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Zh Vyssh Nerv Deiat Im I P Pavlova. 1998 Jul-Aug;48(4):654-63.

[The persistent negative potential provoked in different structures of the rat brain by a single wave of spreading cortical depression].

[Article in Russian]

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Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.


The persistent negative potential (PNP) developed after a single wave of cortical spreading depression (SD) in the cortex, hippocampus, thalamus, and caudate nucleus. The PNP lasted for about 3-4 hours, its amplitude was 6-7 mV in the ipsilateral and 3-4 mV in the contralateral structures. After development of bilateral primary cortical SD waves the amplitudes of the respective PNP were summed up and reached 9-11 mV. However, after the repeated waves of cortical SD produced with 15-30-min intervals, the PNP level remained unchanged. We think that the PNP is an electrographic manifestation of the well known persistent vasoconstriction after a single wave of cortical SD. It seems to be related with reticular activation due to functional decortication.

[Indexed for MEDLINE]

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