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Alzheimers Dement (N Y). 2016 Sep 15;2(4):241-249. doi: 10.1016/j.trci.2016.08.004. eCollection 2016 Nov.

Mnemonic strategy training of the elderly at risk for dementia enhances integration of information processing via cross-frequency coupling.

Author information

1
Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK.
2
Cardiff University Brain Research Imaging Center (CUBRIC), School of Psychology, Cardiff University, Cardiff, UK.
3
Artificial Intelligence and Information Analysis Laboratory, Department of Informatics, Aristotle University, Thessaloniki, Greece.
4
NeuroInformatics Group, Department of Informatics, Aristotle University, Thessaloniki, Greece.
5
Health-IS Lab, Chair of Information Management, Department of Management, ETH Zurich, Zurich, Switzerland.
6
3rd Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
7
Division of Cognitive and Restorative Neurology, Virtual Reality Medical Center, San Diego, CA, USA.
8
Virtual Reality Medical Institute, Brussels, Belgium.
9
University of St. Gallen, St. Gallen, Switzerland.

Abstract

INTRODUCTION:

We sought to identify whether intensive 10-week mobile health mnemonic strategy training (MST) could shift the resting-state brain network more toward cortical-level integration, which has recently been proven to reflect the reorganization of the brain networks compensating the cognitive decline.

METHODS:

One hundred fifty-eight patients with mild cognitive impairment (MCI) were selected and participated in 10-week training lasting 90 min/d of memory training. They benefited from an initial and a follow-up neuropsychological evaluation and resting-state electroencephalography (EEG).

RESULTS:

At follow-up, MST revealed an extensive significant training effect that changed the network with an increase of synchronization between parietotemporal and frontal areas; frontalθ-parietalα2 causal strengthening as part of top-down inhibitory control; enhancement of sensorimotor connections in β band; and a general increase of cortical-level integration. More precisely, MST induced gain as an increase of the global cost efficiency (GCE) of the whole cortical network and a neuropsychological performance improvement, which was correlated with it (r = 0.32, P = .0001). The present study unfolded intervention changes based on EEG source activity via novel neuroinformatic tools for revealing intrinsic coupling modes in both amplitude-phase representations and in the mixed spectrospatiotemporal domain.

DISCUSSION:

Further work should identify whether the GCE enhancement of the functional cortical brain networks is a compensation mechanism to the brain network dysfunction or a more permanent neuroplasticity effect.

KEYWORDS:

Augmented reality; Brain plasticity; Cognitive function; Cognitive training; Intrinsic coupling modes; Older adults; Physical activity

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