling loop involving prostaglandin E receptor-4.

Ochs K, Ott M, Rauschenbach KJ, Deumelandt K, Sahm F, Opitz CA, von Deimling A, Wick W, Platten M.

J Neurochem. 2015 Dec 27. doi: 10.1111/jnc.13503. [Epub ahead of print]

17.

Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors.

Schiffler MA, Antonysamy S, Bhattachar SN, Campanale KM, Chandrasekhar S, Condon B, Desai PV, Fisher MJ, Groshong C, Harvey A, Hickey MJ, Hughes NE, Jones SA, Kim EJ, Kuklish SL, Luz JG, Norman BH, Rathmell RE, Rizzo JR, Seng TW, Thibodeaux SJ, Woods TA, York JS, Yu XP.

J Med Chem. 2016 Jan 14;59(1):194-205. doi: 10.1021/acs.jmedchem.5b01249. Epub 2015 Dec 18.

PMID:
26653180
18.

Genetic-deletion of Cyclooxygenase-2 Downstream Prostacyclin Synthase Suppresses Inflammatory Reactions but Facilitates Carcinogenesis, unlike Deletion of Microsomal Prostaglandin E Synthase-1.

Sasaki Y, Kamiyama S, Kamiyama A, Matsumoto K, Akatsu M, Nakatani Y, Kuwata H, Ishikawa Y, Ishii T, Yokoyama C, Hara S.

Sci Rep. 2015 Nov 27;5:17376. doi: 10.1038/srep17376.

19.

Positive correlation between patency and mRNA levels for cyclooxygenase-2 and prostaglandin E synthase in the uterine cervix of bitches with pyometra.

Tamada H, Adachi N, Kawate N, Inaba T, Hatoya S, Sawada T.

J Vet Med Sci. 2016 Mar;78(3):525-8. doi: 10.1292/jvms.15-0520. Epub 2015 Nov 22.

20.

Statins Modulate Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1 in Human Hepatic Myofibroblasts.

Mouawad CA, Mrad MF, El-Achkar GA, Abdul-Sater A, Nemer GM, Creminon C, Lotersztajn S, Habib A.

J Cell Biochem. 2016 May;117(5):1176-86. doi: 10.1002/jcb.25401. Epub 2015 Oct 18.

PMID:
26477987

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